GB1182008A - Resolution of d1-(3-Trifluoromethylphenoxy)-(4-Chlorophenyl)Acetic Acid - Google Patents

Resolution of d1-(3-Trifluoromethylphenoxy)-(4-Chlorophenyl)Acetic Acid

Info

Publication number
GB1182008A
GB1182008A GB44021/67A GB4402167A GB1182008A GB 1182008 A GB1182008 A GB 1182008A GB 44021/67 A GB44021/67 A GB 44021/67A GB 4402167 A GB4402167 A GB 4402167A GB 1182008 A GB1182008 A GB 1182008A
Authority
GB
United Kingdom
Prior art keywords
acid
chlorophenyl
salt
acetic acid
trifluoromethylphenoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB44021/67A
Other languages
English (en)
Inventor
Floyd Edward Roberts Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1182008A publication Critical patent/GB1182008A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB44021/67A 1966-10-03 1967-09-27 Resolution of d1-(3-Trifluoromethylphenoxy)-(4-Chlorophenyl)Acetic Acid Expired GB1182008A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58393966A 1966-10-03 1966-10-03

Publications (1)

Publication Number Publication Date
GB1182008A true GB1182008A (en) 1970-02-25

Family

ID=24335229

Family Applications (1)

Application Number Title Priority Date Filing Date
GB44021/67A Expired GB1182008A (en) 1966-10-03 1967-09-27 Resolution of d1-(3-Trifluoromethylphenoxy)-(4-Chlorophenyl)Acetic Acid

Country Status (3)

Country Link
CH (1) CH487101A (zh)
GB (1) GB1182008A (zh)
NL (1) NL6712585A (zh)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000074666A2 (en) * 1999-06-04 2000-12-14 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidaemia and hyperuricaemia
EP1343493A2 (en) * 2000-11-28 2003-09-17 Metabolex, Inc. Use of(-) (3-halomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
EP1635809A1 (en) * 2003-06-20 2006-03-22 Metabolex, Inc. Resolution of alpha-(phenoxy)phenylacetic acid derivatives
US7199259B2 (en) * 2003-06-20 2007-04-03 Metabolex, Inc. Resolution of α-(phenoxy)phenylacetic acid derivatives
US7576131B2 (en) 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US7714131B2 (en) 2005-09-23 2010-05-11 Metabolex, Inc. Process for the stereoselective preparation of (−)-halofenate and derivatives thereof

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1614418A1 (en) * 1999-06-04 2006-01-11 Metabolex, Inc. use of(-)(3-trihalomethylphenoxy) (4-halophenyl)acetic acid derivatives for treatment of hyperuricaemia
US7576131B2 (en) 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
WO2000074666A2 (en) * 1999-06-04 2000-12-14 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidaemia and hyperuricaemia
JP2003501383A (ja) * 1999-06-04 2003-01-14 メタボレックス， インコーポレイテッド インスリン抵抗性、２型糖尿病、高脂血症および高尿酸血症の処置のための、（−）（３−トリハロメチルフェノキシ）（４−ハロフェニル）酢酸誘導体の使用
US6613802B1 (en) 1999-06-04 2003-09-02 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US6262118B1 (en) 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
US6624194B1 (en) 1999-06-04 2003-09-23 Metabolex, Inc. Use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US6646004B1 (en) 1999-06-04 2003-11-11 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
WO2000074666A3 (en) * 1999-06-04 2001-11-08 Metabolex Inc Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidaemia and hyperuricaemia
US8481597B2 (en) 1999-06-04 2013-07-09 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US8354448B2 (en) 1999-06-04 2013-01-15 Metabolex, Inc. Use of (−)(3-trihalomethylphenoxy)(4-halophenyl) acetic acid derivatives for treatment of type 2 diabetes
US8329749B2 (en) 1999-06-04 2012-12-11 Metabolex, Inc. Use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of hyperuricemia
JP2007099784A (ja) * 1999-06-04 2007-04-19 Metabolex Inc インスリン抵抗性、２型糖尿病、高脂血症および高尿酸血症の処置のための、（−）（３−トリハロメチルフェノキシ）（４−ハロフェニル）酢酸誘導体の使用
EP1343493A2 (en) * 2000-11-28 2003-09-17 Metabolex, Inc. Use of(-) (3-halomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
EP1343493A4 (en) * 2000-11-28 2009-06-24 Metabolex Inc USE OF (-) (3-HALOMETHYLPHENOXY) (4-HALOPHENYL) ACETIC ACID DERIVATIVES IN THE TREATMENT OF INSULIN RESISTANCE, TYPE 2 DIABETES, HYPERLIPIDEMIA AND HYPERURICEMIA
EP1635809A4 (en) * 2003-06-20 2006-09-27 Metabolex Inc RESOLUTION OF ALPHA (PHENOXY) PHENYLACETIC ACID DERIVATIVES
US7199259B2 (en) * 2003-06-20 2007-04-03 Metabolex, Inc. Resolution of α-(phenoxy)phenylacetic acid derivatives
EP1635809A1 (en) * 2003-06-20 2006-03-22 Metabolex, Inc. Resolution of alpha-(phenoxy)phenylacetic acid derivatives
US7714131B2 (en) 2005-09-23 2010-05-11 Metabolex, Inc. Process for the stereoselective preparation of (−)-halofenate and derivatives thereof

Also Published As

Publication number Publication date
CH487101A (de) 1970-03-15
NL6712585A (zh) 1968-04-04

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