GB0724860D0 - Screening - Google Patents

Screening

Info

Publication number
GB0724860D0
GB0724860D0 GBGB0724860.2A GB0724860A GB0724860D0 GB 0724860 D0 GB0724860 D0 GB 0724860D0 GB 0724860 A GB0724860 A GB 0724860A GB 0724860 D0 GB0724860 D0 GB 0724860D0
Authority
GB
United Kingdom
Prior art keywords
screening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0724860.2A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nxera Pharma UK Ltd
Original Assignee
Heptares Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heptares Therapeutics Ltd filed Critical Heptares Therapeutics Ltd
Priority to GBGB0724860.2A priority Critical patent/GB0724860D0/en
Publication of GB0724860D0 publication Critical patent/GB0724860D0/en
Priority to CA2710145A priority patent/CA2710145C/en
Priority to ES12192130T priority patent/ES3006458T3/es
Priority to AU2008339595A priority patent/AU2008339595C1/en
Priority to GB1000386.1A priority patent/GB2468006C/en
Priority to JP2010538902A priority patent/JP5763343B2/ja
Priority to US12/809,181 priority patent/US8790933B2/en
Priority to EP12192130.8A priority patent/EP2573563B1/en
Priority to PCT/GB2008/004223 priority patent/WO2009081136A2/en
Priority to EP08865061.9A priority patent/EP2235533B1/en
Priority to US14/255,939 priority patent/US9260505B2/en
Priority to JP2015117562A priority patent/JP6425620B2/ja
Priority to US14/989,744 priority patent/US10126313B2/en
Priority to US16/151,991 priority patent/US20190094247A1/en
Priority to US17/107,617 priority patent/US20210148939A1/en
Ceased legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Neurology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
GBGB0724860.2A 2007-12-20 2007-12-20 Screening Ceased GB0724860D0 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
GBGB0724860.2A GB0724860D0 (en) 2007-12-20 2007-12-20 Screening
EP08865061.9A EP2235533B1 (en) 2007-12-20 2008-12-19 Screening
US12/809,181 US8790933B2 (en) 2007-12-20 2008-12-19 Screening
PCT/GB2008/004223 WO2009081136A2 (en) 2007-12-20 2008-12-19 Screening
AU2008339595A AU2008339595C1 (en) 2007-12-20 2008-12-19 Screening
GB1000386.1A GB2468006C (en) 2007-12-20 2008-12-19 Screening
JP2010538902A JP5763343B2 (ja) 2007-12-20 2008-12-19 スクリーニング
CA2710145A CA2710145C (en) 2007-12-20 2008-12-19 Screening of conformation specific binding partners of gpcrs
EP12192130.8A EP2573563B1 (en) 2007-12-20 2008-12-19 Screening
ES12192130T ES3006458T3 (en) 2007-12-20 2008-12-19 Screening
US14/255,939 US9260505B2 (en) 2007-12-20 2014-04-17 Methods for screening for binding partners of G-protein coupled receptors
JP2015117562A JP6425620B2 (ja) 2007-12-20 2015-06-10 スクリーニング
US14/989,744 US10126313B2 (en) 2007-12-20 2016-01-06 Methods for screening for binding partners of G-protein coupled receptors
US16/151,991 US20190094247A1 (en) 2007-12-20 2018-10-04 Methods for screening for binding partners of g-protein coupled receptors
US17/107,617 US20210148939A1 (en) 2007-12-20 2020-11-30 Methods for screening for binding partners of g-protein coupled receptors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0724860.2A GB0724860D0 (en) 2007-12-20 2007-12-20 Screening

Publications (1)

Publication Number Publication Date
GB0724860D0 true GB0724860D0 (en) 2008-01-30

Family

ID=39048448

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB0724860.2A Ceased GB0724860D0 (en) 2007-12-20 2007-12-20 Screening
GB1000386.1A Active GB2468006C (en) 2007-12-20 2008-12-19 Screening

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1000386.1A Active GB2468006C (en) 2007-12-20 2008-12-19 Screening

Country Status (8)

