FR2621482A1 - DENTAL CREAM CONDITIONED IN POLYOLEFIN PACKAGING - Google Patents

Abstract

Disclosed is a dental cream packaged in direct contact with the polyolefin resin surface of a package such as a laminate tube, mechanical dispenser or flexible sachet. The dental cream contains a water insoluble alkaline earth metal salt acceptable for dental use as a polishing agent, a liquid vehicle, a gelling agent and an additive which prevents syneresis. The liquid vehicle contains water, glycerin and sorbitol. The additive which prevents syneresis due to contact between dental cream and polyolefin resin is a nonionic block copolymer containing polyoxyethylene and polyoxypropylene moieties. Field of application: Production and packaging of toothpastes.

Description

The present invention relates to a dental cream packaged in a

  tube, mechanical dispenser, flexible bag, etc., of plastic laminate. It relates in particular to a dental cream in contact compatible with a polyolefinic surface of a package such as a laminated tube, a mechanical dispenser or a sachet

  flexible for dental cream, plastic.

  Dental creams have been packaged

  for many years in metal tubes

  such as paraffin-lined lead tubes, unlined aluminum tubes or aluminum tubes with an epoxy resin coating. In recent years, more and more flexible laminated tubes have been used

  plastics retaining their shape.

  Laminated plastic tubes

  for dental cream generally comprise a

  polyolefinic resin interior which is

  in direct contact with the dental cream and at least one intermediate layer, including a layer of aluminum foil which prevents loss of aroma of the dental cream. Advantageously, it is provided

  also a layer of intermediate paper which

  has rigidity to the tube. The outer layers

  typically consist of polyolefin resins

  some of them may be white

  and bear printed inscriptions that are

  by a transparent laminate overlayer in

  polyolefin. There may also be other

  Intermediate layered laminates made of flexible plastic material.

  The mechanical distributors of cream

  may also include a poly-

  olefinic in contact with the dental cream they contain. In fact, the polyolefin may itself constitute the casing of the dispenser. Packets in a flexible bag may also include a

  polyolefin surface in contact with the cream

silent.

  Dental creams generally contain

  a liquid carrier consisting of water and a humectant, a solid carrier consisting of a gelling agent, and a dental polishing agent.

  insoluble in water. A surfactant is also

  usually incorporated. Dental creams consisting of these materials in which the humectant comprises glycerin and sorbitol

  and the polishing material is an alkali metal salt

  lino-earths such as dicalcium phosphate have

  have been packaged successfully in medium containers

  flexible toothpaste tubes, comprising aluminum tubes which are not lined or which are internally coated with a layer of epoxy resin varnish. However, we note that when these dental creams are conditioned differently

  in containers with an inner surface

  polyolefin such as laminated tubes for

  dental creams, toothpaste

  mechanically operated or soft bags,

  plastic material, syneresis becomes a problem

  me and the liquids separate from the solids, which

  makes the dental cream unattractive.

  In the applicant's earlier patent applications and patents, it has been described

  additives intended to prevent syneresis of creams

  my teeth during contact with a polyolefin surface for dental creams containing a

  polishing agent of the alkali metal phosphate type

  lino-terrestrial or alpha-alumina trihydrate. These

  The following are the following: - French Patent Application No. 86.12 067, filed August 26, 1986, according to which the anti-syneresis additive for an alkali metal phosphate dental cream or alpha-alumina trihydrate is a polyethylene glycol glycol; the patent application of E. U. A. N 808 755,

  deposited on 13 December 1985, according to which the

  anti-syneresis for a dental cream, in the

  what the polishing agent is primarily a

  alkaline earth metal phosphate, is the propy-

lene glycol;

  - the French patent application 86.17 506 filed

  on December 15, 1986, according to which the anti-syneresis additive for a dental cream, in which the polishing agent is mainly an alkaline earth metal phosphate, is an alkyl ester of parahydroxybenzoic acid;

  - the French patent application 87.00 739, de-

  on January 22, 1987, according to which the anti-syneresis additive for a dental cream containing an alpha-alumina trihydrate or an alkaline earth metal phosphate is a vegetable oil; and

  - the French patent application 87.02 266, de-

  20 February 1987, according to which the additive

  anti-syneresis for a dental cream, in which

  the polishing agent is mainly alpha-

  alumina trihydrate, is benzoic acid.

