GB1008173A - Isoxazole compounds and production thereof - Google Patents

Isoxazole compounds and production thereof

Info

Publication number
GB1008173A
GB1008173A GB4520763A GB4520763A GB1008173A GB 1008173 A GB1008173 A GB 1008173A GB 4520763 A GB4520763 A GB 4520763A GB 4520763 A GB4520763 A GB 4520763A GB 1008173 A GB1008173 A GB 1008173A
Authority
GB
United Kingdom
Prior art keywords
amine
formula
carbon atoms
heterocyclic ring
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4520763A
Inventor
Hideo Kano
Ikuo Adachi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to GB4520763A priority Critical patent/GB1008173A/en
Publication of GB1008173A publication Critical patent/GB1008173A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the formula <FORM:1008173/C2/1> wherein R is an alkyl group having not more than 5 carbon atoms and each of R1 and R11 is an alkyl group having not more than 5 carbon atoms or R1 and R11 together complete a 5- or 6-membered heterocyclic ring and A is an alkylene group having not more than 5 carbon atoms and the acid addition and quaternary salts thereof. Suitable values of R1 and R11, where R1 and R11 complete a heterocyclic ring, are pyrrolidino, piperidino, piperazino, N-alkylpiperazino, morpholino or thiomorpholino. The compounds are prepared by heating a compound of the formula <FORM:1008173/C2/2> wherein X is a halogen atom, with an amine of the formula NHR1R11 in the presence of an inert solvent or, when the amine is a liquid, excess of the amine and optionally in the presence of an acid eliminating agent. Examples describe the preparation of 3-piperidinomethyl-, 3-morpholinomethyl-, 3-diethylaminomethyl-, 3 - (b - piperidinoethyl)-, 3 - (b - morpholinoethyl)-, 3 - (b - pyrrolidinoethyl)- and 3 - (b -diethylaminoethyl)-5-methyl-isoxazole.
GB4520763A 1963-11-15 1963-11-15 Isoxazole compounds and production thereof Expired GB1008173A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB4520763A GB1008173A (en) 1963-11-15 1963-11-15 Isoxazole compounds and production thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4520763A GB1008173A (en) 1963-11-15 1963-11-15 Isoxazole compounds and production thereof

Publications (1)

Publication Number Publication Date
GB1008173A true GB1008173A (en) 1965-10-27

Family

ID=10436297

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4520763A Expired GB1008173A (en) 1963-11-15 1963-11-15 Isoxazole compounds and production thereof

Country Status (1)

Country Link
GB (1) GB1008173A (en)

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