GB1066325A - A method for preparing guanine and its derivatives - Google Patents

A method for preparing guanine and its derivatives

Info

Publication number
GB1066325A
GB1066325A GB1809264A GB1809264A GB1066325A GB 1066325 A GB1066325 A GB 1066325A GB 1809264 A GB1809264 A GB 1809264A GB 1809264 A GB1809264 A GB 1809264A GB 1066325 A GB1066325 A GB 1066325A
Authority
GB
United Kingdom
Prior art keywords
guanine
derivatives
hydrogen
prepared
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1809264A
Inventor
Yasuo Fujimoto
Keizo Tatsukawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of GB1066325A publication Critical patent/GB1066325A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Guanine and derivatives thereof having the formula <FORM:1066325/C2/1> or <FORM:1066325/C2/2> wherein R1 and R2 represent H or C1- 6 alkyl groups, are prepared by reacting 2,4-diamino-6-hydroxy -5-nitrosopyrimidine or a derivative thereof of the formula <FORM:1066325/C2/3> or <FORM:1066325/C2/4> with formamide under reducing conditions and with heating to complete ring closure, without isolation of intermediate products. The starting materials may be prepared in situ by a nitrosation reaction. Reducing conditions may be provided by hydrogen and a hydrogenation catalyst or by means of a reducing agent with or without hydrogen. Various solvents may also be present during the reaction. The examples describe the preparation of guanine and 3-methylguanine hydrochlorides.
GB1809264A 1963-04-30 1964-04-30 A method for preparing guanine and its derivatives Expired GB1066325A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2225363 1963-04-30
JP6162563 1963-11-18

Publications (1)

Publication Number Publication Date
GB1066325A true GB1066325A (en) 1967-04-26

Family

ID=26359426

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1809264A Expired GB1066325A (en) 1963-04-30 1964-04-30 A method for preparing guanine and its derivatives

Country Status (2)

Country Link
BE (1) BE647302A (en)
GB (1) GB1066325A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0304004A1 (en) 1987-08-18 1989-02-22 Boehringer Ingelheim Kg Process for the production of sodium purines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0304004A1 (en) 1987-08-18 1989-02-22 Boehringer Ingelheim Kg Process for the production of sodium purines

Also Published As

Publication number Publication date
BE647302A (en) 1964-08-17

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