GB1030372A - Vasodilators comprising nicotinoyl derivatives - Google Patents

Vasodilators comprising nicotinoyl derivatives

Info

Publication number
GB1030372A
GB1030372A GB10741/64A GB1074164A GB1030372A GB 1030372 A GB1030372 A GB 1030372A GB 10741/64 A GB10741/64 A GB 10741/64A GB 1074164 A GB1074164 A GB 1074164A GB 1030372 A GB1030372 A GB 1030372A
Authority
GB
United Kingdom
Prior art keywords
glycerine
trinicotinoyl
acid
acid addition
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB10741/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wander AG
Original Assignee
Wander AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wander AG filed Critical Wander AG
Publication of GB1030372A publication Critical patent/GB1030372A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises trinicotinoyl glycer ine, and acid addition salts thereof. The compound is prepared by reacting nicotinic acid, or its metal salts, esters, anhydrides or halides, or acid addition salts, with glycerine (or partially nicotinoylated glycerine) or reactive derivatives of glycerine, such as a boric acid ester, or a glycerine halohydrin. The trinicotinoyl ester, when prepared, may be converted into its acid addition salts by a sufficient amount of acid, e.g. hydrohalic acids, sulphuric, phosphoric, toluene-sulphonic, acetic, oxalic, malonic, succinic, malic, maleic, and tartaric acids. The trinicotinyl ester may also be prepared from derivatives of nicotinic acid from which can be liberated a nicotinoyl residue, e.g. pyridine-a ,b -dicarboxylic acid. Two examples are given: (1) nicotinic acid is converted to the chloride-hydrochloride by reaction with thionyl chloride; this is reacted with glycerine in the presence of triethylamine, in dimethyl formamide as a solvent, to give, after working up, trinicotinoyl glycerine; (2) nicotinic acid anhydride and glycerine are reacted in the presence of pyridine, and the product worked up to give trinicotinoyl glycerine. The compound is for use as a vasodilating and fibrinolytic agent (see Division A5).ALSO:Vasodilator compositions for external and internal application, comprise trinicotinoyl glycerine, or an acid addition salt thereof, together with a pharmaceutically acceptable carrier. The composition also may contain a xanthine base, such as theophylline or a water-soluble derivative thereof, theobromine, or caffeine. The composition may be applied externally, as liniments or ointments; orally as tablets, pills, coated tablets, powders, or capsules; rectally, as retention suppositories; or parenterally in a suitable solution. Examples are given for preparation of tablets, with conventional exceipients; suppositories; and an injectable solution of the active agent in polyoxyethylene glycol/water, or propylene glycol/water, optimally with 2% of benzyl alcohol.
GB10741/64A 1963-03-19 1964-03-13 Vasodilators comprising nicotinoyl derivatives Expired GB1030372A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH346263 1963-03-19
CH872463 1963-07-12

Publications (1)

Publication Number Publication Date
GB1030372A true GB1030372A (en) 1966-05-25

Family

ID=25693060

Family Applications (1)

Application Number Title Priority Date Filing Date
GB10741/64A Expired GB1030372A (en) 1963-03-19 1964-03-13 Vasodilators comprising nicotinoyl derivatives

Country Status (3)

Country Link
BE (1) BE645428A (en)
FR (1) FR3305M (en)
GB (1) GB1030372A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986001507A1 (en) * 1984-08-23 1986-03-13 Sandoz Ag Cyclimmonium salts

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986001507A1 (en) * 1984-08-23 1986-03-13 Sandoz Ag Cyclimmonium salts

Also Published As

Publication number Publication date
BE645428A (en) 1964-07-16
FR3305M (en) 1965-05-10

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