GB1020309A - Alkanoyloxy acetals of prednisolone derivatives - Google Patents
Alkanoyloxy acetals of prednisolone derivativesInfo
- Publication number
- GB1020309A GB1020309A GB4799864A GB4799864A GB1020309A GB 1020309 A GB1020309 A GB 1020309A GB 4799864 A GB4799864 A GB 4799864A GB 4799864 A GB4799864 A GB 4799864A GB 1020309 A GB1020309 A GB 1020309A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkanoyloxy
- acetals
- prednisolone derivatives
- prednisolone
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Alkanoyloxy acetals Chemical class 0.000 title 1
- 150000003116 prednisolone derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 239000000499 gel Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of formula <FORM:1020309/C2/1> wherein X is a hydrogen or fluorine atom and R1 and R2 are methyl or ethyl groups, and their preparation by reaction of the corresponding 16a ,17a -diol with the appropriate ketone. The compounds of the invention have antiinflammatory activity and may be used in tablets, ointments or gels.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE26264A SE301969B (en) | 1964-01-10 | 1964-01-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1020309A true GB1020309A (en) | 1966-02-16 |
Family
ID=20256280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4799864A Expired GB1020309A (en) | 1964-01-10 | 1964-11-25 | Alkanoyloxy acetals of prednisolone derivatives |
Country Status (9)
| Country | Link |
|---|---|
| BR (1) | BR6464857D0 (en) |
| CH (1) | CH463499A (en) |
| DE (1) | DE1253268B (en) |
| DK (1) | DK116435B (en) |
| FI (1) | FI41395C (en) |
| FR (1) | FR5011M (en) |
| GB (1) | GB1020309A (en) |
| NO (1) | NO125890B (en) |
| SE (1) | SE301969B (en) |
-
1964
- 1964-01-10 SE SE26264A patent/SE301969B/xx unknown
- 1964-11-13 FI FI238064A patent/FI41395C/en active
- 1964-11-25 GB GB4799864A patent/GB1020309A/en not_active Expired
- 1964-11-27 BR BR16485764A patent/BR6464857D0/en unknown
- 1964-12-17 DE DEA47920A patent/DE1253268B/en active Pending
-
1965
- 1965-01-04 DK DK1165A patent/DK116435B/en unknown
- 1965-01-05 NO NO15621765A patent/NO125890B/no unknown
- 1965-01-07 CH CH21065A patent/CH463499A/en unknown
- 1965-03-03 FR FR820A patent/FR5011M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR5011M (en) | 1967-04-24 |
| FI41395B (en) | 1969-07-31 |
| CH463499A (en) | 1968-10-15 |
| DK116435B (en) | 1970-01-12 |
| NO125890B (en) | 1972-11-20 |
| SE301969B (en) | 1968-07-01 |
| BR6464857D0 (en) | 1973-08-02 |
| FI41395C (en) | 1969-11-10 |
| DE1253268B (en) | 1967-11-02 |
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