GB1093378A - Process for the production of n-acyl-ª‡-amino acid amides and peptides - Google Patents
Process for the production of n-acyl-ª‡-amino acid amides and peptidesInfo
- Publication number
- GB1093378A GB1093378A GB4813764A GB4813764A GB1093378A GB 1093378 A GB1093378 A GB 1093378A GB 4813764 A GB4813764 A GB 4813764A GB 4813764 A GB4813764 A GB 4813764A GB 1093378 A GB1093378 A GB 1093378A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- peptides
- acyl
- production
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compounds of formula R5CONHCR3R4CONHR6 are prepared by saponification, in a solvent with a strong base at - 40 DEG to + 50 DEG C., of compounds of formula <FORM:1093378/C2/1> these compounds having been made by simultaneous reaction in a solvent at - 70 DEG to + 80 DEG C., of R1CH(NH2)CHR2X, R3COR4, R5CO2H and R6NC. In these formulae, R1 and R2 are H, alkyl, cycloalkyl, aryl, CO2 alkyl or CO2 aralkyl; X is CN, CO2 alkyl or CO2 aryl, and may form a ring with R1 or R2; R3 is H or C1- 15 hydrocarbyl (possibly Cl, CO, SH, S alkyl, CO2 alkyl, OH or N3 substituted, or may contain O, S or N in a heterocyclic system); R4 is H or C1- 4 alkyl, R5 is H, C1- 20 hydrocarbyl (possibly halogen, N3, NO2, CO2 alkyl or protected amino substituted) or N-heterocyclyl; and R6 is alkyl, alkenyl, aralkyl or aryl (possibly substituted).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF41366A DE1212552B (en) | 1963-11-26 | 1963-11-26 | Process for the preparation of N-acyl-alpha-amino acid amides and peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1093378A true GB1093378A (en) | 1967-11-29 |
Family
ID=7098640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4813764A Expired GB1093378A (en) | 1963-11-26 | 1964-11-26 | Process for the production of n-acyl-ª‡-amino acid amides and peptides |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE656263A (en) |
| DE (1) | DE1212552B (en) |
| GB (1) | GB1093378A (en) |
-
1963
- 1963-11-26 DE DEF41366A patent/DE1212552B/en active Pending
-
1964
- 1964-11-26 BE BE656263D patent/BE656263A/xx unknown
- 1964-11-26 GB GB4813764A patent/GB1093378A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE656263A (en) | 1965-03-16 |
| DE1212552B (en) | 1966-03-17 |
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