FR2854875A1 - ISOTHERMAL PACKAGING DEVICE FOR TEMPERATURE-SENSITIVE PRODUCTS AND MANUFACTURING METHOD - Google Patents

Abstract

The process involves pairing and maintaining a cold accumulator (32) frozen to temperature lower than 0 degreeC with a cold regulation barrier container (31) whose temperature is greater than 3 degreeC to form a coolant distribution unit (3). The unit (3) is inserted in a space with the container placed at a side of an inner envelope to form a separation between the accumulator and the envelope. An independent claim is also included for an isothermal packaging device.

Description

Insulated packaging device for temperature sensitive products

and manufacturing process

  The present invention relates to the field of insulated packaging.

  The invention relates more particularly to an isothermal packaging device 5 intended for heat-sensitive products, dangerous, infectious materials, biologically active products, etc. used in particular in biotechnology, chemistry, pharmacy or any other type of product tolerating only a very small temperature variation.

  It is known in the prior art, from US Pat. No. 5,435,573, a packaging process for heat-sensitive products to be stored between 2 and C. The product is stored between two or more internal walls of thermal insulation forming a cavity inside in contact with cold accumulators refrigerated at a temperature of the order of -20 C. A bottle of product is thus wrapped in a first insulation container, itself placed in a plastic envelope filled with insulating foam. Such a packaging mode allows the transport of sensitive products while maintaining the desired temperature, even in cold or hot environments.

  However, this process requires a large volume of insulation to avoid freezing of the product to be stored. Freezing must however be avoided because it irreversibly alters the essential properties of the products, by causing for example a deterioration of the active principle of a pharmaceutical composition. Consequently, such a system is not suitable for storing large volumes of heat-sensitive product which does not accept freezing. In fact, the thickness of the insulating layer must not be too high, under penalty of providing a package with excessive bulk and weight and generating an excessive transport cost.

  Patent WO 00/12409 discloses a packaging provided with an external enveloping layer incorporating a cooling material cooled to a temperature below 0 C, and an internal removable separation layer between the product to be preserved and the external layer. The separation layer contains a volume of water depending on the amount of coolant in the outer layer. Such packaging makes it possible to extend the shelf life of the product. However, this packaging, intended for the transport of individualized tubes or vials, is absolutely not suitable for the transport of large quantities.

  It is known to position cold accumulators previously frozen at temperatures of around -20 C. in transport boxes or coolers. The slightest contact of the products with the accumulators can cause the products to freeze. This type of method requires that the accumulators be partially thawed beforehand so as not to cool the product too quickly. The major drawback of this method is the cumbersome and inflexible nature of the partial defrosting protocol, which is poorly suited to the usual conditions of transport. In addition, this method takes into account the estimated duration of the transport, which varies frequently.

  There is therefore a need for a method of packaging in a box-type packaging which is suitable for both undergoing any transport condition, and at the same time allowing very good thermal insulation of products to be stored at substantially constant temperature, without risk of freezing.

  The object of the present invention is therefore to overcome one or more of the drawbacks of the prior art by defining a reliable method for packaging thermosensitive products in a transport packaging to maintain a storage temperature always above 0 C.

  To this end, the invention relates to a method of packaging heat-sensitive products, by means of a packaging device comprising an inner envelope shaped to delimit a housing for storage of 30 heat-sensitive products, an outer envelope or a transport case for determined volume sufficient to incorporate the housing and define at least one spacing located on a part of the periphery of the housing, said method being characterized in that it comprises: - at least one step of pairing and holding, by means of 5 maintenance, of a frozen cold accumulator at a temperature strictly below 0 ° C. in contact with a cold regulation barrier container filled with substance having a viscosity index at least equal to 100 Pa.s and whose temperature is higher than 3 C to form a removable cooling unit capable of occupying a space 10 at the periphery of the housing, - a step of inserting tion of the cooling unit in said spacing with the cold control barrier container positioned on the side of the inner casing to form a separation between the cold accumulator and the inner casing.

  According to another particular feature, the cold accumulator contains a volume of 2 to 5 times greater than the volume contained in the cold regulation barrier container, the cold accumulator being frozen at a temperature below -150C before pairing step and maintaining contact while the cold regulation barrier container is at a temperature of the order of 3 to 25 ° C.