Country Link
US (5) US8790933B2 (https=)
EP (2) EP2573563B1 (https=)
JP (2) JP5763343B2 (https=)
AU (1) AU2008339595C1 (https=)
CA (1) CA2710145C (https=)
ES (1) ES3006458T3 (https=)
GB (2) GB0724860D0 (https=)
WO (1) WO2009081136A2 (https=)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2121919T3 (da) 2007-03-22 2012-05-21 Heptares Therapeutics Ltd Mutante g-proteinkoblede receptorer og fremgangsmåder til udvælgelse heraf
GB0724051D0 (en) * 2007-12-08 2008-01-16 Medical Res Council Mutant proteins and methods for producing them
GB0724860D0 (en) 2007-12-20 2008-01-30 Heptares Therapeutics Ltd Screening
GB0802474D0 (en) * 2008-02-11 2008-03-19 Heptares Therapeutics Ltd Mutant proteins and methods for selecting them
US20110112037A1 (en) * 2008-03-05 2011-05-12 Heptares Therapeutics Limited BioPark Crystal structure
GB0910725D0 (en) 2009-06-22 2009-08-05 Heptares Therapeutics Ltd Mutant proteins and methods for producing them
US9772272B2 (en) 2009-09-28 2017-09-26 Koninklijke Philips N.V. Substance determining apparatus
GB201014715D0 (en) 2010-09-06 2010-10-20 Vib Vzw Nanobodies stabilizing functional conformational states of GPCRS
WO2012022928A2 (en) 2010-08-20 2012-02-23 Heptares Therapeutic Ltd Biological materials and uses thereof
WO2011033322A2 (en) * 2011-01-07 2011-03-24 Heptares Therapeutics Ltd Crystal structure
SG10201701547VA (en) 2011-02-23 2017-03-30 Massachusetts Inst Technology Water soluble membrane proteins and methods for the preparation and use thereof
WO2012120315A2 (en) * 2011-03-10 2012-09-13 Heptares Therapeutics Limited Mutant proteins and methods for producing them
DK2742066T3 (en) 2011-08-10 2018-03-05 Heptares Therapeutics Ltd STABLE PROTEINS
EP2578695A1 (en) * 2011-10-05 2013-04-10 Albert-Ludwigs-Universität Freiburg Assay for Clostridium botulinum Neurotoxin
ES2676827T3 (es) 2012-06-01 2018-07-25 Heptares Therapeutics Limited Ensayos
WO2014045081A1 (en) * 2012-09-18 2014-03-27 Adocia Stable pharmaceutical composition, comprising an aqueous solution of an antibody-derived therapeutically active protein
WO2014045213A1 (en) 2012-09-18 2014-03-27 Adocia Stable pharmaceutical composition, comprising an aqueous solution of an antibody-derived therapeutically active protein
WO2014118297A1 (en) * 2013-01-30 2014-08-07 Vib Vzw Novel chimeric polypeptides for screening and drug discovery purposes
WO2014124020A1 (en) 2013-02-05 2014-08-14 The Board Of Trustees Of The Leland Stanford Junior University Method for selecting agents that bind to transmembrane receptors in a conformationally-selective manner
CA2914831C (en) * 2013-06-11 2022-10-11 Paul Scherrer Institut Method for determining mutateable ligand-gpcr binding at single amino acid resolution and pairs of mutated ligand and gpcr
US10373702B2 (en) 2014-03-27 2019-08-06 Massachusetts Institute Of Technology Water-soluble trans-membrane proteins and methods for the preparation and use thereof
