GB1083250A - New, anti-diabetically active sulphonamides - Google Patents
New, anti-diabetically active sulphonamidesInfo
- Publication number
- GB1083250A GB1083250A GB3638666A GB3638666A GB1083250A GB 1083250 A GB1083250 A GB 1083250A GB 3638666 A GB3638666 A GB 3638666A GB 3638666 A GB3638666 A GB 3638666A GB 1083250 A GB1083250 A GB 1083250A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- reacting
- radical
- substituted
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
-
- D—TEXTILES; PAPER
- D05—SEWING; EMBROIDERING; TUFTING
- D05B—SEWING
- D05B85/00—Needles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Textile Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Sewing Machines And Sewing (AREA)
- Registering, Tensioning, Guiding Webs, And Rollers Therefor (AREA)
- Preliminary Treatment Of Fibers (AREA)
Abstract
Novel compounds of the Formula I, wherein X represents a straight or branched C1- 4 hydro-carbon radical. A represents an unsubstituted or substituted thienyl or furyl radical, n represents 0, 1 or 2, R1 represents a hydrogen atom or a 1- 3 alkyl or unsubstituted or substituted phenylalkyl radical and R2 represents an unsubstituted or substituted alkyl, cycloalkyl, aryl, aralkyl, alkoxy, alkylmercapto, alkoxyalkyl or alkoxyalkoxy radical, are prepared by reacting a compound of the Formula II wherein m represents 0, 1 or 2 with a 2-amino-5-R2 -substituted)-pyrimidine and, where necessary, oxidizing the product to the corresponding sulphonamide; by reacting a sulphonylguanidine of the Formula IV with a compound of the Formula V wherein Y and Y1, the same or different, represent hydrogen atoms or alkoxy radicals or with a functional derivative thereof and, if necessary, replacing the hydroxy groups in the 4- and/or 6-positions of the resultant pyrimidine ring by halogen atoms and reductively dehalogenating; by acylating a compound of the Formula VI with a reactive derivative of an acid of the formula A-(CH2)nCOOH; by reacting a sulphonamide of the Formula VIII with a pyrimidine of the Formula IX wherein Z represents a reactive ester group or a tri-(C1- 3 alkyl) quaternary ammonium group or by reacting a sulphonic acid of the Formula X with a 2-acetylaminopyrimidine. <FORM:1083250/C2/1> <FORM:1083250/C2/2> <FORM:1083250/C2/3> <FORM:1083250/C2/4> <FORM:1083250/C2/5> <FORM:1083250/C2/6> <FORM:1083250/C2/7> <FORM:1083250/C2/8>
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEB83296A DE1301817B (en) | 1965-08-17 | 1965-08-17 | Process for the preparation of 2-benzenesulfonamidopyrimidines substituted in the 5-position |
| CH1895968A CH501088A (en) | 1965-08-17 | 1968-12-19 | Threading needle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1083250A true GB1083250A (en) | 1967-09-13 |
Family
ID=25721809
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3638666A Expired GB1083250A (en) | 1965-08-17 | 1966-08-15 | New, anti-diabetically active sulphonamides |
| GB1258017D Expired GB1258017A (en) | 1965-08-17 | 1969-12-04 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1258017D Expired GB1258017A (en) | 1965-08-17 | 1969-12-04 |
Country Status (12)
| Country | Link |
|---|---|
| BE (1) | BE685537A (en) |
| BR (1) | BR6682108D0 (en) |
| CH (2) | CH476011A (en) |
| DE (2) | DE1301817B (en) |
| DK (1) | DK118717B (en) |
| FI (1) | FI45178C (en) |
| FR (2) | FR1505417A (en) |
| GB (2) | GB1083250A (en) |
| IL (1) | IL26338A (en) |
| NL (1) | NL6611549A (en) |
| NO (1) | NO118917B (en) |
| SE (1) | SE344200B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3711564A (en) * | 1968-10-17 | 1973-01-16 | Boehringer Mannheim Gmbh | Novel sulfonylaminopyrimidines and compositions containing them |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2048906A1 (en) * | 1970-10-06 | 1972-04-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Blood sugar lowering sulfonylaminopyrimidines and processes for their preparation |
| FR2474546A1 (en) * | 1979-12-21 | 1981-07-31 | Vrau Sa Ets | Plastic needle for sewing canvas - has eye which widens up under pressure, for ease in threading |
| DE9102151U1 (en) * | 1990-03-06 | 1991-05-16 | Geberit Ag, Jona, St.Gallen | Double pipe connection on plastic pipes |
| DE19711602C2 (en) * | 1997-03-20 | 2003-12-24 | Dallmer Gmbh & Co Kg | Drain with height-adjustable inlet part |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1101428B (en) * | 1959-07-08 | 1961-03-09 | Schering Ag | Process for the preparation of long-acting aminobenzenesulfonic acid amide derivatives |
-
1965
- 1965-08-17 DE DEB83296A patent/DE1301817B/en active Pending
-
1966
- 1966-08-15 GB GB3638666A patent/GB1083250A/en not_active Expired
- 1966-08-15 CH CH1171666A patent/CH476011A/en not_active IP Right Cessation
- 1966-08-15 NO NO16430466A patent/NO118917B/no unknown
- 1966-08-15 IL IL2633866A patent/IL26338A/en unknown
- 1966-08-16 BE BE685537D patent/BE685537A/xx unknown
- 1966-08-16 FI FI213966A patent/FI45178C/en active
- 1966-08-16 FR FR73111A patent/FR1505417A/en not_active Expired
- 1966-08-16 DK DK419566A patent/DK118717B/en unknown
- 1966-08-16 BR BR18210866A patent/BR6682108D0/en unknown
- 1966-08-16 SE SE1108066A patent/SE344200B/xx unknown
- 1966-08-17 NL NL6611549A patent/NL6611549A/xx unknown
-
1968
- 1968-12-19 CH CH1895968A patent/CH501088A/en not_active IP Right Cessation
-
1969
- 1969-12-03 FR FR6941712A patent/FR2026516A1/fr not_active Withdrawn
- 1969-12-04 GB GB1258017D patent/GB1258017A/en not_active Expired
- 1969-12-16 DE DE19691962886 patent/DE1962886A1/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3711564A (en) * | 1968-10-17 | 1973-01-16 | Boehringer Mannheim Gmbh | Novel sulfonylaminopyrimidines and compositions containing them |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2026516A1 (en) | 1970-09-18 |
| SE344200B (en) | 1972-04-04 |
| FI45178B (en) | 1971-12-31 |
| CH476011A (en) | 1969-07-31 |
| FI45178C (en) | 1972-04-10 |
| NO118917B (en) | 1970-03-02 |
| IL26338A (en) | 1970-05-21 |
| CH501088A (en) | 1970-12-31 |
| GB1258017A (en) | 1971-12-22 |
| NL6611549A (en) | 1967-02-20 |
| DE1962886A1 (en) | 1970-07-09 |
| BR6682108D0 (en) | 1973-12-04 |
| FR1505417A (en) | 1967-12-15 |
| DE1301817B (en) | 1969-08-28 |
| DK118717B (en) | 1970-09-28 |
| BE685537A (en) | 1967-02-16 |
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