GB1083509A - Chromomycin a derivative and production thereof - Google Patents

Chromomycin a derivative and production thereof

Info

Publication number
GB1083509A
GB1083509A GB47165/64A GB4716564A GB1083509A GB 1083509 A GB1083509 A GB 1083509A GB 47165/64 A GB47165/64 A GB 47165/64A GB 4716564 A GB4716564 A GB 4716564A GB 1083509 A GB1083509 A GB 1083509A
Authority
GB
United Kingdom
Prior art keywords
chromomycin
hemisuccinate
derivative
production
orally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB47165/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of GB1083509A publication Critical patent/GB1083509A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms

Abstract

The invention relates to chromomycin A3 hemisuccinate in which not more than three hydrogen atoms of alcoholic hydroxyl groups of chromomycin A3 are substituted by the corresponding number of -CO.CH2.CH2.COOH radicals; or alkali metal, alkaline earth metal or ammonium salts thereof. The hemisuccinate is prepared by reacting chromomycin A3 with succinic acid, succinic anhydride or succinyl chloride in a solvent at a temperature below 10 DEG C., preferably in the presence of pyridine. Chromomycin A3 hemisuccinate is effective against tumours and Gram-positive bacteria, is soluble in water and has low toxicity. It may be administered parenterally or orally.
GB47165/64A 1963-11-22 1964-11-19 Chromomycin a derivative and production thereof Expired GB1083509A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6283363 1963-11-22

Publications (1)

Publication Number Publication Date
GB1083509A true GB1083509A (en) 1967-09-13

Family

ID=13211699

Family Applications (1)

Application Number Title Priority Date Filing Date
GB47165/64A Expired GB1083509A (en) 1963-11-22 1964-11-19 Chromomycin a derivative and production thereof

Country Status (3)

Country Link
DE (1) DE1493253A1 (en)
FR (1) FR4261M (en)
GB (1) GB1083509A (en)

Also Published As

Publication number Publication date
DE1493253A1 (en) 1970-10-15
FR4261M (en) 1966-07-04

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