EP1477751B1 - Isothermal package for heat sensitive products and method for its production - Google Patents

Isothermal package for heat sensitive products and method for its production Download PDF

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Publication number
EP1477751B1
EP1477751B1 EP04291214A EP04291214A EP1477751B1 EP 1477751 B1 EP1477751 B1 EP 1477751B1 EP 04291214 A EP04291214 A EP 04291214A EP 04291214 A EP04291214 A EP 04291214A EP 1477751 B1 EP1477751 B1 EP 1477751B1
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EP
European Patent Office
Prior art keywords
cold
container
inner shell
order
outer shell
Prior art date
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Application number
EP04291214A
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German (de)
French (fr)
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EP1477751A1 (en
Inventor
Gilles Dulucq
Christophe Langerock
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Kalibox
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Kalibox
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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
    • F25D3/02—Devices using other cold materials; Devices using cold-storage bodies using ice, e.g. ice-boxes
    • F25D3/06—Movable containers
    • F25D3/08—Movable containers portable, i.e. adapted to be carried personally
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2303/00—Details of devices using other cold materials; Details of devices using cold-storage bodies
    • F25D2303/08—Devices using cold storage material, i.e. ice or other freezable liquid
    • F25D2303/082—Devices using cold storage material, i.e. ice or other freezable liquid disposed in a cold storage element not forming part of a container for products to be cooled, e.g. ice pack or gel accumulator
    • F25D2303/0822—Details of the element
    • F25D2303/08221—Fasteners or fixing means for the element
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2331/00—Details or arrangements of other cooling or freezing apparatus not provided for in other groups of this subclass
    • F25D2331/80—Type of cooled receptacles
    • F25D2331/803—Bottles
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2331/00—Details or arrangements of other cooling or freezing apparatus not provided for in other groups of this subclass
    • F25D2331/80—Type of cooled receptacles
    • F25D2331/804—Boxes
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2500/00—Problems to be solved
    • F25D2500/02—Geometry problems
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2600/00—Control issues
    • F25D2600/04—Controlling heat transfer

