FR2767825A1 - Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht°1,2-b!-1, 4-oxazines disubstituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents
Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht°1,2-b!-1, 4-oxazines disubstituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Download PDFInfo
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- FR2767825A1 FR2767825A1 FR9710852A FR9710852A FR2767825A1 FR 2767825 A1 FR2767825 A1 FR 2767825A1 FR 9710852 A FR9710852 A FR 9710852A FR 9710852 A FR9710852 A FR 9710852A FR 2767825 A1 FR2767825 A1 FR 2767825A1
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- DIVDFFZHCJEHGG-UHFFFAOYSA-N oxidopamine Chemical compound NCCC1=CC(O)=C(O)C=C1O DIVDFFZHCJEHGG-UHFFFAOYSA-N 0.000 description 1
- BHAAPTBBJKJZER-UHFFFAOYSA-N p-anisidine Chemical compound COC1=CC=C(N)C=C1 BHAAPTBBJKJZER-UHFFFAOYSA-N 0.000 description 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000001242 postsynaptic effect Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229950001518 raclopride Drugs 0.000 description 1
- 239000002287 radioligand Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 230000002295 serotoninergic effect Effects 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
- 210000004515 ventral tegmental area Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9710852A FR2767825A1 (fr) | 1997-09-01 | 1997-09-01 | Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht°1,2-b!-1, 4-oxazines disubstituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| NO19984007A NO311218B1 (no) | 1997-09-01 | 1998-08-31 | Nye disubstituerte trans-3,4,4a,5,6,10b-heksahydro-2H- naft[1,2-b]-1,4-oksaziner, en fremgangsmåte ved deres fremstillingog farmasöytiske sammensetninger inneholder disse |
| BR9803933-4A BR9803933A (pt) | 1997-09-01 | 1998-08-31 | Trans-3,4,4a,5,6,10b-hexahidro-2h-nafto [1,2-b]-1,4-oxazinas dissubstituìdas, um processo para sua preparação e composições farmacêuticas que as contêm |
| HU9801951A HU226059B1 (en) | 1997-09-01 | 1998-08-31 | Novel disubstituted trans-3,4,4a,5,6,10b-hexahydro-2h-naphto[1,2-b][1,4]oxazine derivatives, process for producing them and pharmaceutical compositions containing them |
| PL328285A PL194533B1 (pl) | 1997-09-01 | 1998-08-31 | Nowe dipodstawione trans-3,4,4a,5,6,10b-heksahydro-2H-nafto[1,2-b]-1,4-oksazyny oraz zawierające je kompozycje farmaceutyczne |
| NZ331637A NZ331637A (en) | 1997-09-01 | 1998-08-31 | Trans 9-substituted 3,4,4a,5,6,10b-hexahydro-4(alkyl, alkenyl or alkynyl)-2h-naphth[1,2-b]-1,4-oxazine derivatives and medicaments |
| CA002246482A CA2246482C (fr) | 1997-09-01 | 1998-08-31 | Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht [1,2-b]-1,4-oxazines disubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN98119987A CN1088064C (zh) | 1997-09-01 | 1998-08-31 | 萘并噁嗪衍生物、其制备方法及含有它们的药物组合物 |
| US09/144,025 US6025356A (en) | 1997-09-01 | 1998-08-31 | Disubstituted trans-3,4,4a,5,6,10b-hexahydro-2H-naphth[1,2-b]-1,4-oxazines |
| ZA987963A ZA987963B (en) | 1997-09-01 | 1998-09-01 | Disubstituted trans-3,4,4a,5,6,10b-haxahydro-2H-naphth(1,2-b)-1,4-oxazines a process for their preparation and pharmaceutical compositions containing them |
| AU83024/98A AU740928C (en) | 1997-09-01 | 1998-09-01 | New disubstituted trans-3,4,4a,5,6,10b-hexahydro-2H-naphth (1,2-b)-1,4-oxazines, a process for their preparation and pharmaceutical compositions containing them |
| JP24691098A JP4417451B2 (ja) | 1997-09-01 | 1998-09-01 | 新規な二置換ｔｒａｎｓ−３，４，４ａ，５，６，１０ｂ−ヘキサヒドロ−２Ｈ−ナフト〔１，２−ｂ〕−１，４−オキサジン、それらの製造方法及びそれらを含有する医薬組成物 |