  In each of the patent applications

  above, condensation products of ethylene oxide

  and propylene glycol, that is to say

  of the "Pluronic" type, are generally mentioned as a type of surfactant material which can be

  present in the various dental creams con-

  taking the particular anti-syneresis additives de-

crits.

  Japanese Published Patent Application No. 410/85 (Lion Corporation) describes a toothpaste

  in which glycerine is the only moisture agent

  or is mixed with another humectant such as sorbitol, glycerin being, in any case, present in a proportion greater than 20% by weight relative to the weight of the dentifrice, because lower proportions would result in undesirable evaporation of water when the

  toothpaste is packaged in a container

  carrying a plastic body of which at least the cylindrical portion has a water permeability of at least 5 a / m2.day.50 μm. High glycerin toothpaste is formulated to prevent evaporation and weight loss in this type

  particular container. The description includes

  the general proposition to use a polymer of ethylene oxide and propylene oxide as

surfactant.

  U.S. Patent 4,556,553 (Lion Corporation) discloses toothpastes containing an aluminum oxide type abrasive.

  in a container with oxygen permeability

  not less than 3 cm3 / m2.day.atm., whose

  The antiseptics are improved by the presence of a polyhydric alcohol, comprising a mixture of sorbitol

  and glycerine. There is a generic description there

  line according to which the ethylene oxide and propylene oxide condensation products can be used as surfactants in

  toothpastes containing aluminum oxide. What-

  toothpaste samples are described for comparison, which contain dicalcium phosphate with sodium lauryl sulfate as sole agent

surfactant.

  Japanese Patent Publication No. 86,526 / 78 (Lion Toothpaste Company) discloses that a separation of liquids and solids in a toothpaste containing anionic surfactant and a surfactant of

  block copolymer type of polyoxyethylene (that is,

  that is, a surfactant of the "Pluronic" type t) can be avoided by using a binder or a gelling agent consisting of at least one hydroxyethylcellulose and / or a xanthan gum instead of carrageenan, gum tragacanth, sodium carboxymethylcellulose, poly (sodium acrylate) or guar gum. The

  toothpastes described contain a human agent

  such as glycerine, sorbitol, propylene

  ethylene glycol or polyethylene glycol. The only

  humectant agents described in the formulas

  particulars, including those which avoid separation when using a gelling agent other than hydroxyethylcellulose or xanthan,

  contain glycerine and propylene glycol.

  U.S. Patent No. 4,353,890 (Col.

  gate-Palmolive Company) discloses toothpastes containing carrageenan as a gelling agent, which is stabilized by microwave radiation to maintain viscosity. A dicalcium phosphate toothpaste containing such carrageenan stabilized with a mixed humectant consisting of 4.5% by weight of glycerol and 17.5% by weight of sorbitol is exemplified and indicated as having been subjected to conservation tests. , including being packaged in containers having polyethylene parts. The detergent or

  the surfactant used in the toothpaste.

  this example is sodium lauryl sulphate.

  The patent contains a general description of the

"Pluronic" products as detergents.

  An advantage of the present invention is that a phase separation of a conditioned dental cream in contact with a final polyol material which would undergo a phase separation without the presence of an additive which obviates syneresis, is substantially

  enpêchée. Other benefits will emerge from the

following description.

