GB1148717A - Phenylbenz (f)-2,5-oxazocine derivatives and homologues and pharmaceutical compositions - Google Patents
Phenylbenz (f)-2,5-oxazocine derivatives and homologues and pharmaceutical compositionsInfo
- Publication number
- GB1148717A GB1148717A GB20698/66A GB2069866A GB1148717A GB 1148717 A GB1148717 A GB 1148717A GB 20698/66 A GB20698/66 A GB 20698/66A GB 2069866 A GB2069866 A GB 2069866A GB 1148717 A GB1148717 A GB 1148717A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- phenyl
- oxazocine
- bear
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GKJLBCCOYHLILR-UHFFFAOYSA-N 2-phenyl-3h-4,1-benzoxazocine Chemical class C1OC=CC2=CC=CC=C2N=C1C1=CC=CC=C1 GKJLBCCOYHLILR-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 229910010082 LiAlH Inorganic materials 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 239000003638 chemical reducing agent Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 239000012442 inert solvent Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 2
- 238000010992 reflux Methods 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 239000002269 analeptic agent Substances 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 125000005191 hydroxyalkylamino group Chemical group 0.000 abstract 1
- 229910052987 metal hydride Inorganic materials 0.000 abstract 1
- 150000004681 metal hydrides Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229940041735 rexall Drugs 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000002027 skeletal muscle Anatomy 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/22—Eight-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00454738A US3830803A (en) | 1965-05-10 | 1965-05-10 | 5-loweralkyl-1-phenyl-1,3,4,6-tetrahydro-5h-benz(f)-2,5-oxazocines and 4-ones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1148717A true GB1148717A (en) | 1969-04-16 |
Family
ID=23805870
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB20698/66A Expired GB1148717A (en) | 1965-05-10 | 1966-05-10 | Phenylbenz (f)-2,5-oxazocine derivatives and homologues and pharmaceutical compositions |
| GB1931/68A Expired GB1148718A (en) | 1965-05-10 | 1966-05-10 | Phenyl benzoxazocineones and their preparation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1931/68A Expired GB1148718A (en) | 1965-05-10 | 1966-05-10 | Phenyl benzoxazocineones and their preparation |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3830803A (forum.php) |
| DE (1) | DE1620198C3 (forum.php) |
| DK (3) | DK120341B (forum.php) |
| FR (2) | FR1590067A (forum.php) |
| GB (2) | GB1148717A (forum.php) |
| NL (1) | NL153188B (forum.php) |
| SE (2) | SE319176B (forum.php) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2399405A1 (fr) * | 1977-08-05 | 1979-03-02 | Riker Laboratories Inc | Procede de preparation et d'utilisation de 2-(n-(2-hydroxyethyl)-n-alkyl inferieur-aminomethyl) benzhydrols |
| US4208349A (en) * | 1978-07-27 | 1980-06-17 | Riker Laboratories, Inc. | Process for the preparation of 2-[N-(2-hydroxyethyl)-N-lower alkylaminomethyl]benzhydrols |
| WO2004056788A1 (en) * | 2002-12-20 | 2004-07-08 | Arakis Ltd. | Benzoxazocines and their use as monoamine-reuptake inhibitors |
| WO2005103019A1 (en) * | 2004-04-21 | 2005-11-03 | Sosei R&D Ltd. | Benzoxazocines and their therapeutic use as monoamine reuptake inhibitors |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3446820A (en) * | 1967-04-03 | 1969-05-27 | Rexall Drug Chemical | Substituted benzoxazocines and intermediates |
| US3728460A (en) * | 1968-12-20 | 1973-04-17 | Boehringer Sohn Ingelheim | Anorectic pharmaceutical composition containing certain {60 -(methylamino-methyl)-alpha-(4{40 -halo-phenyl)-benzyl alcohols as active ingredients |
