FR2795958A1 - Cosmetic compositions contain a polyunsaturated fatty acid derived from plant or algal lipids to counteract fatty tissue formation - Google Patents
Cosmetic compositions contain a polyunsaturated fatty acid derived from plant or algal lipids to counteract fatty tissue formation Download PDFInfo
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- FR2795958A1 FR2795958A1 FR9909128A FR9909128A FR2795958A1 FR 2795958 A1 FR2795958 A1 FR 2795958A1 FR 9909128 A FR9909128 A FR 9909128A FR 9909128 A FR9909128 A FR 9909128A FR 2795958 A1 FR2795958 A1 FR 2795958A1
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- microalgae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/06—Preparations for care of the skin for countering cellulitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
Abstract
Description
La présente invention concerne un produit cosmétique qui contient un principe actif pour lutter contre l'adiposité et ainsi affiner la silhouette. The present invention relates to a cosmetic product that contains an active ingredient to fight against adiposity and thus refine the silhouette.
On connaît déjà de tels produits et on sait que les principes actifs utilisés présentent une activité lipolytique par laquelle ils stimulent la dégradation (ou lyse) des graisses stockées dans les adipocytes humains, notamment sous forme de triglycérides, et favorisent l'élimination des produits de cette dégradation, notamment les acides gras et les glycérols. Such products are already known and it is known that the active principles used exhibit lipolytic activity by which they stimulate the degradation (or lysis) of the fats stored in human adipocytes, especially in the form of triglycerides, and promote the elimination of this degradation, in particular fatty acids and glycerols.
Par exemple, dans le document du brevet français n 98 02152, on utilise en tant que principe actif un groupement pyrone qui a pour effet d'activer la phosphorylation d'une enzyme du type lypase pour la dégradation des triglycérides en acides gras. Par exemple, ce groupement pyrone est la mangostine extraite d'un arbre de l'espèce Garcinia Mangostana. For example, in French Patent No. 98 02152, the active ingredient used is a pyrone group which has the effect of activating the phosphorylation of a lypase enzyme for the degradation of triglycerides to fatty acids. For example, this pyrone group is mangostine extracted from a tree of the species Garcinia Mangostana.
On sait également que, dans les adipocytes, la lipolyse est en compétition avec la lipogénèse qui consiste en la formation des graisses, notamment des triglycérides, et qui met en jeu toute une série de réactions biochimiques faisant intervenir des protéines à activité enzymatique telle l'Acyl-CoA synthétase et l'acide gras synthétase connue également sous le nom FAS (fatty acid synthase). It is also known that, in adipocytes, lipolysis is in competition with lipogenesis which consists of the formation of fats, in particular triglycerides, and which involves a series of biochemical reactions involving proteins with enzymatic activity such as Acyl-CoA synthetase and fatty acid synthase also known as FAS (fatty acid synthase).
Le but de la présente invention est de proposer un produit cosmétique qui contient un principe actif pour lutter contre l'adiposité et qui soit nouveau, notamment par rapport aux produits dont le principe actif favorise la lipolyse. The purpose of the present invention is to provide a cosmetic product that contains an active ingredient to fight against adiposity and is new, especially compared to products whose active ingredient promotes lipolysis.
A cet effet, un produit cosmétique selon la présente invention contient en tant que principe actif les acides gras polyinsaturés d'un extrait lipidique de plantes ou d'algues. For this purpose, a cosmetic product according to the present invention contains as active ingredient the polyunsaturated fatty acids of a lipid extract of plants or algae.
On a pu constater qu'un tel produit cosmétique permet de limiter l'accumulation des acides gras dans les adipocytes humains. On pense que les acides gras polyinsaturés contenus dans ledit extrait sont responsables d'un effet d'inhibition de l'action d'une enzyme qui intervient dans la lipogenèse, notamment la synthèse des acides gras par l'acide gras synthétase FAS. En utilisant un produit qui contient un tel principe actif, on inhibe ou limite la lipogenèse des acides gras et on diminue ainsi leur concentration dans les adipocytes. It has been observed that such a cosmetic product makes it possible to limit the accumulation of fatty acids in human adipocytes. It is believed that the polyunsaturated fatty acids contained in said extract are responsible for an effect of inhibiting the action of an enzyme involved in lipogenesis, in particular the synthesis of fatty acids by fatty acid synthetase FAS. By using a product which contains such an active ingredient, the lipogenesis of the fatty acids is inhibited or limited and their concentration in the adipocytes is thus reduced.