  According to some of its aspects, the present invention relates to a packaged dental cream which

  is in direct contact with a surface of poly-

  ethylene or polypropylene at low or medium density

  in which syneresis occurs due to direct contact when said dental cream essentially comprises, as ingredients, about 20-75%

  by weight of a liquid vehicle essentially constituting

  killed by about 10 to 50% by weight of water and about 5.0

  15% by weight of glycerine and sorbitol, the

  a portion of glycerin and sorbitol totaling about 15 to 50% by weight, the weight ratio of glycerin to sorbitol being from about 0.25: 1 to about 1: 1, about 0.5 to 10% by weight a gelling agent for dental cream chosen from the foam

  of Ireland, la as tragacanth, carboxymethylcellulose,

  sodium hydroxide, hydroxyethylcellulose, polyvinyl

  pyrrolidone, sodium alginate, guar gowme,

  starch, xanthan and iota-carrageenan, and

  from 20 to 75% by weight of a polishing agent of

  type of alkaline earth metal salt (calcium or magnesium

  sium) insoluble in water, acceptable for use

  dental; said dental cream consisting essentially of

  in the said ingredients and, as the only additive

  intended to prevent syneresis in said cream

  during said direct contact, approximately 0.1 to 5% in

  weight of a polyoxy-nonionic block copolymer

ethylene-polyoxypropylene.

  In dental cream formulations,

  liquids and solids are necessarily

  portioned to form a creamy mass of desired consistency that can be extruded from

  of its packaging. The liquids contained in the pre-

  Dental creams include mainly water, glycerin and sorbitol. The total liquid vehicle amount is 20 to 75% by weight, based on the weight of the formulation. A gelling agent for dental creams is a natural or synthetic gum or a gum-like material, in particular, for example, Irish moss (carrageenan), gum tragacanth,

  sodium carboxymethylcellulose, hydroxyethylcellulose

  lose, polyvinylpyrrolidone, sodium alginate,

  guar gum, starch, xanthan or iota-car-

  raggenine, as well as their mixtures. The foam of Ir-

  heath, sodium carboxymethylcellulose and iota

  carrageenan, including their mixtures are particularly

  are compatible, and are gelling agents

  preferred. The gum content is in the

  from about 0.05 to 10%, and preferably from about

  0.5 to 5% by weight based on the weight of the formulation.

  Water is incorporated into the dentine cream

262 1,482

  in a proportion of about 10 to 50% by weight, preferably about 15 to 35%. Alycerin and sorbitol together generally constitute about 50% by weight, preferably about 20% to 35%, of the dental cream, the proportion of glycerine being about 5.0% to 15% by weight and the weight ratio of sorbitol glycerin being from about 0.25: 1 to about 0.8: 1, and preferably from about 0.25: 1 to about 0, about 25: 1 to about 1: 1; , 6: 1. It is preferable to use about 6 to 10% by weight of glycerin and about 17 to 24%

  by weight of sorbitol. The quantities of sorbitol used

  here are those of a sorbitol syrup as it is commercially available, that is to say

  70% by weight of sorbitol in 30% by weight of water.

  The polishing agent consisting of an alkali metal salt insoluble in water, acceptable in

  Oral use is present in the cream

  in a proportion of about 20 to 75% by weight, preferably about 35 to 60%. Examples of salts include dicalcium phosphate dihydrate,

  anhydrous dicalcium phosphate, calcium carbonate

  tricalcium phosphate, calcium pyrophosphate, dimagnesium phosphate trihydrate and

  magnesium carbonate, and mixtures thereof.

  More preferably, the salt present is a calcium salt, especially dicalcium phosphate dihydrate or dicalcium phosphate melanae dihydrate and

anhydrous dicalcium phosphate.

  In addition to the alkaline earth metal salt used as polishing agent, the dental cream can

  contain another polishing agent such as

  hydrated luminescence and calcined alumina, for example

  in a ratio by weight of the alkali metal salt

  no-earthy alumina from about 2.5: 1 to about

262 1,482

  4: 1, the total proportion of polishing material in the dental cream being from about 25 to 75% by weight.