| PT98402155T PT899267E (pt) | 1997-09-01 | 1998-09-01 | Novas trans-3,4,4a,5,6,10b-hexa-hidro-2h-naft(1,2b)-1,4-oxazinas di-substituidas processo para a sua preparacao e as composicoes farmaceuticas que as contem |
| ES98402155T ES2189108T3 (es) | 1997-09-01 | 1998-09-01 | Nuevas oxazinas dissustituidas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen. |
| AT98402155T ATE229513T1 (de) | 1997-09-01 | 1998-09-01 | Disubstituierte trans-3,4,4a,5,6,10b-hexahydro-2h-napht(1,2-b)- ,4-oxazine, verfahren zu deren herstellung und diese enthaltende pharmazeutigsche zusammensetzungen |
| DE69810034T DE69810034T2 (de) | 1997-09-01 | 1998-09-01 | Disubstituierte trans-3,4,4a,5,6,10b-Hexahydro-2H-napht(1,2-b)-1,4-Oxazine, Verfahren zu deren Herstellung und diese enthaltende pharmazeutigsche Zusammensetzungen |
| DK98402155T DK0899267T3 (da) | 1997-09-01 | 1998-09-01 | Disubstituerede trans-3,4,4a,5,6,10b-hexahydro-2H-napht[1,2-b]-1,4-oxiner, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger indeholdende disse |
| EP98402155A EP0899267B1 (fr) | 1997-09-01 | 1998-09-01 | Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2H-napht(1,2-b)-1,4-oxazines disubstituées, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
| HK99105446.1A HK1020340B (en) | 1997-09-01 | 1999-11-25 | New disubstituted trans-3,4,4a,5,6,10b-hexahydro-2h-naphth (1,2-b)-1,4-oxazines, a process for their preparation and pharmaceutical compositions containing them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9710852A FR2767825A1 (fr) | 1997-09-01 | 1997-09-01 | Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht°1,2-b!-1, 4-oxazines disubstituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2767825A1 true FR2767825A1 (fr) | 1999-02-26 |
Family
ID=9510643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR9710852A Pending FR2767825A1 (fr) | 1997-09-01 | 1997-09-01 | Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht°1,2-b!-1, 4-oxazines disubstituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6025356A (OSRAM) |
| EP (1) | EP0899267B1 (OSRAM) |
| JP (1) | JP4417451B2 (OSRAM) |
| CN (1) | CN1088064C (OSRAM) |
| AT (1) | ATE229513T1 (OSRAM) |
| AU (1) | AU740928C (OSRAM) |
| BR (1) | BR9803933A (OSRAM) |
| CA (1) | CA2246482C (OSRAM) |
| DE (1) | DE69810034T2 (OSRAM) |
| DK (1) | DK0899267T3 (OSRAM) |
| ES (1) | ES2189108T3 (OSRAM) |
| FR (1) | FR2767825A1 (OSRAM) |
| HU (1) | HU226059B1 (OSRAM) |
| NO (1) | NO311218B1 (OSRAM) |
| NZ (1) | NZ331637A (OSRAM) |
| PL (1) | PL194533B1 (OSRAM) |
| PT (1) | PT899267E (OSRAM) |
| ZA (1) | ZA987963B (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0130219D0 (en) * | 2001-12-18 | 2002-02-06 | Pfizer Ltd | Compounds for the treatment of sexual dysfunction |
| MXPA05002331A (es) * | 2002-08-30 | 2005-08-18 | Biostratum Inc | Inhibidores de productos terminales de glicacion avanzada post-amadori. |
| MXPA05011225A (es) * | 2003-04-18 | 2005-12-14 | Pharmacia & Upjohn Co Llc | Politerapias. |
| FR2906249B1 (fr) * | 2006-09-26 | 2008-12-19 | Servier Lab | Composes tetracycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP2098511A1 (en) | 2008-03-07 | 2009-09-09 | Solvias AG | Process for preparing compounds containing a hydronaphtalene structure with an unsymmetrically substituted benzene ring |
| EP2303851A1 (en) * | 2008-06-27 | 2011-04-06 | H. Lundbeck A/S | Novel phenolic and catecholic amines and prodrugs thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0080115A2 (en) * | 1981-11-20 | 1983-06-01 | Merck & Co. Inc. | Hexahydronaphth(1,2-b)-1,4-oxazines, process for their preparation and pharmaceutical formulation containing them |
