FR2584723B1 - Nouveaux derives du dihydro-2,3 benzofuranne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives du dihydro-2,3 benzofuranne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2584723B1
FR2584723B1 FR8510459A FR8510459A FR2584723B1 FR 2584723 B1 FR2584723 B1 FR 2584723B1 FR 8510459 A FR8510459 A FR 8510459A FR 8510459 A FR8510459 A FR 8510459A FR 2584723 B1 FR2584723 B1 FR 2584723B1
Authority
FR
France
Prior art keywords
radical
dihydro
novel
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8510459A
Other languages
English (en)
French (fr)
Other versions
FR2584723A1 (fr
Inventor
Gilbert Lavielle
Yves-Michel Gargouil
Jean-Paul Vilaine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Priority to FR8510459A priority Critical patent/FR2584723B1/fr
Priority to US06/880,169 priority patent/US4727086A/en
Priority to CA000513161A priority patent/CA1268764A/fr
Priority to DE8686401513T priority patent/DE3661913D1/de
Priority to AT86401513T priority patent/ATE40358T1/de
Priority to AU59840/86A priority patent/AU584718B2/en
Priority to PT82945A priority patent/PT82945B/pt
Priority to IE183186A priority patent/IE58539B1/en
Priority to GR861778A priority patent/GR861778B/el
Priority to JP61160670A priority patent/JPS6284073A/ja
Priority to EP86401513A priority patent/EP0213006B1/fr
Priority to NZ216785A priority patent/NZ216785A/xx
Priority to OA58900A priority patent/OA08358A/xx
Priority to ZA865124A priority patent/ZA865124B/xx
Priority to DK326986A priority patent/DK165953C/da
Priority to ES8600208A priority patent/ES2000481A6/es
Publication of FR2584723A1 publication Critical patent/FR2584723A1/fr
Priority to US07/074,131 priority patent/US4751230A/en
Application granted granted Critical
Publication of FR2584723B1 publication Critical patent/FR2584723B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR8510459A 1985-07-09 1985-07-09 Nouveaux derives du dihydro-2,3 benzofuranne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent Expired FR2584723B1 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
FR8510459A FR2584723B1 (fr) 1985-07-09 1985-07-09 Nouveaux derives du dihydro-2,3 benzofuranne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US06/880,169 US4727086A (en) 1985-07-09 1986-06-30 Certain anti-hypertensive 2,3-dihydrobenzofuran compounds
CA000513161A CA1268764A (fr) 1985-07-09 1986-07-04 Derives du dihydro-2,3 benzofuranne, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
JP61160670A JPS6284073A (ja) 1985-07-09 1986-07-08 ２，３−ジヒドロベンゾフラン誘導体
AU59840/86A AU584718B2 (en) 1985-07-09 1986-07-08 New derivatives of 2,3-dihydro benzofuran, their preparation and the pharmaceutical compositions containing them
PT82945A PT82945B (pt) 1985-07-09 1986-07-08 Processo para a preparacao de novos derivados de 2,3-dihidro-benzofurano
IE183186A IE58539B1 (en) 1985-07-09 1986-07-08 New derivatives of 2,3-dihydro benzofuran, their preparation and the pharmaceutical compositions containing them
GR861778A GR861778B (en) 1985-07-09 1986-07-08 Method for preparing novel dihydro-2,3 benzofurane
DE8686401513T DE3661913D1 (en) 1985-07-09 1986-07-08 Derivatives of 2,3-dihydro-benzofurane, processes for their preparation and pharmaceutical compositions containing them
EP86401513A EP0213006B1 (fr) 1985-07-09 1986-07-08 Nouveaux dérivés du dihydro-2,3 benzofuranne, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
NZ216785A NZ216785A (en) 1985-07-09 1986-07-08 3-phenyl-3-(3-aminopropyl)-dihydrobenzofuran derivatives and pharmaceutical compositions
AT86401513T ATE40358T1 (de) 1985-07-09 1986-07-08 2,3-dihydrobenzofuran-derivate, mehrere verfahren zu ihrer herstellung und sie enthaltende arzneimittel.
OA58900A OA08358A (fr) 1985-07-09 1986-07-09 Nouveaux dérivés du dihydro-2,3 benzofuranne, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
ZA865124A ZA865124B (en) 1985-07-09 1986-07-09 Derivatives of 2,3 dihydro benzofuran,their preparation and the pharmaceutical compositions containing them
DK326986A DK165953C (da) 1985-07-09 1986-07-09 Fremgangsmaade til fremstilling af 2,3-dihydrobenzofuranderivater
ES8600208A ES2000481A6 (es) 1985-07-09 1986-07-09 Procecimiento de preparacion de nuevos derivados del dihidro-2,3 benzofurano
US07/074,131 US4751230A (en) 1985-07-09 1987-07-16 2,3-dihydrobenzofuran compounds, composition and their method of use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8510459A FR2584723B1 (fr) 1985-07-09 1985-07-09 Nouveaux derives du dihydro-2,3 benzofuranne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2584723A1 FR2584723A1 (fr) 1987-01-16
FR2584723B1 true FR2584723B1 (fr) 1988-02-12

