GB1163103A - Ribofuranosyl Purine Derivatives - Google Patents

Ribofuranosyl Purine Derivatives

Info

Publication number
GB1163103A
GB1163103A GB4992466A GB4992466A GB1163103A GB 1163103 A GB1163103 A GB 1163103A GB 4992466 A GB4992466 A GB 4992466A GB 4992466 A GB4992466 A GB 4992466A GB 1163103 A GB1163103 A GB 1163103A
Authority
GB
United Kingdom
Prior art keywords
alkyl
acyl
formula
halogen
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4992466A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1163103A publication Critical patent/GB1163103A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
GB4992466A 1965-11-15 1966-11-08 Ribofuranosyl Purine Derivatives Expired GB1163103A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50771865A 1965-11-15 1965-11-15

Publications (1)

Publication Number Publication Date
GB1163103A true GB1163103A (en) 1969-09-04

Family

ID=24019834

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4992466A Expired GB1163103A (en) 1965-11-15 1966-11-08 Ribofuranosyl Purine Derivatives

Country Status (5)

Country Link
CH (1) CH490395A (enExample)
DE (1) DE1620053A1 (enExample)
FR (1) FR1504091A (enExample)
GB (1) GB1163103A (enExample)
NL (1) NL6615905A (enExample)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001092282A3 (en) * 2000-05-26 2002-05-02 Novirio Pharmaceuticals Ltd Methods and compositions for treating flaviviruses and pestiviruses
WO2001090121A3 (en) * 2000-05-23 2002-05-02 Novirio Pharmaceuticals Ltd Methods and compositions for treating hepatitis c virus
WO2004003000A3 (en) * 2002-06-28 2004-11-04 Idenix Cayman Ltd 1’-, 2'- and 3'- modified nucleoside derivatives for treating flaviviridae infections
US7094770B2 (en) 2000-04-13 2006-08-22 Pharmasset, Ltd. 3′-or 2′-hydroxymethyl substituted nucleoside derivatives for treatment of hepatitis virus infections
US7138376B2 (en) 2001-09-28 2006-11-21 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
US7192936B2 (en) 2002-06-28 2007-03-20 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7456155B2 (en) 2002-06-28 2008-11-25 Idenix Pharmaceuticals, Inc. 2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7582618B2 (en) 2002-06-28 2009-09-01 Idenix Pharmaceuticals, Inc. 2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7781576B2 (en) 2005-12-23 2010-08-24 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation

Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7094770B2 (en) 2000-04-13 2006-08-22 Pharmasset, Ltd. 3′-or 2′-hydroxymethyl substituted nucleoside derivatives for treatment of hepatitis virus infections
US7169766B2 (en) 2000-05-23 2007-01-30 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus
WO2001090121A3 (en) * 2000-05-23 2002-05-02 Novirio Pharmaceuticals Ltd Methods and compositions for treating hepatitis c virus
SG156517A1 (en) * 2000-05-23 2009-11-26 Idenix Cayman Ltd Methods and compositions for treating hepatitis c virus
US10758557B2 (en) 2000-05-23 2020-09-01 Idenix Pharmaceuticals Llc Methods and compositions for treating hepatitis C virus
US6914054B2 (en) 2000-05-23 2005-07-05 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus
EA007178B1 (ru) * 2000-05-23 2006-08-25 Айденикс (Кайман) Лимитед Производные beta-d-нуклеозида в качестве лекарственного средства для лечения инфекции вируса гепатита c у хозяина
US8299038B2 (en) 2000-05-23 2012-10-30 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus
EA011720B1 (ru) * 2000-05-23 2009-04-28 Айденикс (Кайман) Лимитед ПРОИЗВОДНЫЕ β-D-НУКЛЕОЗИДА И ИХ ПРИМЕНЕНИЕ
US10363265B2 (en) 2000-05-23 2019-07-30 Idenix Pharmaceuticals Llc Methods and compositions for treating hepatitis C virus
US7608597B2 (en) 2000-05-23 2009-10-27 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus
US7157441B2 (en) 2000-05-23 2007-01-02 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus
US7148206B2 (en) 2000-05-26 2006-12-12 Idenix Pharmaceuticals, Inc. Methods and compositions for treating flaviviruses and pestiviruses
US7163929B2 (en) 2000-05-26 2007-01-16 Idenix Pharmaceuticals, Inc. Methods and compositions for treating flaviviruses and pestiviruses
EA007867B1 (ru) * 2000-05-26 2007-02-27 Айденикс (Кайман) Лимитед Композиции для лечения флавивирусных и пестивирусных инфекций и способы их применения
AP1727A (en) * 2000-05-26 2007-03-06 Idenix Cayman Ltd Methods and compositions for treating flaviviruses and pestiviruses.
US9968628B2 (en) 2000-05-26 2018-05-15 Idenix Pharmaceuticals Llc Methods and compositions for treating flaviviruses and pestiviruses
WO2001092282A3 (en) * 2000-05-26 2002-05-02 Novirio Pharmaceuticals Ltd Methods and compositions for treating flaviviruses and pestiviruses
US8343937B2 (en) 2000-05-26 2013-01-01 Idenix Pharmaceuticals, Inc. Methods and compositions for treating flaviviruses and pestiviruses
US7105493B2 (en) 2000-05-26 2006-09-12 Idenix Pharmaceuticals, Inc. Methods and compositions for treating flaviviruses and pestiviruses
US7101861B2 (en) 2000-05-26 2006-09-05 Indenix Pharmaceuticals, Inc. Methods and compositions for treating flaviviruses and pestiviruses
US6812219B2 (en) 2000-05-26 2004-11-02 Idenix Pharmaceuticals, Inc. Methods and compositions for treating flaviviruses and pestiviruses
US7138376B2 (en) 2001-09-28 2006-11-21 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
US7384924B2 (en) 2002-06-28 2008-06-10 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7365057B2 (en) 2002-06-28 2008-04-29 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flavivridae infections
US7582618B2 (en) 2002-06-28 2009-09-01 Idenix Pharmaceuticals, Inc. 2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7625875B2 (en) 2002-06-28 2009-12-01 Idenix Pharmaceuticals, Inc. 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7635689B2 (en) 2002-06-28 2009-12-22 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7662798B2 (en) 2002-06-28 2010-02-16 Idenix Pharmaceuticals, Inc. 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
WO2004003000A3 (en) * 2002-06-28 2004-11-04 Idenix Cayman Ltd 1’-, 2'- and 3'- modified nucleoside derivatives for treating flaviviridae infections
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7547704B2 (en) 2002-06-28 2009-06-16 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7456155B2 (en) 2002-06-28 2008-11-25 Idenix Pharmaceuticals, Inc. 2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7192936B2 (en) 2002-06-28 2007-03-20 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
US8674085B2 (en) 2002-11-15 2014-03-18 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
US10525072B2 (en) 2002-11-15 2020-01-07 Idenix Pharmaceuticals Llc 2′-branched nucleosides and flaviviridae mutation
US7781576B2 (en) 2005-12-23 2010-08-24 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides

Also Published As

Publication number Publication date
DE1620053A1 (de) 1970-03-12
FR1504091A (fr) 1967-12-01
NL6615905A (enExample) 1967-05-16
CH490395A (de) 1970-05-15

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees