GB1148718A - Phenyl benzoxazocineones and their preparation - Google Patents
Phenyl benzoxazocineones and their preparationInfo
- Publication number
- GB1148718A GB1148718A GB1931/68A GB193168A GB1148718A GB 1148718 A GB1148718 A GB 1148718A GB 1931/68 A GB1931/68 A GB 1931/68A GB 193168 A GB193168 A GB 193168A GB 1148718 A GB1148718 A GB 1148718A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- benzhydrol
- phenyl
- treatment
- benz
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- FICTZKRUYFPQBH-UHFFFAOYSA-N 4-phenyl-4H-1,2-benzoxazocin-3-one Chemical class C1(=CC=CC=C1)C1C(NOC2=C(C=C1)C=CC=C2)=O FICTZKRUYFPQBH-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229960001760 dimethyl sulfoxide Drugs 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 abstract 2
- LUANDPUYXVFNEG-UHFFFAOYSA-N 2-chloro-N-[[2-[hydroxy(phenyl)methyl]phenyl]methyl]-N-methylacetamide Chemical compound CN(C(CCl)=O)CC1=C(C(C2=CC=CC=C2)O)C=CC=C1 LUANDPUYXVFNEG-UHFFFAOYSA-N 0.000 abstract 1
- VGCXGMAHQTYDJK-UHFFFAOYSA-N Chloroacetyl chloride Chemical compound ClCC(Cl)=O VGCXGMAHQTYDJK-UHFFFAOYSA-N 0.000 abstract 1
- OOJAOGKXAKBVSY-UHFFFAOYSA-N [2-(methylaminomethyl)phenyl]-phenylmethanol Chemical compound CNCC1=CC=CC=C1C(O)C1=CC=CC=C1 OOJAOGKXAKBVSY-UHFFFAOYSA-N 0.000 abstract 1
- UIIFKADMTXBBLW-UHFFFAOYSA-N [[2-[[(2-chloroacetyl)-methylamino]methyl]phenyl]-phenylmethyl] 2-chloroacetate Chemical compound ClCC(=O)OC(C1=C(C=CC=C1)CN(C(CCl)=O)C)C1=CC=CC=C1 UIIFKADMTXBBLW-UHFFFAOYSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- -1 haloacetyl halide Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229940041735 rexall Drugs 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/22—Eight-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00454738A US3830803A (en) | 1965-05-10 | 1965-05-10 | 5-loweralkyl-1-phenyl-1,3,4,6-tetrahydro-5h-benz(f)-2,5-oxazocines and 4-ones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1148718A true GB1148718A (en) | 1969-04-16 |
Family
ID=23805870
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB20698/66A Expired GB1148717A (en) | 1965-05-10 | 1966-05-10 | Phenylbenz (f)-2,5-oxazocine derivatives and homologues and pharmaceutical compositions |
| GB1931/68A Expired GB1148718A (en) | 1965-05-10 | 1966-05-10 | Phenyl benzoxazocineones and their preparation |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB20698/66A Expired GB1148717A (en) | 1965-05-10 | 1966-05-10 | Phenylbenz (f)-2,5-oxazocine derivatives and homologues and pharmaceutical compositions |
Country Status (7)
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3446820A (en) * | 1967-04-03 | 1969-05-27 | Rexall Drug Chemical | Substituted benzoxazocines and intermediates |
| US3728460A (en) * | 1968-12-20 | 1973-04-17 | Boehringer Sohn Ingelheim | Anorectic pharmaceutical composition containing certain {60 -(methylamino-methyl)-alpha-(4{40 -halo-phenyl)-benzyl alcohols as active ingredients |
| US4100277A (en) * | 1976-11-08 | 1978-07-11 | American Home Products Corporation | 4,1-Benzoxazonine derivatives and process therefor |
