GB1063891A - Method for preparation of benzodiazepinones - Google Patents
Method for preparation of benzodiazepinonesInfo
- Publication number
- GB1063891A GB1063891A GB169264A GB169264A GB1063891A GB 1063891 A GB1063891 A GB 1063891A GB 169264 A GB169264 A GB 169264A GB 169264 A GB169264 A GB 169264A GB 1063891 A GB1063891 A GB 1063891A
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzodiazepinones
- preparation
- hydrogen atom
- formula
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZHYMGSPDEVXULU-UHFFFAOYSA-N 1,2-benzodiazepin-3-one Chemical class N1=NC(=O)C=CC2=CC=CC=C21 ZHYMGSPDEVXULU-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 abstract 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000003143 4-hydroxybenzyl group Chemical group [H]C([*])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB169364A GB1056289A (en) | 1964-01-14 | 1964-01-14 | 2-phthalimido acetamido benzophenones and their preparation |
| GB169264A GB1063891A (en) | 1964-01-14 | 1964-01-14 | Method for preparation of benzodiazepinones |
| IL2267864A IL22678A (en) | 1964-01-14 | 1964-12-27 | 2-phthalimido acetamido benzophenones and their preparation |
| IL2267964A IL22679A (en) | 1964-01-14 | 1964-12-28 | Method for the preparation of benzodiazepinones |
| ES0308038A ES308038A1 (es) | 1964-01-14 | 1965-01-12 | Un procedimiento para la produccion de 5-fenil-1,4-3h-benzodiazepin-2 (1h)-onas. |
| FI5765A FI47104C (fi) | 1964-01-14 | 1965-01-12 | Menetelmä 5-fenyyli-1,4-3H-bentsodiatsepiini-2(1H)-onien valmistamisek si. |
| DK14365A DK138494B (da) | 1964-01-14 | 1965-01-12 | Fremgangsmåde til fremstilling af 5-phenyl-1, 4-3H-benzodiazepin-2(1H)-oner. |
| NO15632865A NO119797B (enrdf_load_html_response) | 1964-01-14 | 1965-01-13 | |
| NL6500446A NL6500446A (enrdf_load_html_response) | 1964-01-14 | 1965-01-14 | |
| SE1695169A SE363104B (enrdf_load_html_response) | 1964-01-14 | 1965-01-14 | |
| SE490/65A SE320377B (enrdf_load_html_response) | 1964-01-14 | 1965-01-14 | |
| CH396367A CH459240A (fr) | 1964-01-14 | 1965-01-14 | Procédé de préparation de benzodiazépinones |
| DE1965D0046248 DE1545724B2 (de) | 1964-01-14 | 1965-01-14 | Verfahren zur herstellung von 5-phenyl-2,3-dihydro-1h-1,4-benzodiazepin-2-onverbindungen |
| CH48365A CH450418A (fr) | 1964-01-14 | 1965-01-14 | Procédé de préparation de phtalimidoacylamido-benzophénones |
| CH1534967A CH486449A (fr) | 1964-01-14 | 1965-01-14 | Procédé de préparation de phtalimidoacylamido-benzophénones |
| NO16632167A NO122974B (enrdf_load_html_response) | 1964-01-14 | 1967-01-10 | |
| CY53270A CY532A (en) | 1964-01-14 | 1970-03-23 | Method for preparation of benzodiazepinones |
| NL7017982A NL7017982A (enrdf_load_html_response) | 1964-01-14 | 1970-12-09 | |
| MY7000102A MY7000102A (en) | 1964-01-14 | 1970-12-31 | Method for preparation of benzodiazepinones |
| FI231872A FI50120C (fi) | 1964-01-14 | 1972-08-22 | 2-ftaalimido-asyyliamido-bentsofenonit, jotka ovat välituotteita tai l ähtöaineita diatsepinonien valmistamiseksi, jotka ovat kemoterapeuttis ia aineita. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB169364A GB1056289A (en) | 1964-01-14 | 1964-01-14 | 2-phthalimido acetamido benzophenones and their preparation |
| GB169264A GB1063891A (en) | 1964-01-14 | 1964-01-14 | Method for preparation of benzodiazepinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1063891A true GB1063891A (en) | 1967-04-05 |
Family
ID=26236912
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB169264A Expired GB1063891A (en) | 1964-01-14 | 1964-01-14 | Method for preparation of benzodiazepinones |
