FR3125295B1 - Polysaccharide de sélénium et procédé de préparation et utilisation de celui-ci - Google Patents
Polysaccharide de sélénium et procédé de préparation et utilisation de celui-ci Download PDFInfo
- Publication number
- FR3125295B1 FR3125295B1 FR2110765A FR2110765A FR3125295B1 FR 3125295 B1 FR3125295 B1 FR 3125295B1 FR 2110765 A FR2110765 A FR 2110765A FR 2110765 A FR2110765 A FR 2110765A FR 3125295 B1 FR3125295 B1 FR 3125295B1
- Authority
- FR
- France
- Prior art keywords
- selenium
- polysaccharide
- present disclosure
- lead
- pectin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229920001282 polysaccharide Polymers 0.000 title abstract 9
- 239000005017 polysaccharide Substances 0.000 title abstract 9
- -1 SELENIUM POLYSACCHARIDE Chemical class 0.000 title abstract 5
- 229910052711 selenium Inorganic materials 0.000 title abstract 5
- 239000011669 selenium Substances 0.000 title abstract 5
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000004676 glycans Chemical class 0.000 abstract 4
- 229920001277 pectin Polymers 0.000 abstract 4
- 235000010987 pectin Nutrition 0.000 abstract 4
- 239000001814 pectin Substances 0.000 abstract 4
- 208000004852 Lung Injury Diseases 0.000 abstract 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 abstract 2
- 206010069363 Traumatic lung injury Diseases 0.000 abstract 2
- 231100000515 lung injury Toxicity 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 241000700159 Rattus Species 0.000 abstract 1
- 210000002821 alveolar epithelial cell Anatomy 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000005779 cell damage Effects 0.000 abstract 1
- 208000037887 cell injury Diseases 0.000 abstract 1
- 238000010668 complexation reaction Methods 0.000 abstract 1
- 229910001385 heavy metal Inorganic materials 0.000 abstract 1
- 229940046892 lead acetate Drugs 0.000 abstract 1
- 150000002611 lead compounds Chemical class 0.000 abstract 1
- PIJPYDMVFNTHIP-UHFFFAOYSA-L lead sulfate Chemical compound [PbH4+2].[O-]S([O-])(=O)=O PIJPYDMVFNTHIP-UHFFFAOYSA-L 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- IMRYETFJNLKUHK-UHFFFAOYSA-N traseolide Chemical compound CC1=C(C(C)=O)C=C2C(C(C)C)C(C)C(C)(C)C2=C1 IMRYETFJNLKUHK-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/732—Pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
- C08B37/0048—Processes of extraction from organic materials
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/06—Pectin; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Materials Engineering (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente description propose un polysaccharide de sélénium et un procédé de préparation et une utilisation de celui-ci. Le polysaccharide de sélénium selon la présente description inclut un polysaccharide de pectine et du sélénium élémentaire chargé sur le polysaccharide de pectine. Le polysaccharide de pectine selon la présente description a une activité antioxydante plus significative ainsi qu’une capacité de complexation pour du plomb de métal lourd. Dans le même temps, le polysaccharide de pectine à une surface superficielle spécifique plus grande, permettant à une grande quantité de sélénium élémentaire d’être chargée sur la surface, ce qui améliore davantage l’activité biologique de polysaccharides de sélénium. Les données des exemples indiquent que le polysaccharide de sélénium selon la présente description a un effet thérapeutique sur une lésion pulmonaire provoquée par des composés de plomb, un effet thérapeutique significatif sur une lésion pulmonaire subaiguë provoquée par du sulfate de plomb chez des rats, et un effet protecteur significatif sur la détérioration de cellules épithéliales alvéolaires (ATII) provoquée par de l’acétate de plomb.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110788132.5 | 2021-07-13 | ||
| CN202110788132.5A CN113368127B (zh) | 2021-07-13 | 2021-07-13 | 一种硒多糖及其制备方法和应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR3125295A1 FR3125295A1 (fr) | 2023-01-20 |
| FR3125295B1 true FR3125295B1 (fr) | 2024-01-12 |
Family
ID=77581788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR2110765A Active FR3125295B1 (fr) | 2021-07-13 | 2021-10-12 | Polysaccharide de sélénium et procédé de préparation et utilisation de celui-ci |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN113368127B (fr) |
| FR (1) | FR3125295B1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117430728B (zh) * | 2023-12-20 | 2024-03-22 | 青岛海大生物集团股份有限公司 | 一种高纯度硒化浒苔多糖的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105520953A (zh) * | 2011-07-25 | 2016-04-27 | 香港理工大学 | 具有抗肿瘤活性的虎奶菇多糖功能化纳米硒水溶胶及其制备方法 |
| CN102643361B (zh) * | 2012-04-25 | 2014-04-09 | 山西大学 | 纳米硒小分子微生物多糖及其制备方法和应用 |
| CN104987433B (zh) * | 2015-07-23 | 2017-04-12 | 中国科学院西北高原生物研究所 | 一种具有抗衰老活性的rg‑i型枸杞果胶的制备方法 |
| CN106084080A (zh) * | 2016-06-01 | 2016-11-09 | 石河子大学 | 一种甘草硒多糖及其制备方法 |
| KR20180058251A (ko) * | 2016-11-23 | 2018-06-01 | 충남태안영농조합법인 | 굼벵이를 이용한 체내 미네랄 균형 유지, 중금속의 생체 내 흡수 방지 및 체외 배출을 위한 기능성 식품 조성물 |
| CN107586347B (zh) * | 2017-09-27 | 2019-12-31 | 西北师范大学 | 一种以酸性离子液体为催化剂合成圆头蒿多糖衍生物的方法 |
| CN108477618A (zh) * | 2018-02-05 | 2018-09-04 | 江苏大学 | 一种果胶纳米硒的可控制备方法 |
| CN109136412B (zh) * | 2018-09-07 | 2021-09-17 | 海南古遵科技有限公司 | 一种富硒红糖的制备方法 |
-
2021
- 2021-07-13 CN CN202110788132.5A patent/CN113368127B/zh active Active
- 2021-10-12 FR FR2110765A patent/FR3125295B1/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| FR3125295A1 (fr) | 2023-01-20 |
| CN113368127A (zh) | 2021-09-10 |
| CN113368127B (zh) | 2023-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PLFP | Fee payment |
Year of fee payment: 2 |
|
| PLSC | Publication of the preliminary search report |
Effective date: 20230519 |
|
| PLFP | Fee payment |
Year of fee payment: 3 |