GB1072414A - New dihydrothieno(3,2-d)pyrimidines - Google Patents
New dihydrothieno(3,2-d)pyrimidinesInfo
- Publication number
- GB1072414A GB1072414A GB2509464A GB2509464A GB1072414A GB 1072414 A GB1072414 A GB 1072414A GB 2509464 A GB2509464 A GB 2509464A GB 2509464 A GB2509464 A GB 2509464A GB 1072414 A GB1072414 A GB 1072414A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- alkyl
- formula
- free
- halogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 3
- 231100000252 nontoxic Toxicity 0.000 abstract 3
- 230000003000 nontoxic effect Effects 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- WNRMSBYKUXFYMP-UHFFFAOYSA-N 2,4-dichloro-1,2-dihydrothieno[3,2-d]pyrimidine Chemical compound ClC1N=C(C2=C(N1)C=CS2)Cl WNRMSBYKUXFYMP-UHFFFAOYSA-N 0.000 abstract 1
- RVPDJNSIEIRLMI-UHFFFAOYSA-N 4-(2-chloro-1,2-dihydrothieno[3,2-d]pyrimidin-4-yl)morpholine Chemical compound ClC1N=C(C2=C(N1)C=CS2)N2CCOCC2 RVPDJNSIEIRLMI-UHFFFAOYSA-N 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- -1 bacteriostatic Substances 0.000 abstract 1
- 230000003385 bacteriostatic effect Effects 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 230000005792 cardiovascular activity Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 239000006196 drop Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US288491A US3272811A (en) | 1962-07-04 | 1963-06-17 | Dihydrothieno-[3, 4-d]-pyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1072414A true GB1072414A (en) | 1967-06-14 |
Family
ID=23107339
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2509364A Expired GB1072413A (en) | 1963-06-17 | 1964-06-17 | New dihydrothieno[3,2-d]pyrimidines |
| GB2509464A Expired GB1072414A (en) | 1963-06-17 | 1964-06-17 | New dihydrothieno(3,2-d)pyrimidines |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2509364A Expired GB1072413A (en) | 1963-06-17 | 1964-06-17 | New dihydrothieno[3,2-d]pyrimidines |
Country Status (7)
| Country | Link |
|---|---|
| BE (2) | BE649348A (enrdf_load_stackoverflow) |
| CH (2) | CH442328A (enrdf_load_stackoverflow) |
| ES (1) | ES301103A1 (enrdf_load_stackoverflow) |
| FR (4) | FR3824M (enrdf_load_stackoverflow) |
| GB (2) | GB1072413A (enrdf_load_stackoverflow) |
| NL (4) | NL6406834A (enrdf_load_stackoverflow) |
| SE (2) | SE300214B (enrdf_load_stackoverflow) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI380984B (zh) * | 2006-04-19 | 2013-01-01 | Boehringer Ingelheim Int | 用於治療炎性疾病之新穎化合物 |
| US8604039B2 (en) | 2006-04-19 | 2013-12-10 | Boehringer Ingelheim International Gmbh | Dihydrothienopyrimidines for the treatment of inflammatory diseases |
| US8637519B2 (en) | 2007-10-19 | 2014-01-28 | Boehringer Ingelheim International Gmbh | Heterocycle-substituted piperazino-dihydrothienopyrimidines |
| US8754073B2 (en) | 2007-10-19 | 2014-06-17 | Boehringer Ingelheim International Gmbh | Substituted piperazino-dihydrothienopyrimidines |
| US9090626B2 (en) | 2007-10-19 | 2015-07-28 | Boehringer Ingelheim International Gmbh | Piperazino-dihydrothienopyrimidine derivatives |
| US9150586B2 (en) | 2011-08-24 | 2015-10-06 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
