FR3122573B1 - Compositions de conjugués poly-lysine et de micelles et/ou de copolymères de poly-lysine - Google Patents

Compositions de conjugués poly-lysine et de micelles et/ou de copolymères de poly-lysine Download PDF

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Publication number
FR3122573B1
FR3122573B1 FR2104925A FR2104925A FR3122573B1 FR 3122573 B1 FR3122573 B1 FR 3122573B1 FR 2104925 A FR2104925 A FR 2104925A FR 2104925 A FR2104925 A FR 2104925A FR 3122573 B1 FR3122573 B1 FR 3122573B1
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FR
France
Prior art keywords
poly
lysine
micelles
compositions
molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR2104925A
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English (en)
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FR3122573A1 (fr
Inventor
Jean-Pascal Zambaux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PLL Therapeutics SAS
Original Assignee
Hydro Fill Technology SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hydro Fill Technology SAS filed Critical Hydro Fill Technology SAS
Priority to FR2104925A priority Critical patent/FR3122573B1/fr
Priority to CA3218197A priority patent/CA3218197A1/fr
Priority to AU2022273846A priority patent/AU2022273846A1/en
Priority to EP22729063.2A priority patent/EP4337262A1/fr
Priority to PCT/EP2022/062634 priority patent/WO2022238400A1/fr
Publication of FR3122573A1 publication Critical patent/FR3122573A1/fr
Application granted granted Critical
Publication of FR3122573B1 publication Critical patent/FR3122573B1/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Polyamides (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne une composition comprenant :- au moins une molécule conjuguée de façon covalente à une poly-lysine, et- au moins une molécule hydrophobe et non conjugable de façon covalente à une poly-lysine, ladite molécule étant encapsulée dans une micelle, et/ou au moins une molécule conjuguée à une poly-lysine par polymérisation, ladite molécule et la poly-lysine formant un copolymère. L’invention a également pour objet son procédé de fabrication et ses utilisations.
FR2104925A 2021-05-10 2021-05-10 Compositions de conjugués poly-lysine et de micelles et/ou de copolymères de poly-lysine Active FR3122573B1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
FR2104925A FR3122573B1 (fr) 2021-05-10 2021-05-10 Compositions de conjugués poly-lysine et de micelles et/ou de copolymères de poly-lysine
CA3218197A CA3218197A1 (fr) 2021-05-10 2022-05-10 Compositions de conjugues poly-lysine et de micelles et/ou de copolymeres de poly-lysine
AU2022273846A AU2022273846A1 (en) 2021-05-10 2022-05-10 Compositions of polylysine conjugates and of micelles and/or copolymers of polylysine
EP22729063.2A EP4337262A1 (fr) 2021-05-10 2022-05-10 Compositions de conjugues poly-lysine et de micelles et/ou de copolymeres de poly-lysine
PCT/EP2022/062634 WO2022238400A1 (fr) 2021-05-10 2022-05-10 Compositions de conjugues poly-lysine et de micelles et/ou de copolymeres de poly-lysine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR2104925A FR3122573B1 (fr) 2021-05-10 2021-05-10 Compositions de conjugués poly-lysine et de micelles et/ou de copolymères de poly-lysine
FR2104925 2021-05-10

Publications (2)

Publication Number Publication Date
FR3122573A1 FR3122573A1 (fr) 2022-11-11
FR3122573B1 true FR3122573B1 (fr) 2024-03-29

Family

ID=76284026

Family Applications (1)

Application Number Title Priority Date Filing Date
FR2104925A Active FR3122573B1 (fr) 2021-05-10 2021-05-10 Compositions de conjugués poly-lysine et de micelles et/ou de copolymères de poly-lysine

Country Status (5)

Country Link
EP (1) EP4337262A1 (fr)
AU (1) AU2022273846A1 (fr)
CA (1) CA3218197A1 (fr)
FR (1) FR3122573B1 (fr)
WO (1) WO2022238400A1 (fr)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2727117A1 (fr) * 1994-11-18 1996-05-24 Geffard Michel Utilisation de conjugues de la polylysine pour la preparation de medicaments utiles dans le traitement des maladies neurodegeneratives et des affections degeneratives a caractere autoimmun
GB9811059D0 (en) * 1998-05-23 1998-07-22 Univ Strathclyde Polyamino acid vesicles
DE10305661A1 (de) * 2003-02-12 2004-08-26 Degussa Ag Darreichungsform zur Kolon-spezifischen Wirkstofffreisetzung
FR2886153B1 (fr) * 2005-05-27 2009-04-10 Gemac Sa Composition destinee au traitement de la sclerose en plaques
FR2905868B1 (fr) * 2006-09-18 2012-12-21 Gemac Composition destinee au traitement de la sclerose laterale amyotrophique
FR2913335B1 (fr) * 2007-03-06 2009-06-05 Michel Geffard Utilisation de conjugues d'acides gras et de poly-l-lysine pour lutter contre des microorganismes pathogenes.
CN103656652B (zh) * 2013-12-10 2015-09-09 深圳先进技术研究院 一种双敏感响应型聚合物纳米胶束及其制备方法和应用
FR3048616B1 (fr) * 2016-03-14 2018-04-06 Polyneuros Polycomplexes de composes poly-lysine pour la prevention et/ou la lutte contre la sclerose laterale amyotrophique

Also Published As

Publication number Publication date
EP4337262A1 (fr) 2024-03-20
WO2022238400A1 (fr) 2022-11-17
FR3122573A1 (fr) 2022-11-11
AU2022273846A1 (en) 2023-12-07
CA3218197A1 (fr) 2022-11-17

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