  The only material used according to the present

  the invention to prevent syneresis when the dental cream is in direct contact with a low or medium polyethylene or polypropylene

  density is a poly-nonionic block copolymer

  oxyethylene-polyoxypropylene. The sequenced copolymer is also effective in the dental cream as a surfactant. He is present in one

  about 0.1 to 5% by weight, preferably

from about 0.5 to 3%.

  The nonionic surfactant used

  in the present invention is a block copolymer

  containing polyoxyethylene and polyoxypropyl

  lene. These block copolymers are available from Wyandotte Chemicals Corporation under the trademark "Pluronic". They can be liquid, paste or solid and they are usually defined

  chemically in terms of the molecular weight of the frag-

  hydrophobic polyoxypropylene and the percentage

  by weight of the hydrophilic polyoxyethylene moiety.

  The following block copolymers are available from Wyandotte: Pluronic Character% Fragment Molecular Weight N Physical Hydrophilic Hydrophobic Fragment

-------------------__----

  L121 Liquid 10 4000 L101 Liquid 10 3250 L81 Liquid 10 2250 L61 Liquid 10 1750 L31 Liquid 10 950 L122 Liquid 4000 L92 Liquid 20 2750 L72 Liquid 20 2050 L52 Liquid 20 1750 L42 Liquid 20 1200 P123 Paste 4000 P103 Paste 30 3250 L63 Liquid 30 1750 L43 Liquid 30 1200 P104 Paste 40 3250 P94 Paste 40 2750 P84 Paste 40 2250 P64 Liquid 40 1750 P44 Liquid 40 1200 P105 Paste 50 3250 P85 Paste 50 2250 P75 Paste 50 2050 P65 Paste 50 1750 P35 Liquid 50 950 F127 Solid 70 4000 F87 Solid 70 2250 P77 Solid 70 2050 F108 Solid 80 3250 F98 Solid 80 2750 F88 Solid 80 2250 F68 Solid 80 1750 F38 Solid 80 950 Preferred nonionic block copolymers are solid (or flaked)

262 1,482

  the most preferred ones are Pluronic F-108 (80%

  ether; polyoxypropylene of molecular weight

  3250) and F-87 (70% polyoxyethylene;

  oxypropylene of molecular weight 2250), F-127 (70%

  polyoxyethylene; polyoxypropylene of molecular weight

  4000) and L-72 (20% polyoxyethylene;

  lyoxypropylene with a molecular weight of 2050).

  Since the anti-syneresis agent which is the nonionic block copolymer produces substantially no foam in the dental cream, it can also be provided a surfactant

  anionic for its foaming character and for improving

  the detergent power. Surfactants can increase the prophylactic action, promote

  an intimate and total dispersion of the present

  throughout the oral cavity and

  more acceptable tooth creams

  cosmetic view. Anionic surfactant materials

  appropriate substances are water-soluble monosulphates

  monoglycerides of higher fatty acids such as the sodium salt of monosulphated monoglyceride

  of hydrogenated coconut oil fatty acids, (al-

  kyle higher) sulphates such as lauryl sulphate

  sodium, alkylaryl sulfonates such as dodecyl

  sodium cylbenzenesulphonate, olefin-sulfonate

  such as sodium olefin sulphonate in

  which the final ol group contains 12 to 22 carbon atoms, (higher alkyl) sulfoacetates,

  higher fatty acid esters of 1,2-dihydroxy-

  propane sulfonates and aliphatic acylamides

  substantially saturated aminocarboxylic acid

  lower aliphatic xylics such as those having

  12 to 16 carbon atoms in the fatty acid, the

  alkyl or acyl radicals, etc. Examples of amides

  mentioned last are N-lauroyl-sarco-

  sine and the sodium, potassium and ethanol

  mine of N-lauroyl-, N-myristoyl- or N-palmitoyl-

  sarcosine, which must be substantially free of

  soap or similar higher fatty acid that has

  to substantially reduce the effect of these compounds in the compositions of the present invention. The

  amides are particularly advantageous because they exert

  a prolonged and marked effect of inhibition of

  acid formation in the oral cavity due to

  composition of carbohydrates in addition to the fact

  that they reduce to a certain extent the solubility

  of dental enamel in acidic solutions.

