FR2561916B1 - Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau - Google Patents

Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau

Info

Publication number
FR2561916B1
FR2561916B1 FR8405058A FR8405058A FR2561916B1 FR 2561916 B1 FR2561916 B1 FR 2561916B1 FR 8405058 A FR8405058 A FR 8405058A FR 8405058 A FR8405058 A FR 8405058A FR 2561916 B1 FR2561916 B1 FR 2561916B1
Authority
FR
France
Prior art keywords
temperature
lyophilization
phase
preparation
galenic form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8405058A
Other languages
English (en)
French (fr)
Other versions
FR2561916A1 (fr
Inventor
Louis Lafon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Priority to FR8405058A priority Critical patent/FR2561916B1/fr
Priority to CA000476784A priority patent/CA1233119A/en
Priority to DE8585400528T priority patent/DE3562555D1/de
Priority to AT85400528T priority patent/ATE34078T1/de
Priority to AU40153/85A priority patent/AU567271B2/en
Priority to EP85400528A priority patent/EP0159237B1/en
Priority to US06/714,686 priority patent/US4616047A/en
Priority to ZA852168A priority patent/ZA852168B/xx
Priority to ES542483A priority patent/ES8607011A1/es
Priority to JP60064081A priority patent/JPS60224617A/ja
Publication of FR2561916A1 publication Critical patent/FR2561916A1/fr
Application granted granted Critical
Publication of FR2561916B1 publication Critical patent/FR2561916B1/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
FR8405058A 1984-03-30 1984-03-30 Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau Expired FR2561916B1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR8405058A FR2561916B1 (fr) 1984-03-30 1984-03-30 Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau
CA000476784A CA1233119A (en) 1984-03-30 1985-03-18 Method for preparing a galenic form for oral administration by lyophilization of an oil-in-water emulsion
AT85400528T ATE34078T1 (de) 1984-03-30 1985-03-20 Arzneiform zur oralen verabreichung sowie verfahren zu deren herstellung durch gefriertrocknen einer oel-in-wasser-emulsion.
AU40153/85A AU567271B2 (en) 1984-03-30 1985-03-20 Lyophilization of oil in water emulsion to give galenic form for oral administration
DE8585400528T DE3562555D1 (en) 1984-03-30 1985-03-20 Galenical form for oral administration and its method of preparation by lyophilization of an oil-in-water emulsion
EP85400528A EP0159237B1 (en) 1984-03-30 1985-03-20 Galenical form for oral administration and its method of preparation by lyophilization of an oil-in-water emulsion
US06/714,686 US4616047A (en) 1984-03-30 1985-03-21 Galenic form for oral administration and its method of preparation by lyophilization of an oil-in-water emulsion
ZA852168A ZA852168B (en) 1984-03-30 1985-03-22 Galenic form for oral administration and its method of preparation by lyophilization of an oil-in-water emulsion
ES542483A ES8607011A1 (es) 1984-03-30 1985-03-29 Procedimiento de preparacion de una forma galenica para ad- ministracion por via oral
JP60064081A JPS60224617A (ja) 1984-03-30 1985-03-29 経口投与用の製剤及びその水中油型エマルジヨン凍結乾燥による調製方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8405058A FR2561916B1 (fr) 1984-03-30 1984-03-30 Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau

Publications (2)

Publication Number Publication Date
FR2561916A1 FR2561916A1 (fr) 1985-10-04
FR2561916B1 true FR2561916B1 (fr) 1987-12-11

Family

ID=9302670

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8405058A Expired FR2561916B1 (fr) 1984-03-30 1984-03-30 Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau

Country Status (10)

