GB1037380A - Process for the production of basic esters of pyridine-carboxylic acids - Google Patents

Process for the production of basic esters of pyridine-carboxylic acids

Info

Publication number
GB1037380A
GB1037380A GB172665A GB172665A GB1037380A GB 1037380 A GB1037380 A GB 1037380A GB 172665 A GB172665 A GB 172665A GB 172665 A GB172665 A GB 172665A GB 1037380 A GB1037380 A GB 1037380A
Authority
GB
United Kingdom
Prior art keywords
carboxylic acids
pyridine
production
basic esters
alkyl groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB172665A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orgamol AG
Original Assignee
Orgamol AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orgamol AG filed Critical Orgamol AG
Publication of GB1037380A publication Critical patent/GB1037380A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

Basic esters of pyridine carboxylic acids of the formula <FORM:1037380/C2/1> in which R1 and R4 are hydrogen, halogen, alkoxy or alkyl groups, and R2 and R3 are alkyl groups are made by subjecting a mixture of the corresponding pyridine carboxylic acid and the dialkylaminoethanol to continuous azeotropic distillation with a neutral organic solvent, b.pt. 130-160 DEG C., in order to remove the reaction water. Suitable solvents are chlorobenzene, ethylbenzene, xylene and cumene. Examples relate to the preparation of the diethylamino-ethyl esters of nicotinic and isonicotinic acids.
GB172665A 1964-01-20 1965-01-14 Process for the production of basic esters of pyridine-carboxylic acids Expired GB1037380A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH57264 1964-01-20

Publications (1)

Publication Number Publication Date
GB1037380A true GB1037380A (en) 1966-07-27

Family

ID=4190104

Family Applications (1)

Application Number Title Priority Date Filing Date
GB172665A Expired GB1037380A (en) 1964-01-20 1965-01-14 Process for the production of basic esters of pyridine-carboxylic acids

Country Status (3)

Country Link
CH (1) CH458344A (en)
FR (1) FR1421096A (en)
GB (1) GB1037380A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2088018A1 (en) * 1970-05-03 1972-01-07 Rabot Ets David Vasodilatory, substd nicotinic acid amino ester derivs
FR2088019A1 (en) * 1970-05-08 1972-01-07 Rabot Ets David Esters of 2 and 6-substituted nicotinic acids - with vasomotor active

Also Published As

Publication number Publication date
FR1421096A (en) 1965-12-10
CH458344A (en) 1968-06-30

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