GB1017431A - 17ª‰-acetoacetoxy steroids and process for the preparation thereof - Google Patents
17ª‰-acetoacetoxy steroids and process for the preparation thereofInfo
- Publication number
- GB1017431A GB1017431A GB4721663A GB4721663A GB1017431A GB 1017431 A GB1017431 A GB 1017431A GB 4721663 A GB4721663 A GB 4721663A GB 4721663 A GB4721663 A GB 4721663A GB 1017431 A GB1017431 A GB 1017431A
- Authority
- GB
- United Kingdom
- Prior art keywords
- steroids
- groups
- alkyl
- acetoacetoxy
- ones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003431 steroids Chemical class 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 abstract 1
- RCHDLEVSZBOHOS-UHFFFAOYSA-N 1,4-dichlorobut-2-yne Chemical compound ClCC#CCCl RCHDLEVSZBOHOS-UHFFFAOYSA-N 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 230000021736 acetylation Effects 0.000 abstract 1
- 238000006640 acetylation reaction Methods 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- WASQWSOJHCZDFK-UHFFFAOYSA-N diketene Chemical compound C=C1CC(=O)O1 WASQWSOJHCZDFK-UHFFFAOYSA-N 0.000 abstract 1
- 150000002081 enamines Chemical class 0.000 abstract 1
- 150000002084 enol ethers Chemical class 0.000 abstract 1
- 230000001076 estrogenic effect Effects 0.000 abstract 1
- 229960003399 estrone Drugs 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 230000016087 ovulation Effects 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001072 progestational effect Effects 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- -1 tetrahydropyranyl-oxy Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE656362D BE656362A (enExample) | 1963-11-29 | ||
| GB4721663A GB1017431A (en) | 1963-11-29 | 1963-11-29 | 17ª‰-acetoacetoxy steroids and process for the preparation thereof |
| BR16484264A BR6464842D0 (pt) | 1963-11-29 | 1964-11-26 | Processo para preparar esteroides |
| NL6413823A NL6413823A (enExample) | 1963-11-29 | 1964-11-27 | |
| CH1536764A CH457418A (de) | 1963-11-29 | 1964-11-27 | Verfahren zur Herstellung von neuen 17B-Acetoacetoxysteroiden |
| DEB79533A DE1274125B (de) | 1963-11-29 | 1964-11-27 | Verfahren zur Herstellung von gegebenenfalls ringsubstituierten und Ringdoppelbindungen aufweisenden 17ª‰-Acetoacetoxysteroiden |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4721663A GB1017431A (en) | 1963-11-29 | 1963-11-29 | 17ª‰-acetoacetoxy steroids and process for the preparation thereof |
| GB4890863 | 1963-12-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1017431A true GB1017431A (en) | 1966-01-19 |
Family
ID=26266003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4721663A Expired GB1017431A (en) | 1963-11-29 | 1963-11-29 | 17ª‰-acetoacetoxy steroids and process for the preparation thereof |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE656362A (enExample) |
| BR (1) | BR6464842D0 (enExample) |
| CH (1) | CH457418A (enExample) |
| DE (1) | DE1274125B (enExample) |
| GB (1) | GB1017431A (enExample) |
| NL (1) | NL6413823A (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1364858A (en) * | 1970-09-10 | 1974-08-29 | Sandoz Ltd | 17alpha-propadienyl-17beta-acetoacetoxy substituted steroids |
-
0
- BE BE656362D patent/BE656362A/xx unknown
-
1963
- 1963-11-29 GB GB4721663A patent/GB1017431A/en not_active Expired
-
1964
- 1964-11-26 BR BR16484264A patent/BR6464842D0/pt unknown
- 1964-11-27 CH CH1536764A patent/CH457418A/de unknown
- 1964-11-27 NL NL6413823A patent/NL6413823A/xx unknown
- 1964-11-27 DE DEB79533A patent/DE1274125B/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| BE656362A (enExample) | |
| NL6413823A (enExample) | 1965-05-31 |
| CH457418A (de) | 1968-06-15 |
| DE1274125C2 (enExample) | 1969-03-20 |
| BR6464842D0 (pt) | 1973-08-02 |
| DE1274125B (de) | 1968-08-01 |
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