Selon une autre caractéristique de l'invention, ledit extrait est un extrait lipidique d'une algue ou d'une microalgue. According to another characteristic of the invention, said extract is a lipid extract of an algae or a microalgae.
On a réalisé à titre d'exemple un produit cosmétique à base d'un extrait lipidique d'une microalgue qui est, en l'occurrence, une cyanobactérie nommée Odontella aurita. Elle fait partie des diatomés dont la classe est celle des Bacilariophycées, l'ordre celui des Bidulphiales, et la famille celle des Eurodiscaceaes. An example of a cosmetic product based on a lipid extract of a microalgae which is, in this case, a cyanobacterium named Odontella aurita. It is one of the diatoms of which the class is that of the Bacilariophyceae, the order that of the Bidulphiales, and the family that of the Eurodiscaceae.
Cette microalgue particulière contient des acides gras polyinsaturés tels que l'acide eicopentanoïque (5, 8,<I>11, 14, 17-</I> eicosapentaenoic acid) connu sous le nom EPA en une concentration de l'ordre de 22 % des acides gras totaux, soit approximativement 2 % du poids sec de la microalgue. Elle est donc riche en un EPA. This particular microalga contains polyunsaturated fatty acids such as eicopentanoic acid (5, 8, 11, 14, 17, eicosapentaenoic acid) known under the name EPA in a concentration of the order of 22%. total fatty acids, ie approximately 2% of the dry weight of the microalgae. She is therefore rich in an EPA.
Cette microalgue est obtenue par culture contrôlée en bassins de plein air (de type race way ). This microalga is obtained by controlled culture in outdoor pools (race way type).
La présente invention concerne également un procédé de préparation d'un produit qui contient en tant que principe actif un extrait lipidique de plantes ou d'algues. Il est caractérisé en ce que ledit extrait est réalisé par extraction au gaz carbonique C02 supercritique à partir d'une poudre lyophilisée de ladite plante ou de ladite algue préalablement congelée. The present invention also relates to a process for preparing a product which contains as an active ingredient a lipid extract of plants or algae. It is characterized in that said extract is produced by supercritical CO 2 carbon dioxide extraction from a lyophilized powder of said plant or said previously frozen algae.
L'effet d'un extrait lipidique de la microalgue Odontella aurita sur la néosynthèse des acides gras a été évalué<I>in vitro</I> sur des cellules graisseuses. Pour ce faire, on a procédé de la manière maintenant décrite. The effect of a lipid extract of the microalga Odontella aurita on the neosynthesis of fatty acids was evaluated <i> in vitro </ I> on fat cells. To do this, we proceeded in the manner now described.
Des adipocytes isolés de graisse sous-cutanée humaine qui provenaient d'une opération de chirurgie plastique ont été incubés en présence d'un précurseur radiomarqué. Ce dernier était l'acétate marqué au carbone 14. Adipocytes isolated from human subcutaneous fat that came from a plastic surgery operation were incubated in the presence of a radiolabelled precursor. The latter was carbon-14-labeled acetate.
Différents produits ont été testés pour moduler la néosynthèse des acides gras Different products have been tested to modulate the neosynthesis of fatty acids
<B>1</B> La cérulénine (qui est connue pour inhiber l'expression de l'acide gras synthétase FAS) a été utilisée comme inhibiteur de référence. Elle a été testée à 3 concentrations différentes<B>:</B> 0.1 gM, 1 pM et 10 pM, diluée dans le milieu aqueux d'incubation. <B> 1 </ B> Cerulenine (which is known to inhibit the expression of FAS fatty acid synthetase) has been used as a reference inhibitor. It was tested at 3 different concentrations: 0.1 μM, 1 μM and 10 μM, diluted in the aqueous incubation medium.
<B>1</B> L'extrait lipidique de microalgue (avec ou sans conservateur) a été testé à 3 concentrations : 0.1 % , 1 % et 10 % dilué dans de l'huile de paraffine. <B> 1 </ B> The lipid extract of microalgae (with or without preservative) was tested at 3 concentrations: 0.1%, 1% and 10% diluted in paraffin oil.
