GB1039923A - Benzimidazolinyl piperidine and corresponding 1,2,3,6-tetrahydro-pyridine derivatives - Google Patents
Benzimidazolinyl piperidine and corresponding 1,2,3,6-tetrahydro-pyridine derivativesInfo
- Publication number
- GB1039923A GB1039923A GB23483/63A GB2348363A GB1039923A GB 1039923 A GB1039923 A GB 1039923A GB 23483/63 A GB23483/63 A GB 23483/63A GB 2348363 A GB2348363 A GB 2348363A GB 1039923 A GB1039923 A GB 1039923A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- alkyl
- give
- formula
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000008083 1,2,3,6-tetrahydropyridines Chemical class 0.000 title 1
- JUYQSMXGDBGGSX-UHFFFAOYSA-N 2-piperidin-1-yl-1h-benzimidazole Chemical compound C1CCCCN1C1=NC2=CC=CC=C2N1 JUYQSMXGDBGGSX-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 18
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- -1 arylmethylene radical Chemical group 0.000 abstract 6
- 238000006243 chemical reaction Methods 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical compound C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 abstract 2
- 239000007818 Grignard reagent Substances 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 150000004795 grignard reagents Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 238000005984 hydrogenation reaction Methods 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- BYNBAMHAURJNTR-UHFFFAOYSA-N 3-piperidin-4-yl-1h-benzimidazol-2-one Chemical compound O=C1NC2=CC=CC=C2N1C1CCNCC1 BYNBAMHAURJNTR-UHFFFAOYSA-N 0.000 abstract 1
- KMTRUDSVKNLOMY-UHFFFAOYSA-N Ethylene carbonate Chemical compound O=C1OCCO1 KMTRUDSVKNLOMY-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- AYLIEDQYYJIGDP-UHFFFAOYSA-N [C]1=CC=CS1 Chemical compound [C]1=CC=CS1 AYLIEDQYYJIGDP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005036 alkoxyphenyl group Chemical group 0.000 abstract 1
- 150000001350 alkyl halides Chemical class 0.000 abstract 1
- 125000005037 alkyl phenyl group Chemical group 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 150000005840 aryl radicals Chemical group 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005059 halophenyl group Chemical group 0.000 abstract 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 1
- 125000004853 tetrahydropyridinyl group Chemical class N1(CCCC=C1)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20205662A | 1962-06-13 | 1962-06-13 | |
| US286911A US3196157A (en) | 1962-06-13 | 1963-06-11 | Benzimidazolinyl piperidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1039923A true GB1039923A (en) | 1966-08-24 |
Family
ID=26897320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB23483/63A Expired GB1039923A (en) | 1962-06-13 | 1963-06-12 | Benzimidazolinyl piperidine and corresponding 1,2,3,6-tetrahydro-pyridine derivatives |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3196157A (en, 2012) |
| BE (1) | BE633495A (en, 2012) |
| BR (1) | BR6349833D0 (en, 2012) |
| CH (1) | CH450437A (en, 2012) |
| DE (1) | DE1470124B2 (en, 2012) |
| DK (1) | DK119165C (en, 2012) |
| FR (2) | FR3695M (en, 2012) |
| GB (1) | GB1039923A (en, 2012) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4080328A (en) * | 1971-07-13 | 1978-03-21 | Sumitomo Chemical Company, Limited | N-substituted heterocyclic derivatives and preparation thereof |
| JPS5527915B2 (en, 2012) * | 1971-11-25 | 1980-07-24 | ||
| US3910930A (en) * | 1973-01-04 | 1975-10-07 | Janssen Pharmaceutica Nv | 1-{55 1-{8 2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl{9 -4-piperidyl{56 -2-benzimidazolinones |
| US3929801A (en) * | 1973-11-20 | 1975-12-30 | Janssen Pharmaceutica Nv | 2-Benzimidazolinones |
| JPS5416505B2 (en, 2012) * | 1973-11-30 | 1979-06-22 | ||