Definitions

  • the present invention relates to the field of isothermal packaging.
  • the invention relates more particularly to an isothermal packaging device for thermosensitive products, hazardous materials, infectious substances, biologically active products, etc. used in particular in biotechnology, chemistry, pharmacy or any other type of product tolerating only a very small variation in temperature.
  • thermosensitive products it is known, in the prior art, a packaging process for thermosensitive products to be stored between 2 and 10 ° C.
  • the product is stored between two or more inner walls of thermal insulation forming an internal cavity in contact with accumulators refrigerated cold at a temperature of the order of -20 ° C.
  • a bottle of product is thus wrapped in a first insulation container, itself placed in a plastic envelope filled with insulating foam.
  • Such a mode of packaging allows the transport of sensitive products while maintaining the desired temperature, even in cold or hot environments.
  • this process requires a large volume of insulation to avoid freezing the product to be preserved.
  • freezing must be avoided because it irreversibly alters the essential properties of the products, for example causing a deterioration of the active principle of a pharmaceutical composition. Therefore, such a system is not suitable for storing large volumes of thermosensitive product not accepting freezing.
  • the thickness of the insulating layer must not be too high, otherwise the packaging will be too bulky and excessively heavy and cause excessive transportation costs.
  • the WO 00/12409 discloses a package provided with an outer wrapping layer incorporating coolant material cooled to a temperature below 0 ° C, and an inner layer of removable separation between the product to be preserved and the outer layer.
  • the separation layer contains a volume of water depending on the amount of refrigerant material of the outer layer.
  • the present invention therefore aims to overcome one or more of the disadvantages of the prior art by defining a reliable method of packaging heat-sensitive products in a transport packaging to maintain a conservation temperature always greater than 0 ° C.
  • the cold accumulator contains a volume 2 to 5 times higher than the volume contained in the cold regulating barrier container, the cold accumulator being frozen at a temperature below -15 ° C before the step of pairing and keeping in contact while the cold regulating barrier container is at a temperature of the order of 3 to 25 ° C.
  • the inner envelope and the outer envelope are parallelepipedal, the inner envelope being provided with two flaps oriented in a first horizontal direction to form a basket and placed in the center of the outer envelope, the dimension of the inner envelope in the first direction being determined to provide a lateral spacing between the outer shell and each of the two side faces of the inner shell perpendicular to the first direction, the flaps being extended in the first direction to cover the two lateral spacings thus formed.
  • the step of pairing and keeping in contact comprises a junction of the male-female type between the cold regulating barrier container and the cold accumulator, the cold regulating barrier container being of flattened shape.
  • the step of pairing and keeping in contact is carried out in a holster sufficiently narrow to press the cold regulating barrier container against the cold accumulator, the cold regulating barrier container being of flattened shape. .
  • a cooling unit is inserted between the flaps of the inner casing and a closure member of the outer casing.
  • An object of the invention is also to define an isothermal packaging device for temperature sensitive products.
  • the invention relates to an isothermal packaging device for implementing the method of packaging heat-sensitive products according to the invention, comprising an inner envelope shaped to delimit a heat-sensitive product storage compartment, an outer envelope or a transport case of determined volume sufficient to incorporate the housing and define at least one localized spacing on a part of the periphery of the housing, characterized in that a removable cooling unit is housed in said spacing, the cooling unit comprising a cold accumulator positioned against the outer casing and a cold regulating barrier container filled with a substance having a viscosity number of at least 100 Pa.s, the cold regulating barrier container being contiguous and held in contact by holding means with at least one surface of the cold accumulator for sea a separation between the inner envelope and the cold accumulator.
  • the cold accumulator contains a gel capable of being frozen at a temperature below -15 ° C., the filling volume of the cold accumulator being 2 to 5 times higher than the volume of the cold accumulator. filling the cold barrier container, so as to maintain the housing at a temperature above 0 ° C.
  • the inner envelope and the outer envelope are parallelepipedal, the inner envelope being provided with two flaps oriented in a first horizontal direction to form a basket and placed in the center of the outer envelope, the dimension of the inner shell in the first direction being determined to provide a lateral spacing between the outer shell and each of the two side faces of the inner shell perpendicular to the first direction, the flaps being extended in the first direction to cover the two lateral spacings thus formed.
  • the outer casing comprises a foam layer of thermal insulation material, the thickness of the spacings and cooling units being between 2 and 12 cm.
  • the holding means comprise a narrow case for pressing the cold regulating barrier container against the cold accumulator.
  • the case has walls of thin thickness determined to allow the transmission of cold between the cooling unit and the inner casing.
  • the holding means comprise male and female complementary parts positioned respectively on the cold barrier container and the cold accumulator.
  • a cooling unit is inserted between the flaps of the inner casing and a closure member of the outer casing.
  • the cooling unit occupying a spacing formed between a side face of the envelope and a side face of the outer casing, comprises a cold accumulator and at least one substantially flat cold control barrier container.
  • the cooling unit occupies a spacing formed between the inner casing and a corner of the outer casing.
  • the isothermal packaging device may comprise a transport case.
  • the outer part of the body is formed by an open envelope associated with a lid (10) to form an outer envelope (1) of volume adapted according to the quantities of heat-sensitive products (5) to be transported.
  • the outer casing (1) may comprise a layer of thermal insulation foam material, for example polyurethane.
  • the packaging device also comprises an inner envelope (2) shaped to define a housing (20) for storing thermosensitive products (5).
  • the inner (2) and outer (1) envelopes are for example parallelepipedal and comprise a cardboard layer.
  • the envelopes (1, 2) comprise an olefin type plastic material, for example polypropylene.
  • the volume of the outer casing (1) is determined to allow both to incorporate the housing (20) and to provide at least one spacing (100) on a portion of the periphery of the housing (20), as illustrated in FIG. the figure 1 .
  • the inner casing (1) forming a bottom and side walls defining the housing (20) for storage, is for example centered in the outer casing (1) and spaced from at least two side walls of the outer casing (1).
  • the spacings (100) defined between the outer casing (2) and the inner casing (1) are intended to each receive at least one removable cooling unit (3) making it possible to keep the products stored in the housing at low temperature ( 20).
  • the cover (10) or similar part of the outer casing (1) covering the top of the housing (20) can also incorporate such a spacing (100).
  • each cooling unit (3) comprises a cold accumulator (32) or refrigerant briquette, for example of the rigid plastic rectangular pack type that can be frozen and containing a eutectic gel with slow thawing or water, and a cold regulating barrier container (31) filled with a substance of high viscosity, for example with a viscosity of greater than 100 Pa.s or 100000 centipoise.
  • the cold regulating barrier container (31) is for example flattened and attached to at least one surface of the cold accumulator (32). This cold regulating barrier container (31), permanently remaining at a temperature strictly greater than 0 ° C.
  • each spacing (100) has a thickness (e) limited to between 2 and 12 cm.
  • Each spacing (100) may for example receive a cooling unit (3) of dimensions substantially equal to the dimensions of the spacing (100).
  • the number of cooling units (3) to be inserted into the spacings may depend on the envisaged transport time.
  • the cooling units (3) must make it possible to keep the housing (20) at a temperature greater than 0 ° C, for example between 3 and 8 ° C during a transport time that can be particularly long.
  • the cold accumulator (32) contains a gel capable of being frozen at a temperature below -15 ° C and the filling volume of the cold accumulator (32) is 2 to 5 times more high than the filling volume of the cold regulating barrier container (31). The ratio between these volumes is for example 3 to 1.
  • the inner casing (2) comprises flaps (21) to form a basket, the flaps (21) closing on the housing (20).
  • the parallelepiped formed by the inner envelope (2) may comprise a width dimension (I) to allow for example the insertion of cooling units on either side of the width (I) of the housing (20).
  • the inner casing (2) may comprise two flaps (21) oriented along the width (I) and of dimension in length (L) greater than the width (I) of the inner casing (2) to cover the spacings ( 100). These flaps (21) may be provided with handles (22) or equivalent gripping means.
  • the inner casing (2) can be formed using a single sheet of cardboard, as shown in FIG. figure 8 .
  • the figure 3 illustrates the overlap of the spacings (100) allowed by the flaps (21).
  • a cooling unit (3) can then occupy a spacing between the flaps (21) in the closed position and the cover (10) or similar shutter member of the outer casing (1).
  • the cold control barrier container (31) acts as a regulator so that the products to be stored are not initially cooled below 0 ° C.
  • the regulating barrier container (31) may be of flattened shape and substantially the dimensions of the face of the inner envelope (2) that it covers.
  • the cold regulating barrier container (31) is brought together and kept in contact with the cold accumulator by means of holding means.
  • these means for holding the cooling unit (3) comprise male and female complementary parts positioned respectively on the cold regulating barrier container (31) and the cold accumulator ( 32).
  • a male-female junction is formed by at least two studs (310) protruding from the regulating barrier container (31) which are housed in two cavities (320) of the cold accumulator (32) .
  • lugs, pins or pins may be placed on the cold accumulator (32) to be inserted into cavities of the cold regulating barrier (31).
  • the Figures 4a and 4b are a cold regulating barrier container (31) flattened provided with two pins (310) disposed on either side of the center of a first face or front of the container (31).
  • the distance (a) between the two pins (310) is for example of the order of 4 to 10 cm for a container with a height (H) of between 15 and 30 cm. This distance (a) represents about one third of the height (H) of the container (31) in one embodiment of the invention. Alternatively, the number of pins (310) may be higher.
  • At least two cavities (311) of diameter (b) substantially equal to the diameter of the pins (310) are arranged on the second face or the back of the container (31), with the same positioning as that of the pins (310) to allow the assembly between two cold regulating barrier containers (31) identical.
  • An asymmetrical positioning between nipples (310) and cavities (311) allowing assembly can also be envisaged.
  • the cold barrier resulting from such an assembly, twice as thick, can be matched with a cold accumulator (32) for forming a cooling unit (3).
  • a cold accumulator (32) for forming a cooling unit (3).
  • the thickness (d2) of the cold regulating barrier container (31) is for example between 15 and 35 mm. In one embodiment of the invention, the width (d1) of the container (31) is at least 80% of the length of the spacing (100) between the inner envelope (2) and the envelope outside (1).
  • the interior volume of the cold regulating barrier container (31) can be filled and emptied via an opening (313) closed by a plug.
  • the Figures 4c and 4d represent an example of a cold accumulator (32) of flattened form used in the invention.
  • Each of the faces of the accumulator (32) comprises at least two cavities (320) to allow pairing and keeping in contact with the cold barrier by inserting the pins (310) into the cavities (320). Alternatively, only one of the faces may be provided with such cavities.
  • the width (d3) of the accumulator is substantially equal to the length of the spacings (100) and its thickness (d4) is for example about twice as large as the thickness (d2) of a container (31). cold regulation of the type corresponding to the figure 4a .
  • the internal volume of the cold accumulator (32) can be filled and emptied via an opening (321) closed by a plug.
  • the cold regulating barrier (31) in contact with the cold accumulator is carried out in a case (30) sufficiently narrow to constantly press the cold regulating barrier container (31) against the cold storage barrier (31).
  • cold accumulator (32) can be made of a plastic material, for example a thin polypropylene, and comprise a tab (300) closing the case (30) for maintaining in contiguous position face against face of the elements (31, 32) of the cooling unit (3).
  • the thickness of the case (30) is determined to allow the transmission of cold between the cooling unit (3) and the inner casing (2).
  • the thickness of the case (30) is for example of the order of 0.8 to 3 mm.
  • the cold regulating barrier (31) may consist of a simple plastic bag (310) containing the viscous substance which absorbs the frigories of the accumulator (32).
  • cooling units (3) occupy substantially planar spacings parallel to the side faces, it may be envisaged in a different embodiment to provide spacings (100) between the inner casing (2) and a corner of the casing outside (1), as shown in figure 7 .
  • the packaging device according to the invention then comprises cooling units (3) arranged at an angle.
  • other arrangements and shapes for example with a curved or L-shaped profile, can be envisaged for the realization of the cooling units (3).
  • the packaging device allows the implementation of a simple and effective process for packaging heat-sensitive products at a temperature above 0 ° C, for example between 3 and 8 ° C.
  • the cold accumulator (32) is previously frozen at a temperature strictly below 0 ° C, and preferably below -15 ° C before being assembled with the cold control barrier (31) which remains at an ambient temperature of the order of 3 to 25 ° C.
  • the barrier (31) can be distinguished from the cold accumulator (32) by color marking or other visual signaling, so as to avoid confusion when placing the cooling units (3).
  • the user must initially open the flaps (21) to both install the sensitive products (5) in the housing (20), and also install on for example two opposite sides of the units. coolers (3) previously assembled.
  • the user can install one or more other cooling units (3) on the flaps (21), as illustrated in FIG. figure 3 and finally closing the outer casing (1).
  • This method can be adapted to different housing shapes (20) and to different sizes for the outer shell (1). It allows to transport under usual conditions several doses or bottles of heat-sensitive products.
  • a cold regulating barrier (31) in the cooling units (3) makes it possible to cool in a very controlled manner the contents of the storage housing (20), as illustrated with the Figures 9 and 10 .
  • the temperature curve of the figure 9 was carried out from a temperature probe placed in a sensitive product stored in a storage package provided only with frozen cold storage accumulators at temperatures of the order of -18 ° C. The beginning of the measurements corresponds to the introduction of the cold accumulators. It can be seen that without a cold barrier, the temperature of the products drops very rapidly below 0 ° C.
  • FIG. 9 A same series of measurements carried out with the device according to the invention is presented to the figure 9 .
  • the sensitive products are at a low temperature of the order of 4 ° C.
  • the measurements begin when the just assembled cooling units (3) are inserted.
  • Contact of the inner casing (2) with the cold regulating barrier (31) initially at room temperature causes an initial increase in temperature. This increase lasts about one hour, while the barrier (31) is cooled by the cold accumulator (32).
  • the keeping at a substantially constant low temperature is ensured for twenty hours. In this example, it takes at least 40 hours in total for the measured temperature to reach 8 ° C. An even longer time can be achieved by increasing the number of cooling units.
  • the packaging process is therefore effective and particularly suitable for the transport of heat-sensitive products.
  • One of the advantages of the invention lies in the simplicity of use of the packaging device.
  • the packaging process can be easily adapted very quickly, the shape of the housing (20) and the amount of cooling units (3) can be very easily changed.
  • the use of envelopes cardboard or other conventional thin packaging material and cold accumulators (32) of conventional type is economically advantageous.
  • Another advantage of the invention lies in the fact that with a regulating barrier, the risk of degradation of the product is avoided.
  • the method makes it possible to overcome the heavy procedures of freezing / defrosting the batteries according to their use on a case-by-case basis.

Abstract

The process involves pairing and maintaining a cold accumulator (32) frozen to temperature lower than 0 degreeC with a cold regulation barrier container (31) whose temperature is greater than 3 degreeC to form a coolant distribution unit (3). The unit (3) is inserted in a space with the container placed at a side of an inner envelope to form a separation between the accumulator and the envelope. An independent claim is also included for an isothermal packaging device.

Description

La présente invention concerne le domaine de l'emballage isotherme. L'invention concerne plus particulièrement un dispositif d'emballage isotherme destiné aux produits thermosensibles, matières dangereuses, infectieuses, produits biologiquement actifs, etc. utilisés notamment en biotechnologie, chimie, pharmacie ou tout autre type de produit ne tolérant qu'une très faible variation de température.The present invention relates to the field of isothermal packaging. The invention relates more particularly to an isothermal packaging device for thermosensitive products, hazardous materials, infectious substances, biologically active products, etc. used in particular in biotechnology, chemistry, pharmacy or any other type of product tolerating only a very small variation in temperature.

