GB1035005A - Local anesthetic preparations and process of making same - Google Patents

Local anesthetic preparations and process of making same

Info

Publication number
GB1035005A
GB1035005A GB8735/64A GB873564A GB1035005A GB 1035005 A GB1035005 A GB 1035005A GB 8735/64 A GB8735/64 A GB 8735/64A GB 873564 A GB873564 A GB 873564A GB 1035005 A GB1035005 A GB 1035005A
Authority
GB
United Kingdom
Prior art keywords
anaesthetic
carbon dioxide
base
solutions
aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8735/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astra USA Inc
Original Assignee
Astra Pharmaceutical Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharmaceutical Products Inc filed Critical Astra Pharmaceutical Products Inc
Publication of GB1035005A publication Critical patent/GB1035005A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Aqueous anaesthetic solutions, prepared by adding carbon dioxide to an aqueous suspension of a local anaesthetic of the basically substituted acid amide type, e.g. lidocaine, until the anaesthetic base is dissolved, are applied from pressure resistant dispensers in which the propellant may be a mixture of chlorofluorohydrocarbons.ALSO:Aqueous solutions of local anaesthetics of the basically substituted acid amide type are prepared by introducing carbon dioxide, in an amount in excess over that stoichiometrically required for carbonate salt formation, into an aqueous suspension of the anaesthetic, at a temperature not exceeding ambient temperature, until the anaesthetic base has been dissolved. In a modification, an acid addition salt of the anaesthetic base is used together with a water-soluble, acid-neutralizing agent, e.g. sodium bicarbonate, sodium carbonate or sodium hydroxide, in an amount equimolecular to the acid moiety of the addition salt, and carbon dioxide is then introduced to dissolve the liberated base. Anaesthetics specified are lidocaine, mepivacaine, a -(n-propylamino)-propionyl-toluide-(2), (n-butyl-amino)-acetyl-2-methyl-6-chloroanilide and diethylamino-acetyl-2, 6-dimethyl-4-butoxyanilide. The solutions may be used in vials, ampoules or pressure resistant dispensers and may be incorporated into jellies, ointments and creams. When used in pressurised form, the propellant may be excess carbon dioxide, nitrogen or a chloro-fluorohydrocarbon.
GB8735/64A 1962-03-05 1963-03-05 Local anesthetic preparations and process of making same Expired GB1035005A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US177172A US3136691A (en) 1962-03-05 1962-03-05 Aqueous solution of local anesthetic maintained under pressure

Publications (1)

Publication Number Publication Date
GB1035005A true GB1035005A (en) 1966-07-06

Family

ID=22647491

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8735/64A Expired GB1035005A (en) 1962-03-05 1963-03-05 Local anesthetic preparations and process of making same

Country Status (6)

Country Link
US (1) US3136691A (en)
CH (1) CH465767A (en)
DE (1) DE1220967B (en)
DK (1) DK109053C (en)
GB (1) GB1035005A (en)
SE (1) SE315689B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4811691B1 (en) * 1967-07-07 1973-04-14
US3940483A (en) * 1971-02-05 1976-02-24 E. R. Squibb & Sons, Inc. Antibiotic compositions and method
US4218477A (en) * 1971-07-28 1980-08-19 Astra Pharmaceutical Products, Inc. Primary aminoacylanilides, methods of making the same and use as antiarrhythmic drugs
US4935225A (en) * 1987-09-11 1990-06-19 Curtis John P Appetite suppresant dentifrice
US5331012A (en) * 1990-07-30 1994-07-19 Riddick Kenneth B Topical pharmaceutical preparation for fever blisters and other viral infections and method of use
WO2005032521A2 (en) * 2003-10-02 2005-04-14 Collegium Pharmaceutical, Inc. Non-flammable topical anesthetic liquid aerosols
US20060188449A1 (en) * 2003-10-03 2006-08-24 Jane Hirsh Topical aerosol foams
US8652443B2 (en) * 2008-02-14 2014-02-18 Precision Dermatology, Inc. Foamable microemulsion compositions for topical administration

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR981029A (en) * 1949-02-17 1951-05-21 Method of fine spraying a liquid
US2953284A (en) * 1957-12-06 1960-09-20 Aerosol Tech Inc Pressurized dispenser

Also Published As

Publication number Publication date
US3136691A (en) 1964-06-09
DE1220967B (en) 1966-07-14
CH465767A (en) 1968-11-30
DK109053C (en) 1968-03-11
SE315689B (en) 1969-10-06

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