GB1166681A - Production of 7-Chloro-6-Demethyltetracycline Fermentation - Google Patents
Production of 7-Chloro-6-Demethyltetracycline FermentationInfo
- Publication number
- GB1166681A GB1166681A GB48781/66A GB4878166A GB1166681A GB 1166681 A GB1166681 A GB 1166681A GB 48781/66 A GB48781/66 A GB 48781/66A GB 4878166 A GB4878166 A GB 4878166A GB 1166681 A GB1166681 A GB 1166681A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nrrl
- chloro
- reflectance
- point
- tetracycline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P29/00—Preparation of compounds containing a naphthacene ring system, e.g. tetracycline
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
- C12R2001/485—Streptomyces aureofaciens
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
1,166,681. 7-Chloro-6-demethyl tetracycline. AMERICAN CYANAMID CO. 31 Oct., 1966 [15 Nov., 1965; 16 Sept., 19661, No. 48781/66. Heading C2A. 7 - Chloro - 6 - demethyl tetracycline is produced in a conventional manner by the submerged aerobic cultivation of a 7-ohloro-6-demethyltetracycline-producing strain of Streptomyces aureofaciens which is characterized by its ability to impart to a 200 fold aqueous dilution of the whole harvest mash (defined) a colour characterized by either, (a) A reflectance curve, when plotted linearly, wherein the values of the per cent reflectance at 460 mÁ, 540 mÁ, 560 mÁ and 660 mÁ when substituted into the formula gives a positive value for #R; or (b) a reflectance curve such that when the per cent reflectance is plotted linearly against the wavelength, the resulting curve between 460 mÁ and 530 mÁ will have one point of inflection and will have at least one point of zero slope and will be convex upward to the left of the point of inflection and concave upward to the right of the point of inflection. 7 - Chloro - 6 - demethyl tetracycline is produced with no more than 5% of 6-demethyltetracycline. The strains specified are direct descendants of the 7-chloro tetracycline-producing strain Streptomyces aureofaciens NRRL 2209 (Specification 690,381) and have been obtained therefrom by mutagenic processes known to the art. They have been designated, NRRL 3201 (IE 1352), NRRL 3202, NRRL 3203, NRRL 3204, NRRL 3234 and NRRL 3235 and their reflectance curves are shown in Figs. 11, and 12 to 16 (not shown). 7-Chloro-6-demethyl tetracycline is disclosed in Specification 855,169.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA945388 | 1965-11-15 | ||
| CA970545 | 1966-09-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1166681A true GB1166681A (en) | 1969-10-08 |
Family
ID=25673596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB48781/66A Expired GB1166681A (en) | 1965-11-15 | 1966-10-31 | Production of 7-Chloro-6-Demethyltetracycline Fermentation |
Country Status (15)
| Country | Link |
|---|---|
| BE (1) | BE689013A (en) |
| BR (1) | BR6684265D0 (en) |
| CH (2) | CH501727A (en) |
| DE (1) | DE1617281A1 (en) |
| DK (1) | DK113983B (en) |
| ES (1) | ES333366A1 (en) |
| FI (1) | FI43721C (en) |
| FR (1) | FR1504086A (en) |
| GB (1) | GB1166681A (en) |
| IL (1) | IL26762A (en) |
| LU (1) | LU52319A1 (en) |
| MC (1) | MC623A1 (en) |
| NL (1) | NL6616081A (en) |
| NO (1) | NO123470B (en) |
| SE (1) | SE346564B (en) |
-
1966
- 1966-10-24 NO NO165323A patent/NO123470B/no unknown
- 1966-10-26 IL IL26762A patent/IL26762A/en unknown
- 1966-10-28 BE BE689013D patent/BE689013A/xx unknown
- 1966-10-31 GB GB48781/66A patent/GB1166681A/en not_active Expired
- 1966-11-03 BR BR184265/66A patent/BR6684265D0/en unknown
- 1966-11-08 LU LU52319D patent/LU52319A1/xx unknown
- 1966-11-10 FR FR83332A patent/FR1504086A/en not_active Expired
- 1966-11-10 FI FI662970A patent/FI43721C/en active
- 1966-11-14 CH CH303270A patent/CH501727A/en not_active IP Right Cessation
- 1966-11-14 DK DK589866AA patent/DK113983B/en unknown
- 1966-11-14 CH CH1632266A patent/CH492019A/en not_active IP Right Cessation
- 1966-11-15 NL NL6616081A patent/NL6616081A/xx unknown
- 1966-11-15 SE SE15604/66A patent/SE346564B/xx unknown
- 1966-11-15 MC MC655A patent/MC623A1/en unknown
- 1966-11-15 ES ES333366A patent/ES333366A1/en not_active Expired
- 1966-11-15 DE DE19661617281 patent/DE1617281A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| LU52319A1 (en) | 1967-01-09 |
| NO123470B (en) | 1971-11-22 |
| DE1617281A1 (en) | 1971-04-08 |
| BE689013A (en) | 1967-04-28 |
| CH492019A (en) | 1970-06-15 |
| FI43721B (en) | 1971-03-01 |
| ES333366A1 (en) | 1968-03-16 |
| FR1504086A (en) | 1967-12-01 |
| CH501727A (en) | 1971-01-15 |
| MC623A1 (en) | 1967-07-04 |
| DK113983B (en) | 1969-05-19 |
| SE346564B (en) | 1972-07-10 |
| BR6684265D0 (en) | 1973-12-26 |
| FI43721C (en) | 1971-06-10 |
| NL6616081A (en) | 1967-05-16 |
| IL26762A (en) | 1970-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE | Patent expired |