| GB1586578A (en) * | 1977-08-05 | 1981-03-18 | Riker Laboratories Inc | Process for the preparation of 2-(n-(2-hydroxyyethyl)-n-lower alkylaminomethyl) benzhydrols |
| US4208349A (en) * | 1978-07-27 | 1980-06-17 | Riker Laboratories, Inc. | Process for the preparation of 2-[N-(2-hydroxyethyl)-N-lower alkylaminomethyl]benzhydrols |
| DE2846567A1 (de) * | 1978-10-26 | 1980-05-08 | Basf Ag | Neue 1,4-cycloalkanooxazepine, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| DE2901180A1 (de) * | 1979-01-13 | 1980-07-24 | Basf Ag | Hexahydro-1,4-oxazepine, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| US4318909A (en) * | 1980-01-17 | 1982-03-09 | John Wyeth & Brother Limited | Benzoxazocines |
| NZ539488A (en) * | 2002-12-20 | 2008-03-28 | Arakis Ltd | Benzoxazocines and their use as monoamine-reuptake inhibitors |
| GB0328871D0 (en) * | 2003-12-12 | 2004-01-14 | Arakis Ltd | Resolution process |
| AU2005235786A1 (en) * | 2004-04-21 | 2005-11-03 | Sosei R&D Ltd. | Benzoxazocines and their therapeutic use as monoamine reuptake inhibitors |
| FR2880275B1 (fr) | 2005-01-06 | 2007-04-13 | Biocodex | Utilisation de composes pharmacologiques pour la prevention ou le traitement de la tolerance aigue aux morphiniques |
| CN107556263A (zh) * | 2016-06-30 | 2018-01-09 | 康普药业股份有限公司 | 一种盐酸奈福泮的制备方法 |
| US10736905B1 (en) | 2016-09-09 | 2020-08-11 | Shahin Fatholahi | Nefopam dosage forms and methods of treatment |
| US11446311B2 (en) | 2017-09-08 | 2022-09-20 | Shahin Fatholahi | Methods for treating pain associated with sickle cell disease |
| US10736874B1 (en) | 2017-09-08 | 2020-08-11 | Shahin Fatholahi | Methods for treating pain associated with sickle cell disease |
-
1965
- 1965-05-10 US US00454738A patent/US3830803A/en not_active Expired - Lifetime
-
1966
- 1966-05-05 DE DE1620198A patent/DE1620198C3/de not_active Expired
- 1966-05-09 DK DK235766AA patent/DK120341B/da unknown
- 1966-05-10 FR FR1590067D patent/FR1590067A/fr not_active Expired
- 1966-05-10 GB GB20698/66A patent/GB1148717A/en not_active Expired
- 1966-05-10 SE SE6387/66A patent/SE319176B/xx unknown
- 1966-05-10 NL NL666606390A patent/NL153188B/xx not_active IP Right Cessation
- 1966-05-10 GB GB1931/68A patent/GB1148718A/en not_active Expired
- 1966-05-10 SE SE12010/68A patent/SE352883B/xx unknown
- 1966-08-09 FR FR72604A patent/FR5721M/fr not_active Expired
-
1970
- 1970-01-26 DK DK33570AA patent/DK121083B/da unknown
- 1970-01-26 DK DK33670AA patent/DK125024B/da unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK125024B (da) | 1972-12-18 |
| NL153188B (nl) | 1977-05-16 |
| SE352883B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-01-15 |
| DE1620198C3 (de) | 1975-05-28 |
| US3830803A (en) | 1974-08-20 |
| FR5721M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-01-22 |
| DE1620198A1 (de) | 1972-04-06 |
| DK121083B (da) | 1971-09-06 |
| GB1148717A (en) | 1969-04-16 |
| SE319176B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1970-01-12 |
| FR1590067A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1970-04-13 |
| DE1620198B2 (de) | 1974-09-19 |
| NL6606390A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1966-11-11 |
| DK120341B (da) | 1971-05-17 |
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