Le document WO-A-01/02268 montre un procédé et un dispositif selon le préambule des revendications indépendantes.The document WO-A-01/02268 shows a method and a device according to the preamble of the independent claims.

Il est connu, dans l'art antérieur, un procédé de conditionnement pour des produits thermosensibles à conserver entre 2 et 10 DEG C. Le produit est conservé entre deux ou plusieurs parois intérieures d'isolation thermique formant une cavité intérieure en contact avec des accumulateurs de froid réfrigérés à une température de l'ordre de -20 DEG C. Un flacon de produit est ainsi enveloppé dans un premier conteneur d'isolation, lui-même placé dans une enveloppe plastique rempli de mousse isolante. Un tel mode de conditionnement permet le transport de produits sensibles en conservant la température souhaitée, même dans des environnements froids ou chauds.It is known, in the prior art, a packaging process for thermosensitive products to be stored between 2 and 10 ° C. The product is stored between two or more inner walls of thermal insulation forming an internal cavity in contact with accumulators refrigerated cold at a temperature of the order of -20 ° C. A bottle of product is thus wrapped in a first insulation container, itself placed in a plastic envelope filled with insulating foam. Such a mode of packaging allows the transport of sensitive products while maintaining the desired temperature, even in cold or hot environments.

Toutefois, ce procédé nécessite un volume d'isolation important pour éviter la congélation du produit à conserver. La congélation doit pourtant être évitée car elle altère irréversiblement les propriétés essentielles des produits, en entraînant par exemple une détérioration du principe actif d'une composition pharmaceutique. Par conséquent, un tel système n'est pas adapté pour stocker des volumes importants de produit thermosensible n'acceptant pas la congélation. En effet l'épaisseur de la couche isolante ne doit pas être trop élevée, sous peine de fournir un emballage à l'encombrement et au poids démesuré et engendrer un coût de transport excessif.However, this process requires a large volume of insulation to avoid freezing the product to be preserved. However, freezing must be avoided because it irreversibly alters the essential properties of the products, for example causing a deterioration of the active principle of a pharmaceutical composition. Therefore, such a system is not suitable for storing large volumes of thermosensitive product not accepting freezing. In fact, the thickness of the insulating layer must not be too high, otherwise the packaging will be too bulky and excessively heavy and cause excessive transportation costs.

Le brevet WO 00/12409 divulgue un emballage pourvu d'une couche enveloppante externe incorporant un matériau réfrigérant refroidi à une température inférieure à 0°C, et d'une couche interne de séparation amovible entre le produit à conserver et la couche externe. La couche de séparation contient un volume d'eau fonction de la quantité de matériau réfrigérant de la couche externe. Un tel emballage permet d'allonger la durée de conservation du produit. Toutefois, cet emballage, destiné au transport de tubes ou flacons individualisés, n'est absolument pas adapté pour le transport de quantités importantes.The WO 00/12409 discloses a package provided with an outer wrapping layer incorporating coolant material cooled to a temperature below 0 ° C, and an inner layer of removable separation between the product to be preserved and the outer layer. The separation layer contains a volume of water depending on the amount of refrigerant material of the outer layer. Such packaging allows to extend the shelf life of the product. However, this packaging, intended for the transport of individualized tubes or flasks, is absolutely not suitable for the transport of large quantities.

Il est connu de positionner dans des caisses ou glacières de transport des accumulateurs de froid préalablement congelés à des températures de l'ordre de -20°C. Le moindre contact des produits avec les accumulateurs peut provoquer la congélation des produits. Ce type de méthode exige préalablement de décongeler partiellement les accumulateurs pour ne pas refroidir trop vite le produit à conserver. L'inconvénient majeur de cette méthode est la lourdeur et le caractère peu flexible du protocole de décongélation partielle, peu adapté aux conditions usuelles de transport. De plus, cette méthode prend en compte la durée estimée du transport alors que celle-ci varie fréquemment.It is known to position cold storage accumulators previously frozen at temperatures of the order of -20 ° C. in transport crates or coolers. The slightest contact of the products with the accumulators can cause the freezing of the products. This type of method requires previously to partially defrost the accumulators to not cool too quickly the product to keep. The major disadvantage of this method is the heaviness and the inflexibility of the partial defrosting protocol, poorly adapted to the usual conditions of transport. In addition, this method takes into account the estimated duration of the transport while the latter varies frequently.

Il existe dès lors un besoin pour un procédé de conditionnement dans un emballage de type caisse qui soit adapté pour à la fois subir n'importe quelle condition de transport, et en même temps permettre une très bonne isolation thermique de produits devant être conservés à température sensiblement constante, sans risque de congélation.There is therefore a need for a packaging method in a box type packaging that is adapted to both undergo any transport condition, and at the same time allow very good thermal insulation of products to be kept at temperature. substantially constant, without risk of freezing.

La présente invention a donc pour objet de pallier un ou plusieurs des inconvénients de l'art antérieur en définissant un procédé fiable de conditionnement de produits thermosensibles dans un emballage de transport pour maintenir une température de conservation toujours supérieure à 0°C.The present invention therefore aims to overcome one or more of the disadvantages of the prior art by defining a reliable method of packaging heat-sensitive products in a transport packaging to maintain a conservation temperature always greater than 0 ° C.

A cet effet, l'invention concerne un procédé de conditionnement de produits thermosensibles, au moyen d'un dispositif d'emballage comprenant une enveloppe intérieure conformée pour délimiter un logement de stockage de produits thermosensibles, une enveloppe extérieure ou une caisse de transport de volume déterminé suffisant pour incorporer le logement et définir au moins un espacement localisé sur une partie de la périphérie du logement, ledit procédé étant caractérisé en ce qu'il comporte :

  • au moins une étape d'appariement et de maintien, par des moyens de maintien, d'un accumulateur de froid congelé à une température strictement inférieure à 0°C en contact avec un récipient barrière de régulation de froid rempli de substance à indice de viscosité au moins égal à 100 Pa.s et dont la température est supérieure à 3°C pour former une unité de refroidissement amovible apte à occuper un espacement en périphérie du logement,
  • une étape d'insertion de l'unité de refroidissement dans ledit espacement avec le récipient barrière de régulation de froid positionné du côté de l'enveloppe intérieure pour former une séparation entre l'accumulateur de froid et l'enveloppe intérieure.
For this purpose, the invention relates to a method for packaging heat-sensitive products, by means of a packaging device comprising an inner envelope shaped to delimit a heat-sensitive product storage compartment, an outer envelope or a transport box. determined volume sufficient to incorporate the housing and define at least a localized spacing on a portion of the periphery of the housing, said method being characterized in that it comprises:
  • at least one step of pairing and holding, by holding means, a frozen cold accumulator at a temperature strictly below 0 ° C in contact with a cold regulating barrier container filled with viscosity index substance at least equal to 100 Pa.s and whose temperature is higher than 3 ° C to form a removable cooling unit capable of occupying a spacing at the periphery of the housing,
  • a step of inserting the cooling unit in said spacing with the cold regulating barrier container positioned on the side of the inner casing to form a separation between the cold accumulator and the inner casing.

Selon une autre particularité, l'accumulateur de froid contient un volume de 2 à 5 fois plus élevé que le volume contenu dans le récipient barrière de régulation de froid, l'accumulateur de froid étant congelé à une température inférieure à -15°C avant l'étape d'appariement et de maintien en contact tandis que le récipient barrière de régulation de froid est à une température de l'ordre de 3 à 25°C.In another feature, the cold accumulator contains a volume 2 to 5 times higher than the volume contained in the cold regulating barrier container, the cold accumulator being frozen at a temperature below -15 ° C before the step of pairing and keeping in contact while the cold regulating barrier container is at a temperature of the order of 3 to 25 ° C.

Selon une autre particularité de l'invention, l'enveloppe intérieure et l'enveloppe extérieure sont parallélépipédiques, l'enveloppe intérieure étant pourvue de deux rabats orientés selon une première direction horizontale pour former un panier et placée au centre de l'enveloppe extérieure, la dimension de l'enveloppe intérieure selon la première direction étant déterminée pour ménager un espacement latéral entre l'enveloppe extérieure et chacune des deux faces latérales de l'enveloppe intérieure perpendiculaires à la première direction, les rabats étant rallongés suivant la première direction pour recouvrir les deux espacements latéraux ainsi formés.According to another feature of the invention, the inner envelope and the outer envelope are parallelepipedal, the inner envelope being provided with two flaps oriented in a first horizontal direction to form a basket and placed in the center of the outer envelope, the dimension of the inner envelope in the first direction being determined to provide a lateral spacing between the outer shell and each of the two side faces of the inner shell perpendicular to the first direction, the flaps being extended in the first direction to cover the two lateral spacings thus formed.

