GB1128234A - 5-benzylpyrimidine derivatives and process for the preparation thereof - Google Patents

5-benzylpyrimidine derivatives and process for the preparation thereof

Info

Publication number
GB1128234A
GB1128234A GB737666A GB737666A GB1128234A GB 1128234 A GB1128234 A GB 1128234A GB 737666 A GB737666 A GB 737666A GB 737666 A GB737666 A GB 737666A GB 1128234 A GB1128234 A GB 1128234A
Authority
GB
United Kingdom
Prior art keywords
group
benzyl
hydrogen
halogen
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB737666A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB737666A priority Critical patent/GB1128234A/en
Priority to IL2742467A priority patent/IL27424A/xx
Priority to GR670133641A priority patent/GR33641B/el
Priority to CA983,015A priority patent/CA977754A/en
Priority to NO16687667A priority patent/NO124601B/no
Priority to AT153867A priority patent/AT270653B/de
Priority to AT409368A priority patent/AT275534B/de
Priority to DE19671795635 priority patent/DE1795635C3/de
Priority to FI48067A priority patent/FI49714C/fi
Priority to NL6702397A priority patent/NL146811B/xx
Priority to ES336945A priority patent/ES336945A1/es
Priority to CH237967A priority patent/CH511239A/de
Priority to DE1967W0043385 priority patent/DE1720012B2/de
Priority to BE694244D priority patent/BE694244A/xx
Priority to CH191468A priority patent/CH513179A/de
Priority to DK91167A priority patent/DK120344B/da
Priority to SE227867A priority patent/SE338998B/xx
Priority to SE796270A priority patent/SE390412B/xx
Priority to FR95595A priority patent/FR1536204A/fr
Priority to FR106573A priority patent/FR6595M/fr
Priority to FI26868A priority patent/FI55031C/fi
Priority to DE19681720031 priority patent/DE1720031A1/de
Priority to FR138498A priority patent/FR94837E/fr
Publication of GB1128234A publication Critical patent/GB1128234A/en
Priority to DK59371A priority patent/DK128247B/da
Priority to FI250271A priority patent/FI55032C/fi
Priority to NO377771A priority patent/NO133550C/no
Priority to MY7100226A priority patent/MY7100226A/xx
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lubricants (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
GB737666A 1966-02-19 1966-02-19 5-benzylpyrimidine derivatives and process for the preparation thereof Expired GB1128234A (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
GB737666A GB1128234A (en) 1966-02-19 1966-02-19 5-benzylpyrimidine derivatives and process for the preparation thereof
IL2742467A IL27424A (en) 1966-02-19 1967-02-13 Method of preparing 5-benzylpyrimidines and novel 5-benzylpyrimidines
GR670133641A GR33641B (el) 1966-02-19 1967-02-13 Χημικαι συνθεσεις και μεθοδος.
CA983,015A CA977754A (en) 1966-02-19 1967-02-15 2-(3',4',5'-trisubstituted-benzyl) pyrimidine compounds
NO16687667A NO124601B (enrdf_load_stackoverflow) 1966-02-19 1967-02-16
AT153867A AT270653B (de) 1966-02-19 1967-02-16 Verfahren zur Herstellung von neuen 5-Benzylpyrimidinen
AT409368A AT275534B (de) 1966-02-19 1967-02-16 Verfahren zur Herstellung von 5-Benzylpyrimidinen
BE694244D BE694244A (enrdf_load_stackoverflow) 1966-02-19 1967-02-17
FI48067A FI49714C (fi) 1966-02-19 1967-02-17 Menetelmä 5-bentsyylipyrimidiinien valmistamiseksi.
NL6702397A NL146811B (nl) 1966-02-19 1967-02-17 Werkwijze ter bereiding van 5-benzylpyrimidinederivaten.
ES336945A ES336945A1 (es) 1966-02-19 1967-02-17 Un metodo de preparar 5-bencil-pirimidinas.
CH237967A CH511239A (de) 1966-02-19 1967-02-17 Verfahren zur Herstellung von 5-Benzylpyrimidinen
DE1967W0043385 DE1720012B2 (de) 1966-02-19 1967-02-17 Verfahren zur herstellung von 2,4-diamino-5-(3,4,5-trimethoxybenzyl)- pyrimidin
DE19671795635 DE1795635C3 (de) 1966-02-19 1967-02-17 2,4-Diamino-5-benzyIpyrimidine
CH191468A CH513179A (de) 1966-02-19 1967-02-17 Verfahren zur Herstellung von 5-Benzylpyrimidinen
FR95595A FR1536204A (fr) 1966-02-19 1967-02-20 Procédé de préparation de dérivés de la pyrimidine
SE227867A SE338998B (enrdf_load_stackoverflow) 1966-02-19 1967-02-20
SE796270A SE390412B (sv) 1966-02-19 1967-02-20 2,4-diamino-5-(4'-hydroxybensyl)pyrimidiner till anvendning, som utgangsmaterial for framstellning av 2,4-diamino-5-(3',4',5'-trialikocibensyl)pyrimidiner
DK91167A DK120344B (da) 1966-02-19 1967-02-20 Fremgangsmåde til fremstilling af 5-benzyl-pyrimidiner.
FR106573A FR6595M (enrdf_load_stackoverflow) 1966-02-19 1967-05-16
FR138498A FR94837E (fr) 1966-02-19 1968-02-02 Procédé de préparation de dérivés de la pyrimidine.
DE19681720031 DE1720031A1 (de) 1966-02-19 1968-02-02 Biologisch wirksame 5-Benzylpyrimidin-Derivate und Verfahren zu ihrer Herstellung
FI26868A FI55031C (fi) 1966-02-19 1968-02-02 Foerfarande foer framstaellning av antibakteriella 5-bensylpyrimidiner
DK59371A DK128247B (da) 1966-02-19 1971-02-10 2,4-Diamino-5-(4'-hydroxybenzyl)-pyrimidiner til anvendelse som udgangsmaterialer ved fremstilling af tilsvarende forbindelser, hvori hydroxygruppens hydrogenatom er substitueret.
FI250271A FI55032C (fi) 1966-02-19 1971-09-07 Som utgaongsmaterial vid framstaellning av antibakteriella 2,4-diamino-5-(3',4',5'-trialkoxibensyl)-pyrimidiner anvaendbara 2,4-diamino-5-(4'-hydroxibensyl)-pyrimidiner
NO377771A NO133550C (enrdf_load_stackoverflow) 1966-02-19 1971-10-13
MY7100226A MY7100226A (en) 1966-02-19 1971-12-31 5-benzylpyrimidine derivatives and process for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB737666A GB1128234A (en) 1966-02-19 1966-02-19 5-benzylpyrimidine derivatives and process for the preparation thereof