  According to another feature of the invention, the inner envelope and the outer envelope are parallelepipedal, the inner envelope being provided with two flaps oriented in a first horizontal direction to form a basket and placed in the center of the outer envelope, the dimension of the inner envelope in the first direction being determined to provide a lateral spacing between the outer envelope and each of the two lateral faces of the inner envelope perpendicular to the first direction, the flaps being extended in the first direction to cover the two lateral gaps thus formed.

  According to another particularity, the step of pairing and maintaining contact comprises a male-female type junction between the cold regulation barrier container and the cold accumulator, the cold regulation barrier container being of flattened shape. .

  According to another particular feature, the pairing and contact-keeping step is carried out in a case which is sufficiently narrow to press the cold control barrier container against the cold accumulator, the cold control barrier container being of flat shape. .

  According to another feature of the invention, a cooling unit io is inserted between the flaps of the inner envelope and a shutter element of the outer envelope.

  An objective of the invention is also to define an isothermal packaging device for temperature-sensitive products.

  To this end, the invention relates to an isothermal packaging device for implementing the method for packaging heat-sensitive products according to the invention, comprising an inner envelope shaped to delimit a housing for storing heat-sensitive products, an outer envelope or a transport crate of determined volume sufficient to incorporate the housing and define at least one spacing located on a part of the periphery of the housing, characterized in that a removable cooling unit is housed in said spacing, the cooling unit comprising a cold accumulator positioned against the outer casing and a cold control barrier container filled with a substance with a viscosity index at least equal to 100 Pa.s, the cold control barrier container being attached and kept in contact by holding means with at least one surface of the cold accumulator in. ur form a separation between the inner casing and the cold accumulator.

  According to another particular feature, the cold accumulator contains a gel capable of being frozen at a temperature below -15 ° C., the filling volume 30 of the cold accumulator being 2 to 5 times greater than the filling volume of the cold barrier container, so as to maintain the housing at a temperature above 0 C.

  According to another particular feature, the interior envelope and the exterior envelope are parallelepipedic, the interior envelope being provided with two flaps oriented in a first horizontal direction to form a basket and placed in the center of the exterior envelope, the dimension of the inner envelope in the first direction being determined to provide a lateral spacing between the outer envelope and each of the two lateral faces of the inner envelope perpendicular to the first direction, the flaps being extended in the first direction to cover the two spacings lateral thus formed.

  According to another particular feature, the outer envelope comprises a layer of foam of thermal insulation material, the thickness of the spacings and of the cooling units being between 2 and 12 cm.

  According to another particular feature, the holding means comprise a narrow case for pressing the cold regulation barrier container against the cold accumulator.

  According to another particular feature, the case has walls of thin thickness determined to allow the transmission of cold between the cooling unit and the inner envelope.

  According to another particular feature, the holding means comprise complementary male and female parts positioned respectively on the cold barrier container and the cold accumulator.

  According to another feature of the invention, a cooling unit 25 is inserted between the flaps of the inner envelope and a shutter element of the outer envelope.

  According to another feature of the invention, the cooling unit, occupying a space formed between a lateral face of the inner envelope and a lateral face of the outer envelope, comprises a cold accumulator and at least one barrier container of substantially flat cold regulation.

  According to another particular feature, the cooling unit occupies a space formed between the inner casing and a corner of the outer casing.

  The invention, with its characteristics and advantages, will emerge more clearly on reading the description made with reference to the accompanying drawings in which: - Figure 1 shows a sectional view of an embodiment of a packing case isothermal according to the present invention, - Figure 2 shows an exploded perspective view of different components of the interior of an insulated packaging device according to the invention, - Figure 3 shows a perspective view an arrangement of the elements inserted in the outer envelope of the insulated packaging device according to the invention, - Figure 4 shows an example of cooling unit with cold control barrier that can be used in the device 20 according to the invention, - Figure 4a and 4b show a top view, respectively a sectional view along a vertical plane of an example of a cold control barrier container used in the invention. tion, - Figure 4c and 4d show a top view, respectively a sectional view along a vertical plane of an example of a cold accumulator used in the invention, - Figure 4e shows an example of assembly of 'a cooling unit with two barrier containers for regulating cold allowed by the invention, - Figure 5 shows an alternative embodiment of cooling unit which can be used in the invention, - Figure 6 shows an example of barrier of cold control usable in the invention, - Figure 7 shows a sectional view along a horizontal plane of an alternative embodiment of a packaging device according to the invention, - Figure 8 shows an embodiment of the inner envelope used in the invention, FIG. 9 illustrates the change in temperature measured in a sensitive product 10 placed in a storage package provided only with cold accumulators, from from the moment of insertion of the accumulators, - Figure 10 illustrates the temperature change of a sensitive product placed in the housing of a packaging device according to the invention, measured after insertion of the cooling units in the device.

