GB1034188A - Process for preparing 17ª-alkylated pregnane derivatives - Google Patents
Process for preparing 17ª-alkylated pregnane derivativesInfo
- Publication number
- GB1034188A GB1034188A GB11073/63A GB1107363A GB1034188A GB 1034188 A GB1034188 A GB 1034188A GB 11073/63 A GB11073/63 A GB 11073/63A GB 1107363 A GB1107363 A GB 1107363A GB 1034188 A GB1034188 A GB 1034188A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atoms
- compounds
- straight
- hydrogen atom
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Abstract
The invention comprises compounds of formula <FORM:1034188/C2/1> wherein X is a hydrogen atom or a methyl group and R1 is a straight-chain alkyl group having 2 to 4 carbon atoms, except in the case of the 6-methyl-6-dehydro compounds, when R1 has 1 to 4 carbon atoms, compounds of formula <FORM:1034188/C2/2> and their 3-acetates, wherein X is as hereinbefore defined and R1 is a straight-chain alkyl group having, when X is a hydrogen atom, 2 to 4 carbon atoms and, when X is a methyl group, 1 to 4 carbon atoms, and the preparation of compounds of the above formulae wherein R1 has in all cases 1 to 4 carbon atoms by reacting a compound of formula <FORM:1034188/C2/3> wherein R is a hydrogen atom or an acyl group, in a hydroxyl-full solvent with a solution of an alkali metal in liquid ammonia and then with a straight-chain alkyl halide having 1 to 4 carbon atoms to give the desired pregnenolone derivative, and, if desired, subjecting these to an Oppenauer-type oxidation to give the desired progesterone derivatives. The progesterone derivatives of the invention have progestational activity and may be used in combination with a pharmaceutical carrier in forms suitable for oral or parenteral administration, for example as capsules, tablets, solutions or suspensions.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA845095 | 1962-03-23 | ||
| CA863339 | 1962-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1034188A true GB1034188A (en) | 1966-06-29 |
Family
ID=25673393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB11073/63A Expired GB1034188A (en) | 1962-03-23 | 1963-03-20 | Process for preparing 17ª-alkylated pregnane derivatives |
Country Status (3)
| Country | Link |
|---|---|
| CH (1) | CH423770A (en) |
| FR (1) | FR3379M (en) |
| GB (1) | GB1034188A (en) |
-
1963
- 1963-03-20 GB GB11073/63A patent/GB1034188A/en not_active Expired
- 1963-03-22 CH CH371763A patent/CH423770A/en unknown
- 1963-06-18 FR FR938530A patent/FR3379M/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| FR3379M (en) | 1965-06-21 |
| CH423770A (en) | 1966-11-15 |
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