Family

ID=9321095

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8510459A Expired FR2584723B1 (fr) 1985-07-09 1985-07-09 Nouveaux derives du dihydro-2,3 benzofuranne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (16)

Country Link
US (2) US4727086A (enExample)
EP (1) EP0213006B1 (enExample)
JP (1) JPS6284073A (enExample)
AT (1) ATE40358T1 (enExample)
AU (1) AU584718B2 (enExample)
CA (1) CA1268764A (enExample)
DE (1) DE3661913D1 (enExample)
DK (1) DK165953C (enExample)
ES (1) ES2000481A6 (enExample)
FR (1) FR2584723B1 (enExample)
GR (1) GR861778B (enExample)
IE (1) IE58539B1 (enExample)
NZ (1) NZ216785A (enExample)
OA (1) OA08358A (enExample)
PT (1) PT82945B (enExample)
ZA (1) ZA865124B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58555B1 (en) * 1984-12-10 1993-10-06 Warner Almbert Company Novel benzothiophenes and benzofurans having antiallergy activity
FR2594438B1 (fr) * 1986-02-14 1990-01-26 Labaz Sanofi Nv Derives d'indolizine, leur procede de preparation ainsi que les compositions en contenant
IL87451A0 (en) * 1987-09-04 1989-01-31 Tanabe Seiyaku Co Benzofuran derivatives,their preparation and pharmaceutical compositions containing them
TW472051B (en) 1997-05-23 2002-01-11 Chugai Pharmaceutical Co Ltd 2,3-dihydrobenzofuran derivatives
US7186726B2 (en) 1998-06-30 2007-03-06 Neuromed Pharmaceuticals Ltd. Preferentially substituted calcium channel blockers
US6943168B2 (en) 1998-06-30 2005-09-13 Neuromed Technologies Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US6387897B1 (en) 1998-06-30 2002-05-14 Neuromed Technologies, Inc. Preferentially substituted calcium channel blockers
US6951862B2 (en) 1998-06-30 2005-10-04 Neuromed Technologies, Inc. Calcium channel blockers comprising two benzhydril moieties
US20040266784A1 (en) * 1998-06-30 2004-12-30 Snutch Terrance P. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US20060084660A1 (en) * 1998-06-30 2006-04-20 Neuromed Technologies Inc. Calcium channel blockers comprising two benzhydril moieties
US7855755B2 (en) * 2005-11-01 2010-12-21 Donnelly Corporation Interior rearview mirror assembly with display
US20050227999A1 (en) * 2004-04-09 2005-10-13 Neuromed Technologies Inc. Diarylamine derivatives as calcium channel blockers
US8362021B2 (en) * 2006-05-11 2013-01-29 Zalicus Pharmaceuticals Ltd. Method for increasing the bioavailability of benzhydryl piperazine containing compounds
FR2954962B1 (fr) 2010-01-07 2012-04-13 Valeo Materiaux De Friction Disque d'embrayage et garniture de friction comportant un materiau de friction d'inertie reduite colle sur un clinquant.
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
AU2012225459A1 (en) 2011-03-08 2013-10-10 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
CN114846001B (zh) * 2019-12-27 2024-01-23 南京明德新药研发有限公司 苯并稠环类化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2891955A (en) * 1956-11-23 1959-06-23 Merck Ag E Process of manufacturing isoquinolinium and 5, 6, 7, 8-tetrahydro-isoquinolinium salts
US3156688A (en) * 1962-11-05 1964-11-10 Abbott Lab Nu-alkyl and nu-aralkyl benzoxacycloalkanemethylamines
US4276294A (en) * 1978-11-30 1981-06-30 Ciba-Geigy Corporation Benzofurylpiperazines
US4291042A (en) * 1979-01-26 1981-09-22 John Wyeth & Brother Limited Antidepressant piperidine derivatives
US4602035A (en) * 1983-12-07 1986-07-22 Hoechst-Roussel Pharmaceuticals Inc. Antidepressant (3-aryl-2,3-dihydrobenzofuran-3-yl)alkylamines

Also Published As

Publication number Publication date
AU584718B2 (en) 1989-06-01
CA1268764A (fr) 1990-05-08
GR861778B (en) 1986-11-10
FR2584723A1 (fr) 1987-01-16
DK165953B (da) 1993-02-15
PT82945A (pt) 1986-08-01
OA08358A (fr) 1988-02-29
DK326986A (da) 1987-01-10
IE58539B1 (en) 1993-10-06
EP0213006B1 (fr) 1989-01-25
NZ216785A (en) 1988-10-28
US4751230A (en) 1988-06-14
JPH0433794B2 (enExample) 1992-06-04
IE861831L (en) 1987-01-09
PT82945B (pt) 1988-07-01
JPS6284073A (ja) 1987-04-17
EP0213006A1 (fr) 1987-03-04
DE3661913D1 (en) 1989-03-02
AU5984086A (en) 1987-01-15
ZA865124B (en) 1987-03-25
ES2000481A6 (es) 1988-03-01
DK165953C (da) 1993-07-05
ATE40358T1 (de) 1989-02-15
DK326986D0 (da) 1986-07-09
US4727086A (en) 1988-02-23

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Legal Events

Date Code Title Description
ST Notification of lapse