  The invention will now be described with reference to FIG. 1.

  As shown in Figure 1, the isothermal packaging device according to the invention may include a transport case. The external part of the box is formed by an open envelope associated with a cover (10) 20 to form an external envelope (1) of volume adapted according to the quantities of heat-sensitive products (5) to be transported. The outer casing (1) may include a layer of thermal insulation foam material, for example polyurethane. The packaging device also comprises an inner envelope (2) shaped to delimit a housing (20) for storing heat-sensitive products (5). Without limitation, the inner (2) and outer (1) envelopes are for example parallelepipedic and include a cardboard layer. In an alternative embodiment, the envelopes (1, 2) comprise a plastic material of olefin type, for example polypropylene.

  The volume of the outer envelope (1) is determined to allow both to incorporate the housing (20) and to provide at least one space (100) located on a part of the periphery of the housing (20), as illustrated in Figure 1. The inner envelope (1), forming a bottom and side walls 5 delimiting the housing (20) for storage, is for example centered in the outer envelope (1) and spaced by at least two side walls of the outer casing (1). The spacings (100) defined between the outer casing (2) and the inner casing (1) are each intended to receive at least one removable cooling unit (3) enabling the products stored in the housing to be kept at a low temperature. (20). The cover (10) or similar part of the outer envelope (1) covering the top of the housing (20) can also integrate such a spacing (100).

  In the preferred embodiment of the invention, each cooling unit (3) comprises a cold accumulator (32) or cooling briquette, for example of the rectangular rigid plastic pack type which can be frozen and which contains a slow thaw eutectic gel. or water, and a cold control barrier container (31) filled with a substance of high viscosity, for example of viscosity greater than 100 Pa.s or 100,000 centipoises. The cold control barrier container (31) is for example flattened and attached to at least one surface of the cold accumulator (32). This cold regulation barrier container (31), permanently remaining at a temperature strictly above 0 ° C. and for example greater than 3 or 4 ° C., serves to form, after insertion into one of the spaces (100), a separation between the envelope interior (2) and the cold accumulator (32). This accumulator (32) is positioned against the outer casing (1). In the embodiment of Figure 1, three cooling units (3) are positioned respectively against a first side face of the inner casing (2), against the opposite side face, and on top of the housing (20). In this variant, the three spaces (100) are directly accessible, the inner envelope (1) being previously positioned. One can possibly consider placing an additional cooling unit under the inner casing (2) or in the bottom of the housing (20). To reduce the volume of the packaging device as much as possible, each spacing (100) has a limited thickness (e), between 2 and 12 cm.

  Each spacing (100) can receive, for example, a cooling unit (3) of dimensions substantially equal to the dimensions of the spacing (100). The number of cooling units (3) to be inserted in the spacings may depend on the envisaged transport time.

  The cooling units (3) must make it possible to maintain the housing (20) at a temperature above 0 ° C., for example between 3 and 8 ° C. for a transport period which can be particularly long. To achieve this result, the cold accumulator (32) contains a gel capable of being frozen at a temperature below -15 ° C. and the filling volume of the cold accumulator (32) is 2 to 5 times higher. than the filling volume of the cold control barrier container (31). The ratio between these volumes is for example 3 to 1.

  The invention will now be described with reference to FIGS. 1 to 8.

  In the embodiment of Figures 2 and 8, the inner envelope (2) comprises flaps (21) to form a basket, the flaps (21) closing on the housing (20). The parallelepiped formed by the inner envelope (2) may include a width dimension (I) to allow for example the insertion of cooling units on either side of the width (I) of the housing (20). As illustrated in FIG. 2, the inner envelope (2) may comprise two flaps (21) oriented along the width (I) and of length dimension (L) greater than said width (I) of the inner envelope (2 ) to cover the gaps (100). These flaps (21) can be provided with 25 handles (22) or equivalent gripping means. The inner envelope (2) can be formed using a single sheet of cardboard, as shown in Figure 8. Figure 3 illustrates the overlap of the gaps (100) allowed by the flaps (21). A cooling unit (3) can then occupy a space located between the flaps (21) in the closed position and the cover (10) or similar closure element of the outer envelope (1).

