GB1068814A - Pyrogiutamic acid derivative and process for the preparation thereof - Google Patents
Pyrogiutamic acid derivative and process for the preparation thereofInfo
- Publication number
- GB1068814A GB1068814A GB1897265A GB1897265A GB1068814A GB 1068814 A GB1068814 A GB 1068814A GB 1897265 A GB1897265 A GB 1897265A GB 1897265 A GB1897265 A GB 1897265A GB 1068814 A GB1068814 A GB 1068814A
- Authority
- GB
- United Kingdom
- Prior art keywords
- anhydride
- preparation
- ester
- prepared
- acid derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The novel compound 3,5,8,10-tetraoxoperhydrodipyrrolo [a, d] pyrazine, hereinafter referred to as "pyroglutamic anhydride," and of formula <FORM:1068814/C2/1> may be prepared by dehydration and condensation of two molecules of pyroglutamic acid or dealcoholization of an ester thereof, using as condensing agent a carboxylic anhydride (usually acetic anhydride) or an alcohol, and a reaction temperature of 50-250 DEG C. Both D- and L-forms, also an optically inactive form may be prepared, and the optical activity of any one reaction product depends on that of the starting acid or ester, and the reaction temperature; above about 190 DEG C. only the racemic mixture is obtained. The product is obtained by crystallization and has a m.p. of 320 DEG C. with decomposition. It exhibits anti-microbial activity.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2603564 | 1964-05-09 | ||
| JP5030164 | 1964-05-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1068814A true GB1068814A (en) | 1967-05-17 |
Family
ID=26363763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1897265A Expired GB1068814A (en) | 1964-05-09 | 1965-05-05 | Pyrogiutamic acid derivative and process for the preparation thereof |
Country Status (2)
| Country | Link |
|---|---|
| CH (1) | CH447179A (en) |
| GB (1) | GB1068814A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109988180B (en) * | 2019-04-26 | 2021-09-28 | 中国科学院烟台海岸带研究所 | Diketopiperazine derivative and preparation and application thereof |
-
1965
- 1965-05-05 GB GB1897265A patent/GB1068814A/en not_active Expired
- 1965-05-06 CH CH631865A patent/CH447179A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH447179A (en) | 1967-11-30 |
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