GB201415094D0 (en) 2014-08-26 2014-10-08 Heptares Therapeutics Ltd GPCR receptor binding domain and uses thereof
EP4177899A1 (en) 2014-10-27 2023-05-10 King Abdullah University Of Science And Technology Methods and systems for identifying ligand-protein binding sites
WO2016070022A1 (en) 2014-10-31 2016-05-06 Abilita Bio, Inc. Modified membrane spanning proteins and methods for the preparation and use thereof
US20180224438A1 (en) * 2015-08-10 2018-08-09 Arizona Board Of Regents On Behalf Of The University Of Arizona Stabilized vesicle-functionalized microparticles for chemical separations and rapid formation of polymer frits in silica capillaries using spatially-defined thermal polymerization
GB201601690D0 (en) 2016-01-29 2016-03-16 Heptares Therapeutics Ltd G proteins
EP3452516A4 (en) 2016-05-04 2019-11-27 Abilita Bio, Inc. Methods and platform for preparing multispanning membrane proteins
US11293021B1 (en) 2016-06-23 2022-04-05 Inscripta, Inc. Automated cell processing methods, modules, instruments, and systems
US10320280B2 (en) * 2016-11-08 2019-06-11 Analog Devices Global Unlimited Company LC filter including coupled inductors for reducing ripple in switching power supplies
US9982279B1 (en) 2017-06-23 2018-05-29 Inscripta, Inc. Nucleic acid-guided nucleases
US10011849B1 (en) 2017-06-23 2018-07-03 Inscripta, Inc. Nucleic acid-guided nucleases
MX2019015505A (es) 2017-06-30 2020-07-28 Inscripta Inc Metodos, modulos, instrumentos y sistemas de procesamiento de celulas automatizados.
FR3069644B1 (fr) * 2017-07-28 2024-07-12 Cisbio Bioassays Methode pour mesurer la modulation de l'activation d'un recepteur couple a une proteine g
US11292846B2 (en) * 2017-11-02 2022-04-05 Bayer Aktiengesellschaft Bispecific antibodies binding ALK-1 and BMPR-2
US10376889B1 (en) 2018-04-13 2019-08-13 Inscripta, Inc. Automated cell processing instruments comprising reagent cartridges
US10526598B2 (en) 2018-04-24 2020-01-07 Inscripta, Inc. Methods for identifying T-cell receptor antigens
US10858761B2 (en) 2018-04-24 2020-12-08 Inscripta, Inc. Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells
US10508273B2 (en) 2018-04-24 2019-12-17 Inscripta, Inc. Methods for identifying selective binding pairs
AU2019292919A1 (en) 2018-06-30 2021-03-11 Inscripta, Inc. Instruments, modules, and methods for improved detection of edited sequences in live cells
US11262309B2 (en) * 2018-07-11 2022-03-01 Advanced Cytometry Instrumentation Systems, Llc Methods for lipid measurement in cells
US11142740B2 (en) 2018-08-14 2021-10-12 Inscripta, Inc. Detection of nuclease edited sequences in automated modules and instruments
US10532324B1 (en) 2018-08-14 2020-01-14 Inscripta, Inc. Instruments, modules, and methods for improved detection of edited sequences in live cells
MY204234A (en) 2018-08-27 2024-08-16 Regeneron Pharma Use of raman spectroscopy in downstream purification
US11965154B2 (en) 2018-08-30 2024-04-23 Inscripta, Inc. Detection of nuclease edited sequences in automated modules and instruments
AU2019368215B2 (en) 2018-10-22 2023-05-18 Inscripta, Inc. Engineered enzymes
US11214781B2 (en) 2018-10-22 2022-01-04 Inscripta, Inc. Engineered enzyme
US12522647B2 (en) 2019-01-22 2026-01-13 Paul Scherrer Institut Beta-arrestin mutants
US11001831B2 (en) 2019-03-25 2021-05-11 Inscripta, Inc. Simultaneous multiplex genome editing in yeast
CN113631713A (zh) 2019-03-25 2021-11-09 因思科瑞普特公司 酵母中的同时多重基因组编辑
US12360107B2 (en) 2019-05-31 2025-07-15 Arizona Board Of Regents On Behalf Of The Univeristy Of Arizona Synthesis of nanoSCINT particles
AU2020288623A1 (en) 2019-06-06 2022-01-06 Inscripta, Inc. Curing for recursive nucleic acid-guided cell editing
US10920189B2 (en) 2019-06-21 2021-02-16 Inscripta, Inc. Genome-wide rationally-designed mutations leading to enhanced lysine production in E. coli
US10927385B2 (en) 2019-06-25 2021-02-23 Inscripta, Inc. Increased nucleic-acid guided cell editing in yeast
WO2021064610A1 (en) * 2019-10-01 2021-04-08 Ac Immune Sa Micro-radiobinding assays for ligand screening
US11203762B2 (en) 2019-11-19 2021-12-21 Inscripta, Inc. Methods for increasing observed editing in bacteria
KR102776469B1 (ko) 2019-12-10 2025-03-05 인스크립타 인코포레이티드 신규 mad 뉴클레아제
US10704033B1 (en) 2019-12-13 2020-07-07 Inscripta, Inc. Nucleic acid-guided nucleases
EP4069851A4 (en) 2019-12-18 2023-11-22 Inscripta, Inc. Cascade/dcas3 complementation assays for in vivo detection of nucleic acid-guided nuclease edited cells
US10689669B1 (en) 2020-01-11 2020-06-23 Inscripta, Inc. Automated multi-module cell processing methods, instruments, and systems
AU2021213705A1 (en) 2020-01-27 2022-06-16 Inscripta, Inc. Electroporation modules and instrumentation
US20210332388A1 (en) 2020-04-24 2021-10-28 Inscripta, Inc. Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells
US11787841B2 (en) 2020-05-19 2023-10-17 Inscripta, Inc. Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli
WO2022060749A1 (en) 2020-09-15 2022-03-24 Inscripta, Inc. Crispr editing to embed nucleic acid landing pads into genomes of live cells
US11512297B2 (en) 2020-11-09 2022-11-29 Inscripta, Inc. Affinity tag for recombination protein recruitment
AU2021415461A1 (en) 2021-01-04 2023-08-17 Inscripta, Inc. Mad nucleases
US20240376451A1 (en) 2021-01-07 2024-11-14 Inscripta, Inc. Mad nucleases
US11884924B2 (en) 2021-02-16 2024-01-30 Inscripta, Inc. Dual strand nucleic acid-guided nickase editing
CN114836517B (zh) * 2022-04-20 2026-03-17 合肥中科普瑞昇生物医药科技有限公司 一种A2aR拮抗剂的高通量筛选体系及其应用
WO2024160721A1 (en) 2023-01-30 2024-08-08 Kymab Limited Antibodies
EP4689151A2 (en) * 2023-03-28 2026-02-11 Ibrahim, Yasir, H. Methods of enzyme purification using g-proteins as controllable affinity probes
EP4621788A1 (en) * 2024-03-22 2025-09-24 Genome Research Limited Gpcr
WO2026018204A1 (en) * 2024-07-18 2026-01-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Method for the quantification of plasma amyloid-beta biomarkers in alzheimer's disease

