GB0223380D0 - Combination therapy - Google Patents

Combination therapy

Info

Publication number
GB0223380D0
GB0223380D0 GBGB0223380.7A GB0223380A GB0223380D0 GB 0223380 D0 GB0223380 D0 GB 0223380D0 GB 0223380 A GB0223380 A GB 0223380A GB 0223380 D0 GB0223380 D0 GB 0223380D0
Authority
GB
United Kingdom
Prior art keywords
gemcitabine
human
antiangiogenic
warm
treated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0223380.7A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Priority to GBGB0223380.7A priority Critical patent/GB0223380D0/en
Publication of GB0223380D0 publication Critical patent/GB0223380D0/en
Priority to PCT/GB2003/004334 priority patent/WO2004032937A1/en
Priority to JP2004542620A priority patent/JP5416328B2/ja
Priority to AU2003269253A priority patent/AU2003269253B2/en
Priority to US10/530,567 priority patent/US20060009418A1/en
Priority to NZ538999A priority patent/NZ538999A/en
Priority to DE60312715T priority patent/DE60312715T2/de
Priority to CA2501651A priority patent/CA2501651C/en
Priority to BR0315088-7A priority patent/BR0315088A/pt
Priority to HK05110642.6A priority patent/HK1078771B/en
Priority to SI200330784T priority patent/SI1551409T1/sl
Priority to CNB2003801011766A priority patent/CN100363004C/zh
Priority to AT03751032T priority patent/ATE357236T1/de
Priority to MXPA05003595A priority patent/MXPA05003595A/es
Priority to EP03751032A priority patent/EP1551409B1/en
Priority to ES03751032T priority patent/ES2282656T3/es
Priority to PT03751032T priority patent/PT1551409E/pt
Priority to KR1020057005960A priority patent/KR101098061B1/ko
Priority to DK03751032T priority patent/DK1551409T3/da
Priority to IL167633A priority patent/IL167633A/en
Priority to NO20051575A priority patent/NO330601B1/no
Priority to ZA200502753A priority patent/ZA200502753B/en
Priority to CY20071100670T priority patent/CY1106601T1/el
Priority to US12/541,647 priority patent/US20100120708A1/en
Priority to JP2010287659A priority patent/JP2011088921A/ja
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
GBGB0223380.7A 2002-10-09 2002-10-09 Combination therapy Ceased GB0223380D0 (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
GBGB0223380.7A GB0223380D0 (en) 2002-10-09 2002-10-09 Combination therapy
DK03751032T DK1551409T3 (da) 2002-10-09 2003-10-06 Anvendelse af quinazolinderivatet ZD6474 kombineret med gemcitabin og eventuelt ioniserende stråling ved behandling af cancer
AT03751032T ATE357236T1 (de) 2002-10-09 2003-10-06 Verwendung von dem quinazolin derivat zd6474 kombiniert mit gemcitabin und gegebenenfalls ionisierender strahlung für die behandlung von krebs
EP03751032A EP1551409B1 (en) 2002-10-09 2003-10-06 Use of the quinazoline derivative zd6474 combined with gemcitabine and optionally ionising radiation in the treatment of cancer
AU2003269253A AU2003269253B2 (en) 2002-10-09 2003-10-06 Use of the quinazoline derivative ZD6474 combined with gemcitabine and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability
US10/530,567 US20060009418A1 (en) 2002-10-09 2003-10-06 Use of the quinazoline derivative zd6474 combined with gemcitabine and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability
NZ538999A NZ538999A (en) 2002-10-09 2003-10-06 Use of the quinazoline derivative ZD6474 combined with gemcitabine and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability
