FR2940288B1 - Phenyl-alkyl-piperazines ayant une activite modulatrice du tnf - Google Patents

Phenyl-alkyl-piperazines ayant une activite modulatrice du tnf

Info

Publication number
FR2940288B1
FR2940288B1 FR0807361A FR0807361A FR2940288B1 FR 2940288 B1 FR2940288 B1 FR 2940288B1 FR 0807361 A FR0807361 A FR 0807361A FR 0807361 A FR0807361 A FR 0807361A FR 2940288 B1 FR2940288 B1 FR 2940288B1
Authority
FR
France
Prior art keywords
piperazines
phenyl
alkyl
modulating activity
tnf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0807361A
Other languages
English (en)
Other versions
FR2940288A1 (fr
Inventor
Marco Baroni
Olaf Ritzeler
Marco Zanchet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0807361A priority Critical patent/FR2940288B1/fr
Priority to JO2009205A priority patent/JO2857B1/en
Priority to ARP090102132A priority patent/AR072120A1/es
Priority to PL09766076T priority patent/PL2313384T3/pl
Priority to AU2009261783A priority patent/AU2009261783B2/en
Priority to KR1020107028188A priority patent/KR20110028452A/ko
Priority to MYPI20105969 priority patent/MY153051A/en
Priority to JP2011514097A priority patent/JP5536050B2/ja
Priority to SI200930774T priority patent/SI2313384T1/sl
Priority to MX2010013947A priority patent/MX2010013947A/es
Priority to BRPI0914815A priority patent/BRPI0914815A2/pt
Priority to EP09766076.5A priority patent/EP2313384B1/fr
Priority to UY0001031902A priority patent/UY31902A/es
Priority to CA2727911A priority patent/CA2727911C/fr
Priority to CN201510688427.XA priority patent/CN105198803A/zh
Priority to PCT/FR2009/051138 priority patent/WO2009153514A1/fr
Priority to CN2009801315519A priority patent/CN102123995A/zh
Priority to DK09766076.5T priority patent/DK2313384T3/da
Priority to PT97660765T priority patent/PT2313384E/pt
Priority to ES09766076T priority patent/ES2433218T3/es
Priority to TW098120169A priority patent/TW201002687A/zh
Priority to RU2011101396/04A priority patent/RU2512567C2/ru
Publication of FR2940288A1 publication Critical patent/FR2940288A1/fr
Priority to IL209944A priority patent/IL209944A/en
Priority to US12/970,047 priority patent/US8153637B2/en
Application granted granted Critical
Publication of FR2940288B1 publication Critical patent/FR2940288B1/fr
Priority to CY20131101052T priority patent/CY1114823T1/el
Priority to HRP20131183AT priority patent/HRP20131183T1/hr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0807361A 2008-06-16 2008-12-23 Phenyl-alkyl-piperazines ayant une activite modulatrice du tnf Expired - Fee Related FR2940288B1 (fr)

Priority Applications (26)