  During transport in the packaging device, the cold regulation barrier container (31) acts as a regulator so that the products to be stored are not initially cooled below 0 C. In one embodiment of the Invention, to perform this function, the regulating barrier container (31) can be flattened and substantially the dimensions of the face of the inner envelope (2) which it covers. To make the cold transmission homogeneous, the cold regulation barrier container (31) is attached and kept in contact with the cold accumulator using holding means. In one embodiment of the invention, these means io for holding the cooling unit (3) comprise complementary male and female parts positioned respectively on the cold regulation barrier container (31) and the cold accumulator. (32). As illustrated in FIG. 4, a male-female type junction is for example produced by at least two studs (310) projecting from the regulating barrier container 15 (31) which are housed in two cavities (320) of the 'cold accumulator (32). Conversely, lugs, pins or nipples can be placed on the cold accumulator (32) so as to be inserted into cavities of the cold regulation barrier (31).

  FIGS. 4a and 4b show a flattened cold regulation barrier container (31) provided with two pins (310) disposed on either side of the center of a first face or front of the container (31). The distance (a) between the two pins (310) is for example of the order of 4 to 10 cm for a container with a height (H) of between 15 and 30 cm. This distance (a) represents approximately one third of the height (H) of the container (31) in an embodiment of the invention. Alternatively, the number of nipples (310) may be higher. At least two cavities (311) of diameter (b) substantially equal to the diameter of the studs (310) are arranged on the second face or back of the container (31), with the same positioning as that of the studs (310) to allow the assembly between two identical cold control barrier containers (31) 30. An asymmetrical positioning between pins (310) and cavities (311) allowing assembly can also be envisaged. The cold barrier resulting from such an assembly, twice as thick, can be paired with a cold accumulator (32) to form a cooling unit (3).

  As illustrated in FIG. 4e, it is thus possible to form a cooling unit (3) with a cold barrier of greater thickness formed by at least two cold control barrier containers (31) 5 contiguous to each other other. This makes it possible to use a cold accumulator (32) highly charged with frigories for long-term transport of thermally sensitive products.

  The thickness (d2) of the cold regulation barrier container (31) is for example between 15 and 35 mm. In one embodiment of the invention, the width (dl) of the container (31) is at least equal to 80% of the length of the space (100) formed between the inner envelope (2) and the outer casing (1). The interior volume of the cold regulation barrier container (31) can be filled and emptied via an opening (313) closed by a plug.

  Figures 4c and 4d show an example of a cold accumulator (32) of flattened shape used in the invention. Each of the faces of the accumulator (32) comprises at least two cavities (320) to allow pairing and keeping in contact with the cold barrier by inserting the pins (310) into the cavities (320). Alternatively, only one of the faces can be provided with such cavities. The width (d3) of the accumulator is substantially equal to the length of the gaps (100) and its thickness (d4) is for example approximately twice as large as the thickness (d2) of a container (31) barrier of cold regulation of the type corresponding to FIG. 4a. The interior volume of the cold accumulator (32) can be filled and emptied via an opening (321) closed by a plug.

  Alternatively, the cold control barrier (31) is kept in contact with the cold accumulator in a case (30) which is sufficiently narrow to constantly press the cold control barrier container (31) against the cold accumulator (32). As illustrated in FIG. 5, the case (30) can be made of a plastic material, for example thin polypropylene, and include a tongue (300) for closing the case (30) to maintain it in the contiguous position face to face of the elements (31, 32) of the cooling unit (3). The thickness of the case (30) is determined to allow the transmission of cold between the cooling unit (3) and the inner casing (2). The thickness of the case (30) is for example of the order of 0.8 to 3 mm. In this variant with case (30), the cold regulation barrier (31) can consist of a simple plastic pocket (310) containing the viscous substance which absorbs the frigories of the accumulator (32).

  While in the embodiment of FIG. 3, cooling units (3) occupy spacings substantially planar parallel to the lateral faces, it can be envisaged in a different embodiment to provide spacings (100) between the inner envelope (2) and a corner of the outer envelope (1), as shown in FIG. 7. The packaging device according to the invention then comprises cooling units (3) 15 arranged at an angle. Naturally, other arrangements and forms, for example with a curved or L-shaped profile, can be envisaged for the production of the cooling units (3).

