FR2628429B1 - Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir - Google Patents
Variants de l'hirudine, leurs utilisations et les procedes pour les obtenirInfo
- Publication number
- FR2628429B1 FR2628429B1 FR8802925A FR8802925A FR2628429B1 FR 2628429 B1 FR2628429 B1 FR 2628429B1 FR 8802925 A FR8802925 A FR 8802925A FR 8802925 A FR8802925 A FR 8802925A FR 2628429 B1 FR2628429 B1 FR 2628429B1
- Authority
- FR
- France
- Prior art keywords
- hirudine
- variants
- obtaining
- processes
- improving
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000007625 Hirudins Human genes 0.000 abstract 1
- 108010007267 Hirudins Proteins 0.000 abstract 1
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 abstract 1
- 229940006607 hirudin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/855—Proteins from animals other than mammals or birds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Removal Of Specific Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8802925A FR2628429B1 (fr) | 1988-03-08 | 1988-03-08 | Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir |
| EP89400621A EP0332523B1 (fr) | 1988-03-08 | 1989-03-06 | Variants de l'hirudine, leurs utilisations et les procédés pour les obtenir |
| ES198989400621T ES2036809T3 (es) | 1988-03-08 | 1989-03-06 | Variantes de la hirudina, sus utilizaciones y los procedimientos para obtenerlas. |
| AT89400621T ATE84571T1 (de) | 1988-03-08 | 1989-03-06 | Hirudin-varianten, deren verwendung und verfahren zu deren herstellung. |
| DE8989400621T DE68904330T2 (de) | 1988-03-08 | 1989-03-06 | Hirudin-varianten, deren verwendung und verfahren zu deren herstellung. |
| PT89923A PT89923B (pt) | 1988-03-08 | 1989-03-07 | Processo para a preparacao de variantes da hiridina |
| CA000592974A CA1341429C (fr) | 1988-03-08 | 1989-03-07 | Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir |
| JP1057693A JP2961118B2 (ja) | 1988-03-08 | 1989-03-08 | ヒルジン変異体とその用途及び製造方法 |
| US07/320,530 US5087613A (en) | 1988-03-08 | 1989-03-08 | Hirudin variants |
| GR930400475T GR3007254T3 (enExample) | 1988-03-08 | 1993-03-05 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8802925A FR2628429B1 (fr) | 1988-03-08 | 1988-03-08 | Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2628429A1 FR2628429A1 (fr) | 1989-09-15 |
| FR2628429B1 true FR2628429B1 (fr) | 1990-12-28 |
Family
ID=9364012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8802925A Expired - Fee Related FR2628429B1 (fr) | 1988-03-08 | 1988-03-08 | Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5087613A (enExample) |
| EP (1) | EP0332523B1 (enExample) |
| JP (1) | JP2961118B2 (enExample) |
| AT (1) | ATE84571T1 (enExample) |
| CA (1) | CA1341429C (enExample) |
| DE (1) | DE68904330T2 (enExample) |
| ES (1) | ES2036809T3 (enExample) |
| FR (1) | FR2628429B1 (enExample) |
| GR (1) | GR3007254T3 (enExample) |
| PT (1) | PT89923B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8907110D0 (en) * | 1988-05-04 | 1989-05-10 | Ciba Geigy Ag | Improvements in the production of polypeptides |
| US5268296A (en) * | 1988-06-11 | 1993-12-07 | Ciba-Geigy Corporation | DNA vector and recombinant host cell for production of hirullin P6 and P18 |
| DE3835815A1 (de) * | 1988-10-21 | 1990-04-26 | Hoechst Ag | Neue isohirudine |
| FR2646437B1 (fr) * | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| US5663141A (en) * | 1989-12-01 | 1997-09-02 | Basf Aktiengesellschaft | Hirudin/polyalkylene glycol conjugates and hirudin muteins |