Chaque expérience a été réalisée en trois exemplaires (n = 3) d'où l'on a pu déduire un écart type dans les mesures. Après une incubation de 4 heures à 37 C, l'acétate non incorporée a été éliminée par lavage des adipocytes alors que la quantité de l'acétate incorporée est mesurée au moyen d'un appareil de mesure de radioactivité à scintillation liquide et ce, après hydrolyse alcaline et extraction des lipides. Un contrôle sans incubation (to) a été réalisé pour évaluer le bruit de fond. Un contrôle avec l'huile de paraffine a égaiement été réalisé. Les résultats obtenus sont présentés dans le tableau 1 ci-dessous. On peut constater que Each experiment was performed in three copies (n = 3) from which a standard deviation could be deduced in the measurements. After incubation for 4 hours at 37 ° C., the unincorporated acetate was removed by washing the adipocytes while the amount of the incorporated acetate is measured by means of a liquid scintillation radioactivity measuring device and this, after alkaline hydrolysis and lipid extraction. A control without incubation (to) was performed to evaluate the background noise. Paraffin oil control was also performed. The results obtained are shown in Table 1 below. We can note that
1, Les adipocytes incorporent effectivement l'acétate radiomarqué (133 372 cpm après 4 heures contre 1635 cpm au début de la réaction). 1, the adipocytes actually incorporate the radiolabelled acetate (133 372 cpm after 4 hours against 1635 cpm at the beginning of the reaction).
2. La cérulénine testée à 0.1 pM n'a pas d'effet. Par contre, à 1 pM et 10 pM, elle diminue l'incorporation d'acétate de 56 % et 93 % respectivement. Ce résultat confirme l'effet inhibiteur de cette molécule sur la néosynthèse des acides gras (via une inhibition de l'enzyme FAS), et valide l'expérience réalisée sur des adipocytes humains. 2. Cerulenin tested at 0.1 μM has no effect. On the other hand, at 1 μM and 10 μM, it decreases acetate incorporation by 56% and 93% respectively. This result confirms the inhibitory effect of this molecule on the neosynthesis of fatty acids (via an inhibition of the FAS enzyme), and validates the experiment carried out on human adipocytes.
3. L'huile de paraffine utilisée pour diluer l'extrait lipidique de microalgue n'a pas d'effet sur l'incorporation d'acétate (l53 449 cpm après 4 heures contre 133 372 cpm en solution aqueuse après également 4 heures). 3. The paraffin oil used to dilute the lipid extract of microalgae has no effect on the incorporation of acetate (1659 cpm after 4 hours against 133 372 cpm in aqueous solution after also 4 hours).
4. L'extrait lipidique de microalgue, testé à 0.1 % et 1 %, inhibe l'incorporation d'acétate de respectivement 78 et 74 %. Testé à 10 %, il l'inhibe totalement <B>(98%).</B> De plus, un extrait contenant 0.5 % d'antioxydant provoque un effet inhibiteur identique à celui obtenu avec l'extrait conservé sans antioxydant.