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US6780613B1 (en) 1988-10-28 2004-08-24 Genentech, Inc. Growth hormone variants
EP0397834B1 (en) 1988-10-28 2000-02-02 Genentech, Inc. Method for identifying active domains and amino acid residues in polypeptides and hormone variants
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
EP0585287B1 (en) 1990-07-10 1999-10-13 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
CA2405246A1 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with alterred binding properties
EP0575485A1 (en) 1991-03-01 1993-12-29 Dyax Corp. Process for the development of binding mini-proteins
JP3147916B2 (ja) 1991-03-08 2001-03-19 森永製菓株式会社 体外免疫方法
DK0580737T3 (da) 1991-04-10 2004-11-01 Scripps Research Inst Heterodimere receptorbiblioteker ved anvendelse af phagemider
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
US20030036092A1 (en) 1991-11-15 2003-02-20 Board Of Regents, The University Of Texas System Directed evolution of enzymes and antibodies
US5585277A (en) 1993-06-21 1996-12-17 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
WO1995032425A1 (en) 1994-05-23 1995-11-30 Smithkline Beecham Corporation Encoded combinatorial libraries
US20020028443A1 (en) 1999-09-27 2002-03-07 Jay M. Short Method of dna shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process
AU2020497A (en) 1996-03-27 1997-10-17 Susan R. George Receptor and transporter antagonists
US5925549A (en) 1996-04-15 1999-07-20 The Board Of Trustees Of The Leland Stanford Junior University Soluble 7-transmembrane domain G-protein-coupled receptor compositions and methods
US6153410A (en) 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
US6541209B1 (en) * 1997-04-14 2003-04-01 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof
US6555339B1 (en) 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors
AU3463699A (en) 1998-04-03 1999-10-25 Phylos, Inc. Addressable protein arrays
US6475733B1 (en) * 1998-04-06 2002-11-05 Lerner Pharmaceuticals, Inc. Cell surface receptors for the detection and identification of compounds
US6692696B1 (en) * 1998-06-18 2004-02-17 ARETé ASSOCIATES Biosensor
US7094593B1 (en) * 1998-09-01 2006-08-22 Basf Aktiengesellschaft Method for improving the function of heterologous G protein-coupled receptors
WO2000070343A2 (en) * 1999-05-14 2000-11-23 Repliscent, Inc. G-protein coupled receptor based biosensors and sense replication systems
CN1310945C (zh) 1999-11-17 2007-04-18 阿瑞那制药公司 人g蛋白偶联受体的内源形式和非内源形式
US20020048786A1 (en) * 2000-02-09 2002-04-25 Rosen Craig A. Human G-protein Chemokine Receptor HDGNR10
WO2001071346A2 (en) * 2000-03-21 2001-09-27 Consensus Pharmaceuticals, Inc. Binding compounds for cc chemokine receptor 5 and methods for identifying them
CN1420929A (zh) * 2000-04-07 2003-05-28 阿瑞那制药公司 非内源性组成型活化的已知g蛋白偶联受体
US7678539B2 (en) * 2000-08-10 2010-03-16 Corning Incorporated Arrays of biological membranes and methods and use thereof
WO2002018590A2 (en) 2000-08-30 2002-03-07 John Hopkins University School Of Medicine Identification of activated receptors and ion channels
US6448377B1 (en) 2000-09-27 2002-09-10 The Board Of Trustees Of The Leland Stanford Junior University Modified G protein sunbunits
CA2425149A1 (en) 2000-10-26 2002-08-01 New England Medical Center Hospitals, Inc. Constitutively active, hypersensitive, and nonfunctional receptors as novel therapeutic agents
US20030232331A1 (en) 2000-12-05 2003-12-18 Casman Stacie J. Novel proteins and nucleic acids encoding same
US20030171541A1 (en) 2001-02-14 2003-09-11 Amgen Inc., A Corporation Of The State Of Delaware G-protein coupled receptor molecules and uses thereof
CA2439383A1 (en) 2001-02-26 2002-09-06 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human g protein-coupled receptors
US7294472B2 (en) 2001-03-14 2007-11-13 Caden Biosciences Method for identifying modulators of G protein coupled receptor signaling
US7208279B2 (en) * 2001-03-14 2007-04-24 Caden Biosciences, Inc. Method for identifying inhibitors of G protein coupled receptor signaling
EP1376132A4 (en) 2001-03-30 2005-02-23 Suntory Ltd STRUCTURAL MODEL FOR A G-PROTEIN-COUPLED RECEPTOR AND METHOD FOR DESIGNING LIGANDING BINDING TO THE G-PROTEIN-COUPLED RECEPTOR USING THE STRUCTURE MODEL