| US5780303A (en) * | 1990-04-06 | 1998-07-14 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| US6521594B1 (en) | 1990-04-06 | 2003-02-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| US5612311A (en) * | 1990-04-06 | 1997-03-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| US5672585A (en) * | 1990-04-06 | 1997-09-30 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| JP3111075B2 (ja) * | 1990-07-24 | 2000-11-20 | メレルダウファーマスーティカルズ インコーポレイテッド | 抗凝固ペプチド |
| US5574012A (en) * | 1990-07-24 | 1996-11-12 | Merrell Pharmaceuticals Inc. | Analogs of hirudin having anti-platelet activity |
| AU640502B2 (en) * | 1990-07-24 | 1993-08-26 | Merrell Dow Pharmaceuticals Inc. | Analogs of hirudin having antiplatelet activity |
| GB9023149D0 (en) * | 1990-10-24 | 1990-12-05 | British Bio Technology | Proteins and nucleic acids |
| US5837808A (en) * | 1991-08-20 | 1998-11-17 | Baxter International Inc. | Analogs of hirudin |
| WO1993004082A1 (en) * | 1991-08-20 | 1993-03-04 | Baxter International Inc. | Analogs of hirudin |
| GB9209032D0 (en) * | 1992-04-25 | 1992-06-10 | Ciba Geigy Ag | New peptide derivatives |
| NZ268159A (en) * | 1993-06-11 | 1997-03-24 | Merrell Pharma Inc | Anticoagulant and antiplatelet peptides and their use |
| DE4404168A1 (de) * | 1994-02-10 | 1995-08-17 | Hoechst Ag | Hirudinderivate und Verfahren zu deren Herstellung |
| US8377863B2 (en) * | 2007-05-29 | 2013-02-19 | Unigene Laboratories Inc. | Peptide pharmaceutical for oral delivery |
| CA2973099C (en) | 2015-01-12 | 2021-09-14 | Enteris Biopharma, Inc. | Solid oral dosage forms |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3586333T2 (de) * | 1984-03-27 | 1992-12-10 | Transgene Sa | Expressionsvektoren fuer hirudin, transformierte zellen und verfahren zur herstellung von hirudin. |
| DE3429430A1 (de) * | 1984-08-10 | 1986-02-20 | Hoechst Ag, 6230 Frankfurt | Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens |
| FR2607517B2 (fr) | 1986-12-01 | 1989-12-22 | Transgene Sa | Vecteurs d'expression de variants de l'hirudine dans les levures, procede et produit obtenu |
-
1988
- 1988-03-08 FR FR8802925A patent/FR2628429B1/fr not_active Expired - Fee Related
-
1989
- 1989-03-06 EP EP89400621A patent/EP0332523B1/fr not_active Expired - Lifetime
- 1989-03-06 DE DE8989400621T patent/DE68904330T2/de not_active Expired - Lifetime
- 1989-03-06 ES ES198989400621T patent/ES2036809T3/es not_active Expired - Lifetime
- 1989-03-06 AT AT89400621T patent/ATE84571T1/de not_active IP Right Cessation
- 1989-03-07 CA CA000592974A patent/CA1341429C/fr not_active Expired - Fee Related
- 1989-03-07 PT PT89923A patent/PT89923B/pt not_active IP Right Cessation
- 1989-03-08 US US07/320,530 patent/US5087613A/en not_active Expired - Lifetime
- 1989-03-08 JP JP1057693A patent/JP2961118B2/ja not_active Expired - Fee Related
-
1993
- 1993-03-05 GR GR930400475T patent/GR3007254T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE68904330T2 (de) | 1993-05-19 |
| PT89923B (pt) | 1994-05-31 |
| ES2036809T3 (es) | 1993-06-01 |
| EP0332523B1 (fr) | 1993-01-13 |
| GR3007254T3 (enExample) | 1993-07-30 |
| ATE84571T1 (de) | 1993-01-15 |
| EP0332523A1 (fr) | 1989-09-13 |
| US5087613A (en) | 1992-02-11 |
| CA1341429C (fr) | 2003-05-27 |
| PT89923A (pt) | 1989-11-10 |
| JPH029390A (ja) | 1990-01-12 |
| FR2628429A1 (fr) | 1989-09-15 |
| JP2961118B2 (ja) | 1999-10-12 |
| DE68904330D1 (de) | 1993-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |