FR2727117A1 - Utilisation de conjugues de la polylysine pour la preparation de medicaments utiles dans le traitement des maladies neurodegeneratives et des affections degeneratives a caractere autoimmun - Google Patents

Utilisation de conjugues de la polylysine pour la preparation de medicaments utiles dans le traitement des maladies neurodegeneratives et des affections degeneratives a caractere autoimmun Download PDF

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Publication number
FR2727117A1
FR2727117A1 FR9413861A FR9413861A FR2727117A1 FR 2727117 A1 FR2727117 A1 FR 2727117A1 FR 9413861 A FR9413861 A FR 9413861A FR 9413861 A FR9413861 A FR 9413861A FR 2727117 A1 FR2727117 A1 FR 2727117A1
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FR
France
Prior art keywords
conjugates
sep
ole
acid
farcys
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR9413861A
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English (en)
French (fr)
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FR2727117B1 (https=
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Individual
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Individual
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Filing date
Publication date
Priority to FR9413861A priority Critical patent/FR2727117A1/fr
Application filed by Individual filed Critical Individual
Priority to PT95940329T priority patent/PT792167E/pt
Priority to CA002205557A priority patent/CA2205557C/en
Priority to PCT/FR1995/001517 priority patent/WO1996015810A1/fr
Priority to DE69521521T priority patent/DE69521521T2/de
Priority to JP51662296A priority patent/JP4128618B2/ja
Priority to EP95940329A priority patent/EP0792167B1/fr
Priority to DK95940329T priority patent/DK0792167T3/da
Priority to ES95940329T priority patent/ES2161915T3/es
Priority to US08/836,199 priority patent/US6114388A/en
Priority to AU41811/96A priority patent/AU694825B2/en
Priority to NZ297040A priority patent/NZ297040A/xx
Priority to AT95940329T priority patent/ATE202487T1/de
Publication of FR2727117A1 publication Critical patent/FR2727117A1/fr
Application granted granted Critical
Publication of FR2727117B1 publication Critical patent/FR2727117B1/fr
Priority to GR20010401567T priority patent/GR3036710T3/el
Granted legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FR9413861A 1994-11-18 1994-11-18 Utilisation de conjugues de la polylysine pour la preparation de medicaments utiles dans le traitement des maladies neurodegeneratives et des affections degeneratives a caractere autoimmun Granted FR2727117A1 (fr)

Priority Applications (14)

Application Number Priority Date Filing Date Title
FR9413861A FR2727117A1 (fr) 1994-11-18 1994-11-18 Utilisation de conjugues de la polylysine pour la preparation de medicaments utiles dans le traitement des maladies neurodegeneratives et des affections degeneratives a caractere autoimmun
AU41811/96A AU694825B2 (en) 1994-11-18 1995-11-17 Monofunctional and/or polyfunctional polylysine conjugates
PCT/FR1995/001517 WO1996015810A1 (fr) 1994-11-18 1995-11-17 Conjugues monofonctionnels et/ou polyfonctionnels de la polylysine
DE69521521T DE69521521T2 (de) 1994-11-18 1995-11-17 Mono- oder polyfunktionelle konjugate von polylysine
JP51662296A JP4128618B2 (ja) 1994-11-18 1995-11-17 単官能性および/または多官能性ポリリシン結合体
EP95940329A EP0792167B1 (fr) 1994-11-18 1995-11-17 Conjugues monofonctionnels et/ou polyfonctionnels de la polylysine
PT95940329T PT792167E (pt) 1994-11-18 1995-11-17 Conjugados monofuncionais e/ou polifuncionais da polilisina
ES95940329T ES2161915T3 (es) 1994-11-18 1995-11-17 Conjugados monofuncionales y/o polifuncionales de la polilisina.
US08/836,199 US6114388A (en) 1994-11-18 1995-11-17 Monofunctional and/or polyfunctional polylysine conjuages
CA002205557A CA2205557C (en) 1994-11-18 1995-11-17 Monofunctional and/or polyfunctional polylysine conjugates
NZ297040A NZ297040A (en) 1994-11-18 1995-11-17 Mono- or polyfunctional polylysine conjugates
AT95940329T ATE202487T1 (de) 1994-11-18 1995-11-17 Mono- oder polyfunktionelle konjugate von polylysine
DK95940329T DK0792167T3 (da) 1994-11-18 1995-11-17 Monofunktionelle og/eller polyfunktionelle polylysin-konjugater
GR20010401567T GR3036710T3 (en) 1994-11-18 2001-09-26 Monofunctional and/or polyfunctional polylysine conjugates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9413861A FR2727117A1 (fr) 1994-11-18 1994-11-18 Utilisation de conjugues de la polylysine pour la preparation de medicaments utiles dans le traitement des maladies neurodegeneratives et des affections degeneratives a caractere autoimmun

Publications (2)

Publication Number Publication Date
FR2727117A1 true FR2727117A1 (fr) 1996-05-24
FR2727117B1 FR2727117B1 (https=) 1997-02-21