  Another advantageous material is a long chain (long chain fatty acid monoglyceride) sodium sulfonate

  used alone or in combination with lauryl sulfa

  te of sodium. It is preferable to use about 0.2 to 5% by weight of surfactant in total,

  generally about 1 to 3%, in the case of

  the presence of anionic surfactant.

  The dental cream can also contain

  advantageously a fluorine-containing compound exerting

  beneficial effect on the care and hygiene of the oral cavity, for example a decrease in

  the solubility of enamel in acidic medium and a

  tection of teeth against cavities. Examples are sodium fluoride, stannous fluoride,

  potassium fluoride, the stannous fluoride of potas-

  sium (SnF2.KF), sodium hexafluorostanate, stannous chlorofluoride, sodium fluorozirconate and sodium monofluorophosphate. These materials which dissociate or release fluorine-containing ions in water may advantageously be present in an effective, but non-toxic, amount generally

  in the range of about 0.01 to 1% by weight, ex.

awarded in water-soluble fluorine.

  The preferred fluorine-containing compound is

  sodium monofluorophosphate, usually

  in a proportion of about 0.076 to 7.6% by weight,

  preferably 0.76%. A mixture of monofluorophos

  of sodium and sodium fluoride is also

  advantageously, for example in a ratio by weight

  about 2: 1, based on fluoride.

  Any flavoring substances or sweeteners

  appropriate examples can be used to confer

  a flavor to the composition of the present invention.

  Examples of suitable flavoring components include flavoring essences, for example the essences of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, cinnamon, lemon and orange.

  as well as methyl salicylate. Agents

  Suitable coreants include sucrose,

  lactose, maltose, xylitol, 6-methyl-3,4-di-

  hydro-1,2,3-oxathiazine-4-one sodium, sodium cyclamate, perillartine and sodium salt of

  saccharin. Advantageously, the aromatic agents

  sweeteners and sweeteners may together

* 0.01 to 5% or more of the compositions of the present invention.

this invention.

  Various other materials may be

  in the dental cream. Examples in

  are coloring or whitening agents,

  such as sodium benzoate, anti-corrosion agents, silicones, chlorophyll compounds, ammoniated materials such as

  that urea, diammonium phosphate, and their

  langes, as well as other constituents. The agents

  whiteners such as titanium dioxide, generally

  in approximately 0.5 to 2%

  have a beneficial effect on the appearance of composi-

  because when aging, it can

  appear some discolouration.

  Adjuvants are incorporated into the

  compositions in proportions which do not

  substantially undesirable properties and characteristics desired and they are selected and used in correct proportions that depend

  of the particular type of composition in question.

  It is also possible to incorporate antibacterial agents into oral compositions

  of the present invention, in a proportion of about

  0.01 to 5% by weight. Typical antibacterial agents include the following:

  Nl- (4-chlorobenzyl) -N5- (2,4-dichlorobenzyl) -

  biguanide; p-chlorophenyl biguanide; 4-chlorobenzhydryl biguanide; 4chlorobenzhydrylguanylurée; N-3-lauroxypropyl-N5-chlorobenzylbiguanide; 1,6-dichlorophenylbiguanidohexane; 1,6-bis- (2-éthylhexylbiguanido) -hexane;

  1- (lauryldimethylammonium) dichloride

  (P-chlorobenzyldiméthyl) ammonium) octane; 5,6-dichloro-2guanidinobenzimidazole; N1-p-chlorophenyl-N5-laurylbiguanide; amino-1,3 bis (2-ethylhexyl) -5-methylhexahydro-pyrimidine;

  and their non-toxic acid addition salts.

