GB1035914A - Progesterone derivatives - Google Patents
Progesterone derivativesInfo
- Publication number
- GB1035914A GB1035914A GB15779/63A GB1577963A GB1035914A GB 1035914 A GB1035914 A GB 1035914A GB 15779/63 A GB15779/63 A GB 15779/63A GB 1577963 A GB1577963 A GB 1577963A GB 1035914 A GB1035914 A GB 1035914A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxy
- compound
- dimethyl
- progesterone
- dione
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003145 progesterone derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 238000005805 hydroxylation reaction Methods 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 230000002906 microbiologic effect Effects 0.000 abstract 2
- 230000003647 oxidation Effects 0.000 abstract 2
- 238000007254 oxidation reaction Methods 0.000 abstract 2
- JPJALAQPGMAKDF-UHFFFAOYSA-N selenium dioxide Chemical compound O=[Se]=O JPJALAQPGMAKDF-UHFFFAOYSA-N 0.000 abstract 2
- XMRPGKVKISIQBV-UHFFFAOYSA-N (+-)-5- Pregnane-3,20-dione Natural products C1CC2CC(=O)CCC2(C)C2C1C1CCC(C(=O)C)C1(C)CC2 XMRPGKVKISIQBV-UHFFFAOYSA-N 0.000 abstract 1
- VLMNQNZUJILJLS-GIMYUCPFSA-N (5S,6S,8S,10R,13S,14S,17S)-17-acetyl-5-hydroxy-6,10,13-trimethyl-2,4,6,7,8,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-one Chemical compound O[C@]12[C@H](C[C@H]3[C@@H]4CC[C@H](C(C)=O)[C@]4(CC=C3[C@]2(CCC(C1)=O)C)C)C VLMNQNZUJILJLS-GIMYUCPFSA-N 0.000 abstract 1
- WKAVAGKRWFGIEA-UHFFFAOYSA-N 11-Ketoprogesterone Natural products C1CC2=CC(=O)CCC2(C)C2C1C1CCC(C(=O)C)C1(C)CC2=O WKAVAGKRWFGIEA-UHFFFAOYSA-N 0.000 abstract 1
- YYROPELSRYBVMQ-UHFFFAOYSA-N 4-toluenesulfonyl chloride Chemical compound CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 abstract 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 238000006356 dehydrogenation reaction Methods 0.000 abstract 1
- 125000005594 diketone group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- -1 oxido compound Chemical class 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001850 reproductive effect Effects 0.000 abstract 1
- 235000010269 sulphur dioxide Nutrition 0.000 abstract 1
- 239000004291 sulphur dioxide Substances 0.000 abstract 1
- UGNWTBMOAKPKBL-UHFFFAOYSA-N tetrachloro-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O UGNWTBMOAKPKBL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US198748A US3100777A (en) | 1962-05-31 | 1962-05-31 | 6-methyl-9alpha-fluoro-11beta-hydroxy - 4,6 - pregnadiene-3,20-dione and the 11-keto analogue thereof, their corresponding 16alpha-methyl derivatives and the 1-dehydro counterparts of the foregoing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1035914A true GB1035914A (en) | 1966-07-13 |
Family
ID=22734650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB15779/63A Expired GB1035914A (en) | 1962-05-31 | 1963-04-22 | Progesterone derivatives |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US3100777A (enExample) |
| CH (1) | CH439280A (enExample) |
| FR (2) | FR1559554A (enExample) |
| GB (1) | GB1035914A (enExample) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2883379A (en) * | 1958-08-18 | 1959-04-21 | Pfizer & Co C | Process for producing 3-keto-delta-steroids |
| US2891079A (en) * | 1959-01-23 | 1959-06-16 | Searle & Co | 6-methyl-4, 6-pregnadiene-3, 20-dione and 17alpha-acyloxy derivatives thereof |
| US2968662A (en) * | 1959-03-04 | 1961-01-17 | Syntex Sa | 6-halo-6-dehydro derivatives of 11-oxygenated-9 alpha-haloprogesterones |
-
1962
- 1962-05-31 US US198748A patent/US3100777A/en not_active Expired - Lifetime
-
1963
- 1963-04-22 GB GB15779/63A patent/GB1035914A/en not_active Expired
- 1963-05-27 CH CH660063A patent/CH439280A/de unknown
- 1963-05-30 FR FR1559554D patent/FR1559554A/fr not_active Expired
- 1963-08-29 FR FR946071A patent/FR2915M/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US3100777A (en) | 1963-08-13 |
| FR1559554A (enExample) | 1969-03-14 |
| FR2915M (fr) | 1964-11-09 |
| CH439280A (de) | 1967-07-15 |
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