FR3108260B1 - Hydrogel hétérogène hybride, procédé de fabrication et utilisation comme implant de comblement non-dégradable in-situ - Google Patents

Hydrogel hétérogène hybride, procédé de fabrication et utilisation comme implant de comblement non-dégradable in-situ Download PDF

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Publication number
FR3108260B1
FR3108260B1 FR2002619A FR2002619A FR3108260B1 FR 3108260 B1 FR3108260 B1 FR 3108260B1 FR 2002619 A FR2002619 A FR 2002619A FR 2002619 A FR2002619 A FR 2002619A FR 3108260 B1 FR3108260 B1 FR 3108260B1
Authority
FR
France
Prior art keywords
microbeads
microns
support
filling implant
hybrid heterogeneous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR2002619A
Other languages
English (en)
French (fr)
Other versions
FR3108260A1 (fr
Inventor
Stéphane Woerly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NeuroBioMat SAS
Original Assignee
NeuroBioMat SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR2002619A priority Critical patent/FR3108260B1/fr
Application filed by NeuroBioMat SAS filed Critical NeuroBioMat SAS
Priority to IL296328A priority patent/IL296328B2/en
Priority to MX2022011096A priority patent/MX2022011096A/es
Priority to PCT/EP2021/056753 priority patent/WO2021185881A1/fr
Priority to KR1020227035527A priority patent/KR20220154749A/ko
Priority to US17/912,184 priority patent/US12599703B2/en
Priority to JP2022555660A priority patent/JP7888463B2/ja
Priority to AU2021237753A priority patent/AU2021237753A1/en
Priority to CN202180021887.0A priority patent/CN115297903B/zh
Priority to CA3167699A priority patent/CA3167699A1/en
Priority to BR112022017583A priority patent/BR112022017583A2/pt
Priority to EP21711292.9A priority patent/EP4121133B1/fr
Publication of FR3108260A1 publication Critical patent/FR3108260A1/fr
Application granted granted Critical
Publication of FR3108260B1 publication Critical patent/FR3108260B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/12—Chemical modification
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/005—Dendritic macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/24—Homopolymers or copolymers of amides or imides
    • C08L33/26—Homopolymers or copolymers of acrylamide or methacrylamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/622—Microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Prostheses (AREA)
  • Medicinal Preparation (AREA)
  • Graft Or Block Polymers (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
FR2002619A 2020-03-17 2020-03-17 Hydrogel hétérogène hybride, procédé de fabrication et utilisation comme implant de comblement non-dégradable in-situ Active FR3108260B1 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
FR2002619A FR3108260B1 (fr) 2020-03-17 2020-03-17 Hydrogel hétérogène hybride, procédé de fabrication et utilisation comme implant de comblement non-dégradable in-situ
CN202180021887.0A CN115297903B (zh) 2020-03-17 2021-03-17 杂化多相水凝胶、其制造方法及其作为不可降解原位填充植入物的用途
PCT/EP2021/056753 WO2021185881A1 (fr) 2020-03-17 2021-03-17 Hydrogel hétérogène hybride, procédé de fabrication et utilisation comme implant de comblement non-dégradable in-situ
KR1020227035527A KR20220154749A (ko) 2020-03-17 2021-03-17 하이브리드 이종 하이드로겔, 이의 제조 방법, 및 비-분해성 인-시튜 필러 임플란트로서의 이의 용도
US17/912,184 US12599703B2 (en) 2020-03-17 2021-03-17 Hybrid heterogeneous hydrogel, manufacturing method and use as an in-situ non-degradable filler implant
JP2022555660A JP7888463B2 (ja) 2020-03-17 2021-03-17 不均一ハイブリッドヒドロゲル、その製造方法、および非分解性ｉｎ ｓｉｔｕフィラーインプラントとしての使用
IL296328A IL296328B2 (en) 2020-03-17 2021-03-17 Hybrid heterogeneous hydrogel, method for its production and use as an in situ non-degradable filler implant
MX2022011096A MX2022011096A (es) 2020-03-17 2021-03-17 Hidrogel heterogeneo hibrido, metodo de fabricacion y uso como implante de relleno no degradable in situ.
CA3167699A CA3167699A1 (en) 2020-03-17 2021-03-17 Hybrid heterogeneous hydrogel, method for fabrication and use thereof as non-degradable in-situ filler implant
BR112022017583A BR112022017583A2 (pt) 2020-03-17 2021-03-17 Hidrogel heterogêneo híbrido, método para fabricação e uso do mesmo como implante de enchimento in situ não degradável
EP21711292.9A EP4121133B1 (fr) 2020-03-17 2021-03-17 Hydrogel hétérogène hybride, procédé de fabrication et utilisation comme implant de comblement non-dégradable in-situ
AU2021237753A AU2021237753A1 (en) 2020-03-17 2021-03-17 Hybrid heterogeneous hydrogel, manufacturing method and use as an in-situ non-degradable filller implant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR2002619 2020-03-17
FR2002619A FR3108260B1 (fr) 2020-03-17 2020-03-17 Hydrogel hétérogène hybride, procédé de fabrication et utilisation comme implant de comblement non-dégradable in-situ

Publications (2)

Publication Number Publication Date
FR3108260A1 FR3108260A1 (fr) 2021-09-24
FR3108260B1 true FR3108260B1 (fr) 2024-01-05

Family

ID=71452405

Family Applications (1)