Selon une autre particularité, l'étape d'appariement et de maintien en contact comprend une jonction de type mâle-femelle entre le récipient barrière de régulation de froid et l'accumulateur de froid, le récipient barrière de régulation de froid étant de forme aplatie.According to another particularity, the step of pairing and keeping in contact comprises a junction of the male-female type between the cold regulating barrier container and the cold accumulator, the cold regulating barrier container being of flattened shape. .

Selon une autre particularité, l'étape d'appariement et de maintien en contact est réalisée dans un étui suffisamment étroit pour plaquer le récipient barrière de régulation de froid contre l'accumulateur de froid, le récipient barrière de régulation de froid étant de forme aplatie.According to another particularity, the step of pairing and keeping in contact is carried out in a holster sufficiently narrow to press the cold regulating barrier container against the cold accumulator, the cold regulating barrier container being of flattened shape. .

Selon une autre particularité de l'invention, une unité de refroidissement est insérée entre les rabats de l'enveloppe intérieure et un élément d'obturation de l'enveloppe extérieure.According to another feature of the invention, a cooling unit is inserted between the flaps of the inner casing and a closure member of the outer casing.

Un objectif de l'invention est également de définir un dispositif d'emballage isotherme pour produits sensibles à la température.An object of the invention is also to define an isothermal packaging device for temperature sensitive products.

A cet effet, l'invention concerne un dispositif d'emballage isotherme pour la mise en oeuvre du procédé de conditionnement de produits thermosensibles selon l'invention, comprenant une enveloppe intérieure conformée pour délimiter un logement de stockage de produits thermosensibles, une enveloppe extérieure ou une caisse de transport de volume déterminé suffisant pour incorporer le logement et définir au moins un espacement localisé sur une partie de la périphérie du logement, caractérisé en ce qu'une unité de refroidissement amovible est logée dans ledit espacement, l'unité de refroidissement comprenant un accumulateur de froid positionné contre l'enveloppe extérieure et un récipient barrière de régulation de froid rempli avec une substance à indice de viscosité au moins égal à 100 Pa.s, le récipient barrière de régulation de froid étant accolé et maintenu en contact par des moyens de maintien avec au moins une surface de l'accumulateur de froid pour former une séparation entre l'enveloppe intérieure et l'accumulateur de froid.For this purpose, the invention relates to an isothermal packaging device for implementing the method of packaging heat-sensitive products according to the invention, comprising an inner envelope shaped to delimit a heat-sensitive product storage compartment, an outer envelope or a transport case of determined volume sufficient to incorporate the housing and define at least one localized spacing on a part of the periphery of the housing, characterized in that a removable cooling unit is housed in said spacing, the cooling unit comprising a cold accumulator positioned against the outer casing and a cold regulating barrier container filled with a substance having a viscosity number of at least 100 Pa.s, the cold regulating barrier container being contiguous and held in contact by holding means with at least one surface of the cold accumulator for sea a separation between the inner envelope and the cold accumulator.

Selon une autre particularité, l'accumulateur de froid contient un gel apte à être congelé à une température inférieure à -15°C, le volume de remplissage de l'accumulateur de froid étant 2 à 5 fois plus élevé que le volume de remplissage du récipient barrière de froid, de façon à maintenir le logement à une température supérieure à 0°C.According to another feature, the cold accumulator contains a gel capable of being frozen at a temperature below -15 ° C., the filling volume of the cold accumulator being 2 to 5 times higher than the volume of the cold accumulator. filling the cold barrier container, so as to maintain the housing at a temperature above 0 ° C.

Selon une autre particularité, l'enveloppe intérieure et l'enveloppe extérieure sont parallélépipédiques, l'enveloppe intérieure étant pourvue de deux rabats orientés selon une première direction horizontale pour former un panier et placée au centre de l'enveloppe extérieure, la dimension de l'enveloppe intérieure selon la première direction étant déterminée pour ménager un espacement latéral entre l'enveloppe extérieure et chacune des deux faces latérales de l'enveloppe intérieure perpendiculaires à la première direction, les rabats étant rallongés suivant la première direction pour recouvrir les deux espacements latéraux ainsi formés.According to another feature, the inner envelope and the outer envelope are parallelepipedal, the inner envelope being provided with two flaps oriented in a first horizontal direction to form a basket and placed in the center of the outer envelope, the dimension of the inner shell in the first direction being determined to provide a lateral spacing between the outer shell and each of the two side faces of the inner shell perpendicular to the first direction, the flaps being extended in the first direction to cover the two lateral spacings thus formed.

Selon une autre particularité, l'enveloppe extérieure comprend une couche de mousse de matériau d'isolation thermique, l'épaisseur des espacements et des unités de refroidissement étant comprise entre 2 et 12 cm.According to another feature, the outer casing comprises a foam layer of thermal insulation material, the thickness of the spacings and cooling units being between 2 and 12 cm.

Selon une autre particularité, les moyens de maintien comprennent un étui étroit pour plaquer le récipient barrière de régulation de froid contre l'accumulateur de froid.According to another feature, the holding means comprise a narrow case for pressing the cold regulating barrier container against the cold accumulator.

Selon une autre particularité, l'étui a des parois d'épaisseur mince déterminée pour permettre la transmission de froid entre l'unité de refroidissement et l'enveloppe intérieure.According to another feature, the case has walls of thin thickness determined to allow the transmission of cold between the cooling unit and the inner casing.

Selon une autre particularité, les moyens de maintien comprennent des parties complémentaires mâle et femelle positionnées respectivement sur le récipient barrière de froid et l'accumulateur de froid.According to another feature, the holding means comprise male and female complementary parts positioned respectively on the cold barrier container and the cold accumulator.

Selon une autre particularité de l'invention, une unité de refroidissement est insérée entre les rabats de l'enveloppe intérieure et un élément d'obturation de l'enveloppe extérieure.According to another feature of the invention, a cooling unit is inserted between the flaps of the inner casing and a closure member of the outer casing.

Selon une autre particularité de l'invention, l'unité de refroidissement, occupant un espacement formé entre une face latérale de l'enveloppe intérieure et une face latérale de l'enveloppe extérieure, comprend un accumulateur de froid et au moins un récipient barrière de régulation de froid sensiblement plan.According to another feature of the invention, the cooling unit, occupying a spacing formed between a side face of the envelope and a side face of the outer casing, comprises a cold accumulator and at least one substantially flat cold control barrier container.

Selon une autre particularité, l'unité de refroidissement occupe un espacement formé entre l'enveloppe intérieure et un coin de l'enveloppe extérieure.According to another feature, the cooling unit occupies a spacing formed between the inner casing and a corner of the outer casing.

L'invention, avec ses caractéristiques et avantages, ressortira plus clairement à la lecture de la description faite en référence aux dessins annexés dans lesquels :

  • la figure 1 représente une vue en coupe d'un mode de réalisation d'une caisse d'emballage isotherme selon la présente invention,
  • la figure 2 présente une vue en perspective éclatée de différents éléments constitutifs de l'intérieur d'un dispositif d'emballage isotherme selon l'invention,
  • la figure 3 représente une vue en perspective un agencement des éléments insérés dans l'enveloppe extérieure du dispositif d'emballage isotherme selon l'invention,
  • la figure 4 représente un exemple d'unité de refroidissement avec barrière de régulation de froid pouvant être utilisée dans le dispositif selon l'invention,
  • la figure 4a et 4b montrent une vue de dessus, respectivement une vue en coupe selon un plan vertical d'un exemple de récipient barrière de régulation de froid utilisé dans l'invention,
  • la figure 4c et 4d montrent une vue de dessus, respectivement une vue en coupe selon un plan vertical d'un exemple d'accumulateur de froid utilisé dans l'invention,
  • la figure 4e représente un exemple d'assemblage d'une unité de refroidissement avec deux récipients barrières de régulation de froid permis par l'invention,
  • la figure 5 représente une variante de réalisation d'unité de refroidissement pouvant être utilisée dans l'invention,
  • la figure 6 représente un exemple de barrière de régulation de froid utilisable dans l'invention,
  • la figure 7 représente une vue en coupe selon un plan horizontal d'une variante de réalisation d'un dispositif d'emballage suivant l'invention,
  • la figure 8 représente un mode de réalisation de l'enveloppe intérieure utilisée dans l'invention,
  • la figure 9 illustre l'évolution de température mesurée dans un produit sensible placé dans un emballage de stockage pourvu uniquement d'accumulateurs de froid, à partir du moment d'insertion des accumulateurs,
  • la figure 10 illustre l'évolution de température d'un produit sensible disposé dans le logement d'un dispositif d'emballage selon l'invention, mesurée après insertion des unités de refroidissement dans le dispositif.
The invention, with its features and advantages, will emerge more clearly on reading the description given with reference to the appended drawings in which:
  • the figure 1 represents a sectional view of an embodiment of an insulated packaging box according to the present invention,
  • the figure 2 shows an exploded perspective view of various constituent elements of the interior of an isothermal packaging device according to the invention,
  • the figure 3 represents a perspective view of an arrangement of the elements inserted in the outer casing of the isothermal packaging device according to the invention,
  • the figure 4 represents an example of cooling unit with cold control barrier that can be used in the device according to the invention,
  • the Figure 4a and 4b show a top view, respectively a sectional view along a vertical plane of an example of cold control barrier container used in the invention,
  • the Figure 4c and 4d show a view from above, respectively a sectional view along a vertical plane of an example of a cold accumulator used in the invention,
  • the figure 4e represents an example of assembly of a cooling unit with two refrigeration barrier containers allowed by the invention,
  • the figure 5 represents an alternative embodiment of a cooling unit that can be used in the invention,
  • the figure 6 represents an example of a cold regulating barrier that can be used in the invention,
  • the figure 7 represents a sectional view along a horizontal plane of an alternative embodiment of a packaging device according to the invention,
  • the figure 8 represents an embodiment of the inner envelope used in the invention,
  • the figure 9 illustrates the temperature evolution measured in a sensitive product placed in a storage package provided only with cold accumulators, from the moment of insertion of the accumulators,
  • the figure 10 illustrates the temperature evolution of a sensitive product disposed in the housing of a packaging device according to the invention, measured after insertion of the cooling units in the device.