Country Link
US (1) US4616047A (enExample)
EP (1) EP0159237B1 (enExample)
JP (1) JPS60224617A (enExample)
AT (1) ATE34078T1 (enExample)
AU (1) AU567271B2 (enExample)
CA (1) CA1233119A (enExample)
DE (1) DE3562555D1 (enExample)
ES (1) ES8607011A1 (enExample)
FR (1) FR2561916B1 (enExample)
ZA (1) ZA852168B (enExample)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4572915A (en) * 1984-05-01 1986-02-25 Bioglan Laboratories Clear micellized solutions of fat soluble essential nutrients
JPS60239417A (ja) * 1984-05-15 1985-11-28 Sankyo Co Ltd エマルシヨン凍結乾燥製剤の製法
IL78930A0 (en) * 1985-07-29 1986-09-30 Abbott Lab Lyophilized emulsion compositions for parenteral administration
DE3702029A1 (de) * 1987-01-24 1988-08-04 Basf Ag Waessriges oder pulverfoermiges, wasserdispergierbares praeparat eines in wasser schwerloeslichen pharmazeutischen wirkstoffs und verfahren zu seiner herstellung
IL86892A (en) * 1987-07-08 1993-04-04 Lafon Labor Filter comprising a material obtained by freeze-drying, its preparation and its use, especially in pharmacy
FR2645740B1 (fr) * 1989-04-12 1994-01-28 Fabre Cosmetique Pierre Compositions topiques triphasiques et extemporanement emulsionnables utiles en cosmetologie et/ou dermatologie
US5039540A (en) * 1989-08-14 1991-08-13 Neophore Technologies, Inc. Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
US5079018A (en) * 1989-08-14 1992-01-07 Neophore Technologies, Inc. Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
JP3074731B2 (ja) * 1989-12-01 2000-08-07 日本新薬株式会社 脂肪乳剤
WO1991007964A1 (fr) * 1989-12-01 1991-06-13 Nippon Shinyaku Co., Ltd. Emulsion de graisse
US5188825A (en) * 1989-12-28 1993-02-23 Iles Martin C Freeze-dried dosage forms and methods for preparing the same
KR930006431B1 (ko) * 1990-10-11 1993-07-16 재단법인 한국화학연구소 약물의 미세캡슐화 방법
WO1992017162A1 (en) * 1991-04-05 1992-10-15 Warner-Lambert Company Lyophilized emulsion
GB9200247D0 (en) * 1992-01-07 1992-02-26 Erba Carlo Spa Pharmaceutical compositions containing polymer derivative-bound anthracycline glycosides and a method for their preparation
IL101007A (en) * 1992-02-18 1997-08-14 Pharmos Ltd Dry stable compositions prepared by lyophilization
HUT75616A (en) * 1992-03-17 1997-05-28 Pfizer Method for prooucing porous delivery devices
US5298261A (en) * 1992-04-20 1994-03-29 Oregon Freeze Dry, Inc. Rapidly distintegrating tablet
EP0663818A4 (en) * 1992-09-03 1996-04-24 Ibah Inc TASTE-COVERING PHARMACEUTICAL SUMMARY AND METHOD FOR PRODUCING THE SAME.
DE4244122C1 (de) * 1992-12-24 1994-06-01 Sanol Arznei Schwarz Gmbh Lyophilisierte, wirkstoffhaltige Emulsion zur intravenösen Applikation
US5382437A (en) * 1993-10-25 1995-01-17 Hunter Research Corporation Frozen liquified gas composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
GB9421836D0 (en) * 1994-10-28 1994-12-14 Scherer Corp R P Process for preparing solid pharmaceutical dosage forms of hydrophobic substances
KR0181252B1 (ko) 1996-12-31 1999-03-20 박원훈 에멀젼 방법에 의한 다공성 매트릭스형 서방성 제제의 제조방법
GB9702799D0 (en) * 1997-02-12 1997-04-02 Scherer Corp R P Process for preparing solid pharmaceutical dosage forms
DK1001748T3 (da) * 1997-07-25 2006-08-21 Alpex Pharma Sa Fremgangsmåde til fremstilling af et granulat, som er egnet til fremstilling af i munden oplöselige tabletter, som kan sönderdeles hurtigt
ATE355856T1 (de) * 1998-07-30 2007-03-15 Point Biomedical Corp Neuer wirkstoffträger für die gefriertrocknung von wässrigen suspensionen von mikropartikeln
US20040013613A1 (en) * 2001-05-18 2004-01-22 Jain Rajeev A Rapidly disintegrating solid oral dosage form
US8236352B2 (en) 1998-10-01 2012-08-07 Alkermes Pharma Ireland Limited Glipizide compositions
JP2001089398A (ja) * 1999-09-20 2001-04-03 Meiji Seika Kaisha Ltd 経口投与用の凍結乾燥製剤及びその製造方法
US6316029B1 (en) 2000-05-18 2001-11-13 Flak Pharma International, Ltd. Rapidly disintegrating solid oral dosage form
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
EP1385548B1 (en) * 2001-01-26 2007-05-23 Schering Corporation Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions
KR20070120617A (ko) * 2001-01-26 2007-12-24 쉐링 코포레이션 치환된 아제티딘온 화합물을 포함하는 약제학적 조성물
TW200840563A (en) * 2001-01-26 2008-10-16 Schering Corp Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(S) and treatments for vascular indications
NZ542090A (en) * 2001-01-26 2006-09-29 Schering Corp Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