Family

ID=9468953

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9413861A Granted FR2727117A1 (fr) 1994-11-18 1994-11-18 Utilisation de conjugues de la polylysine pour la preparation de medicaments utiles dans le traitement des maladies neurodegeneratives et des affections degeneratives a caractere autoimmun

Country Status (14)

Country Link
US (1) US6114388A (https=)
EP (1) EP0792167B1 (https=)
JP (1) JP4128618B2 (https=)
AT (1) ATE202487T1 (https=)
AU (1) AU694825B2 (https=)
CA (1) CA2205557C (https=)
DE (1) DE69521521T2 (https=)
DK (1) DK0792167T3 (https=)
ES (1) ES2161915T3 (https=)
FR (1) FR2727117A1 (https=)
GR (1) GR3036710T3 (https=)
NZ (1) NZ297040A (https=)
PT (1) PT792167E (https=)
WO (1) WO1996015810A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2905868A1 (fr) * 2006-09-18 2008-03-21 Gemac Sa Composition destinee au traitement de la sclerose laterale amyotrophique

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO104396A0 (en) * 1996-07-17 1996-08-08 Biomolecular Research Institute Limited Antiviral linear polymers
CA2284729A1 (en) 1997-04-18 1998-10-29 Novartis Ag Neoglycoproteins
FR2763853B1 (fr) * 1997-05-28 2000-01-07 Oreal Association d'un retinoide avec un polymere polyamine
DE19732139C2 (de) 1997-07-25 2002-10-10 Max Planck Gesellschaft Mesomorphe Komplexe aus Vitamin A-Säure und kationischen Polyelektrolyten, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
FR2773808B1 (fr) * 1998-01-20 2000-05-05 Sagebo Composes susceptibles de pieger les ions metalliques, leur procede d'obtention et leur utilisation
US6919076B1 (en) * 1998-01-20 2005-07-19 Pericor Science, Inc. Conjugates of agents and transglutaminase substrate linking molecules
US6686446B2 (en) * 1998-03-19 2004-02-03 The Regents Of The University Of California Methods and compositions for controlled polypeptide synthesis
GB9811059D0 (en) * 1998-05-23 1998-07-22 Univ Strathclyde Polyamino acid vesicles
ES2235499T3 (es) 1998-07-30 2005-07-01 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Uso de derivados de propionil l-carnitina y de acetil l-carnitina en la preparacion de medicamentos con actividad anticancerigena.
CA2372526A1 (en) * 1999-05-10 2000-11-16 Michael D. Wyrsta Methods and compositions for controlled polypeptide synthesis
US20020072509A1 (en) * 2000-10-11 2002-06-13 Stein Donald Gerald Methods for the treatment of a traumatic central nervous system injury
US7658926B2 (en) * 2001-09-14 2010-02-09 Opexa Pharmaceuticals, Inc. Autologous T-cell vaccines materials and methods
FR2842422B1 (fr) * 2002-07-16 2006-06-30 Univ Aix Marseille Ii Compositions destinees au traitement des neuropathies peripheriques, preparation et utilisations
RU2327487C2 (ru) * 2002-08-08 2008-06-27 Бейлор Колледж Оф Медисин Выделение и идентификация т-клеток
DE60321363D1 (de) * 2002-08-28 2008-07-10 Millipore Corp Verfahren zur aufreinigung von sequenzierungsreaktionen
US8338648B2 (en) * 2004-06-12 2012-12-25 Signum Biosciences, Inc. Topical compositions and methods for epithelial-related conditions
US7473687B2 (en) * 2005-03-24 2009-01-06 Emory University Methods for the treatment of a traumatic central nervous system injury
US20090325920A1 (en) 2005-03-24 2009-12-31 Emory University Methods for the treatment of a traumatic central nervous system injury
FR2886153B1 (fr) * 2005-05-27 2009-04-10 Gemac Sa Composition destinee au traitement de la sclerose en plaques
CA2651328A1 (en) * 2006-05-05 2007-11-15 Opexa Therapeutics T-cell vaccine
CN101622017B (zh) 2006-12-22 2018-09-11 克罗马制药有限责任公司 聚合物的用途
FR2913335B1 (fr) 2007-03-06 2009-06-05 Michel Geffard Utilisation de conjugues d'acides gras et de poly-l-lysine pour lutter contre des microorganismes pathogenes.
EP2085082A1 (en) * 2008-01-29 2009-08-05 Nutromnia S.R.L. Treatment of cognitive decline
EP2696868A1 (en) * 2011-04-12 2014-02-19 Nestec S.A. Nutritional compositions including branched chain fatty acids and methods of using same
SI3116887T1 (sl) 2014-03-13 2021-06-30 Universitaet Basel Ogljikohidratni ligandi, ki se vežejo na protitelesa img proti glikoproteinu, ki je povezan z mielinom
FR3030524B1 (fr) * 2014-12-17 2017-01-20 Hydro-Fill Utilisation de pll pour ameliorer la stabilite de molecules en solution
US11091591B2 (en) 2015-09-16 2021-08-17 Universität Basel Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids
FR3048616B1 (fr) * 2016-03-14 2018-04-06 Polyneuros Polycomplexes de composes poly-lysine pour la prevention et/ou la lutte contre la sclerose laterale amyotrophique
FR3122573B1 (fr) * 2021-05-10 2024-03-29 Hydro Fill Tech Compositions de conjugués poly-lysine et de micelles et/ou de copolymères de poly-lysine
FR3122571B1 (fr) * 2021-05-10 2023-05-12 Hydro Fill Tech Compositions et leur utilisation pour rétablir la perméabilité intestinale et/ou prévenir ou lutter contre des maladies multifactorielles

