GB1043154A - Cardenolide derivatives - Google Patents

Cardenolide derivatives

Info

Publication number
GB1043154A
GB1043154A GB1369763A GB1369763A GB1043154A GB 1043154 A GB1043154 A GB 1043154A GB 1369763 A GB1369763 A GB 1369763A GB 1369763 A GB1369763 A GB 1369763A GB 1043154 A GB1043154 A GB 1043154A
Authority
GB
United Kingdom
Prior art keywords
hydroxy
compound
glycosido
radical
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1369763A
Inventor
Albert Von Wartburg
Jacob Binkert
Emil Angliker
Jany Renz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz Patent Ltd
Sandoz AG
Original Assignee
Sandoz Patent Ltd
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH443362A external-priority patent/CH421093A/en
Priority claimed from CH866362A external-priority patent/CH442289A/en
Application filed by Sandoz Patent Ltd, Sandoz AG filed Critical Sandoz Patent Ltd
Publication of GB1043154A publication Critical patent/GB1043154A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of formula <FORM:1043154/C2/1> wherein A-B is a <FORM:1043154/C2/2> group, R1 is a hydrogen atom and R2 is a hydroxy, C1- 4 acylox or glycosido radical or R1 and R2 together are an oxygen atom, or A-B is a <FORM:1043154/C2/3> group and R1 and R2 are an oxygen atom, and their preparation by autoxidation in organic solution of a compound of formula <FORM:1043154/C2/4> wherein R2 is a hydroxy, C1- 4 acyloxy or glycosido glycosido radical to form the corresponding 10-hydroxy compound, followed if desired by (a) oxidation of a 3-hydroxy product to a 3-keto compound and (b) dehydration to form a D 4-compound. The compounds of the invention have cardio-active activity and may be used in pharmaceutical compositions in combination with a carrier.
GB1369763A 1962-04-11 1963-04-05 Cardenolide derivatives Expired GB1043154A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH443362A CH421093A (en) 1962-04-11 1962-04-11 Process for the manufacture of new steroids
CH866362A CH442289A (en) 1962-07-18 1962-07-18 Process for making new steroids

Publications (1)

Publication Number Publication Date
GB1043154A true GB1043154A (en) 1966-09-21

Family

ID=25695445

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1369763A Expired GB1043154A (en) 1962-04-11 1963-04-05 Cardenolide derivatives

Country Status (1)

Country Link
GB (1) GB1043154A (en)

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