Application Number Title Priority Date Filing Date
FR2002619A Active FR3108260B1 (fr) 2020-03-17 2020-03-17 Hydrogel hétérogène hybride, procédé de fabrication et utilisation comme implant de comblement non-dégradable in-situ

Country Status (12)

Country Link
US (1) US12599703B2 (enExample)
EP (1) EP4121133B1 (enExample)
JP (1) JP7888463B2 (enExample)
KR (1) KR20220154749A (enExample)
CN (1) CN115297903B (enExample)
AU (1) AU2021237753A1 (enExample)
BR (1) BR112022017583A2 (enExample)
CA (1) CA3167699A1 (enExample)
FR (1) FR3108260B1 (enExample)
IL (1) IL296328B2 (enExample)
MX (1) MX2022011096A (enExample)
WO (1) WO2021185881A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12640279B2 (en) * 2020-10-13 2026-05-26 President And Fellows Of Harvard College Viscoelastic conductive hydrogel
US20240181137A1 (en) * 2021-05-27 2024-06-06 The Regents Of The University Of California Superporous Gel Matrix for Encapsulation of Cells
CN114103125B (zh) * 2021-09-30 2022-06-28 哈尔滨工业大学（威海） 一种高导热微型器件的制备方法

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US5863551A (en) * 1996-10-16 1999-01-26 Organogel Canada Ltee Implantable polymer hydrogel for therapeutic uses
AU6100700A (en) * 1999-07-16 2001-02-05 Wesley-Jessen Corporation Thermoformable ophthalmic lens
US7163545B2 (en) 2002-07-29 2007-01-16 Mayo Foundation For Medical Education And Research Spinal cord surgical implant
NZ539713A (en) * 2002-10-11 2008-07-31 Novocell Inc Implantation of encapsulated biological materials for treating diseases
US7569222B2 (en) * 2002-11-18 2009-08-04 Woerly Stephane Hydrogel membrane composition and use thereof
US7846466B2 (en) 2004-06-10 2010-12-07 Northwestern University Biodegradable scaffolds and uses thereof
ATE464025T1 (de) * 2004-08-13 2010-04-15 Setagon Inc Herstellungsverfahren für medizinprodukte mit nanoporösen schichten
KR20140009555A (ko) 2006-04-25 2014-01-22 칠드런'즈 메디컬 센터 코포레이션 개방창 및 폐쇄창 척수 손상의 치료를 위한 방법 및 조성물
RU2394593C2 (ru) 2008-09-25 2010-07-20 Андрей Степанович БРЮХОВЕЦКИЙ Имплантируемая нейроэндопротезная система, способ ее получения и способ проведения реконструктивной нейрохирургической операции
FR2942080B1 (fr) 2009-02-09 2011-04-01 Vehicules Electr Soc D Procede de gestion thermique d'une batterie electrique
FR2942408B1 (fr) 2009-02-24 2012-01-27 Stephane Woerly Hydrogel heterogene hybride et son utilisation therapeutique
KR101091028B1 (ko) 2009-07-02 2011-12-09 아주대학교산학협력단 체내 주입형 하이드로젤 및 이의 생의학적 용도
US8877498B2 (en) 2010-12-01 2014-11-04 Drexel University Porous polymer scaffolds for neural tissue engineering and methods of producing the same
TW201313263A (zh) 2011-07-13 2013-04-01 Invivo Therapeutics Corp 聚乳酸-聚乙醇酸(plga)-b-離胺酸及plga與pll(聚e-cbz-l離胺酸)嵌段共聚物合成方法
AU2012349725B2 (en) 2011-12-06 2018-01-18 Bioarctic Neuroscience Ab Spinal cord devices and methods for promoting axonal regeneration
FR2993566B1 (fr) 2012-07-19 2015-05-15 Univ Claude Bernard Lyon Hydrogel de chitosane pour la reparation du tissu nerveux
US20150044259A1 (en) 2013-08-08 2015-02-12 Mauris N. DeSilva Scaffold for enhanced neural tissue regeneration
CN105412935B (zh) * 2015-02-04 2019-02-19 四川大学 一种基于n-(2-羟丙基)甲基丙烯酰胺聚合物的纳米粒及其制备方法
US20180037865A1 (en) 2016-08-05 2018-02-08 Wayne State University Methods and compositions relating to treatment of nervous system injuries
JP2024545175A (ja) * 2021-12-09 2024-12-05 リカルダ、インコーポレイテッド ヒドロゲルマイクロ粒子ベースの軟組織充填剤

Also Published As

Publication number Publication date
EP4121133A1 (fr) 2023-01-25
MX2022011096A (es) 2022-11-10
CA3167699A1 (en) 2021-09-23
JP7888463B2 (ja) 2026-07-13
BR112022017583A2 (pt) 2022-10-18
IL296328A (en) 2022-11-01
FR3108260A1 (fr) 2021-09-24
CN115297903A (zh) 2022-11-04
IL296328B1 (en) 2025-11-01
IL296328B2 (en) 2026-03-01
KR20220154749A (ko) 2022-11-22
EP4121133B1 (fr) 2023-08-16
JP2023518227A (ja) 2023-04-28
US12599703B2 (en) 2026-04-14
CN115297903B (zh) 2024-03-12
EP4121133C0 (fr) 2023-08-16
US20230166005A1 (en) 2023-06-01
WO2021185881A1 (fr) 2021-09-23
AU2021237753A1 (en) 2022-10-20

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