  Various calcium and magnesium ion suppressive agents can also be used to adjust the physical properties of the compositions. Agents

  appropriate are hydrosolated mineral polyphosphates

  such as tetrasodium pyrophosphate, pyrol

  disodium dihydrogen phosphate, a polyphosphate

  partially neutralized or acid being preferred. On au

  very suitable agents are the alkali metal salts

  flax, preferably sodium, citric acid.

  In general, these compounds represent a proportion

  minor wording of the formulation. The exact proportion

  varies according to the particular formulation, for example the physical characteristics of the dental cream, but in general it is about

0.1 to about 3% by weight.

  The dental cream must have a pH permitting

  both its practical use. A pH range of 5 to 10 is particularly advantageous. The pH mentioned must be understood as resulting from the determination of the pH directly on the dental cream. If desired, materials such as citric acid

  can be added to adjust the pH, for example

to 6 - 7.

  - The package in which the dental cream is incorporated may be any tube for

  dental cream, polyolefin laminate. For example

  The tube may be as elemental as that described in U.S. Patent No. 3,260,410.

  whose description is incorporated here by this

  reference. As described in the example of this

  vet, a thick aluminum foil base

  approximately 0.0013 cm is heated to a temperature of

  about 177 C and one side of the leaf

  heated is brought into contact with an extruded

  of a random copolymer of ethylene and acrylic acid (acid content of 3 + 0.5% and

  melt index of 8 1), while a film

  Low density polyethylene is applied

  be its opposite face. Using rollers

  trailed, we obtain a stratified base in which

  the copolymer layer is about 0.15 amm and the polyethylene layer is about 0.125 mm

  thick. The base is then put into the form

bent and welded.

  After having cut the tubular form into tube bodies, the tubes may be lined with the dental cream of the present invention without

  the dental cream undergoes syneresis.

  We can also successfully use

  laminated polyolefin toothpaste tubes

  more intermediate layers with the cream.

  of the present invention without the occurrence of

  syneresis. For example, the sheet structure

  multi-layer plaster for tubes of cream

  described under "prior art" in the context of the

  U.S. Patent No. 4,418,841 may be used.

  as well as structures that are more resistant to

  cracking that are described there. The description of

  U.S. Patent No. 4,418,841 is incorporated herein by this reference. In fact, dental creams

  of the present invention, packaged in

  of sheet material identified as Prior Art A and A-1 in U.S. Patent No. 4

  418 841 are very satisfactory and do not suffer

  if not syneresis. These tubes A and A-1 consist of layers as mentioned below, in the order of the outermost layer to

the innermost layer.

A A-1

  LDPE 37.5 micrometers LDPE 37.5 micrometers

  LDPE 50 micron LDPE pigmented 50 micro-

  meters Paper 40 microns Paper 40 microns LDPE 17.5 microns LDPE 50 microns EAA 82.5 microns PPO 25 microns EAA foil 25 microns 17.5 microns EAA 50 microns Metallic foil 17.5 microns LDPE 30 microns EAA 50 microns Total325 microns LDPE 30 micrometers Total 325 micrometers In columns A and A-1, the abbreviations have the following meanings: LDPE: low density polyethylene EAA: ethylene-acrylic acid copolymer

PP0: Oriented polypropylene.

  Low density polyethylene can be replaced by medium density polyethylene. In

  a package in a sachet for dental cream,

  fers medium density polyethylene.

  In the practice of this

  invention, it is also possible to use

  mechanically actuated devices, such as the

  for pasty substances, in particular, described in incorporated U.S. Patent No. 4,437,591.

  here by this reference. The shoemaker of these

  is commonly made of polyolefin resin

  fine such as polypropylene. Thus, the resin of

  casement forms mainly a layer whose surface

  this inner is in contact with the dental cream.