| GB169364A Expired GB1056289A (en) | 1964-01-14 | 1964-01-14 | 2-phthalimido acetamido benzophenones and their preparation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB169364A Expired GB1056289A (en) | 1964-01-14 | 1964-01-14 | 2-phthalimido acetamido benzophenones and their preparation |
Country Status (12)
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2845417A1 (de) * | 1977-10-18 | 1979-04-19 | Ravizza Spa | Verfahren zur herstellung von 7-chlor-5-(2-chlorphenyl)-benzodiazepinon |
| JPS6163666A (ja) * | 1984-06-26 | 1986-04-01 | メルク エンド カムパニー インコーポレーテッド | ベンゾジアゼピン類似体 |
| US4820834A (en) * | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
| AU679085B2 (en) * | 1984-06-26 | 1997-06-19 | Merck & Co., Inc. | Benzodiazepine analogs |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH602672A5 (enrdf_load_html_response) * | 1974-06-28 | 1978-07-31 | Hoffmann La Roche |
-
1964
- 1964-01-14 GB GB169264A patent/GB1063891A/en not_active Expired
- 1964-01-14 GB GB169364A patent/GB1056289A/en not_active Expired
- 1964-12-28 IL IL2267964A patent/IL22679A/xx unknown
-
1965
- 1965-01-12 FI FI5765A patent/FI47104C/fi active
- 1965-01-12 ES ES0308038A patent/ES308038A1/es not_active Expired
- 1965-01-12 DK DK14365A patent/DK138494B/da unknown
- 1965-01-13 NO NO15632865A patent/NO119797B/no unknown
- 1965-01-14 NL NL6500446A patent/NL6500446A/xx unknown
- 1965-01-14 SE SE1695169A patent/SE363104B/xx unknown
- 1965-01-14 SE SE490/65A patent/SE320377B/xx unknown
- 1965-01-14 DE DE1965D0046248 patent/DE1545724B2/de active Granted
- 1965-01-14 CH CH396367A patent/CH459240A/fr unknown
- 1965-01-14 CH CH48365A patent/CH450418A/fr unknown
-
1970
- 1970-03-23 CY CY53270A patent/CY532A/xx unknown
- 1970-12-09 NL NL7017982A patent/NL7017982A/xx unknown
- 1970-12-31 MY MY7000102A patent/MY7000102A/xx unknown
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2845417A1 (de) * | 1977-10-18 | 1979-04-19 | Ravizza Spa | Verfahren zur herstellung von 7-chlor-5-(2-chlorphenyl)-benzodiazepinon |
| US4511510A (en) * | 1977-10-18 | 1985-04-16 | Ravizza S.P.A. | Process for preparing a 7-chloro-5-(2-chlorophenyl)-benzodiazepinone |
| JPS6163666A (ja) * | 1984-06-26 | 1986-04-01 | メルク エンド カムパニー インコーポレーテッド | ベンゾジアゼピン類似体 |
| EP0167919A3 (en) * | 1984-06-26 | 1986-11-05 | Merck & Co. Inc. | Benzodiazepine derivatives and pharmaceutical compositions containing them |
| US4820834A (en) * | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
| AU679085B2 (en) * | 1984-06-26 | 1997-06-19 | Merck & Co., Inc. | Benzodiazepine analogs |
| EP0284256B1 (en) * | 1987-03-16 | 1994-06-01 | Merck & Co. Inc. | Benzodiazepine analogs |
Also Published As
| Publication number | Publication date |
|---|---|
| GB1056289A (en) | 1967-01-25 |
| IL22679A (en) | 1968-09-26 |
| CY532A (en) | 1970-03-23 |
| MY7000102A (en) | 1970-12-31 |
| CH459240A (fr) | 1968-07-15 |
| SE320377B (enrdf_load_html_response) | 1970-02-09 |
| DE1545724A1 (de) | 1969-10-09 |
| DE1545724B2 (de) | 1977-02-10 |
| FI47104C (fi) | 1973-09-10 |
| NL6500446A (enrdf_load_html_response) | 1965-07-15 |
| NL7017982A (enrdf_load_html_response) | 1971-03-25 |
| SE363104B (enrdf_load_html_response) | 1974-01-07 |
| CH450418A (fr) | 1968-01-31 |
| FI47104B (enrdf_load_html_response) | 1973-05-31 |
| NO119797B (enrdf_load_html_response) | 1970-07-06 |
| DK138494C (enrdf_load_html_response) | 1979-02-26 |
| DK138494B (da) | 1978-09-18 |
| ES308038A1 (es) | 1965-06-16 |
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