Publications (1)

Publication Number Publication Date
GB1128234A true GB1128234A (en) 1968-09-25

Family

ID=9831956

Family Applications (1)

Application Number Title Priority Date Filing Date
GB737666A Expired GB1128234A (en) 1966-02-19 1966-02-19 5-benzylpyrimidine derivatives and process for the preparation thereof

Country Status (16)

Country Link
AT (2) AT275534B (enrdf_load_stackoverflow)
BE (1) BE694244A (enrdf_load_stackoverflow)
CA (1) CA977754A (enrdf_load_stackoverflow)
CH (2) CH511239A (enrdf_load_stackoverflow)
DE (2) DE1795635C3 (enrdf_load_stackoverflow)
DK (2) DK120344B (enrdf_load_stackoverflow)
ES (1) ES336945A1 (enrdf_load_stackoverflow)
FI (1) FI49714C (enrdf_load_stackoverflow)
FR (1) FR6595M (enrdf_load_stackoverflow)
GB (1) GB1128234A (enrdf_load_stackoverflow)
GR (1) GR33641B (enrdf_load_stackoverflow)
IL (1) IL27424A (enrdf_load_stackoverflow)
MY (1) MY7100226A (enrdf_load_stackoverflow)
NL (1) NL146811B (enrdf_load_stackoverflow)
NO (1) NO124601B (enrdf_load_stackoverflow)
SE (2) SE338998B (enrdf_load_stackoverflow)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2249532A1 (de) * 1971-10-12 1973-04-26 Wellcome Found Verfahren zur herstellung von 2,4-diamino-5-benzylpyrimidinen
EP0006987A1 (en) * 1978-05-24 1980-01-23 The Wellcome Foundation Limited 2,4-Diamino-5-benzylpyrimidines, especially for the treatment of microbial infections, pharmaceutical compositions containing these compounds and processes for preparing these compounds
DE2944145A1 (de) 1979-11-02 1981-05-14 Dynamit Nobel Ag, 5210 Troisdorf Verfahren zur herstellung von 2,4-diaminopyrimidin

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2249532A1 (de) * 1971-10-12 1973-04-26 Wellcome Found Verfahren zur herstellung von 2,4-diamino-5-benzylpyrimidinen
EP0006987A1 (en) * 1978-05-24 1980-01-23 The Wellcome Foundation Limited 2,4-Diamino-5-benzylpyrimidines, especially for the treatment of microbial infections, pharmaceutical compositions containing these compounds and processes for preparing these compounds
DE2944145A1 (de) 1979-11-02 1981-05-14 Dynamit Nobel Ag, 5210 Troisdorf Verfahren zur herstellung von 2,4-diaminopyrimidin

Also Published As

Publication number Publication date
SE390412B (sv) 1976-12-20
AT275534B (de) 1969-10-27
FI49714C (fi) 1975-09-10
DE1795635C3 (de) 1978-05-11
CH511239A (de) 1971-08-15
MY7100226A (en) 1971-12-31
FI49714B (enrdf_load_stackoverflow) 1975-06-02
NL6702397A (enrdf_load_stackoverflow) 1967-08-21
DK128247B (da) 1974-03-25
ES336945A1 (es) 1968-01-16
DE1720012B2 (de) 1977-06-08
NO124601B (enrdf_load_stackoverflow) 1972-05-08
SE338998B (enrdf_load_stackoverflow) 1971-09-27
AT270653B (de) 1969-05-12
BE694244A (enrdf_load_stackoverflow) 1967-08-17
DE1795635B2 (de) 1977-09-22
DE1720012A1 (de) 1972-04-06
GR33641B (el) 1968-01-03
CA977754A (en) 1975-11-11
IL27424A (en) 1971-02-25
CH513179A (de) 1971-09-30
DK120344B (da) 1971-05-17
NL146811B (nl) 1975-08-15
DE1795635A1 (de) 1972-10-19
FR6595M (enrdf_load_stackoverflow) 1969-01-06

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