L'invention va être à présent décrite en référence à la figure 1.The invention will now be described with reference to the figure 1 .

Comme représenté à la figure 1, le dispositif isotherme d'emballage selon l'invention peut comporter une caisse de transport. La partie externe de la caisse est formée par une enveloppe ouverte associée à un couvercle (10) pour former une enveloppe extérieure (1) de volume adapté selon les quantités de produits thermosensibles (5) à transporter. L'enveloppe extérieure (1) peut comprendre une couche de matériau en mousse d'isolation thermique, par exemple en polyuréthane. Le dispositif d'emballage comporte également une enveloppe intérieure (2) conformée pour délimiter un logement (20) de stockage de produits thermosensibles (5). De manière non limitative, les enveloppes intérieure (2) et extérieure (1) sont par exemple parallélépipédiques et comprennent une couche cartonnée. Dans une variante de réalisation, les enveloppes (1, 2) comprennent un matériau plastique de type oléfine, par exemple polypropylène.As represented in figure 1 , the isothermal packaging device according to the invention may comprise a transport case. The outer part of the body is formed by an open envelope associated with a lid (10) to form an outer envelope (1) of volume adapted according to the quantities of heat-sensitive products (5) to be transported. The outer casing (1) may comprise a layer of thermal insulation foam material, for example polyurethane. The packaging device also comprises an inner envelope (2) shaped to define a housing (20) for storing thermosensitive products (5). In a nonlimiting manner, the inner (2) and outer (1) envelopes are for example parallelepipedal and comprise a cardboard layer. In an alternative embodiment, the envelopes (1, 2) comprise an olefin type plastic material, for example polypropylene.

Le volume de l'enveloppe extérieure (1) est déterminé pour permettre à la fois d'incorporer le logement (20) et ménager au moins un espacement (100) situé sur une partie de la périphérie du logement (20), comme illustré dans la figure 1. L'enveloppe intérieure (1), formant un fond et des parois latérales délimitant le logement (20) de stockage, est par exemple centrée dans l'enveloppe extérieure (1) et espacée d'au moins deux parois latérales de l'enveloppe extérieure (1). Les espacements (100) définis entre l'enveloppe extérieure (2) et l'enveloppe intérieure (1) sont destinés à recevoir chacun au moins une unité de refroidissement (3) amovible permettant de maintenir à basse température les produits stockés dans le logement (20). Le couvercle (10) ou partie analogue de l'enveloppe extérieure (1) recouvrant le dessus du logement (20) peut aussi intégrer un tel espacement (100).The volume of the outer casing (1) is determined to allow both to incorporate the housing (20) and to provide at least one spacing (100) on a portion of the periphery of the housing (20), as illustrated in FIG. the figure 1 . The inner casing (1), forming a bottom and side walls defining the housing (20) for storage, is for example centered in the outer casing (1) and spaced from at least two side walls of the outer casing (1). The spacings (100) defined between the outer casing (2) and the inner casing (1) are intended to each receive at least one removable cooling unit (3) making it possible to keep the products stored in the housing at low temperature ( 20). The cover (10) or similar part of the outer casing (1) covering the top of the housing (20) can also incorporate such a spacing (100).

Dans le mode de réalisation préféré de l'invention, chaque unité de refroidissement (3) comprend un accumulateur de froid (32) ou briquette réfrigérante, par exemple du type pack rectangulaire en plastique rigide pouvant être congelé et contenant un gel eutectique à décongélation lente ou de l'eau, et un récipient barrière de régulation de froid (31) rempli avec une substance de forte viscosité, par exemple de viscosité supérieure à 100 Pa.s ou 100000 centipoises. Le récipient barrière de régulation de froid (31) est par exemple aplati et accolé à au moins une surface de l'accumulateur de froid (32). Ce récipient barrière de régulation de froid (31), restant en permanence à une température strictement supérieure à 0°C et par exemple supérieure à 3 ou 4°C, sert à former après insertion dans un des espacements (100) une séparation entre l'enveloppe intérieure (2) et l'accumulateur de froid (32). Cet accumulateur (32) est positionné contre l'enveloppe extérieure (1). Dans le mode de réalisation de la figure 1, trois unités de refroidissement (3) sont positionnées respectivement contre une première face latérale de l'enveloppe intérieure (2), contre la face latérale opposée, et sur le dessus du logement (20). Dans cette variante, les trois espacements (100) sont directement accessibles, l'enveloppe intérieure (1) étant préalablement positionnée. On peut éventuellement envisager de placer une unité de refroidissement supplémentaire sous l'enveloppe intérieure (2) ou dans le fond du logement (20). Pour réduire au plus le volume du dispositif d'emballage, chaque espacement (100) a une épaisseur (e) limitée, comprise entre 2 et 12 cm. Chaque espacement (100) peut recevoir par exemple une unité de refroidissement (3) de dimensions sensiblement égales aux dimensions de l'espacement (100). Le nombre d'unités de refroidissement (3) à insérer dans les espacements peut dépendre de la durée de transport envisagée.In the preferred embodiment of the invention, each cooling unit (3) comprises a cold accumulator (32) or refrigerant briquette, for example of the rigid plastic rectangular pack type that can be frozen and containing a eutectic gel with slow thawing or water, and a cold regulating barrier container (31) filled with a substance of high viscosity, for example with a viscosity of greater than 100 Pa.s or 100000 centipoise. The cold regulating barrier container (31) is for example flattened and attached to at least one surface of the cold accumulator (32). This cold regulating barrier container (31), permanently remaining at a temperature strictly greater than 0 ° C. and for example greater than 3 or 4 ° C., serves to form, after insertion into one of the spaces (100), a separation between inner casing (2) and the cold accumulator (32). This accumulator (32) is positioned against the outer casing (1). In the embodiment of the figure 1 three cooling units (3) are respectively positioned against a first side face of the inner casing (2) against the opposite side face and on top of the housing (20). In this variant, the three spacings (100) are directly accessible, the inner envelope (1) being previously positioned. It may be possible to consider placing an additional cooling unit under the inner casing (2) or in the bottom of the housing (20). To reduce at least the volume of the packaging device, each spacing (100) has a thickness (e) limited to between 2 and 12 cm. Each spacing (100) may for example receive a cooling unit (3) of dimensions substantially equal to the dimensions of the spacing (100). The number of cooling units (3) to be inserted into the spacings may depend on the envisaged transport time.

Les unités de refroidissement (3) doivent permettre de maintenir le logement (20) à une température supérieure à 0°C, par exemple comprise entre 3 et 8°C pendant une durée de transport qui peut être particulièrement longue. Pour parvenir à ce résultat, l'accumulateur de froid (32) contient un gel apte à être congelé à une température inférieure à -15°C et le volume de remplissage de l'accumulateur de froid (32) est 2 à 5 fois plus élevé que le volume de remplissage du récipient barrière de régulation de froid (31). Le ratio entre ces volumes est par exemple de 3 pour 1.The cooling units (3) must make it possible to keep the housing (20) at a temperature greater than 0 ° C, for example between 3 and 8 ° C during a transport time that can be particularly long. To achieve this result, the cold accumulator (32) contains a gel capable of being frozen at a temperature below -15 ° C and the filling volume of the cold accumulator (32) is 2 to 5 times more high than the filling volume of the cold regulating barrier container (31). The ratio between these volumes is for example 3 to 1.

