GB1100226A - Injectable iron compositions - Google Patents
Injectable iron compositionsInfo
- Publication number
- GB1100226A GB1100226A GB10867/65A GB1086765A GB1100226A GB 1100226 A GB1100226 A GB 1100226A GB 10867/65 A GB10867/65 A GB 10867/65A GB 1086765 A GB1086765 A GB 1086765A GB 1100226 A GB1100226 A GB 1100226A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phosphate
- solution
- iron
- aqueous solution
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title abstract 12
- 229910052742 iron Inorganic materials 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000000243 solution Substances 0.000 abstract 7
- 239000007864 aqueous solution Substances 0.000 abstract 6
- -1 monosaccharide phosphate ester Chemical class 0.000 abstract 5
- 229910019142 PO4 Inorganic materials 0.000 abstract 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 4
- 229960004887 ferric hydroxide Drugs 0.000 abstract 4
- IEECXTSVVFWGSE-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide Chemical compound [OH-].[O-2].[Fe+3] IEECXTSVVFWGSE-UHFFFAOYSA-M 0.000 abstract 4
- 239000010452 phosphate Substances 0.000 abstract 4
- 239000011574 phosphorus Substances 0.000 abstract 4
- 229910052698 phosphorus Inorganic materials 0.000 abstract 4
- HXXFSFRBOHSIMQ-VFUOTHLCSA-N alpha-D-glucose 1-phosphate Chemical compound OC[C@H]1O[C@H](OP(O)(O)=O)[C@H](O)[C@@H](O)[C@@H]1O HXXFSFRBOHSIMQ-VFUOTHLCSA-N 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- 229950010772 glucose-1-phosphate Drugs 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 abstract 2
- ZKLLSNQJRLJIGT-UYFOZJQFSA-N keto-D-fructose 1-phosphate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)COP(O)(O)=O ZKLLSNQJRLJIGT-UYFOZJQFSA-N 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 abstract 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 abstract 1
- 235000011114 ammonium hydroxide Nutrition 0.000 abstract 1
- 239000003957 anion exchange resin Substances 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 abstract 1
- 159000000001 potassium salts Chemical class 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 abstract 1
- 239000001509 sodium citrate Substances 0.000 abstract 1
- 230000003019 stabilising effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
A complex of ferric iron and monosaccharide phosphate ester is prepared by reacting a colloidal aqueous solution of ferric hydroxide and an aqueous solution of an alkali metal salt of the said ester, in such proportions that the atomic ratio of iron to phosphorus does not exceed 10.7:1. The complex may be precipitated from the resulting solution by addition of about 0.5 volumes of ethanol, the complex containing iron and phosphorus in the said atomic ratio and any excess ester remaining in solution. Also described is a preparation, from glucose-1-phosphate, of the potassium salt using an anion exchange resin. The monosaccharide esters may be fructose-1-phosphate or glucose-1-phosphate. The aqueous solution of the complex is for use in pharmaceutical compositions (see Division A5).ALSO:Intravenously administrable iron compositions comprise an aqueous solution of the complex formed by reacting a colloidal aqueous solution of ferric hydroxide with an aqueous solution of an alkali metal salt of a monosaccharide phosphate ester, in such proportions that the atomic ratio of iron to phosphorus does not exceed 10.7:1. The esters may be fructose-1-phosphate or glucose-1-phosphate preferably as sodium or potassium salts. The ferric hydroxide solution is prepared in known manner by adding ammonia solution to ferric chloride solution and dialysing against water; it should contain about 5% Fe2O3. The reaction is preferably performed by adding the ferric hydroxide solution to the sugar phosphate solution, rather than vice-versa, to avoid forming and redissolving a precipitate. The ratio of iron to phosphorus is preferably below 10.7:1, so that unreacted sugar phosphate is present in the composition for its stabilising effect. The final solution may be further stabilised by boiling after preparation, and also by addition thereto of sodium citrate.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HURI000273 | 1964-03-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1100226A true GB1100226A (en) | 1968-01-24 |
Family
ID=11000801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB10867/65A Expired GB1100226A (en) | 1964-03-14 | 1965-03-15 | Injectable iron compositions |
Country Status (4)
| Country | Link |
|---|---|
| AT (1) | AT258472B (en) |
| FR (1) | FR4481M (en) |
| GB (1) | GB1100226A (en) |
| NL (1) | NL6503192A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1627641A1 (en) * | 2004-08-04 | 2006-02-22 | Victor Eluwa | Pharmaceutical compositions comprising metal oxides and uses thereof |
-
1965
- 1965-03-10 AT AT213365A patent/AT258472B/en active
- 1965-03-12 FR FR9041A patent/FR4481M/fr not_active Expired
- 1965-03-12 NL NL6503192A patent/NL6503192A/xx unknown
- 1965-03-15 GB GB10867/65A patent/GB1100226A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1627641A1 (en) * | 2004-08-04 | 2006-02-22 | Victor Eluwa | Pharmaceutical compositions comprising metal oxides and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| NL6503192A (en) | 1965-09-15 |
| FR4481M (en) | 1966-10-03 |
| AT258472B (en) | 1967-11-27 |
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