<B>Produit <SEP> Concentration <SEP> Cpm <SEP> Sd</B>
<tb> <B>témoin <SEP> inhibition</B>
<tb> Contrôle <SEP> to <SEP> <B>1635</B> <SEP> <U>201</U> <SEP> 1 <SEP> /
<tb> Témoin <SEP> (après <SEP> 4 <SEP> h
<tb> d'incubation <SEP> en <SEP> <B>1</B>33372 <SEP> 11532 <SEP> <B>1</B>00 <SEP> 0
<tb> solution <SEP> <U>aqueuse)</U>
<tb> 0.1 <SEP> M <SEP> 136326 <SEP> 3076 <SEP> <U>1</U>02 <SEP> 0
<tb> Cérulénine <SEP> en <SEP> solution <SEP> 1 <SEP> pM <SEP> 59298 <SEP> 4005 <SEP> 44 <SEP> 56
<tb> aqueuse
<tb> 10 <SEP> M <SEP> 9023 <SEP> 714 <SEP> 7 <SEP> 93
<tb> Témoin <SEP> ( <SEP> après <SEP> 4 <SEP> h
<tb> d'incubation <SEP> en <SEP> 153449 <SEP> 10449 <SEP> 100 <SEP> /
<tb> solution <SEP> <U>lipidique)</U>
<tb> Extrait <SEP> lipidique <SEP> <B><U>0.1%</U></B> <SEP> 33081 <SEP> 6708 <SEP> 22 <SEP> 78
<tb> de <SEP> microalgue <SEP> en <SEP> 1 <SEP> % <SEP> 40092 <SEP> 5846 <SEP> 26 <SEP> 74
<tb> solution <SEP> <U>lipidique</U> <SEP> 10 <SEP> % <SEP> <B>2501 <SEP> 318</B> <SEP> 2 <SEP> 98
<tb> 0.1 <SEP> % <SEP> 36960 <SEP> 4792 <SEP> 24 <SEP> 76
<tb> Extrait <SEP> lipidique <SEP> de
<tb> microalgue <SEP> conservé
<tb> avec <SEP> 0.5 <SEP> % <SEP> d'anti- <SEP> 1 <SEP> % <SEP> 44901 <SEP> 1082 <SEP> 29 <SEP> 71
<tb> oxydant <SEP> en
<tb> solution <SEP> <U>lipidique</U> <SEP> 10 <SEP> % <SEP> 2855 <SEP> 632 <SEP> 2 <SEP> 98 cpm : coups par minute de l'appareil de scintillation liquide sd : écart-type de la mesure <B> Product <SEP> Concentration <SEP> Cpm <SEP> Nd </ B>
<tb><B> witness <SEP> muting </ B>
<tb> Control <SEP> to <SEP><B> 1635 <SEP><U> 201 </ U><SEP> 1 <SEP> /
<tb> Witness <SEP> (after <SEP> 4 <SEP> h
<tb> incubation <SEP> in <SEP><B> 1 </ B> 33372 <SEP> 11532 <SEP><B> 1 </ B> 00 <SEP> 0
<tb> solution <SEP><U> aqueous) </ U>
<tb> 0.1 <SEP> M <SEP> 136326 <SEP> 3076 <SEP><U> 1 </ U> 02 <SEP> 0
<tb> Cerulenin <SEP> in <SEP> solution <SEP> 1 <SEP> pM <SEP> 59298 <SEP> 4005 <SEP> 44 <SEP> 56
<tb> aqueous
<tb> 10 <SEP> M <SEP> 9023 <SEP> 714 <SEP> 7 <SEP> 93
<tb> Witness <SEP>(<SEP> after <SEP> 4 <SEP> h
<tb> incubation <SEP> in <SEP> 153449 <SEP> 10449 <SEP> 100 <SEP> /
<tb> solution <SEP><U> lipidic) </ U>
<tb> Extract <SEP> Lipidic <SEP><B><U> 0.1% </ U><SE> 33081 <SEP> 6708 <SEP> 22 <SEP> 78
<tb> of <SEP> microalgae <SEP> in <SEP> 1 <SEP>% <SEP> 40092 <SEQ> 5846 <SEP> 26 <SEP> 74
<tb> solution <SEP><U> lipidic </ U><SEP> 10 <SEP>% <SEP><B> 2501 <SEP> 318 </ B><SEP> 2 <SEP> 98
<tb> 0.1 <SEP>% <SEP> 36960 <SEQ> 4792 <SEP> 24 <SEP> 76
<tb> Extract <SEP> lipidic <SEP> from
<tb> microalgae <SEP> preserved
<tb> with <SEP> 0.5 <SEP>% <SEP> of anti- <SEP> 1 <SEP>% <SEP> 44901 <SEP> 1082 <SE> 29 <SEP> 71
<tb> oxidant <SEP> in
<tb> solution <SEP><U> lipidic </ U><SEP> 10 <SEP>% <SEP> 2855 <SEP> 632 <SEP> 2 <SEP> 98 cpm: counts per minute of the scintillation apparatus liquid sd: standard deviation of the measurement
L'ensemble de ces expériences prouve que l'extrait lipidique ci-dessus a pour effet d'inhiber, à l'instar de la Cérulénine, l'expression de l'acide gras synthétase FAS. Comme cela a déjà été dit ci-dessus, on pense que cet effet est dû à la présence All of these experiments prove that the lipid extract above has the effect of inhibiting, like cerulenin, the expression of fatty acid synthetase FAS. As has already been said above, it is thought that this effect is due to the presence
en quantité relativement importante dans la microalgue étudiée de l'acide eicopéntanoïque (EPA), qui est un acide gras polyinsaturé. On a pu montrer, au moyen d'expériences similaires à celles ci-dessus que l'acide eicopentanoïque (EPA) présentait cet effet inhibiteur (voir tableau II ci-dessous).