L'invention va être à présent décrite en référence aux figures 1 à 8.The invention will now be described with reference to Figures 1 to 8 .

Dans le mode de réalisation des figures 2 et 8, l'enveloppe intérieure (2) comprend des rabats (21) pour former un panier, les rabats (21) se refermant sur le logement (20). Le parallélépipède formé par l'enveloppe intérieure (2) peut comprendre une dimension largeur (I) pour permettre par exemple l'insertion d'unités de refroidissement de part et d'autre de la largeur (I) du logement (20). Comme illustré à la figure 2, l'enveloppe intérieure (2) peut comprendre deux rabats (21) orientés selon la largeur (I) et de dimension en longueur (L) supérieure à ladite largeur (I) de l'enveloppe intérieure (2) pour recouvrir les espacements (100). Ces rabats (21) peuvent être pourvus de poignées (22) ou moyens de préhension équivalents. L'enveloppe intérieure (2) peut être formée à l'aide d'une seule feuille de carton, comme montré à la figure 8. La figure 3 illustre le recouvrement des espacements (100) permis par les rabats (21). Une unité de refroidissement (3) peut alors occuper un espacement situé entre les rabats (21) en position fermée et le couvercle (10) ou élément d'obturation analogue de l'enveloppe extérieure (1).In the embodiment of figures 2 and 8 , the inner casing (2) comprises flaps (21) to form a basket, the flaps (21) closing on the housing (20). The parallelepiped formed by the inner envelope (2) may comprise a width dimension (I) to allow for example the insertion of cooling units on either side of the width (I) of the housing (20). As illustrated in figure 2 the inner casing (2) may comprise two flaps (21) oriented along the width (I) and of dimension in length (L) greater than the width (I) of the inner casing (2) to cover the spacings ( 100). These flaps (21) may be provided with handles (22) or equivalent gripping means. The inner casing (2) can be formed using a single sheet of cardboard, as shown in FIG. figure 8 . The figure 3 illustrates the overlap of the spacings (100) allowed by the flaps (21). A cooling unit (3) can then occupy a spacing between the flaps (21) in the closed position and the cover (10) or similar shutter member of the outer casing (1).

Au cours du transport dans le dispositif d'emballage, le récipient barrière de régulation de froid (31) joue le rôle de régulateur pour que les produits à conserver ne soient pas initialement refroidis en dessous de 0°C. Dans une forme de réalisation de l'invention, pour assurer cette fonction, le récipient barrière de régulation (31) peut être de forme aplatie et sensiblement aux dimensions de la face de l'enveloppe intérieure (2) qu'il recouvre. Pour rendre homogène la transmission de froid, le récipient barrière de régulation de froid (31) est accolé et maintenu en contact avec l'accumulateur de froid à l'aide de moyens de maintien. Dans un mode de réalisation de l'invention, ces moyens de maintien de l'unité de refroidissement (3) comprennent des parties complémentaires mâle et femelle positionnées respectivement sur le récipient barrière de régulation de froid (31) et l'accumulateur de froid (32). Comme illustré à la figure 4, une jonction de type mâle-femelle est par exemple réalisée par au moins deux tétons (310) en saillie sur le récipient barrière de régulation (31) qui viennent se loger dans deux cavités (320) de l'accumulateur de froid (32). Des ergots, picots ou tétons peuvent à l'inverse être disposés sur l'accumulateur de froid (32) pour venir s'insérer dans des cavités de la barrière de régulation de froid (31).During transport in the packaging device, the cold control barrier container (31) acts as a regulator so that the products to be stored are not initially cooled below 0 ° C. In one embodiment of the invention, to provide this function, the regulating barrier container (31) may be of flattened shape and substantially the dimensions of the face of the inner envelope (2) that it covers. In order to render the cold transmission homogeneous, the cold regulating barrier container (31) is brought together and kept in contact with the cold accumulator by means of holding means. In one embodiment of the invention, these means for holding the cooling unit (3) comprise male and female complementary parts positioned respectively on the cold regulating barrier container (31) and the cold accumulator ( 32). As illustrated in figure 4 , for example, a male-female junction is formed by at least two studs (310) protruding from the regulating barrier container (31) which are housed in two cavities (320) of the cold accumulator (32) . On the other hand, lugs, pins or pins may be placed on the cold accumulator (32) to be inserted into cavities of the cold regulating barrier (31).

Les figures 4a et 4b représentent un récipient barrière de régulation de froid (31) aplati pourvu de deux tétons (310) disposés de part et d'autre du centre d'une première face ou recto du récipient (31). La distance (a) entre les deux tétons (310) est par exemple de l'ordre de 4 à 10 cm pour un récipient d'une hauteur (H) comprise entre 15 et 30 cm. Cette distance (a) représente environ le tiers de la hauteur (H) du récipient (31) dans un mode de réalisation de l'invention. En variante, le nombre de tétons (310) peut être plus élevé. Au moins deux cavités (311) de diamètre (b) sensiblement égal au diamètre des tétons (310) sont disposées sur la deuxième face ou verso du récipient (31), avec le même positionnement que celui des tétons (310) pour permettre l'assemblage entre deux récipients barrière de régulation de froid (31) identiques. Un positionnement dissymétrique entre tétons (310) et cavités (311) permettant l'assemblage peut aussi être envisagé. La barrière de froid résultant d'un tel assemblage, deux fois plus épaisse, peut être appariée avec un accumulateur de froid (32) pour former une unité de refroidissement (3). Comme illustré à la figure 4e, il est ainsi possible de former une unité de refroidissement (3) avec une barrière de froid d'épaisseur plus importante formée d'au moins deux récipients barrières de régulation de froid (31) accolées les uns aux autres. Cela permet d'utiliser un accumulateur de froid (32) fortement chargé en frigories pour un transport de longue durée de produits thermiquement sensibles.The Figures 4a and 4b are a cold regulating barrier container (31) flattened provided with two pins (310) disposed on either side of the center of a first face or front of the container (31). The distance (a) between the two pins (310) is for example of the order of 4 to 10 cm for a container with a height (H) of between 15 and 30 cm. This distance (a) represents about one third of the height (H) of the container (31) in one embodiment of the invention. Alternatively, the number of pins (310) may be higher. At least two cavities (311) of diameter (b) substantially equal to the diameter of the pins (310) are arranged on the second face or the back of the container (31), with the same positioning as that of the pins (310) to allow the assembly between two cold regulating barrier containers (31) identical. An asymmetrical positioning between nipples (310) and cavities (311) allowing assembly can also be envisaged. The cold barrier resulting from such an assembly, twice as thick, can be matched with a cold accumulator (32) for forming a cooling unit (3). As illustrated in figure 4e it is thus possible to form a cooling unit (3) with a cold barrier of greater thickness formed of at least two cold regulating barrier containers (31) contiguous to each other. This makes it possible to use a cold accumulator (32) heavily charged with frigories for the long-term transport of thermally sensitive products.

L'épaisseur (d2) du récipient barrière de régulation de froid (31) est par exemple comprise entre 15 et 35 mm. Dans un mode de réalisation de l'invention, la largeur (d1) du récipient (31) est au moins égale à 80% de la longueur de l'espacement (100) ménagé entre l'enveloppe intérieure (2) et l'enveloppe extérieure (1). Le volume intérieur du récipient barrière de régulation de froid (31) peut être rempli et vidé via une ouverture (313) fermée par un bouchon.The thickness (d2) of the cold regulating barrier container (31) is for example between 15 and 35 mm. In one embodiment of the invention, the width (d1) of the container (31) is at least 80% of the length of the spacing (100) between the inner envelope (2) and the envelope outside (1). The interior volume of the cold regulating barrier container (31) can be filled and emptied via an opening (313) closed by a plug.

Les figures 4c et 4d représentent un exemple d'accumulateur de froid (32) de forme aplatie employé dans l'invention. Chacune des faces de l'accumulateur (32) comprend au moins deux cavités (320) pour permettre l'appariement et le maintien en contact avec la barrière de froid via l'insertion des tétons (310) dans les cavités (320). En variante, une seule des faces peut être dotée de telles cavités. La largeur (d3) de l'accumulateur est sensiblement égale à la longueur des espacements (100) et son épaisseur (d4) est par exemple environ deux fois plus grande que l'épaisseur (d2) d'un récipient (31) barrière de régulation de froid du type correspondant à la figure 4a. Le volume intérieur de l'accumulateur de froid (32) peut être rempli et vidé via une ouverture (321) fermée par un bouchon.The Figures 4c and 4d represent an example of a cold accumulator (32) of flattened form used in the invention. Each of the faces of the accumulator (32) comprises at least two cavities (320) to allow pairing and keeping in contact with the cold barrier by inserting the pins (310) into the cavities (320). Alternatively, only one of the faces may be provided with such cavities. The width (d3) of the accumulator is substantially equal to the length of the spacings (100) and its thickness (d4) is for example about twice as large as the thickness (d2) of a container (31). cold regulation of the type corresponding to the figure 4a . The internal volume of the cold accumulator (32) can be filled and emptied via an opening (321) closed by a plug.

