FR3107903B1 - Procédé chimio-enzymatique de coproduction d’un disulfure et d’un sulfoxyde ou d’une sulfone - Google Patents
Procédé chimio-enzymatique de coproduction d’un disulfure et d’un sulfoxyde ou d’une sulfone Download PDFInfo
- Publication number
- FR3107903B1 FR3107903B1 FR2002315A FR2002315A FR3107903B1 FR 3107903 B1 FR3107903 B1 FR 3107903B1 FR 2002315 A FR2002315 A FR 2002315A FR 2002315 A FR2002315 A FR 2002315A FR 3107903 B1 FR3107903 B1 FR 3107903B1
- Authority
- FR
- France
- Prior art keywords
- chemo
- sulfone
- disulfide
- sulfoxide
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title abstract 5
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 150000003457 sulfones Chemical class 0.000 title abstract 3
- 150000003462 sulfoxides Chemical class 0.000 title abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 150000002894 organic compounds Chemical class 0.000 abstract 3
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 3
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 abstract 2
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 abstract 1
- ATTZFSUZZUNHBP-UHFFFAOYSA-N Piperonyl sulfoxide Chemical compound CCCCCCCCS(=O)C(C)CC1=CC=C2OCOC2=C1 ATTZFSUZZUNHBP-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000539 dimer Substances 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 230000008929 regeneration Effects 0.000 abstract 1
- 238000011069 regeneration method Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 125000001174 sulfone group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/06—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P11/00—Preparation of sulfur-containing organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Procédé chimio-enzymatique de coproduction d’un disulfure et d’un sulfoxyde ou d’une sulfone La présente invention concerne un procédé chimio-enzymatique de coproduction de disulfure et de sulfoxyde ou de sulfone à partir d’une composition M comprenant : un sulfure,éventuellement un oxydant,un composé organique porteur d’au moins un groupement thiol,une enzyme E catalysant l’oxydation dudit sulfure en sulfoxyde ou en sulfone,une enzyme D catalysant la formation d’un pont disulfure entre deux équivalents dudit composé organique porteur d’au moins un groupement thiol pour former un dimère, etun cofacteur commun aux deux enzymes E et D ; ainsi qu’une composition permettant notamment la mise en œuvre de ce procédé. La présente invention concerne également l’utilisation d’un mercaptan pour la réduction d’un pont disulfure formé entre deux équivalents d’un composé organique porteur d’au moins un groupement thiol, et plus particulièrement son utilisation en tant que substrat de régénération du procédé décrit ci-dessus.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR2002315A FR3107903B1 (fr) | 2020-03-09 | 2020-03-09 | Procédé chimio-enzymatique de coproduction d’un disulfure et d’un sulfoxyde ou d’une sulfone |
US17/801,109 US20230159447A1 (en) | 2020-03-09 | 2021-03-03 | Chemoenzymatic process for coproduction of a disulfide and a sulfoxide or a sulfone |
EP21714648.9A EP4118223A1 (fr) | 2020-03-09 | 2021-03-03 | Procédé chimio-enzymatique de coproduction d'un disulfure et d'un sulfoxyde ou d'une sulfone |
JP2022554930A JP2023517686A (ja) | 2020-03-09 | 2021-03-03 | ジスルフィド及びスルホキシド又はスルホンの共生成のための化学酵素プロセス |
KR1020227027631A KR20220129024A (ko) | 2020-03-09 | 2021-03-03 | 디설파이드 및 설폭사이드 또는 설폰의 공동생성을 위한 화학효소적 방법 |
PCT/FR2021/050362 WO2021181029A1 (fr) | 2020-03-09 | 2021-03-03 | Procédé chimio-enzymatique de coproduction d'un disulfure et d'un sulfoxyde ou d'une sulfone |
CN202180018140.XA CN115210384A (zh) | 2020-03-09 | 2021-03-03 | 共同生产二硫化物以及亚砜或砜的化学酶促方法 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR2002315 | 2020-03-09 | ||
FR2002315A FR3107903B1 (fr) | 2020-03-09 | 2020-03-09 | Procédé chimio-enzymatique de coproduction d’un disulfure et d’un sulfoxyde ou d’une sulfone |
Publications (2)
Publication Number | Publication Date |
---|---|
FR3107903A1 FR3107903A1 (fr) | 2021-09-10 |
FR3107903B1 true FR3107903B1 (fr) | 2023-05-05 |
Family
ID=70918605
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR2002315A Active FR3107903B1 (fr) | 2020-03-09 | 2020-03-09 | Procédé chimio-enzymatique de coproduction d’un disulfure et d’un sulfoxyde ou d’une sulfone |
Country Status (7)
Country | Link |
---|---|
US (1) | US20230159447A1 (fr) |
EP (1) | EP4118223A1 (fr) |
JP (1) | JP2023517686A (fr) |
KR (1) | KR20220129024A (fr) |
CN (1) | CN115210384A (fr) |
FR (1) | FR3107903B1 (fr) |
WO (1) | WO2021181029A1 (fr) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2532656B2 (fr) | 1982-06-02 | 1985-10-18 | Elf Bio Rech | Nouveau vecteur de clonage et d'expression, levure et bacterie transformees par ce vecteur |
SG181535A1 (en) * | 2009-12-08 | 2012-07-30 | Codexis Inc | Synthesis of prazole compounds |
-
2020
- 2020-03-09 FR FR2002315A patent/FR3107903B1/fr active Active
-
2021
- 2021-03-03 KR KR1020227027631A patent/KR20220129024A/ko unknown
- 2021-03-03 US US17/801,109 patent/US20230159447A1/en active Pending
- 2021-03-03 CN CN202180018140.XA patent/CN115210384A/zh active Pending
- 2021-03-03 JP JP2022554930A patent/JP2023517686A/ja active Pending
- 2021-03-03 WO PCT/FR2021/050362 patent/WO2021181029A1/fr unknown
- 2021-03-03 EP EP21714648.9A patent/EP4118223A1/fr active Pending
Also Published As
Publication number | Publication date |
---|---|
CN115210384A (zh) | 2022-10-18 |
US20230159447A1 (en) | 2023-05-25 |
EP4118223A1 (fr) | 2023-01-18 |
FR3107903A1 (fr) | 2021-09-10 |
JP2023517686A (ja) | 2023-04-26 |
WO2021181029A1 (fr) | 2021-09-16 |
KR20220129024A (ko) | 2022-09-22 |
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PLFP | Fee payment |
Year of fee payment: 2 |
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PLSC | Publication of the preliminary search report |
Effective date: 20210910 |
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Year of fee payment: 3 |
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PLFP | Fee payment |
Year of fee payment: 4 |
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PLFP | Fee payment |
Year of fee payment: 5 |