Produit <SEP> Concentration <SEP> Cpm <SEP> Sd
<tb> témoin <SEP> inhibition
<tb> Contrôle <SEP> t0 <SEP> <B><U>1635</U></B> <SEP> 201 <SEP> 1 <SEP> /
<tb> Témoin <SEP> ( <SEP> après <SEP> 4 <SEP> h
<tb> d'incubation <SEP> en <SEP> 153449 <SEP> 10449 <SEP> 100 <SEP> /
<tb> solution <SEP> <U>lipidique)</U> <SEP> 10 <SEP> M <SEP> 120202 <SEP> 4487 <SEP> 78 <SEP> 22
<tb> EPA <SEP> en <SEP> solution <SEP> 100 <SEP> M <SEP> 116948 <SEP> 11909 <SEP> 76 <SEP> 24
<tb> <U>lipidique</U> <SEP> 1000 <SEP> M <SEP> 109708 <SEP> 9435 <SEP> 71 <SEP> 29 Ainsi, tout extrait lipidique d'une plante ou d'une algue qui contient un acide gras polyinsaturé, et notamment l'acide eicopentanoïque (EPA), peut constituer un principe actif pour un produit cosmétique selon la présente invention.Product <SEP> Concentration <SEP> Cpm <SEP> Sd
<tb> control <SEP> inhibition
<tb> Check <SEP> t0 <SEP><B><U> 1635 </ U></B><SEP> 201 <SEP> 1 <SEP> /
<tb> Witness <SEP>(<SEP> after <SEP> 4 <SEP> h
<tb> incubation <SEP> in <SEP> 153449 <SEP> 10449 <SEP> 100 <SEP> /
<tb> solution <SEP><U> lipidic) </ U><SEP> 10 <SEP> M <SEP> 120202 <SEQ> 4487 <SEQ> 78 <SEP> 22
<tb> EPA <SEP> in <SEP> solution <SEP> 100 <SEP> M <SEP> 116948 <SEQ> 11909 <SEP> 76 <SEP> 24
<tb><U> Lipidic </ U><SEP> 1000 <SEP> M <SEP> 109708 <SEP> 9435 <SEP> 71 <SEP> 29 Thus, any lipid extract from a plant or alga that contains a polyunsaturated fatty acid, and in particular eicopentanoic acid (EPA), may constitute an active ingredient for a cosmetic product according to the present invention.
Claims (8)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9909128A FR2795958B1 (en) | 1999-07-09 | 1999-07-09 | COSMETIC PRODUCT CONTAINING AN ACTIVE INGREDIENT TO FIGHT ADIPOSITY |
| FR0008866A FR2795959B1 (en) | 1999-07-09 | 2000-07-06 | COSMETIC OR PHARMACEUTICAL PRODUCT OF THE TYPE WHICH CONTAINS AN ACTIVE INGREDIENT FOR COMBATING ADIPOSITY |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9909128A FR2795958B1 (en) | 1999-07-09 | 1999-07-09 | COSMETIC PRODUCT CONTAINING AN ACTIVE INGREDIENT TO FIGHT ADIPOSITY |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2795958A1 true FR2795958A1 (en) | 2001-01-12 |
| FR2795958B1 FR2795958B1 (en) | 2001-09-28 |
Family
ID=9548089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR9909128A Expired - Fee Related FR2795958B1 (en) | 1999-07-09 | 1999-07-09 | COSMETIC PRODUCT CONTAINING AN ACTIVE INGREDIENT TO FIGHT ADIPOSITY |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2795958B1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002038109A1 (en) * | 2000-11-10 | 2002-05-16 | Orion Corporation Noiro | Cosmetic compositions containing cloudberry (rubus chamaemorus) seed oil |
| FR2918564A1 (en) * | 2007-07-13 | 2009-01-16 | Pacific Creation Soc Par Actio | Use of lipophilic extract of Odontella aurita as cosmetic agent for restructuring or avoiding destructuration of skin and to improve elasticity and tonicity of the skin and/or regeneration of the skin after e.g. dermabrasion |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1125342A (en) * | 1955-05-27 | 1956-10-29 | Docteur Robert Maurin | Use of freshwater algae cultures (more particularly of the chlorella type) for cosmetic uses |