Dans une variante, le maintien en contact de la barrière de régulation de froid (31) avec l'accumulateur de froid est effectué dans un étui (30) suffisamment étroit pour constamment plaquer le récipient barrière de régulation de froid (31) contre l'accumulateur de froid (32). Comme illustré à la figure 5, l'étui (30) peut être constitué d'un matériau plastique, par exemple polypropylène de fine épaisseur, et comporter une languette (300) de fermeture de l'étui (30) pour assurer le maintien en position accolée face contre face des éléments (31, 32) de l'unité de refroidissement (3). L'épaisseur de l'étui (30) est déterminée pour permettre la transmission de froid entre l'unité de refroidissement (3) et l'enveloppe intérieure (2). L'épaisseur de l'étui (30) est par exemple de l'ordre de 0,8 à 3 mm. Dans cette variante avec étui (30), la barrière de régulation de froid (31) peut être constituée d'une simple pochette plastique (310) renfermant la substance visqueuse qui absorbe les frigories de l'accumulateur (32).Alternatively, keeping the cold regulating barrier (31) in contact with the cold accumulator is carried out in a case (30) sufficiently narrow to constantly press the cold regulating barrier container (31) against the cold storage barrier (31). cold accumulator (32). As illustrated in figure 5 , the case (30) can be made of a plastic material, for example a thin polypropylene, and comprise a tab (300) closing the case (30) for maintaining in contiguous position face against face of the elements (31, 32) of the cooling unit (3). The thickness of the case (30) is determined to allow the transmission of cold between the cooling unit (3) and the inner casing (2). The thickness of the case (30) is for example of the order of 0.8 to 3 mm. In this variant with case (30), the cold regulating barrier (31) may consist of a simple plastic bag (310) containing the viscous substance which absorbs the frigories of the accumulator (32).

Tandis que dans le mode de réalisation de la figure 3, des unités de refroidissement (3) occupent des espacements sensiblement plans parallèles aux faces latérales, il peut être envisagé dans un mode de réalisation différent de ménager des espacements (100) entre l'enveloppe intérieure (2) et un coin de l'enveloppe extérieure (1), comme représenté à la figure 7. Le dispositif d'emballage selon l'invention comprend alors des unités de refroidissement (3) disposées en biais. Naturellement, d'autres dispositions et formes, par exemple avec un profil courbé ou en L, peuvent être envisagées pour la réalisation des unités de refroidissement (3).While in the embodiment of the figure 3 , cooling units (3) occupy substantially planar spacings parallel to the side faces, it may be envisaged in a different embodiment to provide spacings (100) between the inner casing (2) and a corner of the casing outside (1), as shown in figure 7 . The packaging device according to the invention then comprises cooling units (3) arranged at an angle. Naturally, other arrangements and shapes, for example with a curved or L-shaped profile, can be envisaged for the realization of the cooling units (3).

On comprend donc que le dispositif d'emballage selon l'invention permet la mise en oeuvre d'un processus simple et efficace de conditionnement de produits thermosensibles à une température supérieure à 0°C, par exemple comprise entre 3 et 8°C. Pour cela, l'accumulateur de froid (32) est préalablement congelé à une température strictement inférieure à 0°C, et de préférence inférieure à -15°C avant d'être assemblé avec la barrière de régulation de froid (31) qui reste à une température ambiante de l'ordre de 3 à 25°C. La barrière (31) peut être distinguée de l'accumulateur de froid (32) par un marquage de couleur ou autre signalisation visuelle, de façon à éviter toute confusion lors de la mise en place des unités de refroidissement (3). Dans un mode de réalisation de l'invention, l'utilisateur doit initialement ouvrir les rabats (21) pour à la fois installer les produits sensibles (5) dans le logement (20), et également installer sur par exemple deux côtés opposés des unités de refroidissement (3) préalablement assemblées. En option après repliement des rabats (21), l'utilisateur peut installer une ou plusieurs autres unités de refroidissement (3) sur les rabats (21), comme illustré à la figure 3 et enfin fermer l'enveloppe extérieure (1).It is therefore understood that the packaging device according to the invention allows the implementation of a simple and effective process for packaging heat-sensitive products at a temperature above 0 ° C, for example between 3 and 8 ° C. For this, the cold accumulator (32) is previously frozen at a temperature strictly below 0 ° C, and preferably below -15 ° C before being assembled with the cold control barrier (31) which remains at an ambient temperature of the order of 3 to 25 ° C. The barrier (31) can be distinguished from the cold accumulator (32) by color marking or other visual signaling, so as to avoid confusion when placing the cooling units (3). In one embodiment of the invention, the user must initially open the flaps (21) to both install the sensitive products (5) in the housing (20), and also install on for example two opposite sides of the units. coolers (3) previously assembled. Optional after folding flaps (21), the user can install one or more other cooling units (3) on the flaps (21), as illustrated in FIG. figure 3 and finally closing the outer casing (1).

L'invention va à présent être décrite en liaison avec les figures 9 et 10.The invention will now be described in connection with the Figures 9 and 10 .

Ce procédé peut être adapté à différentes formes de logement (20) et à différentes tailles pour l'enveloppe extérieure (1). Il permet de transporter dans des conditions usuelles plusieurs doses ou flacons de produits thermosensibles. De plus l'utilisation d'une barrière de régulation de froid (31) dans les unités de refroidissement (3) permet de refroidir de manière très régulée le contenu du logement (20) de stockage, comme illustré avec les figures 9 et 10. La courbe de température de la figure 9 a été réalisée à partir d'une sonde de température placée dans un produit sensible stocké dans un emballage de stockage pourvu uniquement d'accumulateurs de froid congelés à des températures de l'ordre de -18°C. Le début des mesures correspond à l'introduction des accumulateurs de froid. On constate alors que sans barrière de froid, la température des produits chute très rapidement en dessous de 0°C. Dans l'exemple de la figure 9, les accumulateurs étaient pourtant partiellement décongelés. Cette baisse de température en dessous de 0°C montre qu'un tel dispositif ne peut pas être utilisé pour des produits thermosensibles qui se dégradent après congélation. La seule manière d'éviter cette chute en conservant un tel dispositif est de mettre en oeuvre une procédure de décongélation des accumulateurs, la durée de décongélation devant être calculée au cas par cas.This method can be adapted to different housing shapes (20) and to different sizes for the outer shell (1). It allows to transport under usual conditions several doses or bottles of heat-sensitive products. In addition, the use of a cold regulating barrier (31) in the cooling units (3) makes it possible to cool in a very controlled manner the contents of the storage housing (20), as illustrated with the Figures 9 and 10 . The temperature curve of the figure 9 was carried out from a temperature probe placed in a sensitive product stored in a storage package provided only with frozen cold storage accumulators at temperatures of the order of -18 ° C. The beginning of the measurements corresponds to the introduction of the cold accumulators. It can be seen that without a cold barrier, the temperature of the products drops very rapidly below 0 ° C. In the example of the figure 9 however, the accumulators were partially thawed. This drop in temperature below 0 ° C shows that such a device can not be used for heat-sensitive products that degrade after freezing. The only way to avoid this fall by keeping such a device is to implement a defrosting procedure accumulators, the defrosting time to be calculated on a case by case basis.

Une même série de mesures effectuée avec le dispositif selon l'invention est présentée à la figure 9. Initialement les produits sensibles sont à une température basse de l'ordre de 4°C. Les mesures commencent lors de l'insertion des unités de refroidissement (3) tout juste assemblées. Le contact de l'enveloppe intérieure (2) avec la barrière de régulation de froid (31) initialement à température ambiante provoque une augmentation initiale de la température. Cette augmentation ne dure environ qu'une heure, le temps que la barrière (31) soit refroidie par l'accumulateur de froid (32). Ensuite le maintien à une température basse sensiblement constante est assuré durant une vingtaine heures. Dans cet exemple, il faut au moins une quarantaine d'heures au total pour que la température mesurée n'atteigne 8°C. Une durée encore plus longue peut être obtenue en augmentant le nombre d'unités de refroidissement. Le procédé de conditionnement se révèle donc efficace et particulièrement adapté pour le transport de produits thermosensibles.A same series of measurements carried out with the device according to the invention is presented to the figure 9 . Initially the sensitive products are at a low temperature of the order of 4 ° C. The measurements begin when the just assembled cooling units (3) are inserted. Contact of the inner casing (2) with the cold regulating barrier (31) initially at room temperature causes an initial increase in temperature. This increase lasts about one hour, while the barrier (31) is cooled by the cold accumulator (32). Then the keeping at a substantially constant low temperature is ensured for twenty hours. In this example, it takes at least 40 hours in total for the measured temperature to reach 8 ° C. An even longer time can be achieved by increasing the number of cooling units. The packaging process is therefore effective and particularly suitable for the transport of heat-sensitive products.