  It is therefore understood that the packaging device according to the invention allows the implementation of a simple and effective process for packaging 20 heat-sensitive products at a temperature above OC, for example between 3 and 8 C. For this, The cold accumulator (32) is previously frozen at a temperature strictly below 0 ° C., and preferably below -15 ° C. before being assembled with the cold regulation barrier (31) which remains at an ambient temperature of around 3 to 25 250C. The barrier (31) can be distinguished from the cold accumulator (32) by color marking or other visual signaling, so as to avoid any confusion during the installation of the cooling units (3). In one embodiment of the invention, the user must initially open the flaps (21) to both install the sensitive products (5) in the housing (20), and also install, for example on two opposite sides of the cooling units (3) previously assembled. Optionally after folding the flaps (21), the user can install one or more other cooling units (3) on the flaps (21), as illustrated in Figure 3 and finally close the outer casing (1).

  The invention will now be described in conjunction with FIGS. 9 and 10.

  This process can be adapted to different forms of housing (20) and to different sizes for the outer envelope (1). It makes it possible to transport under usual conditions several doses or bottles of heat-sensitive products. In addition, the use of a cold regulation barrier (31) in the cooling units (3) makes it possible to cool in a very controlled manner the contents of the storage housing (20), as illustrated with FIGS. 9 and 10 The temperature curve in FIG. 9 was produced from a temperature probe placed in a sensitive product stored in a storage package provided only with cold accumulators frozen at temperatures of the order of -18 C. The start of the measurements corresponds to the introduction of the cold accumulators. It is then observed that without a cold barrier, the temperature of the products drops very quickly below 0 C.

  In the example in FIG. 9, the accumulators were however partially defrosted. This drop in temperature below 0 ° C. shows that such a device cannot be used for heat-sensitive products which degrade after freezing. The only way to avoid this fall by keeping such a device is to implement a procedure for defrosting accumulators, the thawing time to be calculated on a case-by-case basis.

  The same series of measurements carried out with the device according to the invention 25 is presented in FIG. 9. Initially the sensitive products are at a low temperature of the order of 4 C. The measurements begin when the cooling units are inserted. (3) just assembled. Contact of the inner casing (2) with the cold control barrier (31) initially at room temperature causes an initial increase in temperature. This increase lasts only about an hour, the time that the barrier (31) is cooled by the cold accumulator (32). Then maintaining at a substantially constant low temperature is ensured for about twenty hours. In this example, it takes at least forty hours in total for the measured temperature to reach 8 C. An even longer duration can be obtained by increasing the number of cooling units. The packaging process therefore proves to be efficient and particularly suitable for transporting heat-sensitive products.

  One of the advantages of the invention lies in the simplicity of use of the packaging device. The packaging process can be easily adapted very quickly, the shape of the housing (20) and the amount of cooling units 1o (3) being very easily modified. In addition, the use of cardboard envelopes or other usual thin packaging material as well as cold accumulators (32) of conventional type is economically advantageous.

  Another advantage of the invention lies in the fact that with a regulatory barrier, the risk of degradation of the product is avoided. In addition, the method makes it possible to overcome the cumbersome procedures consisting in freezing / thawing the accumulators on a case by case basis according to their use.

  It should be obvious to those skilled in the art that the present invention allows embodiments in many other specific forms without departing from the scope of the invention as claimed. Therefore, the present embodiments should be considered by way of illustration, but may be modified in the field defined by the scope of the appended claims, and the invention should not be limited to the details given above.

Claims (16)