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1979000515A1 (en) * 1978-01-16 1979-08-09 Univ Boston Method of effecting cellular uptake of molecules
EP0210412A2 (de) * 1985-06-24 1987-02-04 Hoechst Aktiengesellschaft Membrananker-Wirkstoffkonjugat, seine Herstellung sowie seine Verwendung
WO1991013097A1 (en) * 1990-02-28 1991-09-05 Robin Ewart Offord Polyaminocarboxylic acid derivatives
WO1992016221A1 (en) * 1991-03-15 1992-10-01 Synergen, Inc. Pegylation of polypeptides
WO1993025197A1 (en) * 1992-06-12 1993-12-23 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
WO1994027151A1 (fr) * 1993-05-19 1994-11-24 Michel Geffard Utilisation de molecules reconnues par des autoanticorps de serums humains pour le diagnostic ou le traitement du sida

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1979000515A1 (en) * 1978-01-16 1979-08-09 Univ Boston Method of effecting cellular uptake of molecules
EP0210412A2 (de) * 1985-06-24 1987-02-04 Hoechst Aktiengesellschaft Membrananker-Wirkstoffkonjugat, seine Herstellung sowie seine Verwendung
WO1991013097A1 (en) * 1990-02-28 1991-09-05 Robin Ewart Offord Polyaminocarboxylic acid derivatives
WO1992016221A1 (en) * 1991-03-15 1992-10-01 Synergen, Inc. Pegylation of polypeptides
WO1993025197A1 (en) * 1992-06-12 1993-12-23 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
WO1994027151A1 (fr) * 1993-05-19 1994-11-24 Michel Geffard Utilisation de molecules reconnues par des autoanticorps de serums humains pour le diagnostic ou le traitement du sida

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
A. KAMMEYER ET AL.: "PREPARATION OF MONOCLONAL MOUSE ANTIBODIES AGAINST TWO SPECIFIC EU-MELANIN RELATED COMPOUNDS.", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 15, NEW YORK US, pages 61 - 67 *
BR. J. CANCER (1994), 69(3), 463-7 CODEN: BJCAAI;ISSN: 0007-0920 *
CAMPISTRON, GHISLAINE ET AL: "Specific antibodies against aspartate and their immunocytochemical application in the rat brain", BRAIN RES. (1986), 365(1), 179-84 CODEN: BRREAP;ISSN: 0006-8993 *
CHEMICAL ABSTRACTS, vol. 121, no. 17, 24 October 1994, Columbus, Ohio, US; abstract no. 195099, CITRO, G. ET AL: "Inhibition of leukemia cell proliferation by folic acid-polylysine-mediated introduction of c-myb antisense oligodeoxynucleotides into HL-60 cells" *
PHILIPPE SEGUELA ET AL.: "ANTIBODIES AGAINST GAMMA-AMINOBUTYRIC ACID: SPECIFICITY STUDIES AND IMMUNOCYTOCHEMICAL RESULTS.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 81, WASHINGTON US, pages 3888 - 3892 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2905868A1 (fr) * 2006-09-18 2008-03-21 Gemac Sa Composition destinee au traitement de la sclerose laterale amyotrophique
WO2008035001A3 (fr) * 2006-09-18 2008-05-22 Gemac Composition destinee au traitement de la sclerose laterale amyotrophique

Also Published As

Publication number Publication date
CA2205557C (en) 2008-07-15
EP0792167B1 (fr) 2001-06-27
FR2727117B1 (https=) 1997-02-21
NZ297040A (en) 1999-05-28
PT792167E (pt) 2001-12-28
DK0792167T3 (da) 2001-10-29
WO1996015810A1 (fr) 1996-05-30
AU4181196A (en) 1996-06-17
US6114388A (en) 2000-09-05
AU694825B2 (en) 1998-07-30
DE69521521T2 (de) 2002-04-25
JPH10511643A (ja) 1998-11-10
ATE202487T1 (de) 2001-07-15
CA2205557A1 (en) 1996-05-30
JP4128618B2 (ja) 2008-07-30
ES2161915T3 (es) 2001-12-16
DE69521521D1 (de) 2001-08-02
EP0792167A1 (fr) 1997-09-03
GR3036710T3 (en) 2001-12-31

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