| US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3888215T2 (de) * | 1987-01-21 | 1994-09-08 | Merck & Co Inc | Piperazinylpyrimidine als beta-adrenergische Rezeptoren blockierende Mittel. |
-
0
- NL NL122810A patent/NL122810C/xx active
- NL NL124131A patent/NL124131C/xx active
-
1964
- 1964-05-28 CH CH695364A patent/CH442328A/de unknown
- 1964-05-28 CH CH695264A patent/CH446358A/de unknown
- 1964-06-05 SE SE686864A patent/SE300214B/xx unknown
- 1964-06-05 SE SE686764A patent/SE300213B/xx unknown
- 1964-06-15 FR FR978344A patent/FR3824M/fr not_active Expired
- 1964-06-15 FR FR978342A patent/FR1555459A/fr not_active Expired
- 1964-06-15 FR FR978343A patent/FR1555460A/fr not_active Expired
- 1964-06-16 BE BE649348A patent/BE649348A/xx unknown
- 1964-06-16 NL NL6406834A patent/NL6406834A/xx unknown
- 1964-06-16 ES ES0301103A patent/ES301103A1/es not_active Expired
- 1964-06-16 NL NL6406835A patent/NL6406835A/xx unknown
- 1964-06-16 BE BE649347A patent/BE649347A/xx unknown
- 1964-06-17 GB GB2509364A patent/GB1072413A/en not_active Expired
- 1964-06-17 GB GB2509464A patent/GB1072414A/en not_active Expired
- 1964-09-04 FR FR987185A patent/FR3648M/fr not_active Expired
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8354531B2 (en) | 2005-04-21 | 2013-01-15 | Boehringer Ingelheim International Gmbh | Compounds for the treatment of inflammatory diseases |
| TWI380984B (zh) * | 2006-04-19 | 2013-01-01 | Boehringer Ingelheim Int | 用於治療炎性疾病之新穎化合物 |
| US8604039B2 (en) | 2006-04-19 | 2013-12-10 | Boehringer Ingelheim International Gmbh | Dihydrothienopyrimidines for the treatment of inflammatory diseases |
| US8637519B2 (en) | 2007-10-19 | 2014-01-28 | Boehringer Ingelheim International Gmbh | Heterocycle-substituted piperazino-dihydrothienopyrimidines |
| US8754073B2 (en) | 2007-10-19 | 2014-06-17 | Boehringer Ingelheim International Gmbh | Substituted piperazino-dihydrothienopyrimidines |
| US9090626B2 (en) | 2007-10-19 | 2015-07-28 | Boehringer Ingelheim International Gmbh | Piperazino-dihydrothienopyrimidine derivatives |
| US9115142B2 (en) | 2007-10-19 | 2015-08-25 | Boehringer Ingelheim International Gmbh | Heterocycle-substituted piperazino-dihydrothienopyrimidines |
| US9150586B2 (en) | 2011-08-24 | 2015-10-06 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
| US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
| US10745411B2 (en) | 2011-08-24 | 2020-08-18 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
Also Published As
| Publication number | Publication date |
|---|---|
| NL6406834A (enrdf_load_stackoverflow) | 1964-12-18 |
| CH446358A (de) | 1967-11-15 |
| NL6406835A (enrdf_load_stackoverflow) | 1964-12-18 |
| BE649348A (enrdf_load_stackoverflow) | 1964-12-16 |
| NL122810C (enrdf_load_stackoverflow) | |
| ES301103A1 (es) | 1965-01-16 |
| GB1072413A (en) | 1967-06-14 |
| FR3648M (fr) | 1965-10-25 |
| BE649347A (enrdf_load_stackoverflow) | 1964-12-16 |
| SE300214B (enrdf_load_stackoverflow) | 1968-04-22 |
| CH442328A (de) | 1967-08-31 |
| FR3824M (fr) | 1966-01-10 |
| SE300213B (enrdf_load_stackoverflow) | 1968-04-22 |
| NL124131C (enrdf_load_stackoverflow) | |
| FR1555460A (enrdf_load_stackoverflow) | 1969-01-31 |
| FR1555459A (enrdf_load_stackoverflow) | 1969-01-31 |
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