GB1197313A - Dioxolan Substituted Compounds - Google Patents
Dioxolan Substituted CompoundsInfo
- Publication number
- GB1197313A GB1197313A GB19281/67A GB1928167A GB1197313A GB 1197313 A GB1197313 A GB 1197313A GB 19281/67 A GB19281/67 A GB 19281/67A GB 1928167 A GB1928167 A GB 1928167A GB 1197313 A GB1197313 A GB 1197313A
- Authority
- GB
- United Kingdom
- Prior art keywords
- prepared
- dioxolan
- formula
- substituted
- guanidino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical group C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 title abstract 2
- 150000004862 dioxolanes Chemical group 0.000 abstract 2
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 2
- SSZWWUDQMAHNAQ-UHFFFAOYSA-N 3-chloropropane-1,2-diol Chemical compound OCC(O)CCl SSZWWUDQMAHNAQ-UHFFFAOYSA-N 0.000 abstract 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 150000001805 chlorine compounds Chemical class 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000005543 phthalimide group Chemical class 0.000 abstract 1
- 125000005544 phthalimido group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003003 spiro group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1,197,313. Dioxolan-4-ylalkyl compounds. CUTTER LABORATORIES Inc. 26 April, 1967 [3 May, 1966], No. 19281/67. Heading C2C. The invention comprises dioxolanes substituted at the 4-position by the group-A-B where A is C 1-8 alkylene and B is guanidino or substituted guanidino, and their pharmaceutically acceptable acid addition salts; and their preparation by reacting appropriate 1,3-dixoxolan-4-yl-alkylamines with an S-alky or S- aralkyl-thioisoureas. Modifications of this process are described. The dioxolanes may bear further substituents especially at the 2-position amines of formula wherein R 1 = R 2 = H, Me, EC, Pr<SP>n</SP>, Pr<SP>i</SP>, phenyl or cyclohexyl or R 1 and R 2 together with the the intervening carbon atom form a number of specified carbocyclic rings joined spiro to the dioxolane ring, and A is NH 2 are prepared from the corresponding phthalimides where A is phthalimido which in turn are prepared from the corresponding chlorides wherein A is Cl. The last-named compounds are prepared by reacting a ketone of formula R 1 R 2 CO either with 3-chloro-1,2-propanediol or with epichlorohydrin The aforementioned guanidinoalkyl-dioxolaries are said to possess antihypertensive activity and may be made up with acceptable carriers into pharmaceutical compositions suitable for oral or parenteral administration.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54719466A | 1966-05-03 | 1966-05-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1197313A true GB1197313A (en) | 1970-07-01 |
Family
ID=24183703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB19281/67A Expired GB1197313A (en) | 1966-05-03 | 1967-04-26 | Dioxolan Substituted Compounds |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE697590A (en) |
| DE (1) | DE1593797C3 (en) |
| FR (1) | FR6719M (en) |
| GB (1) | GB1197313A (en) |
| IL (1) | IL28815A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014507377A (en) * | 2010-11-30 | 2014-03-27 | アデッソ アドバーンスト マテリアルズ ウーシー カンパニーリミテッド | New agents for reworkable epoxy resins |
| EP2986665A4 (en) * | 2013-04-18 | 2016-11-16 | Adesso Advanced Materials Wuxi Co Ltd | Novel cyclic acetal, cyclic ketal diamines epoxy curing agents and degradable polymers and composites based thereon |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4060532A (en) | 1972-03-15 | 1977-11-29 | Ici United States Inc. | Halogenated dioxolane tranquilizers |
| US3996376A (en) | 1972-03-28 | 1976-12-07 | Ici United States Inc. | Halogenated dioxolane tranquilizers |
-
1967
- 1967-04-26 GB GB19281/67A patent/GB1197313A/en not_active Expired
- 1967-04-26 BE BE697590D patent/BE697590A/xx not_active IP Right Cessation
- 1967-04-29 DE DE1967C0042201 patent/DE1593797C3/en not_active Expired
- 1967-05-02 FR FR104911A patent/FR6719M/fr not_active Expired
- 1967-10-25 IL IL2881567A patent/IL28815A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014507377A (en) * | 2010-11-30 | 2014-03-27 | アデッソ アドバーンスト マテリアルズ ウーシー カンパニーリミテッド | New agents for reworkable epoxy resins |
| EP2986665A4 (en) * | 2013-04-18 | 2016-11-16 | Adesso Advanced Materials Wuxi Co Ltd | Novel cyclic acetal, cyclic ketal diamines epoxy curing agents and degradable polymers and composites based thereon |
Also Published As
| Publication number | Publication date |
|---|---|
| FR6719M (en) | 1969-02-17 |
| BE697590A (en) | 1967-10-02 |
| DE1593797A1 (en) | 1970-12-23 |
| DE1593797B2 (en) | 1978-01-12 |
| IL28815A (en) | 1973-03-30 |
| DE1593797C3 (en) | 1978-09-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE | Patent expired |