PT1363668E (pt) * 2001-01-26 2007-11-07 Schering Corp Combinaçoes de sequestrante(s) de ácidos biliares e inibidor(es) de absorção de esterol e tratamento de indicações vasculares
IL156445A0 (en) * 2001-01-26 2004-01-04 Schering Corp Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
WO2002083102A1 (en) * 2001-02-23 2002-10-24 Cima Labs Inc. Emulsions as solid dosage forms for oral administration
WO2002096415A2 (en) * 2001-05-25 2002-12-05 Schering Corporation Use of azetidinone substituted derivatives in the treatment of alzheimer's disease
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
DE60229406D1 (de) * 2001-09-21 2008-11-27 Schering Corp Verfahren zur behandlung oder verhinderung von vaskulärer entzündung mit sterol-absorbierungs- inhibitor(en)
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
EP1429756B1 (en) * 2001-09-21 2006-11-22 Schering Corporation Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
JP2005508939A (ja) * 2001-10-12 2005-04-07 エラン ファーマ インターナショナル，リミティド 即時放出および徐放特性を組み合わせて有する組成物
EP1941878A1 (en) 2002-01-10 2008-07-09 Biovail Laboratories International Srl Sedative non-benzodiazepine formulations
US20030215502A1 (en) * 2002-03-20 2003-11-20 Elan Pharma International Limited Fast dissolving dosage forms having reduced friability
CA2504916A1 (en) * 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
ATE514418T1 (de) * 2002-11-12 2011-07-15 Elan Pharma Int Ltd Rasch zerfallende feste darreichungsformen mit nichtbröseliger konsistenz und pullulan
WO2004081004A1 (en) * 2003-03-07 2004-09-23 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
DE602004018617D1 (de) 2003-03-07 2009-02-05 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
WO2004081002A1 (en) 2003-03-07 2004-09-23 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US20050036977A1 (en) * 2003-08-11 2005-02-17 Dilip Gole Taste-masked resinate and preparation thereof
WO2005046797A2 (en) * 2003-11-05 2005-05-26 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
DK1858342T3 (da) * 2005-03-08 2009-08-24 Nestec Sa Fremgangsmåde til fremstilling af ernæringssammensætninger
US7345178B2 (en) 2005-08-04 2008-03-18 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US20160045457A1 (en) 2005-09-09 2016-02-18 Ousama Rachid Epinephrine fine particles and methods for use thereof for treatment of conditions responsive to epinephrine
WO2013059629A1 (en) 2011-10-21 2013-04-25 Nova Southeastern University Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
US9877921B2 (en) 2005-09-09 2018-01-30 Nova Southeastern University Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
US20080031947A1 (en) * 2006-07-24 2008-02-07 Cima Labs Inc. Orally dissolvable/disintegrable lyophilized dosage forms containing protected
DE102008015366A1 (de) * 2008-03-20 2009-09-24 Merck Patent Gmbh Lyophilisierte Nanoemulsion
EP2359812A1 (en) * 2010-01-18 2011-08-24 Cephalon France Oral lyophilised compositions
EP2525783A1 (en) 2010-01-18 2012-11-28 Cephalon France Improved oral lysophilisates containing pvp/va
US20120322884A1 (en) 2010-03-01 2012-12-20 University Of Manitoba Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
KR20130138768A (ko) 2010-09-01 2013-12-19 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 아고니스트의 신속-용해성 투여 형태
TR201007613A2 (tr) * 2010-09-16 2012-04-24 Yed�Tepe �N�Vers�Tes� Liyofilize biyopestisit efervesan granül ve üretim yöntemi
NZ611467A (en) 2010-12-02 2015-06-26 Aptalis Pharmatech Inc Rapidly dispersing granules, orally disintegrating tablets and methods
CA2876883C (en) 2012-06-15 2022-11-01 Nova Southeastern University Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
ES2882530T3 (es) 2013-03-22 2021-12-02 Univ Nova Southeastern Partículas finas de epinefrina y métodos para uso de las mismas para el tratamiento de condiciones que responden a la epinefrina
CN111565716B (zh) 2017-09-08 2023-06-09 因斯格尼斯疗法有限公司 使用地匹福林的方法
EP3866774B1 (en) 2018-10-19 2026-01-28 Nova Southeastern University Sublingual epinephrine compositions including ph-modifying excipients and penetration enhancers and methods for use thereof
WO2020180608A1 (en) 2019-03-01 2020-09-10 Insignis Therapeutics, Inc. Dipivefrin orally disintegrating tablet formulations
WO2021062374A1 (en) 2019-09-27 2021-04-01 Duke University Tabletization of peptide self-assemblies and methods of making and using the same
GB2638418A (en) * 2024-02-21 2025-08-27 Novumgen Ltd An orodispersible tablet of spironolactone and its process of preparation