US20030129649A1 (en) 2001-04-24 2003-07-10 Kobilka Brian K. Conformational assays to detect binding to G protein-coupled receptors
US20050009204A1 (en) * 2003-07-11 2005-01-13 Ye Fang Multiplexed binding assays for receptor arrays
DE60214869T2 (de) 2001-10-25 2007-04-12 Astex Technology Ltd., Cambridge Cytochrome p450 2c9 kristalle, strukturen und dessen verwendung
US7115377B2 (en) 2001-10-26 2006-10-03 Atto Bioscience, Inc. Cell-based assays for G-protein-coupled receptor-mediated activities
JP2004238384A (ja) 2002-03-28 2004-08-26 Takeda Chem Ind Ltd 新規スクリーニング方法
EP1491207A4 (en) 2002-03-28 2006-02-08 Takeda Pharmaceutical NEW SCREENING PROCESS
JP4344928B2 (ja) 2002-04-24 2009-10-14 萬有製薬株式会社 ヒスタミン受容体h3常活性変異体およびその利用
EP1549318B1 (en) 2002-05-01 2010-02-17 Vertex Pharmaceuticals Incorporated Crystal structure of aurora-2 protein and binding pockets thereof
EP1581648A2 (en) * 2002-09-09 2005-10-05 Nura, Inc. G protein coupled receptors and uses thereof
US20040096914A1 (en) * 2002-11-20 2004-05-20 Ye Fang Substrates with stable surface chemistry for biological membrane arrays and methods for fabricating thereof
US7745161B2 (en) 2003-12-19 2010-06-29 Palo Alto Research Center Incorporated Amplification of enzymatic reactions for use with an enthalpy array
US20050287565A1 (en) * 2004-05-12 2005-12-29 Merchiers Pascal G Methods, compositions and compound assays for inhibiting amyloid-beta protein production
KR100575682B1 (ko) * 2004-05-24 2006-05-03 엘지전자 주식회사 실외기간 균압관을 구비한 공기조화기
WO2005121755A1 (en) 2004-06-14 2005-12-22 Commonwealth Scientific And Industrial Research Organisation Cell free g-protein coupled receptor and ligand assay
WO2006007857A1 (en) * 2004-07-23 2006-01-26 Hvidovre Hospital Bilf1, a constitutive active g-protein coupled receptor
WO2006023248A2 (en) 2004-07-28 2006-03-02 The Trustees Of Columbia University In The City Of New York Processes for producing and crystallizing g-protein coupled receptors
JP2006340717A (ja) 2005-05-11 2006-12-21 Sekisui Chem Co Ltd Gタンパク質共役型受容体に対する結合性評価方法及び評価用組成物、融合タンパク質、並びに、遺伝子
FR2890174B1 (fr) 2005-08-30 2009-04-24 Cis Bio Internat Sa Procede pour la mise en evidence d'un processus biologique par mesure d'un fret
US20070154947A1 (en) 2005-08-31 2007-07-05 The Trustees Of Princeton University Chemical biodiscriminator
JP5492418B2 (ja) 2005-11-18 2014-05-14 ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション ウイルス関連疾患を予防するためのウイルス遺伝子産物およびワクチン接種の方法
DK2121919T3 (da) 2007-03-22 2012-05-21 Heptares Therapeutics Ltd Mutante g-proteinkoblede receptorer og fremgangsmåder til udvælgelse heraf
EP2220245B1 (en) 2007-10-17 2015-04-22 The Board of Trustees of The Leland Stanford Junior University Method and composition for crystallizing g protein-coupled receptors
EP2203475B1 (en) * 2007-10-22 2014-04-16 The Scripps Research Institute Methods and compostions for obtaining high-resolution crystals of membrane proteins
GB0724051D0 (en) 2007-12-08 2008-01-16 Medical Res Council Mutant proteins and methods for producing them
GB0724860D0 (en) 2007-12-20 2008-01-30 Heptares Therapeutics Ltd Screening
GB0802474D0 (en) 2008-02-11 2008-03-19 Heptares Therapeutics Ltd Mutant proteins and methods for selecting them
US20110112037A1 (en) 2008-03-05 2011-05-12 Heptares Therapeutics Limited BioPark Crystal structure
GB0910725D0 (en) 2009-06-22 2009-08-05 Heptares Therapeutics Ltd Mutant proteins and methods for producing them
WO2012022928A2 (en) 2010-08-20 2012-02-23 Heptares Therapeutic Ltd Biological materials and uses thereof
DK2611826T3 (en) 2010-08-30 2017-01-09 Confometrx Inc A method and composition for the crystallization of a family-C-GPCR
WO2012098413A1 (en) 2011-01-21 2012-07-26 Heptares Therapeutics Limited Mutant g-protein coupled receptor proteins and methods for producing them
US20120288913A1 (en) 2011-05-13 2012-11-15 The Scripps Research Institute Novel fusion partners for the purpose of crystallizing g-protein coupled receptors
DK2742066T3 (en) 2011-08-10 2018-03-05 Heptares Therapeutics Ltd STABLE PROTEINS
EP2617732A1 (en) 2012-01-19 2013-07-24 Vib Vzw Tools and methods for expression of membrane proteins
ES2676827T3 (es) 2012-06-01 2018-07-25 Heptares Therapeutics Limited Ensayos
US20150261911A1 (en) 2014-03-13 2015-09-17 Heptares Therapeutics Limited Crystal structure

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