GB1101179A - Improvements in or relating to nitrofuryl quinazolines - Google Patents
Improvements in or relating to nitrofuryl quinazolinesInfo
- Publication number
- GB1101179A GB1101179A GB52914/65A GB5291465A GB1101179A GB 1101179 A GB1101179 A GB 1101179A GB 52914/65 A GB52914/65 A GB 52914/65A GB 5291465 A GB5291465 A GB 5291465A GB 1101179 A GB1101179 A GB 1101179A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- nitrofuryl
- quinazolines
- relating
- alkoxyalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HUMQYUYJBQVCSY-UHFFFAOYSA-N 2-(furan-2-yl)-4-nitroquinazoline Chemical class [N+](=O)([O-])C1=NC(=NC2=CC=CC=C12)C=1OC=CC=1 HUMQYUYJBQVCSY-UHFFFAOYSA-N 0.000 title 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- -1 morpholinopropyl group Chemical group 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Novel compounds of the formula <FORM:1101179/C2/1> in which R represents a hydrogen atom or an alkyl, hydroxyalkyl, alkoxyalkyl or amino group and R1 represents a hydroxyalkyl, alkoxyalkyl or morpholinopropyl group, the alkyl groups in R and R1 containing from 1 to 4 carbon atoms, are prepared by reacting a 4-halo - 2 - (5 - nitro - 2 - furyl) - quinazoline wth an amine of the formula HNRR1. Antibacterial compositions for oral or topical administration comprise a compound of the Formula I together with a carrier.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4532167A GB1101180A (en) | 1964-12-14 | 1965-12-13 | Improvements in or relating to nitrofuryl quinazolines |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US418311A US3324122A (en) | 1964-12-14 | 1964-12-14 | Series of 4-substituted-2-(5-nitro-2-furyl) quinazolines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1101179A true GB1101179A (en) | 1968-01-31 |
Family
ID=23657580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB52914/65A Expired GB1101179A (en) | 1964-12-14 | 1965-12-13 | Improvements in or relating to nitrofuryl quinazolines |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US3324122A (en) |
| AT (1) | AT255424B (en) |
| BE (1) | BE672504A (en) |
| BR (1) | BR6575667D0 (en) |
| CH (1) | CH448110A (en) |
| DE (1) | DE1620076A1 (en) |
| DK (1) | DK117902B (en) |
| ES (1) | ES318292A1 (en) |
| FR (2) | FR1460221A (en) |
| GB (1) | GB1101179A (en) |
| IL (1) | IL24359A (en) |
| NL (1) | NL6513634A (en) |
| NO (1) | NO118066B (en) |
| SE (1) | SE325579B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3542784A (en) * | 1968-04-05 | 1970-11-24 | Norwich Pharma Co | 4-(hydroxyanilino)-2-(5-nitro-2-furyl)quinazolines |
| US3705898A (en) * | 1970-01-26 | 1972-12-12 | Morton Norwich Products Inc | Certain 4 - amino - 2-(5-nitro-2-thienyl) quinazolines and the intermediate 4 - chloro-(5 - nitro-2-thienyl)quinazolines therefor |
| CH612432A5 (en) * | 1975-05-12 | 1979-07-31 | Sandoz Ag | |
| JP2657760B2 (en) * | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | 4-aminoquinazoline derivatives and pharmaceuticals containing them |
| CA2534405A1 (en) * | 2003-08-08 | 2005-02-17 | Ulysses Pharmaceutical Products Inc. | Halogenated quinazolinyl nitrofurans as antibacterial agents |
| US20080146562A1 (en) * | 2003-08-08 | 2008-06-19 | Ulysses Pharmaceutical Products Inc., | Halogenated quinazolinyl nitrofurans as antibacterial agents |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL265777A (en) * | 1960-06-09 |
-
1964
- 1964-12-14 US US418311A patent/US3324122A/en not_active Expired - Lifetime
-
1965
- 1965-09-23 IL IL24359A patent/IL24359A/en unknown
- 1965-10-08 ES ES0318292A patent/ES318292A1/en not_active Expired
- 1965-10-13 DE DE19651620076 patent/DE1620076A1/en active Pending
- 1965-10-15 SE SE13375/65A patent/SE325579B/xx unknown
- 1965-10-20 DK DK535765AA patent/DK117902B/en unknown
- 1965-10-21 NL NL6513634A patent/NL6513634A/xx unknown
- 1965-11-15 AT AT1028165A patent/AT255424B/en active
- 1965-11-16 NO NO160494A patent/NO118066B/no unknown
- 1965-11-18 BE BE672504A patent/BE672504A/xx unknown
- 1965-12-10 FR FR41816A patent/FR1460221A/en not_active Expired
- 1965-12-10 FR FR41817A patent/FR4910M/fr not_active Expired
- 1965-12-13 CH CH1713065A patent/CH448110A/en unknown
- 1965-12-13 GB GB52914/65A patent/GB1101179A/en not_active Expired
- 1965-12-14 BR BR175667/65A patent/BR6575667D0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL6513634A (en) | 1966-06-15 |
| SE325579B (en) | 1970-07-06 |
| CH448110A (en) | 1967-12-15 |
| DE1620076A1 (en) | 1970-02-12 |
| IL24359A (en) | 1969-01-29 |
| ES318292A1 (en) | 1967-03-01 |
| BR6575667D0 (en) | 1973-09-06 |
| US3324122A (en) | 1967-06-06 |
| FR1460221A (en) | 1966-06-17 |
| FR4910M (en) | 1967-03-13 |
| DK117902B (en) | 1970-06-15 |
| AT255424B (en) | 1967-07-10 |
| BE672504A (en) | 1966-03-16 |
| NO118066B (en) | 1969-11-03 |
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