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2520939A (en) * 1947-01-27 1950-09-05 Inst Divi Thomae Foundation Process of concentrating milk
GB806723A (en) * 1955-09-02 1958-12-31 Ici Ltd New pharmaceutical compositions
US3464834A (en) * 1963-11-18 1969-09-02 Grace W R & Co Freeze-drying ice milk confections
DE2017373A1 (de) * 1969-04-15 1971-04-22 Orsymonde S A , Paris Lyophihsierte Produkte und Ver fahren zu ihrer Herstellung
CH558659A (fr) * 1969-11-26 1975-02-14 Orsymonde Procede pour la preparation d'une composition lyophilisee a usage hygienique.
ZA738657B (en) * 1973-01-05 1974-10-30 Hoffmann La Roche Emulsions
GB1447988A (en) * 1973-04-03 1976-09-02 Orsymonde Pharmaceutical compositions
US4001944A (en) * 1975-08-25 1977-01-11 Parke, Davis & Company Freeze-drying process
US3961424A (en) * 1975-08-28 1976-06-08 General Foods Corporation Process for freezing coffee extract prior to lyophilization
JPS5296724A (en) * 1976-02-10 1977-08-13 Kyowa Hakko Kogyo Co Ltd Preparation of powdery products
JPS52125615A (en) * 1976-04-09 1977-10-21 Kyowa Hakko Kogyo Co Ltd Method of making powdered products
IL53427A0 (en) * 1976-11-24 1978-01-31 Lilly Co Eli Method of preparing a rapidly dissolving powder of sterile crystalline cefozolin sodium for parenteral administration
US4273762A (en) * 1979-12-03 1981-06-16 Merck & Co., Inc. Lyophilization process for live viral compositions
US4295280A (en) * 1980-03-17 1981-10-20 American Home Products Corporation Method of obtaining a lyophilized product
US4521975A (en) * 1981-05-04 1985-06-11 Marquest Medical Products, Inc. Lyophilizing and forming biologicals having a predetermined unit dosage
FR2539626B2 (fr) * 1983-01-25 1985-06-21 Lafon Labor Nouveau procede de preparation de formes galeniques utiles notamment en therapeutique, dietetique, cosmetique et diagnostic, et formes obtenues selon ce procede