| US4540691A (en) * | 1984-04-13 | 1985-09-10 | Nelson Research & Development Co. | Dopamine agonists and use thereof |
| WO1991019719A1 (en) * | 1990-06-15 | 1991-12-26 | Whitby Research, Inc. | Substituted naphthoxazines useful as dopaminergics |
| US5486611A (en) * | 1989-07-13 | 1996-01-23 | The Upjohn Company | Carboxamido-(1,2N)-carbocyclic-2-aminotetralin derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4420480A (en) * | 1981-11-20 | 1983-12-13 | Merck & Co., Inc. | Hexahydronaphth[1,2-b]-1,4-oxazines |
-
1997
- 1997-09-01 FR FR9710852A patent/FR2767825A1/fr active Pending
-
1998
- 1998-08-31 NO NO19984007A patent/NO311218B1/no not_active IP Right Cessation
- 1998-08-31 PL PL328285A patent/PL194533B1/pl not_active IP Right Cessation
- 1998-08-31 US US09/144,025 patent/US6025356A/en not_active Expired - Lifetime
- 1998-08-31 BR BR9803933-4A patent/BR9803933A/pt not_active Application Discontinuation
- 1998-08-31 NZ NZ331637A patent/NZ331637A/xx not_active IP Right Cessation
- 1998-08-31 CA CA002246482A patent/CA2246482C/fr not_active Expired - Fee Related
- 1998-08-31 HU HU9801951A patent/HU226059B1/hu not_active IP Right Cessation
- 1998-08-31 CN CN98119987A patent/CN1088064C/zh not_active Expired - Fee Related
- 1998-09-01 DE DE69810034T patent/DE69810034T2/de not_active Expired - Lifetime
- 1998-09-01 DK DK98402155T patent/DK0899267T3/da active
- 1998-09-01 ES ES98402155T patent/ES2189108T3/es not_active Expired - Lifetime
- 1998-09-01 EP EP98402155A patent/EP0899267B1/fr not_active Expired - Lifetime
- 1998-09-01 ZA ZA987963A patent/ZA987963B/xx unknown
- 1998-09-01 AU AU83024/98A patent/AU740928C/en not_active Ceased
- 1998-09-01 PT PT98402155T patent/PT899267E/pt unknown
- 1998-09-01 JP JP24691098A patent/JP4417451B2/ja not_active Expired - Fee Related
- 1998-09-01 AT AT98402155T patent/ATE229513T1/de active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0080115A2 (en) * | 1981-11-20 | 1983-06-01 | Merck & Co. Inc. | Hexahydronaphth(1,2-b)-1,4-oxazines, process for their preparation and pharmaceutical formulation containing them |
| US4540691A (en) * | 1984-04-13 | 1985-09-10 | Nelson Research & Development Co. | Dopamine agonists and use thereof |
| US5486611A (en) * | 1989-07-13 | 1996-01-23 | The Upjohn Company | Carboxamido-(1,2N)-carbocyclic-2-aminotetralin derivatives |
| WO1991019719A1 (en) * | 1990-06-15 | 1991-12-26 | Whitby Research, Inc. | Substituted naphthoxazines useful as dopaminergics |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA987963B (en) | 1999-03-04 |
| HU226059B1 (en) | 2008-04-28 |
| PL194533B1 (pl) | 2007-06-29 |
| DK0899267T3 (da) | 2003-03-10 |
| EP0899267B1 (fr) | 2002-12-11 |
| EP0899267A1 (fr) | 1999-03-03 |
| DE69810034D1 (de) | 2003-01-23 |
| JPH11130759A (ja) | 1999-05-18 |
| ATE229513T1 (de) | 2002-12-15 |
| JP4417451B2 (ja) | 2010-02-17 |
| DE69810034T2 (de) | 2003-08-14 |
| HUP9801951A2 (hu) | 2000-02-28 |
| AU8302498A (en) | 1999-03-11 |
| HU9801951D0 (en) | 1998-11-30 |
| AU740928C (en) | 2002-05-16 |
| CN1222516A (zh) | 1999-07-14 |
| US6025356A (en) | 2000-02-15 |
| NO984007D0 (no) | 1998-08-31 |
| NZ331637A (en) | 1999-07-29 |
| BR9803933A (pt) | 2001-04-24 |
| AU740928B2 (en) | 2001-11-15 |
| ES2189108T3 (es) | 2003-07-01 |
| HUP9801951A3 (en) | 2000-04-28 |
| CA2246482C (fr) | 2002-11-26 |
| CN1088064C (zh) | 2002-07-24 |
| PT899267E (pt) | 2003-04-30 |
| NO311218B1 (no) | 2001-10-29 |
| HK1020340A1 (en) | 2000-04-14 |
| CA2246482A1 (fr) | 1999-03-01 |
| NO984007L (no) | 1999-03-02 |
| PL328285A1 (en) | 1999-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TP | Transmission of property |