GB1061571A - N,n'-disubstituted piperazines and process for their manufacture - Google Patents
N,n'-disubstituted piperazines and process for their manufactureInfo
- Publication number
- GB1061571A GB1061571A GB170264A GB170264A GB1061571A GB 1061571 A GB1061571 A GB 1061571A GB 170264 A GB170264 A GB 170264A GB 170264 A GB170264 A GB 170264A GB 1061571 A GB1061571 A GB 1061571A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid addition
- phenyl
- addition salt
- converting
- free base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000004885 piperazines Chemical class 0.000 title 1
- 239000002253 acid Chemical group 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 5
- -1 trifluoromethylphenyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000012458 free base Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000002908 adrenolytic effect Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003440 anti-fibrillation Effects 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25104763A | 1963-01-14 | 1963-01-14 | |
| US25778363A | 1963-02-11 | 1963-02-11 | |
| US25778463A | 1963-02-11 | 1963-02-11 | |
| US27189063A | 1963-04-10 | 1963-04-10 | |
| US32134263A | 1963-11-04 | 1963-11-04 | |
| US32133463A | 1963-11-04 | 1963-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1061571A true GB1061571A (en) | 1967-03-15 |
Family
ID=27559375
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1053301D Active GB1053301A (enrdf_load_stackoverflow) | 1963-01-14 | ||
| GB170264A Expired GB1061571A (en) | 1963-01-14 | 1964-01-14 | N,n'-disubstituted piperazines and process for their manufacture |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1053301D Active GB1053301A (enrdf_load_stackoverflow) | 1963-01-14 |
Country Status (5)
| Country | Link |
|---|---|
| BE (3) | BE642429A (enrdf_load_stackoverflow) |
| CH (5) | CH449030A (enrdf_load_stackoverflow) |
| DE (1) | DE1232587B (enrdf_load_stackoverflow) |
| FR (1) | FR3734M (enrdf_load_stackoverflow) |
| GB (2) | GB1061571A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0034284A3 (en) * | 1980-02-18 | 1981-12-09 | Tanabe Seiyaku Co., Ltd. | Piperazine derivative and processes for preparing the same |
| US7485651B2 (en) | 1998-03-31 | 2009-02-03 | Acadia Pharmaceuticals, Inc. | Compounds with activity on muscarinic receptors |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5513209A (en) * | 1978-07-11 | 1980-01-30 | Synthelabo | Antidepressive made of piperazine derivative |
| FR2568878B1 (fr) * | 1984-08-07 | 1986-11-21 | Cortial | Nouveaux derives de (phenylpiperazinylethylamine ethoxy)-4 phenol, leur methode de preparation et leur application therapeutique |
| DE3715763A1 (de) * | 1987-05-12 | 1988-11-24 | Hoechst Ag | Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel |
| CN1303376A (zh) * | 1998-03-31 | 2001-07-11 | 阿卡蒂亚药品公司 | 对毒蕈碱性受体具有活性的化合物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1197461B (de) | 1962-02-23 | 1965-07-29 | Abbott Lab | Verfahren zur Herstellung von 1, 4-Diazin-derivaten |
-
0
- GB GB1053301D patent/GB1053301A/en active Active
-
1964
- 1964-01-09 CH CH22764A patent/CH449030A/de unknown
- 1964-01-09 CH CH449467A patent/CH449636A/de unknown
- 1964-01-09 CH CH449167A patent/CH449633A/de unknown
- 1964-01-09 CH CH449367A patent/CH449635A/de unknown
- 1964-01-09 CH CH449267A patent/CH449634A/de unknown
- 1964-01-10 DE DEC31848A patent/DE1232587B/de active Pending
- 1964-01-13 BE BE642429A patent/BE642429A/xx unknown
- 1964-01-13 BE BE642427A patent/BE642427A/xx unknown
- 1964-01-13 BE BE642428A patent/BE642428A/xx unknown
- 1964-01-14 GB GB170264A patent/GB1061571A/en not_active Expired
- 1964-04-07 FR FR969932A patent/FR3734M/fr not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0034284A3 (en) * | 1980-02-18 | 1981-12-09 | Tanabe Seiyaku Co., Ltd. | Piperazine derivative and processes for preparing the same |
| US7485651B2 (en) | 1998-03-31 | 2009-02-03 | Acadia Pharmaceuticals, Inc. | Compounds with activity on muscarinic receptors |
Also Published As
| Publication number | Publication date |
|---|---|
| CH449634A (de) | 1968-01-15 |
| CH449635A (de) | 1968-01-15 |
| BE642428A (enrdf_load_stackoverflow) | 1964-07-13 |
| CH449636A (de) | 1968-01-15 |
| BE642427A (enrdf_load_stackoverflow) | 1964-07-13 |
| CH449030A (de) | 1967-12-31 |
| DE1232587B (de) | 1967-01-19 |
| CH449633A (de) | 1968-01-15 |
| BE642429A (enrdf_load_stackoverflow) | 1964-07-13 |
| GB1053301A (enrdf_load_stackoverflow) | |
| FR3734M (fr) | 1965-12-06 |
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