| US4100277A (en) * | 1976-11-08 | 1978-07-11 | American Home Products Corporation | 4,1-Benzoxazonine derivatives and process therefor |
| DE2846567A1 (de) * | 1978-10-26 | 1980-05-08 | Basf Ag | Neue 1,4-cycloalkanooxazepine, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| DE2901180A1 (de) * | 1979-01-13 | 1980-07-24 | Basf Ag | Hexahydro-1,4-oxazepine, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| US4318909A (en) * | 1980-01-17 | 1982-03-09 | John Wyeth & Brother Limited | Benzoxazocines |
| GB0328871D0 (en) * | 2003-12-12 | 2004-01-14 | Arakis Ltd | Resolution process |
| FR2880275B1 (fr) | 2005-01-06 | 2007-04-13 | Biocodex | Utilisation de composes pharmacologiques pour la prevention ou le traitement de la tolerance aigue aux morphiniques |
| CN107556263A (zh) * | 2016-06-30 | 2018-01-09 | 康普药业股份有限公司 | 一种盐酸奈福泮的制备方法 |
| US10736905B1 (en) | 2016-09-09 | 2020-08-11 | Shahin Fatholahi | Nefopam dosage forms and methods of treatment |
| US11446311B2 (en) | 2017-09-08 | 2022-09-20 | Shahin Fatholahi | Methods for treating pain associated with sickle cell disease |
| US10736874B1 (en) | 2017-09-08 | 2020-08-11 | Shahin Fatholahi | Methods for treating pain associated with sickle cell disease |
-
1965
- 1965-05-10 US US00454738A patent/US3830803A/en not_active Expired - Lifetime
-
1966
- 1966-05-05 DE DE1620198A patent/DE1620198C3/de not_active Expired
- 1966-05-09 DK DK235766AA patent/DK120341B/da unknown
- 1966-05-10 FR FR1590067D patent/FR1590067A/fr not_active Expired
- 1966-05-10 GB GB20698/66A patent/GB1148717A/en not_active Expired
- 1966-05-10 SE SE6387/66A patent/SE319176B/xx unknown
- 1966-05-10 NL NL666606390A patent/NL153188B/xx not_active IP Right Cessation
- 1966-05-10 GB GB1931/68A patent/GB1148718A/en not_active Expired
- 1966-05-10 SE SE12010/68A patent/SE352883B/xx unknown
- 1966-08-09 FR FR72604A patent/FR5721M/fr not_active Expired
-
1970
- 1970-01-26 DK DK33570AA patent/DK121083B/da unknown
- 1970-01-26 DK DK33670AA patent/DK125024B/da unknown
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2399405A1 (fr) * | 1977-08-05 | 1979-03-02 | Riker Laboratories Inc | Procede de preparation et d'utilisation de 2-(n-(2-hydroxyethyl)-n-alkyl inferieur-aminomethyl) benzhydrols |
| US4208349A (en) * | 1978-07-27 | 1980-06-17 | Riker Laboratories, Inc. | Process for the preparation of 2-[N-(2-hydroxyethyl)-N-lower alkylaminomethyl]benzhydrols |
| WO2004056788A1 (en) * | 2002-12-20 | 2004-07-08 | Arakis Ltd. | Benzoxazocines and their use as monoamine-reuptake inhibitors |
| AU2003295171B2 (en) * | 2002-12-20 | 2007-09-06 | Arakis Ltd. | Benzoxazocines and their use as monoamine-reuptake inhibitors |
| EP1950206A1 (en) * | 2002-12-20 | 2008-07-30 | Sosei R&D Ltd. | Benzoxazocines and their use as monoamine-reuptake inhibitors |
| WO2005103019A1 (en) * | 2004-04-21 | 2005-11-03 | Sosei R&D Ltd. | Benzoxazocines and their therapeutic use as monoamine reuptake inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| DK125024B (da) | 1972-12-18 |
| NL153188B (nl) | 1977-05-16 |
| SE352883B (forum.php) | 1973-01-15 |
| DE1620198C3 (de) | 1975-05-28 |
| US3830803A (en) | 1974-08-20 |
| FR5721M (forum.php) | 1968-01-22 |
| DE1620198A1 (de) | 1972-04-06 |
| DK121083B (da) | 1971-09-06 |
| SE319176B (forum.php) | 1970-01-12 |
| FR1590067A (forum.php) | 1970-04-13 |
| DE1620198B2 (de) | 1974-09-19 |
| GB1148718A (en) | 1969-04-16 |
| NL6606390A (forum.php) | 1966-11-11 |
| DK120341B (da) | 1971-05-17 |
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