GB1092682A - Undecapeptides having an eledoisine activity and a process for their manufacture - Google Patents
Undecapeptides having an eledoisine activity and a process for their manufactureInfo
- Publication number
- GB1092682A GB1092682A GB460/65A GB46065A GB1092682A GB 1092682 A GB1092682 A GB 1092682A GB 460/65 A GB460/65 A GB 460/65A GB 46065 A GB46065 A GB 46065A GB 1092682 A GB1092682 A GB 1092682A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ala
- phe
- boc
- gly
- ome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- AYLPVIWBPZMVSH-UHFFFAOYSA-N eledoisin Chemical compound C1CCN(C(=O)C2NC(=O)CC2)C1C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CC(O)=O)C(=O)NC(C)C(=O)NC(C(=O)NC(C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(N)=O)CC1=CC=CC=C1 AYLPVIWBPZMVSH-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 108010011559 alanylphenylalanine Proteins 0.000 abstract 5
- -1 L-pyroglutamyl Chemical group 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- FRIISBOVHKVDFX-LURJTMIESA-N (2s)-2-[[2-[(2-methylpropan-2-yl)oxycarbonylamino]acetyl]amino]propanoic acid Chemical compound OC(=O)[C@H](C)NC(=O)CNC(=O)OC(C)(C)C FRIISBOVHKVDFX-LURJTMIESA-N 0.000 abstract 2
- 125000003440 L-leucyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C(C([H])([H])[H])([H])C([H])([H])[H] 0.000 abstract 2
- 125000003580 L-valyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(C([H])([H])[H])(C([H])([H])[H])[H] 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 108010075431 glycyl-alanyl-phenylalanine Proteins 0.000 abstract 2
- 108010050848 glycylleucine Proteins 0.000 abstract 2
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 abstract 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 1
- 125000000570 L-alpha-aspartyl group Chemical group [H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 125000000010 L-asparaginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C(=O)N([H])[H] 0.000 abstract 1
- 125000002061 L-isoleucyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])[C@](C([H])([H])[H])([H])C(C([H])([H])[H])([H])[H] 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- VWMHVZQASBYBBB-UHFFFAOYSA-N benzyl 2-[2-[[2-[(2-methylpropan-2-yl)oxycarbonylamino]acetyl]amino]propanoylamino]-3-phenylpropanoate Chemical compound C=1C=CC=CC=1COC(=O)C(NC(=O)C(NC(=O)CNC(=O)OC(C)(C)C)C)CC1=CC=CC=C1 VWMHVZQASBYBBB-UHFFFAOYSA-N 0.000 abstract 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 108010091871 leucylmethionine Proteins 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DESC034444 | 1964-01-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1092682A true GB1092682A (en) | 1967-11-29 |
Family
ID=7433138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB460/65A Expired GB1092682A (en) | 1964-01-09 | 1965-01-05 | Undecapeptides having an eledoisine activity and a process for their manufacture |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3268502A (enrdf_load_stackoverflow) |
| BE (1) | BE658146A (enrdf_load_stackoverflow) |
| CH (1) | CH454161A (enrdf_load_stackoverflow) |
| DE (1) | DE1518343A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1092682A (enrdf_load_stackoverflow) |
| NL (1) | NL6414277A (enrdf_load_stackoverflow) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT251777B (de) * | 1961-10-05 | 1967-01-25 | Farmaceutici Italia | Verfahren zur Herstellung neuer Hendekapeptide |
| CH436327A (de) * | 1962-12-10 | 1967-05-31 | Sandoz Ag | Verfahren zur Herstellung eines neuen Polypeptids |
| GB1054191A (enrdf_load_stackoverflow) * | 1963-03-01 | |||
| DE1518349C3 (de) * | 1965-09-21 | 1975-03-20 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung eledoisinwirksamer Verbindungen |
| US4215110A (en) * | 1978-09-22 | 1980-07-29 | Merck & Co., Inc. | Method of treating hypertension |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2710858A (en) * | 1952-05-02 | 1955-06-14 | Borden Co | Making ferrilactin |
| US2776923A (en) * | 1953-09-18 | 1957-01-08 | Nishizawa Yoshito | Composition comprising glutamylcholine salts |
| US2850491A (en) * | 1955-07-05 | 1958-09-02 | Ciba Pharm Prod Inc | Peptide derivatives and process for their manufacture |
| US2866783A (en) * | 1956-07-05 | 1958-12-30 | Bovarnick Max | Glutamic and aspartic acid polypeptide polymers as plasma volume extenders |
| GB843118A (en) * | 1957-02-13 | 1960-08-04 | Ici Ltd | Pharmaceutical compositions containing piperidine derivatives |
-
1964
- 1964-01-09 DE DE19641518343 patent/DE1518343A1/de active Pending
- 1964-12-09 NL NL6414277A patent/NL6414277A/xx unknown
- 1964-12-23 US US420788A patent/US3268502A/en not_active Expired - Lifetime
- 1964-12-24 CH CH1669864A patent/CH454161A/de unknown
-
1965
- 1965-01-05 GB GB460/65A patent/GB1092682A/en not_active Expired
- 1965-01-11 BE BE658146A patent/BE658146A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US3268502A (en) | 1966-08-23 |
| BE658146A (enrdf_load_stackoverflow) | 1965-07-12 |
| DE1518343A1 (de) | 1969-12-18 |
| NL6414277A (enrdf_load_stackoverflow) | 1965-07-12 |
| CH454161A (de) | 1968-04-15 |
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