DE60312715T DE60312715T2 (de) 2002-10-09 2003-10-06 Verwendung von dem quinazolin derivat zd6474 kombiniert mit gemcitabin und gegebenenfalls ionisierender strahlung für die behandlung von krebs
CA2501651A CA2501651C (en) 2002-10-09 2003-10-06 Use of the quinazoline derivative zd6474 combined with gemcitabine and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability
BR0315088-7A BR0315088A (pt) 2002-10-09 2003-10-06 Métodos para produção de um efeito antiangiogênico e/ou redutor de permeabilidade vascular em um animal de sangue quente e para tratamento de câncer em um animal de sangue quente, composição farmacêutica, kit, e, uso de zd6474 ou de um sal fermaceuticamento aceitável do mesmo e gencitabina
HK05110642.6A HK1078771B (en) 2002-10-09 2003-10-06 Use of the quinazoline derivative zd6474 combined with gemcitabine and optionally ionising radiation in the treatment of cancer
SI200330784T SI1551409T1 (sl) 2002-10-09 2003-10-06 Uporaba kinazolinskega derivata ZD6474, kombiniranega z gemcitabinom in po želji ionizirajočim obsevanjem, pri zdravljenju raka
CNB2003801011766A CN100363004C (zh) 2002-10-09 2003-10-06 喹唑啉衍生物zd6474组合吉西他滨在制备药物中的用途
PCT/GB2003/004334 WO2004032937A1 (en) 2002-10-09 2003-10-06 Use of the quinazoline derivative zd6474 combined with gemcitabine and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability
MXPA05003595A MXPA05003595A (es) 2002-10-09 2003-10-06 Uso del derivado de quinazolina zd6474 combinado con gencitabina y opcionalmente radiacion ionizante en el tratamiento de enfermedades asociadas con angiogenesis y/o permeabilidad vascular incrementada.
JP2004542620A JP5416328B2 (ja) 2002-10-09 2003-10-06 血管形成及び／又は増加した血管透過性に関連する疾病の治療におけるゲムシタビンと、そして場合により電離放射と組み合わせたキナゾリン誘導体ｚｄ６４７４の使用
ES03751032T ES2282656T3 (es) 2002-10-09 2003-10-06 Uso del derivado de quinazolina zd6474 combinado con gemcitabina y opscionalmente radiacion ionizante en el tratamiento del cancer.
PT03751032T PT1551409E (pt) 2002-10-09 2003-10-06 Utilização do derivado de quinazolina zd6474 combinado com gemcitabina e, opcionalmente, radiação ionizante no tratamento do cancro
KR1020057005960A KR101098061B1 (ko) 2002-10-09 2003-10-06 신생혈관형성 및/또는 증가된 혈관 투과성과 관련된 질병의치료에서 젬시타빈 및 임의로 이온화 방사선과 병용되는퀴나졸린 유도체 ｚｄ6474의 용도
IL167633A IL167633A (en) 2002-10-09 2005-03-24 Use of zd6474 combined with gemcitabine in the preparation of medicaments and as medicaments for the production of an angiogenic and/or vascular permeability reducing effect and pharmaceutical compositions and kits comprising such combination
NO20051575A NO330601B1 (no) 2002-10-09 2005-03-29 Farmasøytisk preparat omfattende kinazolin-derivatet ZD6474 kombinert med gemcitabin, sett omfattende samme samt anvendelse av disse for fremstilling av medikament for behandling av sykdom.
ZA200502753A ZA200502753B (en) 2002-10-09 2006-01-17 Use of the quinazoline derivative ZD6747 combined with gemcitabine and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability
CY20071100670T CY1106601T1 (el) 2002-10-09 2007-05-17 Χρηση του παραγωγου κουιναζολινης zd6474 συνδυασμενου με γκεμσιταμπινη και προαιρετικα με ιοντιζουσα ακτινοβολια στη θεραπεια του καρκινου
US12/541,647 US20100120708A1 (en) 2002-10-09 2009-08-14 Combination therapy comprising ZD6474 and gemcitabine for anti-cancer therapy
JP2010287659A JP2011088921A (ja) 2002-10-09 2010-12-24 血管形成及び／又は増加した血管透過性に関連する疾病の治療におけるゲムシタビンと、そして場合により電離放射と組み合わせたキナゾリン誘導体ｚｄ６４７４の使用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0223380.7A GB0223380D0 (en) 2002-10-09 2002-10-09 Combination therapy