  1. A method of packaging heat-sensitive products (5), by means of a packaging device comprising an inner envelope (2) shaped to delimit a housing (20) for storing heat-sensitive products, an outer envelope (1) or a transport crate of determined volume sufficient to incorporate the housing (20) and define at least one spacing (100) located on a part of the periphery of the housing (20), said method being characterized in that it comprises: - at at least one step of pairing and maintaining, by means of maintenance, a cold accumulator (32) frozen at a temperature strictly below 0 ° C. in contact with a cold regulation barrier container (31) filled with substance with a viscosity index at least equal to 100 Pa.s and whose temperature is strictly above 3 C to form a removable cooling unit (3) suitable for 1 5 occupying a space (100) at the periphery of the l ogement (20), - a step of inserting the cooling unit (3) into said space (100) with the cold-regulating barrier container (31) positioned on the side of the interior envelope (2) to form a separation between the cold accumulator (32) and the inner casing (2).   2. The packaging method as claimed in claim 1, in which the cold accumulator (32) contains a volume of 2 to 5 times greater than the volume contained in the cold regulation barrier container (31), the accumulator of cold (32) being frozen at a temperature below -1 5 C before the step of pairing and keeping in contact while the cold regulation barrier container (31) is at a temperature of the order of 3 at 25 C.   3. A packaging method according to claim 1 or 2, wherein the inner envelope (2) and the outer envelope (1) are parallelepiped, the inner envelope (2) being provided with two flaps (21) oriented in a first horizontal direction to form a basket and placed in the center of the outer envelope (1), the dimension (I) of the inner envelope (2) in the first direction being determined to provide lateral spacing between the outer envelope ( 1) and each of the two lateral faces of the inner casing (1) perpendicular to the first direction, the flaps (21) being extended in the first direction to cover the two lateral spaces thus formed.   4. A packaging method according to any one of claims 1 to 3, in which the step of pairing and maintaining contact comprises a male-female type junction between the cold barrier container and the cold accumulator. , the cold control barrier container (31) being flattened.   5. A packaging method according to any one of claims 1 to 3, in which the step of pairing and maintaining contact is carried out in a narrow case (30) for pressing the cold control barrier container (31). ) against the cold accumulator (32), the cold regulation barrier container (31) being of flattened shape.   6. A packaging method according to any one of claims 3 to 5, wherein a cooling unit (3) is inserted between the flaps 20 (21) of the inner envelope (2) and a sealing element (10 ) of the outer casing (1).   7. Isothermal packaging device for implementing the method for packaging thermosensitive products (5) according to one of claims 1 to 6, comprising an inner envelope (2) shaped to delimit a housing (20) for storage. of heat-sensitive products (5), an outer envelope (1) or a transport case of determined volume sufficient to incorporate the housing (20) and define at least one spacing (100) located on a part of the periphery of the housing (20) , characterized in that a removable cooling unit (3) is housed in said space (100), the cooling unit (3) comprising a cold accumulator (32) positioned against the outer casing (1) and a cold control barrier container (31) filled with a substance having a viscosity index at least equal to 100 Pa.s, the cold control barrier container (31) being attached and kept in contact by holding means with at least one surface of the cold accumulator (32) to form a separation between the inner casing (2) and the cold accumulator (32).   8. Isothermal packaging device according to claim 7, in which the cold accumulator (32) contains a gel capable of being frozen at a temperature below -15 ° C., the filling volume of the cold accumulator ( 32) being 2 to 5 times greater than the filling volume of the cold-regulating barrier container (31), so as to maintain the housing (20) at a temperature above 0 C.   9. Isothermal packaging device according to claim 7 or 8, wherein the inner envelope (2) and the outer envelope (1) are parallelepiped, the inner envelope (2) being provided with two flaps (21) oriented in a first horizontal direction to form a basket and placed in the center of the outer envelope (1), the dimension of the inner envelope (2) in the first direction being determined to provide lateral spacing between the outer envelope ( 1) and each of the two lateral faces of the inner envelope (2) perpendicular to the first direction, the flaps (21) being extended in the first direction to cover the two lateral spaces thus formed.   10. Isothermal packaging device according to any one of claims 7 to 9, in which the outer envelope (1) comprises a layer of foam of thermal insulation material, the thickness (e) of the spacings (100 ) and cooling units (3) being between 2 and 12 cm.   11. Isothermal packaging device according to any one of claims 7 to 10, in which the holding means comprise a narrow case (30) for pressing the cold regulation barrier container (31) against the cold accumulator ( 32).   12.Isothermal packaging device according to claim 11, wherein the case has walls of thin thickness determined to allow the transmission of cold between the cooling unit (3) and the inner casing (2).   13. Isothermal packaging device according to any one of claims 7 to 12, in which the holding means comprise complementary parts (310, 320) male and female positioned respectively on the cold regulation barrier container (31) and io the cold accumulator (32).   14. Isothermal packaging device according to any one of claims 9 to 13, wherein a cooling unit (3) is inserted between the flaps (21) of the inner envelope (2) and a sealing element ( 10) of the outer casing (1).   15. Isothermal packaging device according to any one of claims 7 to 14, wherein the cooling unit (3), occupying a space formed between a side face of the inner casing (2) and a side face of the outer casing (1) comprises a cold accumulator (32) and at least one substantially planar cold regulation barrier container (31).   16. Isothermal packaging device according to any one of claims 7 to 14, wherein the cooling unit (3) occupies a space (100) formed between the inner casing (2) and a corner of the outer casing (1).