Application Number Priority Date Filing Date Title
FR0807361A FR2940288B1 (fr) 2008-12-23 2008-12-23 Phenyl-alkyl-piperazines ayant une activite modulatrice du tnf
JO2009205A JO2857B1 (en) 2008-06-16 2009-06-04 Vinyl pipers with modified activity of tumor-resistant TNF
ARP090102132A AR072120A1 (es) 2008-06-16 2009-06-12 Fenil-alquil-piperazinas que tienen actividad moduladora de tnf, un proceso de preparacion del compuesto, una composicion farmaceutica que lo contiene, un medicamento en base al compuesto y la utilizacion del compuesto para preparar un medicamento
CN2009801315519A CN102123995A (zh) 2008-06-16 2009-06-16 具有tnf调节活性的苯基-烷基哌嗪
KR1020107028188A KR20110028452A (ko) 2008-06-16 2009-06-16 Ｔｎｆ의 조절 활성을 가지는 페닐-알킬 피페라진
MYPI20105969 MY153051A (en) 2008-06-16 2009-06-16 Phenyl-alkyl piperazines having a modulating activity of tnf
JP2011514097A JP5536050B2 (ja) 2008-06-16 2009-06-16 Ｔｎｆの調節活性を有するフェニル−アルキルピペラジン
SI200930774T SI2313384T1 (sl) 2008-06-16 2009-06-16 Fenil-alkil piperazini, ki imajo aktivnost moduliranja TNF
MX2010013947A MX2010013947A (es) 2008-06-16 2009-06-16 Fenil-alquil-piperazinas que tienen actividad moduladora de tnf.
BRPI0914815A BRPI0914815A2 (pt) 2008-06-16 2009-06-16 fenil-alquil-piperazinas com atividade moduladora de tnf
EP09766076.5A EP2313384B1 (fr) 2008-06-16 2009-06-16 Phenyl-alkyl piperazines ayant une activite modulatrice du tnf
UY0001031902A UY31902A (es) 2008-06-16 2009-06-16 Fenil-alquil-piperazinas que tienen actividad moduñadoras de tnf
CA2727911A CA2727911C (fr) 2008-06-16 2009-06-16 Phenyl-alkyl-piperazines ayant une activite modulatrice du tnf
CN201510688427.XA CN105198803A (zh) 2008-06-16 2009-06-16 具有tnf调节活性的苯基-烷基哌嗪
PL09766076T PL2313384T3 (pl) 2008-06-16 2009-06-16 Fenyloalkilopiperazyny wykazujące aktywność modulującą tnf
AU2009261783A AU2009261783B2 (en) 2008-06-16 2009-06-16 Phenyl-alkyl piperazines having a modulating activity of TNF
DK09766076.5T DK2313384T3 (da) 2008-06-16 2009-06-16 Phenyl-alkylpiperaziner med tnf-modulerende aktivitet
PT97660765T PT2313384E (pt) 2008-06-16 2009-06-16 Fenil-alquil-piperazinas tendo uma actividade moduladora do tnf
ES09766076T ES2433218T3 (es) 2008-06-16 2009-06-16 Fenil-alquil piperazinas que tienen una actividad moduladora de TNF
TW098120169A TW201002687A (en) 2008-06-16 2009-06-16 Phenyl-alkylpiperazines with TNF-modulating activity
RU2011101396/04A RU2512567C2 (ru) 2008-06-16 2009-06-16 Фенилалкилпиперазины, модулирующие активность tnf
PCT/FR2009/051138 WO2009153514A1 (fr) 2008-06-16 2009-06-16 Phenyl-alkyl piperazines ayant une activite modulatrice du tnf
IL209944A IL209944A (en) 2008-06-16 2010-12-12 Phenyl-Alkyl Paprazine Compounds, Process for Preparation, Pharmaceutical Composition and Drug Containing them
US12/970,047 US8153637B2 (en) 2008-06-16 2010-12-16 Phenyl-alkyl piperazines having TNF-modulating activity, preparation method, and therapeutic use thereof
CY20131101052T CY1114823T1 (el) 2008-06-16 2013-11-25 Φαινυλ-αλκυλ πιπεραζινες οι οποιες διαθετουν μια ρυθμιστικη δραστηριοτητα του τνf
HRP20131183AT HRP20131183T1 (hr) 2008-06-16 2013-12-12 Fenilalkilpiperazini s aktivnošä†u modulatora tnf

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0807361A FR2940288B1 (fr) 2008-12-23 2008-12-23 Phenyl-alkyl-piperazines ayant une activite modulatrice du tnf

Publications (2)

Publication Number Publication Date
FR2940288A1 FR2940288A1 (fr) 2010-06-25
FR2940288B1 true FR2940288B1 (fr) 2011-02-11

Family

ID=40902704

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0807361A Expired - Fee Related FR2940288B1 (fr) 2008-06-16 2008-12-23 Phenyl-alkyl-piperazines ayant une activite modulatrice du tnf

Country Status (1)

Country Link
FR (1) FR2940288B1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001072660A (ja) * 1999-09-08 2001-03-21 Welfide Corp ＴＮＦ−α産生抑制剤および／またはＩＬ−１０産生促進剤
CA2511646A1 (fr) * 2002-12-27 2004-07-22 Chiron Corporation Thiosemicarbazones antiviraux et immunostimulants

Also Published As

Publication number Publication date
FR2940288A1 (fr) 2010-06-25

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20160831