Publications (1)

Publication Number Publication Date
GB0223380D0 true GB0223380D0 (en) 2002-11-13

Family

ID=9945538

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0223380.7A Ceased GB0223380D0 (en) 2002-10-09 2002-10-09 Combination therapy

Country Status (22)

Country Link
US (2) US20060009418A1 (https=)
EP (1) EP1551409B1 (https=)
JP (2) JP5416328B2 (https=)
KR (1) KR101098061B1 (https=)
CN (1) CN100363004C (https=)
AT (1) ATE357236T1 (https=)
AU (1) AU2003269253B2 (https=)
BR (1) BR0315088A (https=)
CA (1) CA2501651C (https=)
CY (1) CY1106601T1 (https=)
DE (1) DE60312715T2 (https=)
DK (1) DK1551409T3 (https=)
ES (1) ES2282656T3 (https=)
GB (1) GB0223380D0 (https=)
IL (1) IL167633A (https=)
MX (1) MXPA05003595A (https=)
NO (1) NO330601B1 (https=)
NZ (1) NZ538999A (https=)
PT (1) PT1551409E (https=)
SI (1) SI1551409T1 (https=)
WO (1) WO2004032937A1 (https=)
ZA (1) ZA200502753B (https=)

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KR101513326B1 (ko) 2007-11-09 2015-04-17 에자이 알앤드디 매니지먼트 가부시키가이샤 혈관 신생 저해 물질과 항종양성 백금 착물의 병용
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WO2011162343A1 (ja) 2010-06-25 2011-12-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 キナーゼ阻害作用を有する化合物の併用による抗腫瘍剤
CN103402519B (zh) 2011-04-18 2015-11-25 卫材R&D管理有限公司 肿瘤治疗剂
JP6038128B2 (ja) 2011-06-03 2016-12-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
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EP2997377B1 (en) 2013-05-14 2018-07-18 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
PT3524595T (pt) 2014-08-28 2022-09-19 Eisai R&D Man Co Ltd Derivado de quinolina altamente puro e método para produção do mesmo
AU2016224583B2 (en) 2015-02-25 2021-06-03 Eisai R&D Management Co., Ltd. Method for suppressing bitterness of quinoline derivative
KR102662228B1 (ko) 2015-03-04 2024-05-02 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
BR112017027227B1 (pt) 2015-06-16 2023-12-12 Eisai R&D Management Co., Ltd Agente anti-câncer
JP6553726B2 (ja) 2015-08-20 2019-07-31 エーザイ・アール・アンド・ディー・マネジメント株式会社 腫瘍治療剤
CN106727657A (zh) * 2016-12-27 2017-05-31 郑州郑先医药科技有限公司 一种治疗糖尿病的西药组合物及应用
CN106619688A (zh) * 2016-12-27 2017-05-10 郑州郑先医药科技有限公司 一种治疗糖尿病的药物组合物及应用
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PT1592423E (pt) * 2003-02-13 2011-06-16 Astrazeneca Ab Terapia de combinação de zd6474 com 5-fu e/ou cpt-11
EP1648465B1 (en) * 2003-07-10 2010-08-25 AstraZeneca AB Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability
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Also Published As

Publication number Publication date
BR0315088A (pt) 2005-08-16
DE60312715D1 (de) 2007-05-03
JP5416328B2 (ja) 2014-02-12
NO20051575L (no) 2005-04-25
CA2501651A1 (en) 2004-04-22
ZA200502753B (en) 2006-03-29
ATE357236T1 (de) 2007-04-15
JP2011088921A (ja) 2011-05-06
KR20050055070A (ko) 2005-06-10
WO2004032937A1 (en) 2004-04-22
SI1551409T1 (sl) 2007-08-31
NZ538999A (en) 2008-02-29
IL167633A (en) 2013-03-24
AU2003269253A1 (en) 2004-05-04
HK1078771A1 (en) 2006-03-24
EP1551409B1 (en) 2007-03-21
US20060009418A1 (en) 2006-01-12
CN100363004C (zh) 2008-01-23
PT1551409E (pt) 2007-05-31
EP1551409A1 (en) 2005-07-13
US20100120708A1 (en) 2010-05-13
NO330601B1 (no) 2011-05-23
CN1703223A (zh) 2005-11-30
DK1551409T3 (da) 2007-06-11
ES2282656T3 (es) 2007-10-16
KR101098061B1 (ko) 2011-12-26
DE60312715T2 (de) 2007-12-06
AU2003269253B2 (en) 2007-04-05
JP2006504723A (ja) 2006-02-09
MXPA05003595A (es) 2005-06-03
CA2501651C (en) 2011-02-15
CY1106601T1 (el) 2012-01-25

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