| GB2202146A (en) * | 1987-03-18 | 1988-09-21 | Caola Kozmetikai | Skin-regenerating cosmetic composition |
| FR2657012A1 (en) * | 1990-01-17 | 1991-07-19 | Secma | Use of extracts of microscopic algae for the preparation of pharmaceutical, cosmetic or nutrient compositions or compositions for agricultural use |
| WO1994024984A2 (en) * | 1993-04-30 | 1994-11-10 | Winget Rodner R | Anti-inflammatory compositions containing eicosapentaenoic acid bearing monogalactosyldiacylglycerol and methods relating thereto |
| FR2715070A1 (en) * | 1994-01-18 | 1995-07-21 | Codif International Sa | Lipolytic product isolated from algae |
| WO1997037032A2 (en) * | 1996-03-28 | 1997-10-09 | Gist-Brocades B.V. | Preparation of microbial polyunsaturated fatty acid containing oil from pasteurised biomass |
| JPH11130656A (en) * | 1997-10-24 | 1999-05-18 | Kose Corp | Adiposity inhibitor and preparation for external use for skin containing the same |
-
1999
- 1999-07-09 FR FR9909128A patent/FR2795958B1/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1125342A (en) * | 1955-05-27 | 1956-10-29 | Docteur Robert Maurin | Use of freshwater algae cultures (more particularly of the chlorella type) for cosmetic uses |
| GB2202146A (en) * | 1987-03-18 | 1988-09-21 | Caola Kozmetikai | Skin-regenerating cosmetic composition |
| FR2657012A1 (en) * | 1990-01-17 | 1991-07-19 | Secma | Use of extracts of microscopic algae for the preparation of pharmaceutical, cosmetic or nutrient compositions or compositions for agricultural use |
| WO1994024984A2 (en) * | 1993-04-30 | 1994-11-10 | Winget Rodner R | Anti-inflammatory compositions containing eicosapentaenoic acid bearing monogalactosyldiacylglycerol and methods relating thereto |
| FR2715070A1 (en) * | 1994-01-18 | 1995-07-21 | Codif International Sa | Lipolytic product isolated from algae |
| WO1997037032A2 (en) * | 1996-03-28 | 1997-10-09 | Gist-Brocades B.V. | Preparation of microbial polyunsaturated fatty acid containing oil from pasteurised biomass |
| JPH11130656A (en) * | 1997-10-24 | 1999-05-18 | Kose Corp | Adiposity inhibitor and preparation for external use for skin containing the same |
Non-Patent Citations (1)
| Title |
|---|
| PATENT ABSTRACTS OF JAPAN vol. 10, (C - ) * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002038109A1 (en) * | 2000-11-10 | 2002-05-16 | Orion Corporation Noiro | Cosmetic compositions containing cloudberry (rubus chamaemorus) seed oil |
| FR2918564A1 (en) * | 2007-07-13 | 2009-01-16 | Pacific Creation Soc Par Actio | Use of lipophilic extract of Odontella aurita as cosmetic agent for restructuring or avoiding destructuration of skin and to improve elasticity and tonicity of the skin and/or regeneration of the skin after e.g. dermabrasion |
| JP2009029806A (en) * | 2007-07-13 | 2009-02-12 | Pacific Creation | Use of fat-soluble extract of odontella aurita for restructuring skin, composition for use and cosmetic method using the extract |
| CN101357113B (en) * | 2007-07-13 | 2013-01-30 | 株式会社太平洋 | Use of lipophilic extract of long-eared odontoid algae in skin regeneration, combination and cosmetic method using the extract |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2795958B1 (en) | 2001-09-28 |
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Effective date: 20090331 |