JPS5594386A - Preparation of xanthine derivative - Google Patents
Preparation of xanthine derivativeInfo
- Publication number
- JPS5594386A JPS5594386A JP63079A JP63079A JPS5594386A JP S5594386 A JPS5594386 A JP S5594386A JP 63079 A JP63079 A JP 63079A JP 63079 A JP63079 A JP 63079A JP S5594386 A JPS5594386 A JP S5594386A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- reaction
- xanthine derivative
- drug
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain a xanthine derivative useful as a drug of a circulating organ capable of improving sequela of cerebral thrombosis, by reacting a 1-alkyl-4-methylamino-5-N-methylcarboxamido-imidazole with a urea derivative.
CONSTITUTION: A compound shown by the formula I (R is lower alkyl) is reacted with a urea derivative shown by the formula II (R' is lower alkyl; n is 2W5) to give a xanthine derivative shown by the formula III. The reaction is carried out in the absence of a solvent, preferably heated at 140W160°C, but a solvent having no part in reaction may be used. Depending upon compounds used, the reaction time is 1W48 hours sufficiently.
EFFECT: Theobromine is not used as a starting material.
USE: 1-(5-Oxohexyl)-3, 7-dimethylxanthine, a typical one of the compound shown by the formula III is especially useful as a drug for a circulating organ.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63079A JPS5594386A (en) | 1979-01-10 | 1979-01-10 | Preparation of xanthine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63079A JPS5594386A (en) | 1979-01-10 | 1979-01-10 | Preparation of xanthine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5594386A true JPS5594386A (en) | 1980-07-17 |
Family
ID=11479041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63079A Pending JPS5594386A (en) | 1979-01-10 | 1979-01-10 | Preparation of xanthine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5594386A (en) |
-
1979
- 1979-01-10 JP JP63079A patent/JPS5594386A/en active Pending
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