GB1110125A - Ionized sulphates of the pregnene series and method of use thereof for therapeutic purposes - Google Patents
Ionized sulphates of the pregnene series and method of use thereof for therapeutic purposesInfo
- Publication number
- GB1110125A GB1110125A GB29895/65A GB2989565A GB1110125A GB 1110125 A GB1110125 A GB 1110125A GB 29895/65 A GB29895/65 A GB 29895/65A GB 2989565 A GB2989565 A GB 2989565A GB 1110125 A GB1110125 A GB 1110125A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- hydrogen atom
- cation
- methyl group
- alkali metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003130 pregnenes Chemical class 0.000 title 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 3
- 229910052783 alkali metal Inorganic materials 0.000 abstract 3
- -1 isopropylidenedioxy group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 150000001340 alkali metals Chemical class 0.000 abstract 2
- 150000001768 cations Chemical class 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052731 fluorine Chemical group 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000007530 organic bases Chemical class 0.000 abstract 2
- LDSYPJSYQOUQMN-WAJSLEGFSA-N (8R,9S,13S,14S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol sulfuric acid Chemical compound OS(O)(=O)=O.OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)O)[C@@H]4[C@@H]3CCC2=C1 LDSYPJSYQOUQMN-WAJSLEGFSA-N 0.000 abstract 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 abstract 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 abstract 1
- 229960002568 ethinylestradiol Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001072 progestational effect Effects 0.000 abstract 1
- AKEJUJNQAAGONA-UHFFFAOYSA-N sulfur trioxide Inorganic materials O=S(=O)=O AKEJUJNQAAGONA-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Abstract
The invention comprises compounds of formula <FORM:1110125/C2/1> wherein X is the ammonium cation or the cation of an alkali metal or an organic base, R is a hydrogen or fluorine atom, R1 is a C1- 4 alkyl group or an acyloxy group and R11 is a hydrogen atom or a methyl group or R1 and R11 together form an isopropylidenedioxy group, and R111 is a hydrogen atom or a methyl group, and their preparation by reaction of a corresponding 3-ol with an organic base-sulphur trioxide complex, followed if desired by conversion to the ammonium or alkali metal salt.ALSO:Pharmaceutical compositions having progestational activity comprise, in combination with a carrier, a compound of formula: <FORM:1110125/A5-A6/1> wherein X is the ammonium cation or the cation of an alkali metal or an organic base, R is a hydrogen or fluorine atom, R1 is a C1-4 alkyl group or an acyloxy group and R11 is a hydrogen atom or a methyl group or R1 and R11 together form an isopropylidenedioxy group and R111 is a hydrogen atom or a methyl group, optionally in combination with an estrogenic substance, for example estradiol sulphate or ethynyl estradiol. The compositions may be formulated for oral or parenteral administration or added to animal feeds.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38263564A | 1964-07-14 | 1964-07-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1110125A true GB1110125A (en) | 1968-04-18 |
Family
ID=23509822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB29895/65A Expired GB1110125A (en) | 1964-07-14 | 1965-07-14 | Ionized sulphates of the pregnene series and method of use thereof for therapeutic purposes |
Country Status (4)
| Country | Link |
|---|---|
| DE (1) | DE1518492A1 (en) |
| FR (1) | FR6574M (en) |
| GB (1) | GB1110125A (en) |
| NL (1) | NL6509045A (en) |
-
1965
- 1965-07-13 NL NL6509045A patent/NL6509045A/xx unknown
- 1965-07-14 GB GB29895/65A patent/GB1110125A/en not_active Expired
- 1965-07-14 DE DE19651518492 patent/DE1518492A1/en active Pending
- 1965-10-12 FR FR34685A patent/FR6574M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1518492A1 (en) | 1970-02-19 |
| FR6574M (en) | 1968-12-30 |
| NL6509045A (en) | 1966-01-17 |
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