GB1198551A - New Nicotinuric Acid Derivatives - Google Patents

New Nicotinuric Acid Derivatives

Info

Publication number
GB1198551A
GB1198551A GB3298868A GB3298868A GB1198551A GB 1198551 A GB1198551 A GB 1198551A GB 3298868 A GB3298868 A GB 3298868A GB 3298868 A GB3298868 A GB 3298868A GB 1198551 A GB1198551 A GB 1198551A
Authority
GB
United Kingdom
Prior art keywords
formula
acid
nicotinuric
salt
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3298868A
Inventor
Charles Hoffman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNION PHARMA SCIENT APPL
UPSA SAS
Original Assignee
UNION PHARMA SCIENT APPL
UPSA SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UNION PHARMA SCIENT APPL, UPSA SAS filed Critical UNION PHARMA SCIENT APPL
Priority to BE726551D priority Critical patent/BE726551A/xx
Priority to US790477A priority patent/US3538106A/en
Priority to FR6900427A priority patent/FR2000504A1/fr
Priority to SE00691/69A priority patent/SE351211B/xx
Priority to NO00214/69A priority patent/NO126738B/no
Priority to CH84969A priority patent/CH495359A/en
Priority to NL6900954.A priority patent/NL159970C/en
Priority to DE1902694A priority patent/DE1902694C3/en
Priority to DK32269AA priority patent/DK125592B/en
Priority to AT00643/69A priority patent/AT287713B/en
Publication of GB1198551A publication Critical patent/GB1198551A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,198,551. Phenylamino - nicotinuric acid compounds. LABORATOIRES U.P.S.A. 22 Jan., 1969 [22 Jan., 1968; 10 July, 1968], Nos. 3273/68 and 32988/68. Heading C2C. Novel nicotinuric acid derivatives of the formula and their non-toxic, pharmaceutically acceptable salts, esters and amides, wherein R<SP>1</SP> is H, CH 3 or C 2 H 5 , R<SP>11</SP> is H, CH 3 , C 2 H 5 or CH 3 SCH 2 - CH 2 , and R 1 and R 2 may be identical or different and each represents H, halogen, CH 3 , C 2 H 5 , CH 3 O, C 2 H 5 O or trihalogenomethyl, especially CF 3 , are obtained by contacting an acid halide of the formula in which Hal represents a halogen atom, either (a) with an alkali metal salt of a glycine derivative of formula in which M is alkali metal, in aqueous medium, and converting the resulting salt to the free acid by acidification, or (b) with an alkyl ester of glycine of formula in which R 3 is CH 3 or C 2 H 5 , and saponifying the resulting ester in alkaline medium to yield the desired acid. Pharmaceutical compositions, useful as anti-inflammation, antalgic and fibrinolytic agents, comprise a derivative of nicotinuric acid of Formula (I) above, or salt, ester or amide thereof, and a non-toxic pharmaceutically acceptable carrier or vehicle, exemplified in the form of gelatin-coated pills, suppositories, ointment and aqueous solution.
GB3298868A 1968-01-22 1968-01-22 New Nicotinuric Acid Derivatives Expired GB1198551A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
BE726551D BE726551A (en) 1968-01-22 1969-01-07
US790477A US3538106A (en) 1968-01-22 1969-01-10 2-(trihalogenoanilino)-nicotinuric acid,the corresponding glycinates and derivatives thereof
FR6900427A FR2000504A1 (en) 1968-01-22 1969-01-14
SE00691/69A SE351211B (en) 1968-01-22 1969-01-20
NO00214/69A NO126738B (en) 1968-01-22 1969-01-21
CH84969A CH495359A (en) 1968-01-22 1969-01-21 Process for preparing nicotinuric acid derivatives
NL6900954.A NL159970C (en) 1968-01-22 1969-01-21 PROCESS FOR THE PREPARATION OF MEDICINAL PRODUCTS WITH ANTI-INFLAMMATORY AND FIBRINOLYTIC PROPERTIES, SO OBTAINED FORMED MEDICINAL PRODUCTS, AND A PROCESS FOR THE PREPARATION OF SUITABLE ACTIVE SUBSTANCES.
DE1902694A DE1902694C3 (en) 1968-01-22 1969-01-21 2- (3-Trifluoromethylanilino) nicotinic acid amide derivatives, processes for their preparation and pharmaceuticals containing them
DK32269AA DK125592B (en) 1968-01-22 1969-01-21 Analogous process for the preparation of derivatives of nicotinic acid.
AT00643/69A AT287713B (en) 1968-01-22 1969-01-22 PROCESS FOR THE PREPARATION OF NEW NICOTINURIC ACID DERIVATIVES AND THEIR NON-TOXIC, PHARMACEUTICAL SAFETY SALT, LOWER ALKYLESTER AND AMIDE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB327368 1968-01-22

Publications (1)

Publication Number Publication Date
GB1198551A true GB1198551A (en) 1970-07-15

Family

ID=9755225

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3298868A Expired GB1198551A (en) 1968-01-22 1968-01-22 New Nicotinuric Acid Derivatives

Country Status (1)

Country Link
GB (1) GB1198551A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003037869A1 (en) * 2001-11-01 2003-05-08 Janssen Pharmaceutica N.V. Amide derivatives as glycogen synthase kinase 3-beta inhibitors

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003037869A1 (en) * 2001-11-01 2003-05-08 Janssen Pharmaceutica N.V. Amide derivatives as glycogen synthase kinase 3-beta inhibitors
EA007578B1 (en) * 2001-11-01 2006-12-29 Янссен Фармацевтика Н.В. Amide derivatives as glycogen synthase kinase 3-beta inhibitors
US7183288B2 (en) 2001-11-01 2007-02-27 Herwig Josephus Margareta Janssen, legal representative Amide derivatives as glycogen synthase kinase 3-β inhibitors
AU2002363174B2 (en) * 2001-11-01 2008-09-25 Janssen Pharmaceutica N.V. Amide derivatives as glycogen synthase kinase 3-beta inhibitors

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Legal Events

Date Code Title Description
PS Patent sealed
435 Patent endorsed 'licences of right' on the date specified (sect. 35/1949)
PCNP Patent ceased through non-payment of renewal fee
PCNP Patent ceased through non-payment of renewal fee

Free format text: 5193,PAGE 2728

PE20 Patent expired after termination of 20 years