FR2552427B1 - Nouveau procede de preparation de l'hydroxy-2 (hydroxy-1((methyl-1 phenyl-3 propyl) amino)-2 ethyl)-5 benzamide et compositions therapeutiques a base du compose obtenu selon ce nouveau procede - Google Patents

Nouveau procede de preparation de l'hydroxy-2 (hydroxy-1((methyl-1 phenyl-3 propyl) amino)-2 ethyl)-5 benzamide et compositions therapeutiques a base du compose obtenu selon ce nouveau procede

Info

Publication number
FR2552427B1
FR2552427B1 FR8414820A FR8414820A FR2552427B1 FR 2552427 B1 FR2552427 B1 FR 2552427B1 FR 8414820 A FR8414820 A FR 8414820A FR 8414820 A FR8414820 A FR 8414820A FR 2552427 B1 FR2552427 B1 FR 2552427B1
Authority
FR
France
Prior art keywords
hydroxy
new process
benzamide
propyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8414820A
Other languages
English (en)
French (fr)
Other versions
FR2552427A1 (fr
Inventor
Angelo Marai
Giuseppe Cerri
Mario Paini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SCHARPER SpA
Original Assignee
SCHARPER SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SCHARPER SpA filed Critical SCHARPER SpA
Publication of FR2552427A1 publication Critical patent/FR2552427A1/fr
Application granted granted Critical
Publication of FR2552427B1 publication Critical patent/FR2552427B1/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR8414820A 1983-09-27 1984-09-27 Nouveau procede de preparation de l'hydroxy-2 (hydroxy-1((methyl-1 phenyl-3 propyl) amino)-2 ethyl)-5 benzamide et compositions therapeutiques a base du compose obtenu selon ce nouveau procede Expired FR2552427B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23005/83A IT1194406B (it) 1983-09-27 1983-09-27 Procedimento per la preparazione di 2-idrossi-5-01-idrossi-2-((4-fenil-2-butil)ammino) etil benzammide

Publications (2)

Publication Number Publication Date
FR2552427A1 FR2552427A1 (fr) 1985-03-29
FR2552427B1 true FR2552427B1 (fr) 1988-03-25

Family

ID=11202777

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8414820A Expired FR2552427B1 (fr) 1983-09-27 1984-09-27 Nouveau procede de preparation de l'hydroxy-2 (hydroxy-1((methyl-1 phenyl-3 propyl) amino)-2 ethyl)-5 benzamide et compositions therapeutiques a base du compose obtenu selon ce nouveau procede

Country Status (7)

Country Link
JP (1) JPS60105651A (Sortimente)
BE (1) BE900663A (Sortimente)
CH (1) CH661923A5 (Sortimente)
DE (1) DE3435349A1 (Sortimente)
FR (1) FR2552427B1 (Sortimente)
GB (1) GB2149399B (Sortimente)
IT (1) IT1194406B (Sortimente)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017098520A1 (en) * 2015-12-09 2017-06-15 prscDAVALURI RAMAMOHAN RAO Process for the preparation of labetalol hydrochloride

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112225674B (zh) * 2020-10-28 2021-12-03 天津大学 盐酸拉贝洛尔晶型化合物及其制备方法和应用
CN117756659A (zh) * 2024-01-19 2024-03-26 重庆圣华曦药业股份有限公司 一种盐酸拉贝洛尔的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1266058A (Sortimente) * 1969-07-08 1972-03-08
JPS4843341A (Sortimente) * 1971-10-02 1973-06-22
ZA794872B (en) * 1978-09-20 1980-11-26 Schering Corp A phenylalkylaminoethylsalicylamide,its preparation and pharmaceutical compositions containing it

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017098520A1 (en) * 2015-12-09 2017-06-15 prscDAVALURI RAMAMOHAN RAO Process for the preparation of labetalol hydrochloride

Also Published As

Publication number Publication date
GB8424100D0 (en) 1984-10-31
DE3435349A1 (de) 1985-04-18
CH661923A5 (it) 1987-08-31
DE3435349C2 (Sortimente) 1989-09-21
GB2149399A (en) 1985-06-12
GB2149399B (en) 1987-05-13
BE900663A (fr) 1985-01-16
JPS60105651A (ja) 1985-06-11
IT1194406B (it) 1988-09-22
FR2552427A1 (fr) 1985-03-29
IT8323005A0 (it) 1983-09-27
IT8323005A1 (it) 1985-03-27

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Legal Events

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TP Transmission of property
ST Notification of lapse