| US3989707A (en) * | 1974-06-21 | 1976-11-02 | Janssen Pharmaceutica N.V. | Benzimidazolinone derivatives |
| US3996362A (en) * | 1975-05-28 | 1976-12-07 | E. R. Squibb & Sons, Inc. | 2-[[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-(piperidinyl or 1,2,3,6-tetrahydro-1-pyridinyl)]alkyl]-1H-benz[de]isoquinoline-1,3(2H)-diones |
| US4066772A (en) * | 1975-07-21 | 1978-01-03 | Janssen Pharmaceutica N.V. | 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds |
| NZ181256A (en) * | 1975-07-21 | 1978-04-28 | Janssen Pharmaceutica Nv | 1-(w-benzazol-11-ylalkyl)-piperidine derivatives and pharmaceutical compositions containing certain of these derivatives |
| US4005211A (en) * | 1975-09-10 | 1977-01-25 | Janssen Pharmaceutica N.V. | Lactation stimulation employing pimozide |
| US4035369A (en) * | 1975-10-08 | 1977-07-12 | Janssen Pharmaceutica N.V. | 1-Benzazolylalkyl-4-substituted-piperidines |
| US4200755A (en) * | 1979-05-04 | 1980-04-29 | Richardson-Merrell Inc. | 2-Hydroxy-5-[1-hydroxy-2-[4-(2-oxo-1-benzimidazolinyl)piperidino]ethyl]benzoic acid derivatives |
| US4264613A (en) * | 1979-08-01 | 1981-04-28 | Science Union Et Cie, Societe Francaise De Recherche Medicale | Piperidylbenzimidazolinone compounds |
| US4352811A (en) * | 1981-11-12 | 1982-10-05 | Hoechst-Roussel Pharmaceuticals Inc. | 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles |
| US5059600A (en) * | 1989-03-31 | 1991-10-22 | Yale University | Treating habit disorders |
| US5223497A (en) * | 1989-03-31 | 1993-06-29 | Yale University | Treating habit disorders |
| US5114942A (en) * | 1989-03-31 | 1992-05-19 | Yale University | Treating habit disorders |
| ATE341542T1 (de) | 1996-04-19 | 2006-10-15 | Neurosearch As | 1-(4-piperidyl)-benzimidazole mit neurotropher aktivität |
| DE60022226D1 (de) * | 1999-12-06 | 2005-09-29 | Euro Celtique Sa | Benzimidazolverbindungen die nociceptinrezeptoraffinität haben |
| US6790854B2 (en) | 2000-03-24 | 2004-09-14 | Meiji Seika Kaisha, Ltd. | Diphenylalkylamine derivatives useful as opioid receptor agonists |
| KR20030043970A (ko) * | 2000-10-12 | 2003-06-02 | 에스에스 세야쿠 가부시키 가이샤 | 2,2-디페닐부탄아미드 유도체 및 이를 함유하는 의약 |
| US8354434B2 (en) * | 2006-01-30 | 2013-01-15 | Purdue Pharma L.P. | Cyclourea compounds as calcium channel blockers |
| PL2132175T3 (pl) | 2006-12-28 | 2012-09-28 | Inst Univ Ciencia I Tecnologia | Sposób wytwarzania loperamidu |
| CN113637001A (zh) * | 2021-08-09 | 2021-11-12 | 安康市农业科学研究院 | 一种氟哌利多中间体的合成方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3080366A (en) * | 1961-06-13 | 1963-03-05 | Res Lab Dr C Janssen | 1-(omega, omega-diphenylalkyl)-4-amino-4-piperidinecarboxyamides and derivatives thereof |
-
0
- BE BE633495D patent/BE633495A/xx unknown
-
1963
- 1963-06-11 US US286911A patent/US3196157A/en not_active Expired - Lifetime
- 1963-06-12 BR BR149833/63A patent/BR6349833D0/pt unknown
- 1963-06-12 DE DE1963N0023307 patent/DE1470124B2/de active Granted
- 1963-06-12 GB GB23483/63A patent/GB1039923A/en not_active Expired
- 1963-06-13 DK DK279763AA patent/DK119165C/da active
- 1963-06-13 CH CH739463A patent/CH450437A/de unknown
- 1963-09-12 FR FR947310A patent/FR3695M/fr active Active
- 1963-09-12 FR FR947311A patent/FR3042M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1795844B2 (de) | 1977-03-31 |
| BE633495A (en, 2012) | |
| FR3695M (fr) | 1965-11-22 |
| DK119165B (en, 2012) | 1970-11-23 |
| DE1795844A1 (de) | 1976-10-21 |
| BR6349833D0 (pt) | 1973-07-03 |
| DE1470124B2 (de) | 1976-12-09 |
| US3196157A (en) | 1965-07-20 |
| CH450437A (de) | 1968-01-31 |
| DK119165C (da) | 1971-04-05 |
| FR3042M (fr) | 1965-01-04 |
| DE1470124A1 (de) | 1969-05-08 |
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