  When the dental cream of the present invention is packaged in such a polypropylene mechanical dispenser, it undergoes substantially no syneresis. The following properties are typical of low and medium density polyethylenes: Polyethylene Low Density Medium Density Transparent Transparent Clarity to Translucent to Translucent Elastic Limit 1,085,000 1,065,000 cm2 / kg / 0,001 cm Specific Gravity 0,910-0,925 0,926-0,940

resistance to trac-

  ASTM D-882 6900-24-150 13 800-34 500 kPa Elongation (per cent)

ASTM D-882 225-600 225-500

  Impact resistance (kg-cm) 7-11 4-6

Tear resistance

  ASTM D-1922 250-1000 125-750 g / 0, OQ1 cm Elmndorf) Hot welding range 120-175 125-155 ° C

Transfer speed of

  fear of water% relative humidity (HP 7.74 3.23-6.45 g / 24 ASTM E-96 h / 100 cm2 at 37 C Transmission 02-ASTM D-1434 150-515 100-205 cman3 / 0.001 cW / 100 an2 / 24h at ATM;

22.77 ° C; 0% RH)

  Transmission of 300-3050 305-515 ca3 /

CO 2-ASTMD-1434

0.001 c = 100 om2 / 24h at ATM;

22.77 ° C; 0% RH)

  Resistance to grease and oil Variable Good Maximum operating temperature (C) 65.5 82-105 Minimum operating temperature (C) 51 -51 Dimensional variations at a high RH value (% Nil Nil Automatic forming ability Fair Fair Printability Good if it is poor if treated Heat-shrinkable For some For some typical types Examples of polypropylene grades

  which can be used in particular as a bol-

  tier distributor for the dental cream are those

  supplied by Shell Chemical Company under the name

  Polypropylene DP 5A03 and Polypropylene DP 5A03S.

  These rheology-controlled products combine the workability of grades having a melt index of 12 with greater impact resistance (as measured by the drop test of a weight). They are designed for quick shaping in molds

with multiple cavities.

  The polypropylene grades DP 5A03 and DP A03S have the following typical properties: ASTM test Melting index 12 g / 10 min D 12381 Specific weight at 23 C 0.905 g / cm D 1505

Resistance to trac-

at 5.0 cm / min 34 MPa D 6382

Elongation at break

  re, at 5.0 cm / min 9% D 6382 Secant modulus of 1%, at 0.5 cm / min 1300 MPa D 6382 Flexural modulus, at 0.13 cm / min, 5 cm reach 1375 MPa D 790A2 Izod impact resistance

on a test piece

  cut to 23 C 26 J / m D 2562 to -18 C 15 J / m D 2562 Hardness Rockwell R92 D 785

Bending temperature

  under load at 455 kPa 104 C D 648 Vicat softening point 152C D 1525 1Conditions 230 / 2.16 ASTM specimen Type I, thickness 0.32 cm

(injection molded).

  The advantages of the invention are also

  maintained when the dental cream is condi-

  in a flexible bag having a polyolefin surface, generally of low polyethylene

density or medium density.

  The following non-limiting examples

  illustrate the present invention. All quantities

  and proportions are expressed by weight, except

contrary cation.

EXAMPLE 1

  The following creams are prepared with a creamy consistency and packaged in tubes each having laminated structures A and

A-1, described above.

Parts

A B

  Glycerine (99.3%) 10.00 10.00 Sorbitol (70%) 17.00 17.00 Sodium carboxymethylcellulose 0.95 0.95 Sodium saccharinate 0.20 0.20 Tetrasodium pyrophosphate 0.25 0.25 Monofluorophosphate sodium 0.76 0, 76 Dicalcium phosphate dihydrate 48.76 48.76 Sodium lauryl sulfate 1, 10 1.10 Flavor 0.89 0.89

Pluronic F-108 0,50 -

  Water supplement to 100.00 supplement

at 100,00

  The dental cream B begins to undergo a

  syneresis and phase separation after an old

  8-10 days at room temperature.

  The dental cream A remains stable against such a phase separation when it is aged at room temperature for periods exceeding

one year.