Un des avantages de l'invention réside dans la simplicité d'utilisation du dispositif d'emballage. Le procédé de conditionnement peut être aisément adapté de manière très rapide, la forme du logement (20) et la quantité d'unités de refroidissement (3) pouvant être très facilement modifiée. De plus, l'utilisation d'enveloppes en carton ou autre matériau usuel d'emballage de faible épaisseur ainsi que d'accumulateurs de froid (32) de type classique est économiquement avantageuse.One of the advantages of the invention lies in the simplicity of use of the packaging device. The packaging process can be easily adapted very quickly, the shape of the housing (20) and the amount of cooling units (3) can be very easily changed. In addition, the use of envelopes cardboard or other conventional thin packaging material and cold accumulators (32) of conventional type is economically advantageous.

Un autre des avantages de l'invention réside dans le fait qu'avec une barrière de régulation, on évite le risque de dégradation du produit. De plus, le procédé permet de s'affranchir des lourdes procédures consistant à congeler/décongeler au cas par cas les accumulateurs selon leur utilisation.Another advantage of the invention lies in the fact that with a regulating barrier, the risk of degradation of the product is avoided. In addition, the method makes it possible to overcome the heavy procedures of freezing / defrosting the batteries according to their use on a case-by-case basis.

Il doit être évident pour les personnes versées dans l'art que la présente invention permet des modes de réalisation sous de nombreuses autres formes spécifiques sans l'éloigner du domaine d'application de l'invention comme revendiqué. Par conséquent, les présents modes de réalisation doivent être considérés à titre d'illustration, mais peuvent être modifiés dans le domaine défini par la portée des revendications jointes, et l'invention ne doit pas être limitée aux détails donnés ci-dessus.It should be obvious to those skilled in the art that the present invention allows embodiments in many other specific forms without departing from the scope of the invention as claimed. Therefore, the present embodiments should be considered by way of illustration, but may be modified within the scope defined by the scope of the appended claims, and the invention should not be limited to the details given above.

Claims (16)

  1. Method of packaging heat-sensitive products (5) by means of a container comprising an inner shell (2) shaped in order to delimit a compartment (20) for storage of heat-sensitive products, an outer shell (1) or transport casing having a defined volume sufficient for inclusion of the compartment (20) and to define at least one localised space (100) on a part of the periphery of the compartment (20), the method being characterised in that it includes:
    - at least one step of pairing and of maintaining, by maintaining means, cold pack (32) frozen to a temperature strictly below 0°C in contact with a cold regulation barrier container (31) filled with a substance having a viscosity index higher than or equal to 100 Pa.s and a temperature strictly higher than 3 °C in order to form a removable cooling unit (3) capable of occupying the space (100) at the periphery of the compartment (20),
    - a step of insertion of the coaling unit (3) into the said space (100) with the cold regulation barrier container (31) positioned on the side of the inner shell (2) in order to form a separation between the cold pack (32) and the inner shell (2).
  2. Method of packaging as claimed in Claim 1, wherein the cold pack (32) contains a volume 2 to 5 times higher than the volume contained in the cold regulation barrier container (31), the cold pack (32) being frozen to a temperature below -15 °C before the step or pairing and maintaining in contact whilst the cold regulation barrier container (31) is at a temperature of the order of 3 to 25 °C.
  3. Method of packaging as claimed in Claim 1 or Claims 2, wherein the inner shell (2) and the outer shell (1) are parallelepipedal, the inner shell (2) being provided with two flaps (21) oriented in a first horizontal direction in order to form a basket and placed in the centre of the outer shell (1) the dimension (I) of the inner shell (2) in the first direction being defined in order to provide a lateral spacing between the outer shell (1) and each of the two lateral faces of the inner shell (1) perpendicular to the first direction, the flaps (21) being elongated in a first direction in order to cover the two lateral spaces thus formed.
  4. Method of packaging as claimed in any one of Claims 1 to 3, wherein the step of pairing and maintaining in contact comprises a junction of the male-female type between the cold regulation barrier container and the cold pack, the cold regulation barrier container (31) being of flattened shape.
  5. Method of packaging as claimed in any one of Claims 1 to 3, wherein the step of pairing and maintaining in contact is carried out in a narrow case (30) in order to apply the cold regulation barrier container (31) against the cold pack (32), the cold regulation barrier container (31) being of flattened shape.
  6. Method of packaging as claimed in any one of Claims 3 to 5, wherein a cooling unit (3) is inserted between the flaps (21) of the inner shell (2) and a closure element (10) of the outer shell (1).
  7. Isothermal container for carrying out the method of packaging heat-sensitive products (5) as claimed in any one of Claims 1 to 6, comprising an inner shell (2) shaped in order to delimit a compartment (20) for storage of heat-sensitive products (5), an outer shell (1) or transport casing having a defined volume sufficient for inclusion of the compartment (20) and to define at least one localised space (100) on a part of the periphery of the compartment (20), characterised in that a removable cooling unit (3) is accommodated in the said space (100), the cooling unit (3) comprising a cold pack (32) positioned against the outer shell (1) and a cold regulation barrier container (31) filled with a substance having a viscosity index higher than or equal to 100 Pa.s, the cold regulation barrier container (31) being attached and maintained in contact by maintaining means with at least one surface of the cold pack (32) in order to form a separation between the inner shell (2) and the cold pack (32).
  8. Isothermal container as claimed in Claim 7, wherein the cold pack (32) contains a gel capable of being frozen to a temperature below -15 °C, the filling volume of the cold pack (32) being 2 to 5 times higher than the filling volume of the cold regulation barrier container (31), in such a way as to main the compartment (20) at a temperature higher than 0 °C.
  9. Isothermal container as claimed in Claim 7 or Claim 8, wherein the inner shell (2) and the outer shell (1) are parallelepipedal, the inner shell (2) being provided with two flaps (21) oriented in a first horizontal direction in order to form a basket and placed in the centre of the outer shell (1) the dimension of the inner shell (2) in the first direction being defined in order to provide a lateral spacing between the outer shell (1) and each of the two lateral faces or the inner shell (2) perpendicular to the first direction, the flaps (21) being elongated in a first direction in order to cover the two lateral spaces thus formed.
  10. Isothermal container as claimed in any one of Claims 7 to 9, wherein the outer shell (1) comprises a layer of foam or thermal insulating material, the thickness (e) or the spaces (100) and of the cooling units (3) being between 2 and 12 cm.
  11. Isothermal container as claimed in any one of Claims 7 to 10, wherein the maintaining means comprise a narrow case (30) in order to apply the cold regulation barrier container (31) against the cold pack (32).
  12. Isothermal container as claimed in Claim 11, wherein the case has thin walls of a defined thickness in order to enable the transmission of cold between the cooling unit (3) and the inner shell (2).
  13. Isothermal container as claimed in any one of Claims 7 to 12, wherein the maintaining means comprise complimentary male and female parts (310, 320) positioned respectively on the cold regulation barrier container (31) and the cold pack (32).
  14. Isothermal container as claimed in any one of Claims 9 to 13, wherein a cooling unit (3) is inserted between the flaps (21) of the inner shell (2) and a closure element (10) of the outer shell (1).
  15. Isothermal container as claimed in any one of Claims 7 to 14, wherein the cooling unit (3), occupying a space formed between a lateral face of the inner shell (2) and a lateral face of the outer shell (1), comprises a cold pack (32) and at least one substantially planar cold regulation barrier container (31).
  16. Isothermal container as claimed in any one of Claims 7 to 14, wherein the cooling unit (3) occupies a space (100) formed between the inner shell (2) and a corner of the outer shell (1).
EP04291214A 2003-05-12 2004-05-12 Isothermal package for heat sensitive products and method for its production Active EP1477751B1 (en)

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FR0305697 2003-05-12
FR0305697A FR2854875B1 (en) 2003-05-12 2003-05-12 ISOTHERMIC PACKAGING DEVICE FOR TEMPERATURE SENSITIVE PRODUCTS AND METHOD FOR MANUFACTURING THE SAME

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US6325281B1 (en) * 2000-03-30 2001-12-04 Polyfoam Packers Corporation Thermally insulating shipping system
GB2383402A (en) * 2001-08-10 2003-06-25 Adrian Peter Copeland Heat-insulated container

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DE602004029306D1 (en) 2010-11-11
FR2854875B1 (en) 2005-10-14
FR2854875A1 (en) 2004-11-19
EP1477751A1 (en) 2004-11-17
ATE483143T1 (en) 2010-10-15
ES2352790T3 (en) 2011-02-23

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