Also Published As

Publication number Publication date
DE3562555D1 (en) 1988-06-16
JPS60224617A (ja) 1985-11-09
EP0159237A1 (en) 1985-10-23
ZA852168B (en) 1985-11-27
FR2561916A1 (fr) 1985-10-04
ATE34078T1 (de) 1988-05-15
US4616047A (en) 1986-10-07
EP0159237B1 (en) 1988-05-11
ES8607011A1 (es) 1986-05-16
JPH0581567B2 (enExample) 1993-11-15
AU567271B2 (en) 1987-11-12
ES542483A0 (es) 1986-05-16
CA1233119A (en) 1988-02-23
AU4015385A (en) 1985-10-03

Similar Documents

Publication Publication Date Title
AU567271B2 (en) Lyophilization of oil in water emulsion to give galenic form for oral administration
DK1073415T3 (da) Gelerbare farmaceutiske sammensætninger
KR960016908A (ko) 제약학상 담체
DE3176125D1 (en) 1-carboxyalkanoylindolin-2-carboxylic acids and derivatives thereof, processes for their preparation, and pharmaceutical compositions containing these compounds
KR940021050A (ko) 승압 조건하에서의 리포좀 분산물의 제조방법
EP0221041A3 (en) Benzimidazole derivatives, process for their preparation and their pharmaceutical use
DK653688D0 (da) Stabiliserede laegemiddelaktive forbindelser, fremgangsmaade til deres frmstilling samt stabile laegemiddelpraeparater
IT1216570B (it) Composizione farmaceutiche a rilascio controllato e procedimento per la loro preparazione.
NO822222L (no) Fremgangsmaate for fremstilling av pyrrolidinderivater
KR900701174A (ko) 인지질-함유 조성물, 이의 제조방법 및 이의 약제학적 물질용 부형제로서의 용도
NO20012011L (no) Fremstilling og anvendelse av stivnede oljer
EP1097712A4 (en) STAPS CONTAINING CATAPLASMS AND METHOD OF MANUFACTURING SAME
AU8215791A (en) Method for preparing a lipoprotein modified by the incorporation of a lipophilic active substance
JPS6416716A (en) Production of emulsion pharmaceutical containing sparingly soluble drug sealed therein
HUT45537A (en) Process for producing delta-22 derivatives of ll-f 28249 compounds and pharmaceutical compositions containing them as active components, and insecticide compositions
KR950000168A (ko) 반고형 약제 및 그 제조 방법
KR930023338A (ko) 데포우 제제
BR9906975A (pt) Composto, uso do mesmo, composição farmacêutica, e, processo para estimular a liberação do hormÈnio do crescimento pela pituitária de um mamìfero
DE60031557D1 (de) Steroide, ihre herstellung , pharmazeutische zusammensetzungen mit ihnen und verwendungen dieser verbindungen
KR940021524A (ko) 1,2,5,6-테트라하이드로피리딘 유도체와 이의 제조 방법 및 치료시 이의 이용방법
DK159649C (da) 4-hydroxy-alfa-benzhydrolderivater, fremgangsmaade til fremstilling deraf, farmaceutiske praeparater indeholdende disse, samt fremgangsmaade til fremstilling af disse farmaceutiske praeparater
KR930010580B1 (ko) 실리실산메칠, L-멘톨, dl-캄파등의 휘발성 물질을 다량 함유한 크림제의 조성 및 제법
IE48692B1 (en) Endoparasiticidal pastes for horses
SU400299A1 (ru) Состав самопроизвольно эмульгирующегося копцентрата метафоса
KR970009793A (ko) 이부프로펜 용액을 함유한 연질캅셀제

Legal Events

Date Code Title Description
ST Notification of lapse