EXAMPLE 2

  The dental creams (A) and (B) are introduced into a mechanical dispenser according to U.S. Patent No. 4,437,591 consisting of a shoe box.

  polypropylene. The dental cream (1) retains its

  creamy while toothpaste (2)

liquid phase and solid phase.

  Results similar to those described in the Examples above are observed when: (i) each of Pluronic F-127 and F-87 replaces Pluronic F108; (ii) Pluronic L-72 replaces Pluronic F-108; (iii) Pluronic P-84 replaces Pluronic F-108; (iv) the relative proportions of glycerin and sorbitol (70%) are 5:20 and 12:15; (v) Each of the Irish Moss and

  iota-carrageenan replaces carboxymethyl

  sodium ethylcellulose; (vi) Dental creams are packaged in laminated tubes according to U.S. Patent No. 3,260,410; (vii) Dental creams are packaged in crack-resistant laminated tubes according to U.S. Patent No. 4,418,841; (viii) dental creams are packaged

  in flexible bags having the structure

  next step from the outer layer

  to the inner layer: - polyethylene terephthalate, 12.2 μm

  - white ethylene-acrylic acid copolymer

  that 21.3 μm - metal foil, 9.0 μm - ethylene-acrylic acid copolymer, 3.3 μm - medium-density polyethylene, 25.4 μm; and

  (ix) a mixture of 0.3 parts of carboxymethyl

  sodium cellulose and 0.6 part of iota

  carrageenan replaces carboxymethylcellulose

  sodium lulose as the sole gelling material

you.

262 1,482

Claims (10)

  1. Conditioned dental cream in direct contact with a polyethylene surface   or low or medium density polypropylene,   essentially taking, as ingredients,   20 to 75% by weight of a liquid vehicle es-   approximately 10 to 50% by weight of water and about 5.0 to 15% by weight of glycerin and   of sorbitol, the proportion of glycerin and   tol totaling from about 15 to 50% by weight, the weight ratio of glycerin to sorbitol being from about 0.25: 1 to about 1: 1, about 0.05% to 10% by weight of a gelling agent for dental cream chosen from Irish moss, gum tragacanth,   sodium carboxymethyl cellulose, hydroxyethyl   cellulose, polyvinylpyrrolidone, sodium alginate, guar gum, starch, xanthan and iota-carrageenan, and about 20 to 75% by weight   polishing agent consisting of a metal salt   alkaline earth (calcium or magnesium)   ble in water, acceptable for oral use; said dental cream consisting essentially of said ingredients and, as the only additive to prevent syneresis when the dental cream is subjected to said direct contact, about 0.1 to 5% by   weight of a polyoxy-nonionic block copolymer   ethylene-polyoxypropylene. 2. packaged dental cream according to claim 1, characterized in that the weight ratio of glycerin to sorbitol is about 0.25: 1 to about 0.8: 1.   3. Dental cream packaged according to the   claim 1, characterized in that the copolymer   re sequenced is a solid material.   4. Dental cream packaged according to the   Claim 3, characterized in that the copolymer   solid sequencing has a content of about 80% by weight of hydrophilic polyoxyethylene and contains   hydrophobic polyoxypropylene having a molecular weight about 3250.   5. Packaged dental cream according to claim 1, characterized in that said gelling agent is sodium carboxymethylcellulose, present in a proportion of about 0.5 to 5% by weight. weight.   6. packaged dental cream according to claim 1, characterized in that said alkaline earth metal salt insoluble in water is a calcium salt.   7. packaged dental cream according to claim 6, characterized in that the salt of   calcium is dicalcium phosphate dihydrate.   8. packaged dental cream according to claim 1, characterized in that it is   packaged in a laminated plastic tube   whose inner surface is in low density.   9. Dental cream packaged according to the   claim 1, characterized in that it is   packaged in a mechanical distributor comprising   a polypropylene resin box.   10. Dental cream packaged according to the   claim 1, characterized in that it is   packaged in a flexible bag, the surface of which   is low density polyethylene or polyethylene Lyethylene medium density.