GB1028405A - New tetrahydro-pyrido-[4,3-d]-pyrimidines and processes for their preparation - Google Patents
New tetrahydro-pyrido-[4,3-d]-pyrimidines and processes for their preparationInfo
- Publication number
- GB1028405A GB1028405A GB10639/63A GB1063963A GB1028405A GB 1028405 A GB1028405 A GB 1028405A GB 10639/63 A GB10639/63 A GB 10639/63A GB 1063963 A GB1063963 A GB 1063963A GB 1028405 A GB1028405 A GB 1028405A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- acid addition
- group
- addition salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- AESJTDNODAZMEA-UHFFFAOYSA-N 1,2,3,4-tetrahydropyrido[4,3-d]pyrimidine Chemical class N1=CC=C2NCNCC2=C1 AESJTDNODAZMEA-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 7
- 239000002253 acid Substances 0.000 abstract 5
- -1 di-substituted amino group Chemical group 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 231100000252 nontoxic Toxicity 0.000 abstract 3
- 230000003000 nontoxic effect Effects 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000004659 aryl alkyl thio group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- STXKJIIHKFGUCY-UHFFFAOYSA-N 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Chemical class C1=NC=C2CNCCC2=N1 STXKJIIHKFGUCY-UHFFFAOYSA-N 0.000 abstract 1
- 238000006228 Dieckmann condensation reaction Methods 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 230000003385 bacteriostatic effect Effects 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003335 secondary amines Chemical class 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DET0021811 | 1962-03-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1028405A true GB1028405A (en) | 1966-05-04 |
Family
ID=7550278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB10639/63A Expired GB1028405A (en) | 1962-03-22 | 1963-03-18 | New tetrahydro-pyrido-[4,3-d]-pyrimidines and processes for their preparation |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3186991A (enExample) |
| BE (1) | BE642910A (enExample) |
| CA (1) | CA762455A (enExample) |
| CH (1) | CH457472A (enExample) |
| FR (1) | FR2798M (enExample) |
| GB (1) | GB1028405A (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8071766B2 (en) | 2008-02-01 | 2011-12-06 | Takeda Pharmaceutical Company Limited | HSP90 inhibitors |
| CN106632318A (zh) * | 2016-11-04 | 2017-05-10 | 广东环境保护工程职业学院 | 一种四氢吡啶并嘧啶类化合物及其制备方法和应用 |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3342819A (en) * | 1964-07-24 | 1967-09-19 | Boehringer Sohn Ingelheim | Novel 6, 7-dihydro-5h-pyrrolo[3,4-d]pyrimidines |
| US3444168A (en) * | 1966-12-30 | 1969-05-13 | Sterling Drug Inc | 6 - (lower-alkanoyl) - 4 - hydroxy - 2 - mercapto - 5,6,7,8 - tetrahydropyrido(4,3 - d)pyrimidines |
| JPS5130077B2 (enExample) * | 1971-12-28 | 1976-08-30 | ||
| US4085102A (en) * | 1974-11-25 | 1978-04-18 | E. R. Squibb & Sons, Inc. | 2-Amino-8-arylideno-3,4,5,6,7,8-hexahydro-4-arlypyrido[4,3-d]pyrimidines |
| DK270278A (da) * | 1977-06-20 | 1978-12-21 | Krogsgaard Larsen P | Cycliske aminosyrer |
| US4182890A (en) * | 1978-12-07 | 1980-01-08 | Morton-Norwich Products, Inc. | Ethyl 2-oxo-3-phenylethylaminopiperidine-4-carboxylate hydrochloride |
| US4808618A (en) * | 1986-04-16 | 1989-02-28 | Nippon Zoki Pharmaceutical Co., Ltd. | Substituted 1,3-dialkylpyrido[4,3-d]pyrimidine-2,4-diones |
| US5212310A (en) * | 1991-12-19 | 1993-05-18 | Neurogen Corporation | Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands |
| DE59408453D1 (de) * | 1993-04-23 | 1999-08-12 | Hoechst Ag | Pyrido-pyrimidindione, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| PA8539401A1 (es) * | 2001-02-14 | 2002-10-28 | Warner Lambert Co | Quinazolinas como inhibidores de mmp-13 |
| US7105667B2 (en) * | 2001-05-01 | 2006-09-12 | Bristol-Myers Squibb Co. | Fused heterocyclic compounds and use thereof |
| WO2002088079A2 (en) * | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
| CN112771049B (zh) * | 2018-09-27 | 2024-01-26 | 贝达药业股份有限公司 | Fgfr4抑制剂及其应用 |
| CN116490498B (zh) * | 2021-03-19 | 2025-09-02 | 南京迈晟科技有限责任公司 | 嘧啶并环类化合物及其用于制备治疗疼痛、脊髓损伤药物中的用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2697710A (en) * | 1953-01-02 | 1954-12-21 | Burroughs Wellcome Co | Pyrido (2,3-d) pyrimidines and method of preparing same |
| US2686781A (en) * | 1953-01-14 | 1954-08-17 | Burroughs Wellcome Co | Pyrido (3, 2-d) pyrimidines and process of preparing same |
| US2890152A (en) * | 1956-11-29 | 1959-06-09 | Schering Corp | Topical anti-inflammatory compositions |
| US2994640A (en) * | 1957-02-22 | 1961-08-01 | Byk Gulden Lomberg Chem Fab | Anti-inflammatory therapy with purine molecular compounds |
-
0
- CA CA762455A patent/CA762455A/en not_active Expired
-
1963
- 1963-03-11 CH CH302763A patent/CH457472A/de unknown
- 1963-03-14 US US265084A patent/US3186991A/en not_active Expired - Lifetime
- 1963-03-18 GB GB10639/63A patent/GB1028405A/en not_active Expired
- 1963-03-20 FR FR928685A patent/FR2798M/fr not_active Expired
-
1964
- 1964-01-23 BE BE642910A patent/BE642910A/fr unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8071766B2 (en) | 2008-02-01 | 2011-12-06 | Takeda Pharmaceutical Company Limited | HSP90 inhibitors |
| US8618290B2 (en) | 2008-02-01 | 2013-12-31 | Takeda Pharmaceutical Company Limited | HSP90 inhibitors |
| CN106632318A (zh) * | 2016-11-04 | 2017-05-10 | 广东环境保护工程职业学院 | 一种四氢吡啶并嘧啶类化合物及其制备方法和应用 |
| CN106632318B (zh) * | 2016-11-04 | 2018-07-31 | 广东环境保护工程职业学院 | 一种四氢吡啶并嘧啶类化合物及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA762455A (en) | 1967-07-04 |
| US3186991A (en) | 1965-06-01 |
| BE642910A (fr) | 1964-07-23 |
| CH457472A (de) | 1968-06-15 |
| FR2798M (enExample) | 1964-10-23 |
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