GB1092185A - A salt of a nitrogen-containing ester of phosphoric acid and the therapeutic applications thereof - Google Patents
A salt of a nitrogen-containing ester of phosphoric acid and the therapeutic applications thereofInfo
- Publication number
- GB1092185A GB1092185A GB1678465A GB1678465A GB1092185A GB 1092185 A GB1092185 A GB 1092185A GB 1678465 A GB1678465 A GB 1678465A GB 1678465 A GB1678465 A GB 1678465A GB 1092185 A GB1092185 A GB 1092185A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phosphoric acid
- mono
- calcium salt
- salt
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 nitrogen-containing ester Chemical class 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 title 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- SUHOOTKUPISOBE-UHFFFAOYSA-N O-phosphoethanolamine Chemical compound NCCOP(O)(O)=O SUHOOTKUPISOBE-UHFFFAOYSA-N 0.000 abstract 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical class [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
- 239000004606 Fillers/Extenders Substances 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- 229910000019 calcium carbonate Inorganic materials 0.000 abstract 1
- 239000001110 calcium chloride Substances 0.000 abstract 1
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 1
- 235000011148 calcium chloride Nutrition 0.000 abstract 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 abstract 1
- 239000000920 calcium hydroxide Substances 0.000 abstract 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000006210 lotion Substances 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000003883 ointment base Substances 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Birds (AREA)
- Medicinal Preparation (AREA)
Abstract
The mono-calcium salt of phosphoric acid monoaminoethyl ester of the formula <FORM:1092185/C2/1> is prepared by treating 2-aminoethylphosphoric acid with calcium carbonate, other convenient soluble calcium salt, e.g. CaCl2 or calcium hydroxide. The compound, which, from its high stability to hydrolysis, may have an internal ring structure, is a therapeutic agent of wide application.ALSO:Therapeutic compositions comprise the mono-calcium salt of phosphoric acid mono-aminoethyl ester, and magnesium and/or potassium aspartates. Therapeutically acceptable diluents or extenders may also be present. The compositions may take the form of aqueous vials for injection, liquid oral preparations, tablets, suppositories, lotions in aqueous resorbable solution, emulsion or ointment bases, or ophthalmic preparations. They are stated to be useful in the treatment of a wide range of diseases and conditions.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1678465A GB1092185A (en) | 1964-01-28 | 1965-04-21 | A salt of a nitrogen-containing ester of phosphoric acid and the therapeutic applications thereof |
| DE19651492057 DE1492057A1 (en) | 1964-01-28 | 1965-07-01 | Preparations for the care of the skin and hair |
| FR46557A FR5575M (en) | 1964-01-28 | 1966-01-20 | |
| FR58410A FR5577M (en) | 1964-01-28 | 1966-04-21 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR961794A FR3575M (en) | 1964-01-28 | 1964-01-28 | Substituted triphenylhaloethylenes. |
| GB1678464 | 1965-04-21 | ||
| GB1678465A GB1092185A (en) | 1964-01-28 | 1965-04-21 | A salt of a nitrogen-containing ester of phosphoric acid and the therapeutic applications thereof |
| FR46557A FR5575M (en) | 1964-01-28 | 1966-01-20 | |
| FR58410A FR5577M (en) | 1964-01-28 | 1966-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1092185A true GB1092185A (en) | 1967-11-22 |
Family
ID=27514760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1678465A Expired GB1092185A (en) | 1964-01-28 | 1965-04-21 | A salt of a nitrogen-containing ester of phosphoric acid and the therapeutic applications thereof |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE1492057A1 (en) |
| FR (2) | FR5575M (en) |
| GB (1) | GB1092185A (en) |
-
1965
- 1965-04-21 GB GB1678465A patent/GB1092185A/en not_active Expired
- 1965-07-01 DE DE19651492057 patent/DE1492057A1/en active Pending
-
1966
- 1966-01-20 FR FR46557A patent/FR5575M/fr not_active Expired
- 1966-04-21 FR FR58410A patent/FR5577M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR5575M (en) | 1967-11-27 |
| DE1492057A1 (en) | 1969-03-06 |
| FR5577M (en) | 1967-11-27 |
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